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"file_date": "2019-11-25T16:21:57.217354",
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"bcftools_annotateCommand": "annotate -a /mnt/storage/home/gh13047/mr-eve/vcf-reference-datasets/dbsnp/dbsnp.v153.b37.vcf.gz -c ID -o /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-d-import/processed/ukb-d-5012/ukb-d-5012.vcf.gz -O z /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-d-import/processed/ukb-d-5012/ukb-d-5012_data.vcf.gz; Date=Mon Nov 25 16:54:24 2019",
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}
*********************************************************************
* LD Score Regression (LDSC)
* Version 1.0.1
* (C) 2014-2019 Brendan Bulik-Sullivan and Hilary Finucane
* Broad Institute of MIT and Harvard / MIT Department of Mathematics
* GNU General Public License v3
*********************************************************************
Call:
./ldsc.py \
--h2 /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-d-import/processed/ukb-d-5012/ukb-d-5012.vcf.gz \
--ref-ld-chr /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/ \
--out /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-d-import/processed/ukb-d-5012/ldsc.txt \
--w-ld-chr /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/
Beginning analysis at Mon Nov 25 17:20:28 2019
Reading summary statistics from /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-d-import/processed/ukb-d-5012/ukb-d-5012.vcf.gz ...
Read summary statistics for 13560285 SNPs.
Dropped 12681 SNPs with duplicated rs numbers.
Reading reference panel LD Score from /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/[1-22] ...
Read reference panel LD Scores for 1290028 SNPs.
Removing partitioned LD Scores with zero variance.
Reading regression weight LD Score from /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/[1-22] ...
Read regression weight LD Scores for 1290028 SNPs.
After merging with reference panel LD, 1283500 SNPs remain.
After merging with regression SNP LD, 1283500 SNPs remain.
Using two-step estimator with cutoff at 30.
Total Observed scale h2: 0.1036 (0.0082)
Lambda GC: 1.1379
Mean Chi^2: 1.1575
Intercept: 1.0044 (0.007)
Ratio: 0.0279 (0.0448)
Analysis finished at Mon Nov 25 17:22:43 2019
Total time elapsed: 2.0m:14.52s
{
"af_correlation": 0.9521,
"inflation_factor": 1.0818,
"mean_EFFECT": -0,
"n": 75692,
"n_snps": 13560285,
"n_clumped_hits": 4,
"n_p_sig": 79,
"n_mono": 0,
"n_ns": 1251011,
"n_mac": 0,
"is_snpid_unique": false,
"n_miss_EFFECT": 0,
"n_miss_SE": 0,
"n_miss_PVAL": 0,
"n_miss_AF": 0,
"n_miss_AF_reference": 561141,
"n_est": 76013.8246,
"ratio_se_n": 1.0021,
"mean_diff": -0.0001,
"ratio_diff": 41.3318,
"sd_y_est1": 0.4739,
"sd_y_est2": 0.4749,
"r2_sum1": 0.0004,
"r2_sum2": 0.0018,
"r2_sum3": 0.0018,
"r2_sum4": 0.0018,
"ldsc_nsnp_merge_refpanel_ld": 1283500,
"ldsc_nsnp_merge_regression_ld": 1283500,
"ldsc_observed_scale_h2_beta": 0.1036,
"ldsc_observed_scale_h2_se": 0.0082,
"ldsc_intercept_beta": 1.0044,
"ldsc_intercept_se": 0.007,
"ldsc_lambda_gc": 1.1379,
"ldsc_mean_chisq": 1.1575,
"ldsc_ratio": 0.0279
}
name | value |
---|---|
af_correlation | FALSE |
inflation_factor | FALSE |
n | FALSE |
is_snpid_non_unique | TRUE |
mean_EFFECT_nonfinite | FALSE |
mean_EFFECT_05 | FALSE |
mean_EFFECT_01 | FALSE |
mean_chisq | FALSE |
n_p_sig | FALSE |
miss_EFFECT | FALSE |
miss_SE | FALSE |
miss_PVAL | FALSE |
ldsc_ratio | FALSE |
ldsc_intercept_beta | FALSE |
n_clumped_hits | FALSE |
r2_sum1 | FALSE |
r2_sum2 | FALSE |
r2_sum3 | FALSE |
r2_sum4 | FALSE |
General metrics
af_correlation
: Correlation coefficient between AF
and AF_reference
