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"gwas_harmonisation_command": "--json /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-d-import/processed/ukb-d-41219_7/ukb-d-41219_7_data.json --ref /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/QC/genomes/b37/human_g1k_v37.fasta; 1.1.1",
"file_date": "2019-11-25T15:11:51.596355",
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"bcftools_viewCommand": "view -h /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/ukb-d-41219_7/ukb-d-41219_7.vcf.gz; Date=Sun May 10 13:55:52 2020"
}
*********************************************************************
* LD Score Regression (LDSC)
* Version 1.0.1
* (C) 2014-2019 Brendan Bulik-Sullivan and Hilary Finucane
* Broad Institute of MIT and Harvard / MIT Department of Mathematics
* GNU General Public License v3
*********************************************************************
Call:
./ldsc.py \
--h2 /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-d-import/processed/ukb-d-41219_7/ukb-d-41219_7.vcf.gz \
--ref-ld-chr /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/ \
--out /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-d-import/processed/ukb-d-41219_7/ldsc.txt \
--w-ld-chr /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/
Beginning analysis at Mon Nov 25 16:49:55 2019
Reading summary statistics from /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-d-import/processed/ukb-d-41219_7/ukb-d-41219_7.vcf.gz ...
Read summary statistics for 10619707 SNPs.
Dropped 8542 SNPs with duplicated rs numbers.
Reading reference panel LD Score from /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/[1-22] ...
Read reference panel LD Scores for 1290028 SNPs.
Removing partitioned LD Scores with zero variance.
Reading regression weight LD Score from /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/[1-22] ...
Read regression weight LD Scores for 1290028 SNPs.
After merging with reference panel LD, 1280953 SNPs remain.
After merging with regression SNP LD, 1280953 SNPs remain.
Using two-step estimator with cutoff at 30.
Total Observed scale h2: -0.278 (0.1235)
Lambda GC: 0.9891
Mean Chi^2: 0.9942
Intercept: 1.0126 (0.0061)
Ratio: NA (mean chi^2 < 1)
Analysis finished at Mon Nov 25 16:51:38 2019
Total time elapsed: 1.0m:43.55s
{
"af_correlation": 0.9444,
"inflation_factor": 0.9929,
"mean_EFFECT": -0.0001,
"n": 3345,
"n_snps": 10619707,
"n_clumped_hits": 0,
"n_p_sig": 0,
"n_mono": 0,
"n_ns": 1118166,
"n_mac": 0,
"is_snpid_unique": false,
"n_miss_EFFECT": 0,
"n_miss_SE": 0,
"n_miss_PVAL": 0,
"n_miss_AF": 0,
"n_miss_AF_reference": 210025,
"n_est": 3340.6704,
"ratio_se_n": 0.9994,
"mean_diff": -0.0001,
"ratio_diff": 25.0877,
"sd_y_est1": 0.4999,
"sd_y_est2": 0.4996,
"r2_sum1": 0,
"r2_sum2": 0,
"r2_sum3": 0,
"r2_sum4": 0,
"ldsc_nsnp_merge_refpanel_ld": 1280953,
"ldsc_nsnp_merge_regression_ld": 1280953,
"ldsc_observed_scale_h2_beta": "NA",
"ldsc_observed_scale_h2_se": "NA",
"ldsc_intercept_beta": 1.0126,
"ldsc_intercept_se": 0.0061,
"ldsc_lambda_gc": 0.9891,
"ldsc_mean_chisq": 0.9942,
"ldsc_ratio": -2.1724
}
name | value |
---|---|
af_correlation | FALSE |
inflation_factor | FALSE |
n | TRUE |
is_snpid_non_unique | TRUE |
mean_EFFECT_nonfinite | FALSE |
mean_EFFECT_05 | FALSE |
mean_EFFECT_01 | FALSE |
mean_chisq | FALSE |
n_p_sig | FALSE |
miss_EFFECT | FALSE |
miss_SE | FALSE |
miss_PVAL | FALSE |
ldsc_ratio | FALSE |
ldsc_intercept_beta | FALSE |
n_clumped_hits | FALSE |
r2_sum1 | FALSE |
r2_sum2 | FALSE |
r2_sum3 | FALSE |
r2_sum4 | FALSE |
General metrics
af_correlation
: Correlation coefficient between AF
and AF_reference
.inflation_factor
