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"bcftools_annotateCommand": "annotate -a /mnt/storage/home/gh13047/mr-eve/vcf-reference-datasets/dbsnp/dbsnp.v153.b37.vcf.gz -c ID -o /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-d-import/processed/ukb-d-30750_irnt/ukb-d-30750_irnt.vcf.gz -O z /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-d-import/processed/ukb-d-30750_irnt/ukb-d-30750_irnt_data.vcf.gz; Date=Mon Nov 25 14:10:16 2019",
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}
*********************************************************************
* LD Score Regression (LDSC)
* Version 1.0.1
* (C) 2014-2019 Brendan Bulik-Sullivan and Hilary Finucane
* Broad Institute of MIT and Harvard / MIT Department of Mathematics
* GNU General Public License v3
*********************************************************************
Call:
./ldsc.py \
--h2 /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-d-import/processed/ukb-d-30750_irnt/ukb-d-30750_irnt.vcf.gz \
--ref-ld-chr /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/ \
--out /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-d-import/processed/ukb-d-30750_irnt/ldsc.txt \
--w-ld-chr /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/
Beginning analysis at Mon Nov 25 14:54:10 2019
Reading summary statistics from /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-d-import/processed/ukb-d-30750_irnt/ukb-d-30750_irnt.vcf.gz ...
Read summary statistics for 13586179 SNPs.
Dropped 12713 SNPs with duplicated rs numbers.
Reading reference panel LD Score from /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/[1-22] ...
Read reference panel LD Scores for 1290028 SNPs.
Removing partitioned LD Scores with zero variance.
Reading regression weight LD Score from /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/[1-22] ...
Read regression weight LD Scores for 1290028 SNPs.
After merging with reference panel LD, 1283504 SNPs remain.
After merging with regression SNP LD, 1283504 SNPs remain.
Using two-step estimator with cutoff at 30.
Total Observed scale h2: 0.1876 (0.0161)
Lambda GC: 1.6219
Mean Chi^2: 2.4938
Intercept: 1.1777 (0.0198)
Ratio: 0.119 (0.0132)
Analysis finished at Mon Nov 25 14:57:05 2019
Total time elapsed: 2.0m:54.97s
{
"af_correlation": 0.9521,
"inflation_factor": 1.3963,
"mean_EFFECT": 0.0001,
"n": 344182,
"n_snps": 13586179,
"n_clumped_hits": 321,
"n_p_sig": 79337,
"n_mono": 0,
"n_ns": 1251783,
"n_mac": 0,
"is_snpid_unique": false,
"n_miss_EFFECT": 0,
"n_miss_SE": 0,
"n_miss_PVAL": 0,
"n_miss_AF": 0,
"n_miss_AF_reference": 569193,
"n_est": 345493.1417,
"ratio_se_n": 1.0019,
"mean_diff": 4.6196e-06,
"ratio_diff": 12.1874,
"sd_y_est1": 0.957,
"sd_y_est2": 0.9589,
"r2_sum1": 0.1008,
"r2_sum2": 0.11,
"r2_sum3": 0.1096,
"r2_sum4": 0.1093,
"ldsc_nsnp_merge_refpanel_ld": 1283504,
"ldsc_nsnp_merge_regression_ld": 1283504,
"ldsc_observed_scale_h2_beta": 0.1876,
"ldsc_observed_scale_h2_se": 0.0161,
"ldsc_intercept_beta": 1.1777,
"ldsc_intercept_se": 0.0198,
"ldsc_lambda_gc": 1.6219,
"ldsc_mean_chisq": 2.4938,
"ldsc_ratio": 0.119
}
name | value |
---|---|
af_correlation | FALSE |
inflation_factor | TRUE |
n | FALSE |
is_snpid_non_unique | TRUE |
mean_EFFECT_nonfinite | FALSE |
mean_EFFECT_05 | FALSE |
mean_EFFECT_01 | FALSE |
mean_chisq | TRUE |
n_p_sig | TRUE |
miss_EFFECT | FALSE |
miss_SE | FALSE |
miss_PVAL | FALSE |
ldsc_ratio | FALSE |
ldsc_intercept_beta | FALSE |
n_clumped_hits | FALSE |
r2_sum1 | FALSE |
r2_sum2 | FALSE |
r2_sum3 | FALSE |
r2_sum4 | FALSE |
General metrics
af_correlation
: Correlation coefficient between AF
and AF_reference
.inflation_factor