.inflation_factor
(lambda
): Genomic inflation factor.mean_EFFECT
: Mean of EFFECT
size.n
: Maximum value of reported sample size across all SNPs, \(n\).n_clumped_hits
: Number of clumped hits.n_snps
: Number of SNPsn_p_sig
: Number of SNPs with pvalue below 5e-8
.n_mono
: Number of monomorphic (MAF == 1
or MAF == 0
) SNPs.n_ns
: Number of SNPs with nonsense values:
A, C, G or T
.< 0
or > 1
.<= 0
or = Infinity
).< 0
or > 1
.n_mac
: Number of cases where MAC
(\(2 \times N \times MAF\)) is less than 6
.is_snpid_unique
: true
if the combination of ID
REF
ALT
is unique and therefore no duplication in snpid.n_miss_<*>
: Number of NA
observations for <*>
column.se_n metrics
n_est
: Estimated sample size value, \(\widehat{n}\).ratio_se_n
: \(\texttt{ratio_se_n} = \frac{\sqrt{\widehat{n}}}{\sqrt{n}}\). We expect ratio_se_n
to be 1. When it is not 1, it implies that the trait did not have a variance of 1, the reported sample size is wrong, or that the SNP-level effective sample sizes differ markedly from the reported sample size.mean_diff
: \(\texttt{mean_diff} = \sum_{j} \frac{\widehat{\beta_j^{std}} - \beta_j}{\texttt{n_snps}}\), mean difference between the standardised beta, predicted from P-values, and the observed beta. The difference should be very close to zero if trait has a variance of 1.
ratio_diff
: \(\texttt{ratio_diff} = |\frac{\texttt{mean_diff}}{\texttt{mean_diff2}}|\), absolute ratio between the mean of diff
and the mean of diff2
(expected difference between the standardised beta predicted from P-values, and the standardised beta derived from the observed beta divided by the predicted SD; NOT reported). The ratio should be close to 1. If different from 1, then implies that the betas are not in a standard deviation scale.
sd_y_est1
: The standard deviation for the trait inferred from the reported sample size, median standard errors for the SNP-trait assocations and SNP variances.
sd_y_est2
: The standard deviation for the trait inferred from the reported sample size, Z statistics for the SNP-trait effects (beta/se) and allele frequency.
r2 metrics
Sum of variance explained, calculated from the clumped top hits sample.
r2_sum<*>
: r2
statistics under various assumptions
1
: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var1}}}\), \(\texttt{var1} = 1\).2
: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var2}}}\), \(\texttt{var2} = {\widehat{\texttt{sd1}}_{y}}^2\),3
: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var3}}}\), \(\texttt{var3} = {\widehat{\texttt{sd2}}_{y}}^2\),4
: \(r^2 = \sum_j{\frac{F_j}{F_j + n - 2}}\), \(F = \frac{\beta_j^2}{{se}_j^2}\).LDSC metrics
Metrics from LD regression
ldsc_nsnp_merge_refpanel_ld
: Number of remaining SNPs after merging with reference panel LD.ldsc_nsnp_merge_regression_ld
: Number of remaining SNPs after merging with regression SNP LD.ldsc_observed_scale_h2_{beta,se}
Coefficient value and SE for total observed scale h2.ldsc_intercept_{beta,se}
: Coefficient value and SE for intercept. Intercept is expected to be 1.ldsc_lambda_gc
: Lambda GC statistics.ldsc_mean_chisq
: Mean \(\chi^2\) statistics.ldsc_ratio
: \(\frac{\texttt{ldsc_intercept_beta} - 1}{\texttt{ldsc_mean_chisq} - 1}\), the proportion of the inflation in the mean \(\chi^2\) that the LD Score regression intercepts ascribes to causes other than polygenic heritability. The value of ratio should be close to zero, though in practice values of 0.1-0.2 are not uncommon, probably due to sample/reference LD Score mismatch or model misspecification (e.g., low LD variants have slightly higher \(h^2\) per SNP).Flags
When a metric needs attention, the flag should return TRUE.