(lambda
): Genomic inflation factor.mean_EFFECT
: Mean of EFFECT
size.n
: Maximum value of reported sample size across all SNPs, \(n\).n_clumped_hits
: Number of clumped hits.n_snps
: Number of SNPsn_p_sig
: Number of SNPs with pvalue below 5e-8
.n_mono
: Number of monomorphic (MAF == 1
or MAF == 0
) SNPs.n_ns
: Number of SNPs with nonsense values:
A, C, G or T
.< 0
or > 1
.<= 0
or = Infinity
).< 0
or > 1
.n_mac
: Number of cases where MAC
(\(2 \times N \times MAF\)) is less than 6
.is_snpid_unique
: true
if the combination of ID
REF
ALT
is unique and therefore no duplication in snpid.n_miss_<*>
: Number of NA
observations for <*>
column.se_n metrics
n_est
: Estimated sample size value, \(\widehat{n}\).ratio_se_n
: \(\texttt{ratio_se_n} = \frac{\sqrt{\widehat{n}}}{\sqrt{n}}\). We expect ratio_se_n
to be 1. When it is not 1, it implies that the trait did not have a variance of 1, the reported sample size is wrong, or that the SNP-level effective sample sizes differ markedly from the reported sample size.mean_diff
: \(\texttt{mean_diff} = \sum_{j} \frac{\widehat{\beta_j^{std}} - \beta_j}{\texttt{n_snps}}\), mean difference between the standardised beta, predicted from P-values, and the observed beta. The difference should be very close to zero if trait has a variance of 1.
ratio_diff
: \(\texttt{ratio_diff} = |\frac{\texttt{mean_diff}}{\texttt{mean_diff2}}|\), absolute ratio between the mean of diff
and the mean of diff2
(expected difference between the standardised beta predicted from P-values, and the standardised beta derived from the observed beta divided by the predicted SD; NOT reported). The ratio should be close to 1. If different from 1, then implies that the betas are not in a standard deviation scale.
sd_y_est1
: The standard deviation for the trait inferred from the reported sample size, median standard errors for the SNP-trait assocations and SNP variances.
sd_y_est2
: The standard deviation for the trait inferred from the reported sample size, Z statistics for the SNP-trait effects (beta/se) and allele frequency.
r2 metrics
Sum of variance explained, calculated from the clumped top hits sample.
r2_sum<*>
: r2
statistics under various assumptions
1
: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var1}}}\), \(\texttt{var1} = 1\).2
: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var2}}}\), \(\texttt{var2} = {\widehat{\texttt{sd1}}_{y}}^2\),3
: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var3}}}\), \(\texttt{var3} = {\widehat{\texttt{sd2}}_{y}}^2\),4
: \(r^2 = \sum_j{\frac{F_j}{F_j + n - 2}}\), \(F = \frac{\beta_j^2}{{se}_j^2}\).LDSC metrics
Metrics from LD regression
ldsc_nsnp_merge_refpanel_ld
: Number of remaining SNPs after merging with reference panel LD.ldsc_nsnp_merge_regression_ld
: Number of remaining SNPs after merging with regression SNP LD.ldsc_observed_scale_h2_{beta,se}
Coefficient value and SE for total observed scale h2.ldsc_intercept_{beta,se}
: Coefficient value and SE for intercept. Intercept is expected to be 1.ldsc_lambda_gc
: Lambda GC statistics.ldsc_mean_chisq
: Mean \(\chi^2\) statistics.ldsc_ratio
: \(\frac{\texttt{ldsc_intercept_beta} - 1}{\texttt{ldsc_mean_chisq} - 1}\), the proportion of the inflation in the mean \(\chi^2\) that the LD Score regression intercepts ascribes to causes other than polygenic heritability. The value of ratio should be close to zero, though in practice values of 0.1-0.2 are not uncommon, probably due to sample/reference LD Score mismatch or model misspecification (e.g., low LD variants have slightly higher \(h^2\) per SNP).Flags
When a metric needs attention, the flag should return TRUE.