(lambda
): Genomic inflation factor.mean_EFFECT
: Mean of EFFECT
size.n
: Maximum value of reported sample size across all SNPs, \(n\).n_clumped_hits
: Number of clumped hits.n_snps
: Number of SNPsn_p_sig
: Number of SNPs with pvalue below 5e-8
.n_mono
: Number of monomorphic (MAF == 1
or MAF == 0
) SNPs.n_ns
: Number of SNPs with nonsense values:
A, C, G or T
.< 0
or > 1
.<= 0
or = Infinity
).< 0
or > 1
.n_mac
: Number of cases where MAC
(\(2 \times N \times MAF\)) is less than 6
.is_snpid_unique
: true
if the combination of ID
REF
ALT
is unique and therefore no duplication in snpid.n_miss_<*>
: Number of NA
observations for <*>
column.se_n metrics
n_est
: Estimated sample size value, \(\widehat{n}\).ratio_se_n
: \(\texttt{ratio_se_n} = \frac{\sqrt{\widehat{n}}}{\sqrt{n}}\). We expect ratio_se_n
to be 1. When it is not 1, it implies that the trait did not have a variance of 1, the reported sample size is wrong, or that the SNP-level effective sample sizes differ markedly from the reported sample size.mean_diff
: \(\texttt{mean_diff} = \sum_{j} \frac{\widehat{\beta_j^{std}} - \beta_j}{\texttt{n_snps}}\), mean difference between the standardised beta, predicted from P-values, and the observed beta. The difference should be very close to zero if trait has a variance of 1.
ratio_diff
: \(\texttt{ratio_diff} = |\frac{\texttt{mean_diff}}{\texttt{mean_diff2}}|\), absolute ratio between the mean of diff
and the mean of diff2
(expected difference between the standardised beta predicted from P-values, and the standardised beta derived from the observed beta divided by the predicted SD; NOT reported). The ratio should be close to 1. If different from 1, then implies that the betas are not in a standard deviation scale.
sd_y_est1
: The standard deviation for the trait inferred from the reported sample size, median standard errors for the SNP-trait assocations and SNP variances.
sd_y_est2
: The standard deviation for the trait inferred from the reported sample size, Z statistics for the SNP-trait effects (beta/se) and allele frequency.
r2 metrics
Sum of variance explained, calculated from the clumped top hits sample.
r2_sum<*>
: r2
statistics under various assumptions
1
: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var1}}}\), \(\texttt{var1} = 1\).2
: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var2}}}\), \(\texttt{var2} = {\widehat{\texttt{sd1}}_{y}}^2\),3
: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var3}}}\), \(\texttt{var3} = {\widehat{\texttt{sd2}}_{y}}^2\),4
: \(r^2 = \sum_j{\frac{F_j}{F_j + n - 2}}\), \(F = \frac{\beta_j^2}{{se}_j^2}\).LDSC metrics
Metrics from LD regression
ldsc_nsnp_merge_refpanel_ld
: Number of remaining SNPs after merging with reference panel LD.ldsc_nsnp_merge_regression_ld
: Number of remaining SNPs after merging with regression SNP LD.ldsc_observed_scale_h2_{beta,se}
Coefficient value and SE for total observed scale h2.ldsc_intercept_{beta,se}
: Coefficient value and SE for intercept. Intercept is expected to be 1.ldsc_lambda_gc
: Lambda GC statistics.ldsc_mean_chisq
: Mean \(\chi^2\) statistics.ldsc_ratio
: \(\frac{\texttt{ldsc_intercept_beta} - 1}{\texttt{ldsc_mean_chisq} - 1}\), the proportion of the inflation in the mean \(\chi^2\) that the LD Score regression intercepts ascribes to causes other than polygenic heritability. The value of ratio should be close to zero, though in practice values of 0.1-0.2 are not uncommon, probably due to sample/reference LD Score mismatch or model misspecification (e.g., low LD variants have slightly higher \(h^2\) per SNP).Flags
When a metric needs attention, the flag should return TRUE.