af_correlation
: abs(af_correlation)
< 0.7.inflation_factor
: inflation_factor
> 1.2.n
: n
(max reported sample size) < 10000.is_snpid_non_unique
: NOT is_snpid_unique
.mean_EFFECT_nonfinite
: mean(EFFECT)
is NA
, NaN
, or Inf
.mean_EFFECT_05
: abs(mean(EFFECT))
> 0.5.mean_EFFECT_01
: abs(mean(EFFECT))
> 0.1.mean_chisq
: ldsc_mean_chisq
> 1.3 or ldsc_mean_chisq
< 0.7.n_p_sig
: n_p_sig
> 1000.miss_<*>
: n_miss_<*>
/ n_snps
> 0.01.ldsc_ratio
: ldsc_ratio
> 0.5ldsc_intercept_beta
: ldsc_intercept_beta
> 1.5n_clumped_hits
: n_clumped_hits
> 1000r2_sum<*>
: r2_sum<*>
> 0.5Plots
skim_type | skim_variable | n_missing | complete_rate | character.min | character.max | character.empty | character.n_unique | character.whitespace | numeric.mean | numeric.sd | numeric.p0 | numeric.p25 | numeric.p50 | numeric.p75 | numeric.p100 | numeric.hist |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
character | ID | 0 | 1.0000000 | 3 | 94 | 0 | 13548267 | 0 | NA | NA | NA | NA | NA | NA | NA | NA |
character | REF | 0 | 1.0000000 | 1 | 100 | 0 | 57042 | 0 | NA | NA | NA | NA | NA | NA | NA | NA |
character | ALT | 0 | 1.0000000 | 1 | 342 | 0 | 33328 | 0 | NA | NA | NA | NA | NA | NA | NA | NA |
numeric | CHROM | 0 | 1.0000000 | NA | NA | NA | NA | NA | 9.051635e+00 | 6.184905e+00 | 1.000000 | 4.000000e+00 | 8.000000e+00 | 1.300000e+01 | 2.300000e+01 | ▇▅▅▂▂ |
numeric | POS | 0 | 1.0000000 | NA | NA | NA | NA | NA | 7.902396e+07 | 5.591667e+07 | 302.000000 | 3.292773e+07 | 7.013545e+07 | 1.148551e+08 | 2.492309e+08 | ▇▆▅▂▁ |
numeric | EFFECT | 0 | 1.0000000 | NA | NA | NA | NA | NA | -4.770000e-05 | 1.425130e-02 | -0.174012 | -3.951500e-03 | -9.300000e-06 | 3.914000e-03 | 1.609700e-01 | ▁▁▇▁▁ |
numeric | SE | 0 | 1.0000000 | NA | NA | NA | NA | NA | 1.018100e-02 | 9.807600e-03 | 0.002002 | 2.911700e-03 | 5.351600e-03 | 1.461530e-02 | 4.973850e-02 | ▇▂▁▁▁ |
numeric | PVAL | 0 | 1.0000000 | NA | NA | NA | NA | NA | 4.871489e-01 | 2.926428e-01 | 0.000000 | 2.302778e-01 | 4.829676e-01 | 7.408256e-01 | 1.000000e+00 | ▇▇▇▇▇ |
numeric | PVAL_ztest | 0 | 1.0000000 | NA | NA | NA | NA | NA | 4.871468e-01 | 2.926441e-01 | 0.000000 | 2.302739e-01 | 4.829652e-01 | 7.408249e-01 | 9.999999e-01 | ▇▇▇▇▇ |
numeric | AF | 0 | 1.0000000 | NA | NA | NA | NA | NA | 1.911583e-01 | 2.544857e-01 | 0.001000 | 7.530600e-03 | 6.041590e-02 | 2.959770e-01 | 9.990000e-01 | ▇▂▁▁▁ |
numeric | AF_reference | 561141 | 0.9586188 | NA | NA | NA | NA | NA | 1.965855e-01 | 2.471594e-01 | 0.000000 | 5.790700e-03 | 8.466450e-02 | 3.085060e-01 | 1.000000e+00 | ▇▂▁▁▁ |
numeric | N | 0 | 1.0000000 | NA | NA | NA | NA | NA | 7.569200e+04 | 0.000000e+00 | 75692.000000 | 7.569200e+04 | 7.569200e+04 | 7.569200e+04 | 7.569200e+04 | ▁▁▇▁▁ |