af_correlation
: abs(af_correlation)
< 0.7.inflation_factor
: inflation_factor
> 1.2.n
: n
(max reported sample size) < 10000.is_snpid_non_unique
: NOT is_snpid_unique
.mean_EFFECT_nonfinite
: mean(EFFECT)
is NA
, NaN
, or Inf
.mean_EFFECT_05
: abs(mean(EFFECT))
> 0.5.mean_EFFECT_01
: abs(mean(EFFECT))
> 0.1.mean_chisq
: ldsc_mean_chisq
> 1.3 or ldsc_mean_chisq
< 0.7.n_p_sig
: n_p_sig
> 1000.miss_<*>
: n_miss_<*>
/ n_snps
> 0.01.ldsc_ratio
: ldsc_ratio
> 0.5ldsc_intercept_beta
: ldsc_intercept_beta
> 1.5n_clumped_hits
: n_clumped_hits
> 1000r2_sum<*>
: r2_sum<*>
> 0.5Plots
skim_type | skim_variable | n_missing | complete_rate | character.min | character.max | character.empty | character.n_unique | character.whitespace | numeric.mean | numeric.sd | numeric.p0 | numeric.p25 | numeric.p50 | numeric.p75 | numeric.p100 | numeric.hist |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
character | ID | 0 | 1.0000000 | 3 | 94 | 0 | 10611740 | 0 | NA | NA | NA | NA | NA | NA | NA | NA |
character | REF | 0 | 1.0000000 | 1 | 100 | 0 | 50039 | 0 | NA | NA | NA | NA | NA | NA | NA | NA |
character | ALT | 0 | 1.0000000 | 1 | 342 | 0 | 30932 | 0 | NA | NA | NA | NA | NA | NA | NA | NA |
numeric | CHROM | 0 | 1.0000000 | NA | NA | NA | NA | NA | 9.075262e+00 | 6.178795e+00 | 1.0000000 | 4.000000e+00 | 8.000000e+00 | 1.300000e+01 | 2.300000e+01 | ▇▅▅▂▂ |
numeric | POS | 0 | 1.0000000 | NA | NA | NA | NA | NA | 7.880190e+07 | 5.604410e+07 | 302.0000000 | 3.256658e+07 | 6.977522e+07 | 1.147284e+08 | 2.492309e+08 | ▇▆▅▂▁ |
numeric | EFFECT | 0 | 1.0000000 | NA | NA | NA | NA | NA | -8.820000e-05 | 3.420310e-02 | -0.3304530 | -1.441110e-02 | -6.340000e-05 | 1.414060e-02 | 4.022490e-01 | ▁▁▇▁▁ |
numeric | SE | 0 | 1.0000000 | NA | NA | NA | NA | NA | 2.826090e-02 | 1.921380e-02 | 0.0117743 | 1.363580e-02 | 1.937740e-02 | 3.734570e-02 | 1.095460e-01 | ▇▂▁▁▁ |
numeric | PVAL | 0 | 1.0000000 | NA | NA | NA | NA | NA | 5.009596e-01 | 2.885417e-01 | 0.0000005 | 2.513553e-01 | 5.015324e-01 | 7.508393e-01 | 1.000000e+00 | ▇▇▇▇▇ |
numeric | PVAL_ztest | 0 | 1.0000000 | NA | NA | NA | NA | NA | 5.009117e-01 | 2.885705e-01 | 0.0000004 | 2.512721e-01 | 5.014847e-01 | 7.508203e-01 | 9.999998e-01 | ▇▇▇▇▇ |
numeric | AF | 0 | 1.0000000 | NA | NA | NA | NA | NA | 2.408860e-01 | 2.624541e-01 | 0.0056772 | 2.906830e-02 | 1.296760e-01 | 3.857090e-01 | 9.943220e-01 | ▇▂▂▁▁ |
numeric | AF_reference | 210025 | 0.9802231 | NA | NA | NA | NA | NA | 2.408439e-01 | 2.534348e-01 | 0.0000000 | 2.975240e-02 | 1.465650e-01 | 3.829870e-01 | 1.000000e+00 | ▇▂▂▁▁ |
numeric | N | 0 | 1.0000000 | NA | NA | NA | NA | NA | 3.345000e+03 | 0.000000e+00 | 3345.0000000 | 3.345000e+03 | 3.345000e+03 | 3.345000e+03 | 3.345000e+03 | ▁▁▇▁▁ |