af_correlation
: abs(af_correlation)
< 0.7.inflation_factor
: inflation_factor
> 1.2.n
: n
(max reported sample size) < 10000.is_snpid_non_unique
: NOT is_snpid_unique
.mean_EFFECT_nonfinite
: mean(EFFECT)
is NA
, NaN
, or Inf
.mean_EFFECT_05
: abs(mean(EFFECT))
> 0.5.mean_EFFECT_01
: abs(mean(EFFECT))
> 0.1.mean_chisq
: ldsc_mean_chisq
> 1.3 or ldsc_mean_chisq
< 0.7.n_p_sig
: n_p_sig
> 1000.miss_<*>
: n_miss_<*>
/ n_snps
> 0.01.ldsc_ratio
: ldsc_ratio
> 0.5ldsc_intercept_beta
: ldsc_intercept_beta
> 1.5n_clumped_hits
: n_clumped_hits
> 1000r2_sum<*>
: r2_sum<*>
> 0.5Plots
skim_type | skim_variable | n_missing | complete_rate | character.min | character.max | character.empty | character.n_unique | character.whitespace | numeric.mean | numeric.sd | numeric.p0 | numeric.p25 | numeric.p50 | numeric.p75 | numeric.p100 | numeric.hist |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
character | ID | 0 | 1.000000 | 3 | 94 | 0 | 13574130 | 0 | NA | NA | NA | NA | NA | NA | NA | NA |
character | REF | 0 | 1.000000 | 1 | 100 | 0 | 57081 | 0 | NA | NA | NA | NA | NA | NA | NA | NA |
character | ALT | 0 | 1.000000 | 1 | 342 | 0 | 33337 | 0 | NA | NA | NA | NA | NA | NA | NA | NA |
numeric | CHROM | 0 | 1.000000 | NA | NA | NA | NA | NA | 9.051361e+00 | 6.184991e+00 | 1.00000e+00 | 4.000000e+00 | 8.000000e+00 | 1.300000e+01 | 2.300000e+01 | ▇▅▅▂▂ |
numeric | POS | 0 | 1.000000 | NA | NA | NA | NA | NA | 7.902488e+07 | 5.591481e+07 | 3.02000e+02 | 3.293102e+07 | 7.013812e+07 | 1.148586e+08 | 2.492309e+08 | ▇▆▅▂▁ |
numeric | EFFECT | 0 | 1.000000 | NA | NA | NA | NA | NA | 1.165000e-04 | 1.449310e-02 | -5.49810e-01 | -4.386000e-03 | 3.480000e-05 | 4.506500e-03 | 2.099900e-01 | ▁▁▁▇▁ |
numeric | SE | 0 | 1.000000 | NA | NA | NA | NA | NA | 9.693300e-03 | 9.350500e-03 | 1.89640e-03 | 2.759800e-03 | 5.085600e-03 | 1.393000e-02 | 4.731200e-02 | ▇▂▁▁▁ |
numeric | PVAL | 0 | 1.000000 | NA | NA | NA | NA | NA | 4.446068e-01 | 3.047122e-01 | 0.00000e+00 | 1.662501e-01 | 4.254397e-01 | 7.087793e-01 | 1.000000e+00 | ▇▆▅▅▅ |
numeric | PVAL_ztest | 0 | 1.000000 | NA | NA | NA | NA | NA | 4.446063e-01 | 3.047125e-01 | 0.00000e+00 | 1.662480e-01 | 4.254417e-01 | 7.087844e-01 | 9.999999e-01 | ▇▆▅▅▅ |
numeric | AF | 0 | 1.000000 | NA | NA | NA | NA | NA | 1.908070e-01 | 2.544038e-01 | 1.00000e-03 | 7.430800e-03 | 6.004000e-02 | 2.953300e-01 | 9.990000e-01 | ▇▂▁▁▁ |
numeric | AF_reference | 569193 | 0.958105 | NA | NA | NA | NA | NA | 1.963368e-01 | 2.471017e-01 | 0.00000e+00 | 5.591000e-03 | 8.426520e-02 | 3.081070e-01 | 1.000000e+00 | ▇▂▁▁▁ |
numeric | N | 0 | 1.000000 | NA | NA | NA | NA | NA | 3.441820e+05 | 0.000000e+00 | 3.44182e+05 | 3.441820e+05 | 3.441820e+05 | 3.441820e+05 | 3.441820e+05 | ▁▁▇▁▁ |