CHROM | POS | ID | REF | ALT | EFFECT | SE | PVAL | PVAL_ztest | AF | AF_reference | N |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | 692794 | rs530212009 | CA | C | -0.0022908 | 0.0042518 | 0.5900407 | 0.5900394 | 0.1123220 | 0.1894970 | 75692 |
1 | 693731 | rs12238997 | A | G | -0.0022860 | 0.0040217 | 0.5697574 | 0.5697561 | 0.1176250 | 0.1417730 | 75692 |
1 | 707522 | rs371890604 | G | C | -0.0024068 | 0.0045155 | 0.5940254 | 0.5940233 | 0.0986233 | 0.1293930 | 75692 |
1 | 717587 | rs144155419 | G | A | 0.0044302 | 0.0108823 | 0.6839337 | 0.6839315 | 0.0156471 | 0.0045926 | 75692 |
1 | 723329 | rs189787166 | A | T | 0.0111077 | 0.0318330 | 0.7271366 | 0.7271369 | 0.0017292 | 0.0003994 | 75692 |
1 | 730087 | rs148120343 | T | C | -0.0037710 | 0.0055981 | 0.5005552 | 0.5005535 | 0.0573192 | 0.0127796 | 75692 |
1 | 731718 | rs142557973 | T | C | -0.0028162 | 0.0038205 | 0.4610436 | 0.4610417 | 0.1234080 | 0.1543530 | 75692 |
1 | 732032 | rs61770163 | A | C | -0.0026629 | 0.0040696 | 0.5128921 | 0.5128895 | 0.1227430 | 0.1555510 | 75692 |
1 | 734349 | rs141242758 | T | C | -0.0029600 | 0.0038233 | 0.4388064 | 0.4388029 | 0.1225940 | 0.1525560 | 75692 |
1 | 740284 | rs61770167 | C | T | -0.0117095 | 0.0171197 | 0.4939921 | 0.4939890 | 0.0060204 | 0.0023962 | 75692 |
CHROM | POS | ID | REF | ALT | EFFECT | SE | PVAL | PVAL_ztest | AF | AF_reference | N |
---|---|---|---|---|---|---|---|---|---|---|---|
23 | 154923311 | rs141127553 | C | T | 0.0028547 | 0.0044673 | 0.5228137 | 0.5228121 | 0.0550520 | 0.0309934 | 75692 |
23 | 154923374 | rs111332691 | T | A | -0.0060358 | 0.0048684 | 0.2150552 | 0.2150517 | 0.0445027 | 0.0116556 | 75692 |
23 | 154925045 | rs509981 | C | T | -0.0004440 | 0.0023415 | 0.8496119 | 0.8496119 | 0.2435720 | 0.3634440 | 75692 |
23 | 154925895 | rs538470 | C | T | -0.0006132 | 0.0023934 | 0.7977900 | 0.7977891 | 0.2400870 | 0.3634440 | 75692 |
23 | 154927581 | rs644138 | G | A | 0.0003198 | 0.0022032 | 0.8845930 | 0.8845926 | 0.2990340 | 0.4635760 | 75692 |
23 | 154929412 | rs557132 | C | T | -0.0005002 | 0.0023425 | 0.8309250 | 0.8309249 | 0.2433900 | 0.3568210 | 75692 |
23 | 154929637 | rs35185538 | CT | C | -0.0002479 | 0.0024427 | 0.9191500 | 0.9191500 | 0.2277940 | 0.3011920 | 75692 |
23 | 154929952 | rs4012982 | CAA | C | -0.0001849 | 0.0024638 | 0.9401830 | 0.9401824 | 0.2376030 | 0.3165560 | 75692 |
23 | 154930230 | rs781880 | A | G | -0.0005363 | 0.0023421 | 0.8188970 | 0.8188964 | 0.2438310 | 0.3618540 | 75692 |
23 | 154930487 | rs781879 | T | A | 0.0149259 | 0.0081058 | 0.0655692 | 0.0655665 | 0.0190614 | 0.1263580 | 75692 |
1 692794 rs530212009 CA C . PASS AF=0.112322 ES:SE:LP:AF:SS:ID -0.00229078:0.0042518:0.229118:0.112322:75692:1_692794_CA_C
1 693731 rs12238997 A G . PASS AF=0.117625 ES:SE:LP:AF:SS:ID -0.002286:0.00402174:0.24431:0.117625:75692:rs12238997