CHROM | POS | ID | REF | ALT | EFFECT | SE | PVAL | PVAL_ztest | AF | AF_reference | N |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | 692794 | rs530212009 | CA | C | -0.0000094 | 0.0211817 | 0.9996450 | 0.9996445 | 0.1124020 | 0.1894970 | 3345 |
1 | 693731 | rs12238997 | A | G | -0.0044852 | 0.0200971 | 0.8234111 | 0.8233978 | 0.1170260 | 0.1417730 | 3345 |
1 | 707522 | rs371890604 | G | C | -0.0015691 | 0.0228134 | 0.9451691 | 0.9451649 | 0.0975873 | 0.1293930 | 3345 |
1 | 717587 | rs144155419 | G | A | 0.0190694 | 0.0523728 | 0.7158005 | 0.7157767 | 0.0168393 | 0.0045926 | 3345 |
1 | 730087 | rs148120343 | T | C | -0.0047368 | 0.0277014 | 0.8642391 | 0.8642283 | 0.0585521 | 0.0127796 | 3345 |
1 | 731718 | rs142557973 | T | C | -0.0044313 | 0.0190733 | 0.8162949 | 0.8162809 | 0.1229470 | 0.1543530 | 3345 |
1 | 732032 | rs61770163 | A | C | 0.0011403 | 0.0203734 | 0.9553689 | 0.9553649 | 0.1228790 | 0.1555510 | 3345 |
1 | 734349 | rs141242758 | T | C | -0.0056959 | 0.0190584 | 0.7650626 | 0.7650434 | 0.1220140 | 0.1525560 | 3345 |
1 | 740284 | rs61770167 | C | T | -0.1114740 | 0.0781906 | 0.1540561 | 0.1539636 | 0.0068302 | 0.0023962 | 3345 |
1 | 749963 | rs529266287 | T | TAA | -0.0096180 | 0.0185818 | 0.6047683 | 0.6047340 | 0.8685380 | 0.7641770 | 3345 |
CHROM | POS | ID | REF | ALT | EFFECT | SE | PVAL | PVAL_ztest | AF | AF_reference | N |
---|---|---|---|---|---|---|---|---|---|---|---|
23 | 154923311 | rs141127553 | C | T | 0.0196558 | 0.0266789 | 0.4613229 | 0.4612716 | 0.0569700 | 0.0309934 | 3345 |
23 | 154923374 | rs111332691 | T | A | -0.0067490 | 0.0289459 | 0.8156541 | 0.8156392 | 0.0457399 | 0.0116556 | 3345 |
23 | 154925045 | rs509981 | C | T | -0.0058665 | 0.0137185 | 0.6689444 | 0.6689175 | 0.2521760 | 0.3634440 | 3345 |
23 | 154925895 | rs538470 | C | T | -0.0081712 | 0.0140471 | 0.5608065 | 0.5607682 | 0.2482110 | 0.3634440 | 3345 |
23 | 154927581 | rs644138 | G | A | -0.0013481 | 0.0130342 | 0.9176310 | 0.9176246 | 0.3095370 | 0.4635760 | 3345 |
23 | 154929412 | rs557132 | C | T | -0.0062252 | 0.0137196 | 0.6500444 | 0.6500145 | 0.2520330 | 0.3568210 | 3345 |
23 | 154929637 | rs35185538 | CT | C | -0.0135812 | 0.0144510 | 0.3473834 | 0.3473148 | 0.2348110 | 0.3011920 | 3345 |
23 | 154929952 | rs4012982 | CAA | C | -0.0064397 | 0.0144931 | 0.6568346 | 0.6568055 | 0.2454930 | 0.3165560 | 3345 |
23 | 154930230 | rs781880 | A | G | -0.0066589 | 0.0137274 | 0.6276492 | 0.6276174 | 0.2519210 | 0.3618540 | 3345 |
23 | 154930487 | rs781879 | T | A | 0.0161474 | 0.0454251 | 0.7222574 | 0.7222352 | 0.0218471 | 0.1263580 | 3345 |
1 692794 rs530212009 CA C . PASS AF=0.112402 ES:SE:LP:AF:SS:ID -9.43789e-06:0.0211817:0.000154202:0.112402:3345:1_692794_CA_C
1 693731 rs12238997 A G . PASS AF=0.117026 ES:SE:LP:AF:SS:ID -0.00448521:0.0200971:0.0843833:0.117026:3345:rs12238997