1 707522 rs371890604 G C . PASS AF=0.0986233 ES:SE:LP:AF:SS:ID -0.00240685:0.00451554:0.226195:0.0986233:75692:rs371890604
1 717587 rs144155419 G A . PASS AF=0.0156471 ES:SE:LP:AF:SS:ID 0.00443023:0.0108823:0.164986:0.0156471:75692:rs144155419
1 723329 rs189787166 A T . PASS AF=0.00172917 ES:SE:LP:AF:SS:ID 0.0111077:0.031833:0.138384:0.00172917:75692:rs189787166
1 730087 rs148120343 T C . PASS AF=0.0573192 ES:SE:LP:AF:SS:ID -0.00377098:0.00559809:0.300548:0.0573192:75692:rs148120343
1 731718 rs58276399 T C . PASS AF=0.123408 ES:SE:LP:AF:SS:ID -0.00281623:0.00382052:0.336258:0.123408:75692:rs58276399
1 732032 rs61770163 A C . PASS AF=0.122743 ES:SE:LP:AF:SS:ID -0.00266289:0.00406955:0.289974:0.122743:75692:rs61770163
1 734349 rs141242758 T C . PASS AF=0.122594 ES:SE:LP:AF:SS:ID -0.00296003:0.00382326:0.357727:0.122594:75692:rs141242758
1 740284 rs61770167 C T . PASS AF=0.0060204 ES:SE:LP:AF:SS:ID -0.0117095:0.0171197:0.30628:0.0060204:75692:rs61770167
1 742813 rs112573343 C T . PASS AF=0.00178375 ES:SE:LP:AF:SS:ID 0.0221226:0.0345825:0.282025:0.00178375:75692:rs112573343
1 749963 rs529266287 T TAA . PASS AF=0.868143 ES:SE:LP:AF:SS:ID 0.00355743:0.00377183:0.461423:0.868143:75692:rs529266287
1 750230 rs190826124 G C . PASS AF=0.00161654 ES:SE:LP:AF:SS:ID -0.0353787:0.0330865:0.545236:0.00161654:75692:rs190826124
1 751343 rs28544273 T A . PASS AF=0.12446 ES:SE:LP:AF:SS:ID -0.00386841:0.00373463:0.522462:0.12446:75692:rs28544273
1 751488 rs200141114 G GA . PASS AF=0.144111 ES:SE:LP:AF:SS:ID -0.00394747:0.00369948:0.543696:0.144111:75692:rs200141114
1 751756 rs28527770 T C . PASS AF=0.124607 ES:SE:LP:AF:SS:ID -0.0039011:0.00372871:0.529504:0.124607:75692:rs28527770
1 753405 rs3115860 C A . PASS AF=0.869209 ES:SE:LP:AF:SS:ID 0.00369148:0.00363255:0.509303:0.869209:75692:rs3115860
1 753425 rs3131970 T C . PASS AF=0.873939 ES:SE:LP:AF:SS:ID 0.0041707:0.00369266:0.587188:0.873939:75692:rs3131970
1 753541 rs2073813 G A . PASS AF=0.130444 ES:SE:LP:AF:SS:ID -0.00336286:0.00363997:0.44909:0.130444:75692:rs2073813
1 754105 rs12184325 C T . PASS AF=0.0368599 ES:SE:LP:AF:SS:ID -0.0102758:0.00656701:0.929441:0.0368599:75692:rs12184325
1 754182 rs3131969 A G . PASS AF=0.868773 ES:SE:LP:AF:SS:ID 0.00353683:0.00362847:0.481893:0.868773:75692:rs3131969
1 754192 rs3131968 A G . PASS AF=0.868908 ES:SE:LP:AF:SS:ID 0.00343028:0.00363058:0.462497:0.868908:75692:rs3131968
1 754334 rs3131967 T C . PASS AF=0.868773 ES:SE:LP:AF:SS:ID 0.00358265:0.0036283:0.490205:0.868773:75692:rs3131967
1 754433 rs150578204 G A . PASS AF=0.00512101 ES:SE:LP:AF:SS:ID -0.0249113:0.0185363:0.7472:0.00512101:75692:rs150578204
1 754458 rs142682604 G T . PASS AF=0.0050863 ES:SE:LP:AF:SS:ID -0.0255588:0.0185899:0.771666:0.0050863:75692:rs142682604
1 755435 rs184270342 T G . PASS AF=0.0053082 ES:SE:LP:AF:SS:ID 0.00393689:0.0185823:0.0797645:0.0053082:75692:rs184270342