1 707522 rs371890604 G C . PASS AF=0.0975873 ES:SE:LP:AF:SS:ID -0.0015691:0.0228134:0.0244905:0.0975873:3345:rs371890604
1 717587 rs144155419 G A . PASS AF=0.0168393 ES:SE:LP:AF:SS:ID 0.0190694:0.0523728:0.145208:0.0168393:3345:rs144155419
1 730087 rs148120343 T C . PASS AF=0.0585521 ES:SE:LP:AF:SS:ID -0.00473678:0.0277014:0.0633661:0.0585521:3345:rs148120343
1 731718 rs58276399 T C . PASS AF=0.122947 ES:SE:LP:AF:SS:ID -0.00443132:0.0190733:0.0881529:0.122947:3345:rs58276399
1 732032 rs61770163 A C . PASS AF=0.122879 ES:SE:LP:AF:SS:ID 0.00114032:0.0203734:0.0198289:0.122879:3345:rs61770163
1 734349 rs141242758 T C . PASS AF=0.122014 ES:SE:LP:AF:SS:ID -0.00569588:0.0190584:0.116303:0.122014:3345:rs141242758
1 740284 rs61770167 C T . PASS AF=0.00683021 ES:SE:LP:AF:SS:ID -0.111474:0.0781906:0.812321:0.00683021:3345:rs61770167
1 749963 rs529266287 T TAA . PASS AF=0.868538 ES:SE:LP:AF:SS:ID -0.00961803:0.0185818:0.218411:0.868538:3345:rs529266287
1 751343 rs28544273 T A . PASS AF=0.124236 ES:SE:LP:AF:SS:ID 0.0109155:0.0185048:0.25546:0.124236:3345:rs28544273
1 751488 rs200141114 G GA . PASS AF=0.141999 ES:SE:LP:AF:SS:ID 0.0153375:0.0185109:0.389967:0.141999:3345:rs200141114
1 751756 rs28527770 T C . PASS AF=0.124292 ES:SE:LP:AF:SS:ID 0.0107719:0.0184882:0.251675:0.124292:3345:rs28527770
1 753405 rs3115860 C A . PASS AF=0.869637 ES:SE:LP:AF:SS:ID -0.00877786:0.018013:0.203376:0.869637:3345:rs3115860
1 753425 rs3131970 T C . PASS AF=0.873655 ES:SE:LP:AF:SS:ID -0.00693551:0.0182831:0.152144:0.873655:3345:rs3131970
1 753541 rs2073813 G A . PASS AF=0.129651 ES:SE:LP:AF:SS:ID 0.0110828:0.0180886:0.267509:0.129651:3345:rs2073813
1 754105 rs12184325 C T . PASS AF=0.0415546 ES:SE:LP:AF:SS:ID -0.0405085:0.0310417:0.716712:0.0415546:3345:rs12184325
1 754182 rs3131969 A G . PASS AF=0.869262 ES:SE:LP:AF:SS:ID -0.00896972:0.0179898:0.208945:0.869262:3345:rs3131969
1 754192 rs3131968 A G . PASS AF=0.869262 ES:SE:LP:AF:SS:ID -0.00895992:0.0179888:0.208689:0.869262:3345:rs3131968
1 754334 rs3131967 T C . PASS AF=0.869256 ES:SE:LP:AF:SS:ID -0.00897496:0.017988:0.209115:0.869256:3345:rs3131967
1 755435 rs184270342 T G . PASS AF=0.00620651 ES:SE:LP:AF:SS:ID 0.0585031:0.0846623:0.310156:0.00620651:3345:rs184270342
1 755890 rs3115858 A T . PASS AF=0.868938 ES:SE:LP:AF:SS:ID -0.0072767:0.0179461:0.164212:0.868938:3345:rs3115858
1 756434 rs61768170 G C . PASS AF=0.126814 ES:SE:LP:AF:SS:ID 0.00946167:0.0183794:0.217005:0.126814:3345:rs61768170
1 756604 rs3131962 A G . PASS AF=0.868759 ES:SE:LP:AF:SS:ID -0.00685118:0.0179129:0.153579:0.868759:3345:rs3131962
1 757640 rs3115853 G A . PASS AF=0.867793 ES:SE:LP:AF:SS:ID -0.00745817:0.0178913:0.169535:0.867793:3345:rs3115853
1 757734 rs4951929 C T . PASS AF=0.868643 ES:SE:LP:AF:SS:ID -0.00756948:0.0179172:0.172172:0.868643:3345:rs4951929
1 757936 rs4951862 C A . PASS AF=0.868646 ES:SE:LP:AF:SS:ID -0.00758383:0.0179184:0.172537:0.868646:3345:rs4951862
1 758144 rs3131956 A G . PASS AF=0.868658 ES:SE:LP:AF:SS:ID -0.00755202:0.0179196:0.171686:0.868658:3345:rs3131956
1 758626 rs3131954 C T . PASS AF=0.869132 ES:SE:LP:AF:SS:ID -0.00818497:0.0179641:0.187965:0.869132:3345:rs3131954
1 759293 rs10157329 T A . PASS AF=0.0979091 ES:SE:LP:AF:SS:ID 0.00762144:0.0213224:0.142194:0.0979091:3345:rs10157329
1 759600 rs545998451 AGT A . PASS AF=0.00693338 ES:SE:LP:AF:SS:ID 0.081465:0.0785782:0.522976:0.00693338:3345:1_759600_AGT_A
1 759837 rs3115851 T A . PASS AF=0.873294 ES:SE:LP:AF:SS:ID -0.00804113:0.0182696:0.180544:0.873294:3345:rs3115851
1 761732 rs2286139 C T . PASS AF=0.862376 ES:SE:LP:AF:SS:ID -0.00526433:0.0179179:0.114115:0.862376:3345:rs2286139
1 761752 rs1057213 C T . PASS AF=0.868107 ES:SE:LP:AF:SS:ID -0.00759693:0.0180864:0.171026:0.868107:3345:rs1057213
1 762273 rs3115849 G A . PASS AF=0.865048 ES:SE:LP:AF:SS:ID -0.008063:0.0181179:0.182879:0.865048:3345:rs3115849
1 762485 rs12095200 C A . PASS AF=0.100185 ES:SE:LP:AF:SS:ID 0.00818196:0.0215864:0.152004:0.100185:3345:rs12095200
1 762589 rs3115848 G C . PASS AF=0.870606 ES:SE:LP:AF:SS:ID -0.00931051:0.0183448:0.213378:0.870606:3345:rs3115848
1 762592 rs3131950 C G . PASS AF=0.870606 ES:SE:LP:AF:SS:ID -0.00931367:0.0183448:0.213464:0.870606:3345:rs3131950
1 762601 rs3131949 T C . PASS AF=0.870601 ES:SE:LP:AF:SS:ID -0.00929991:0.0183448:0.21309:0.870601:3345:rs3131949
1 762632 rs3131948 T A . PASS AF=0.870733 ES:SE:LP:AF:SS:ID -0.00885863:0.0183433:0.201229:0.870733:3345:rs3131948
1 764191 rs7515915 T G . PASS AF=0.126593 ES:SE:LP:AF:SS:ID 0.0100971:0.0183569:0.234833:0.126593:3345:rs7515915
1 766007 rs61768174 A C . PASS AF=0.10536 ES:SE:LP:AF:SS:ID 0.00423568:0.0200726:0.0794144:0.10536:3345:rs61768174
1 766105 rs2519015 T A . PASS AF=0.853371 ES:SE:LP:AF:SS:ID -0.00948717:0.017799:0.226172:0.853371:3345:rs2519015
1 768116 rs376645387 A AGTTTT . PASS AF=0.833954 ES:SE:LP:AF:SS:ID -0.0163761:0.0175741:0.454082:0.833954:3345:rs376645387
1 768253 rs2977608 A C . PASS AF=0.760547 ES:SE:LP:AF:SS:ID -0.0124511:0.0141848:0.420068:0.760547:3345:rs2977608
1 768448 rs12562034 G A . PASS AF=0.107623 ES:SE:LP:AF:SS:ID 0.0150179:0.0194904:0.35552:0.107623:3345:rs12562034
1 768819 rs12562811 C T . PASS AF=0.00814913 ES:SE:LP:AF:SS:ID 0.0102993:0.0712347:0.0530327:0.00814913:3345:rs12562811
1 769138 rs59306077 CAT C . PASS AF=0.130185 ES:SE:LP:AF:SS:ID 0.0103644:0.0180718:0.246924:0.130185:3345:rs762168062
1 769223 rs60320384 C G . PASS AF=0.1298 ES:SE:LP:AF:SS:ID 0.00933558:0.0180582:0.218094:0.1298:3345:rs60320384
1 769963 rs7518545 G A . PASS AF=0.10685 ES:SE:LP:AF:SS:ID 0.0132972:0.0196516:0.302181:0.10685:3345:rs7518545