1 755890 rs3115858 A T . PASS AF=0.868919 ES:SE:LP:AF:SS:ID 0.00354001:0.00362302:0.483426:0.868919:75692:rs3115858
1 756434 rs61768170 G C . PASS AF=0.127628 ES:SE:LP:AF:SS:ID -0.00348389:0.00369734:0.460851:0.127628:75692:rs61768170
1 756604 rs3131962 A G . PASS AF=0.86848 ES:SE:LP:AF:SS:ID 0.00317447:0.00361435:0.42046:0.86848:75692:rs3131962
1 757640 rs3115853 G A . PASS AF=0.867615 ES:SE:LP:AF:SS:ID 0.00313734:0.00360891:0.414914:0.867615:75692:rs3115853
1 757734 rs4951929 C T . PASS AF=0.868642 ES:SE:LP:AF:SS:ID 0.00338282:0.00361747:0.456278:0.868642:75692:rs4951929
1 757936 rs4951862 C A . PASS AF=0.868649 ES:SE:LP:AF:SS:ID 0.00339008:0.00361772:0.457519:0.868649:75692:rs4951862
1 758144 rs3131956 A G . PASS AF=0.868657 ES:SE:LP:AF:SS:ID 0.00337875:0.00361784:0.455495:0.868657:75692:rs3131956
1 758626 rs3131954 C T . PASS AF=0.869075 ES:SE:LP:AF:SS:ID 0.00359805:0.003627:0.493234:0.869075:75692:rs3131954
1 759293 rs10157329 T A . PASS AF=0.100202 ES:SE:LP:AF:SS:ID -0.00252737:0.00420691:0.261221:0.100202:75692:rs10157329
1 759600 rs545998451 AGT A . PASS AF=0.0060957 ES:SE:LP:AF:SS:ID -0.000785704:0.0168672:0.0164427:0.0060957:75692:1_759600_AGT_A
1 759837 rs3115851 T A . PASS AF=0.873067 ES:SE:LP:AF:SS:ID 0.00348242:0.00368159:0.463188:0.873067:75692:rs3115851
1 761732 rs2286139 C T . PASS AF=0.862343 ES:SE:LP:AF:SS:ID 0.00432962:0.00361079:0.637327:0.862343:75692:rs2286139
1 761752 rs1057213 C T . PASS AF=0.867857 ES:SE:LP:AF:SS:ID 0.00320818:0.00364554:0.421536:0.867857:75692:rs1057213
1 762273 rs3115849 G A . PASS AF=0.864642 ES:SE:LP:AF:SS:ID 0.00410084:0.0036449:0.584102:0.864642:75692:rs3115849
1 762485 rs12095200 C A . PASS AF=0.0997611 ES:SE:LP:AF:SS:ID -0.00548046:0.00437043:0.678089:0.0997611:75692:rs12095200
1 762589 rs3115848 G C . PASS AF=0.869955 ES:SE:LP:AF:SS:ID 0.00431001:0.00368685:0.615471:0.869955:75692:rs3115848
1 762592 rs3131950 C G . PASS AF=0.869954 ES:SE:LP:AF:SS:ID 0.00430972:0.00368685:0.615414:0.869954:75692:rs3131950
1 762601 rs3131949 T C . PASS AF=0.869958 ES:SE:LP:AF:SS:ID 0.0043272:0.00368713:0.618775:0.869958:75692:rs3131949
1 762632 rs3131948 T A . PASS AF=0.870303 ES:SE:LP:AF:SS:ID 0.00466047:0.00368908:0.685122:0.870303:75692:rs3131948
1 764191 rs7515915 T G . PASS AF=0.127192 ES:SE:LP:AF:SS:ID -0.00358811:0.00369235:0.47995:0.127192:75692:rs7515915
1 766007 rs61768174 A C . PASS AF=0.106883 ES:SE:LP:AF:SS:ID -0.0029375:0.00400862:0.333778:0.106883:75692:rs61768174
1 766105 rs2519015 T A . PASS AF=0.853559 ES:SE:LP:AF:SS:ID 0.0026537:0.00360928:0.335176:0.853559:75692:rs2519015
1 767393 rs538667473 A C . PASS AF=0.00161685 ES:SE:LP:AF:SS:ID 0.000649009:0.0321843:0.00704418:0.00161685:75692:rs538667473
1 768116 rs376645387 A AGTTTT . PASS AF=0.837428 ES:SE:LP:AF:SS:ID -0.00139953:0.00354993:0.159014:0.837428:75692:rs376645387