CHROM | POS | ID | REF | ALT | EFFECT | SE | PVAL | PVAL_ztest | AF | AF_reference | N |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | 692794 | rs530212009 | CA | C | -0.0089662 | 0.0040430 | 0.0265748 | 0.0265746 | 0.1104400 | 0.1894970 | 344182 |
1 | 693731 | rs12238997 | A | G | -0.0043466 | 0.0038196 | 0.2551197 | 0.2551319 | 0.1156900 | 0.1417730 | 344182 |
1 | 707522 | rs371890604 | G | C | -0.0092753 | 0.0042946 | 0.0307943 | 0.0307913 | 0.0971900 | 0.1293930 | 344182 |
1 | 717587 | rs144155419 | G | A | 0.0169670 | 0.0102480 | 0.0978048 | 0.0977947 | 0.0156590 | 0.0045926 | 344182 |
1 | 723329 | rs189787166 | A | T | -0.0080245 | 0.0303020 | 0.7911503 | 0.7911501 | 0.0017229 | 0.0003994 | 344182 |
1 | 730087 | rs148120343 | T | C | -0.0115290 | 0.0053233 | 0.0303333 | 0.0303294 | 0.0563600 | 0.0127796 | 344182 |
1 | 731718 | rs142557973 | T | C | -0.0050137 | 0.0036221 | 0.1662999 | 0.1662981 | 0.1216100 | 0.1543530 | 344182 |
1 | 732032 | rs61770163 | A | C | -0.0050187 | 0.0038640 | 0.1940001 | 0.1940004 | 0.1210600 | 0.1555510 | 344182 |
1 | 734349 | rs141242758 | T | C | -0.0048791 | 0.0036241 | 0.1782100 | 0.1782081 | 0.1208300 | 0.1525560 | 344182 |
1 | 740284 | rs61770167 | C | T | 0.0001144 | 0.0166280 | 0.9945100 | 0.9945125 | 0.0057445 | 0.0023962 | 344182 |
CHROM | POS | ID | REF | ALT | EFFECT | SE | PVAL | PVAL_ztest | AF | AF_reference | N |
---|---|---|---|---|---|---|---|---|---|---|---|
23 | 154923311 | rs141127553 | C | T | -0.0002950 | 0.0041811 | 0.9437501 | 0.9437457 | 0.056197 | 0.0309934 | 344182 |
23 | 154923374 | rs111332691 | T | A | 0.0055405 | 0.0045913 | 0.2275302 | 0.2275327 | 0.044889 | 0.0116556 | 344182 |
23 | 154925045 | rs509981 | C | T | -0.0059495 | 0.0022119 | 0.0071497 | 0.0071501 | 0.245480 | 0.3634440 | 344182 |
23 | 154925895 | rs538470 | C | T | -0.0063564 | 0.0022627 | 0.0049656 | 0.0049663 | 0.241790 | 0.3634440 | 344182 |
23 | 154927581 | rs644138 | G | A | -0.0052375 | 0.0020800 | 0.0118021 | 0.0118014 | 0.302060 | 0.4635760 | 344182 |
23 | 154929412 | rs557132 | C | T | -0.0058877 | 0.0022126 | 0.0077900 | 0.0077912 | 0.245330 | 0.3568210 | 344182 |
23 | 154929637 | rs35185538 | CT | C | -0.0047916 | 0.0023095 | 0.0380137 | 0.0380111 | 0.229580 | 0.3011920 | 344182 |
23 | 154929952 | rs4012982 | CAA | C | -0.0056622 | 0.0023270 | 0.0149630 | 0.0149635 | 0.239300 | 0.3165560 | 344182 |
23 | 154930230 | rs781880 | A | G | -0.0057878 | 0.0022122 | 0.0088891 | 0.0088886 | 0.245720 | 0.3618540 | 344182 |
23 | 154930487 | rs781879 | T | A | 0.0064524 | 0.0075818 | 0.3947499 | 0.3947482 | 0.019594 | 0.1263580 | 344182 |
1 692794 rs530212009 CA C . PASS AF=0.11044 ES:SE:LP:AF:SS:ID -0.0089662:0.004043:1.57553:0.11044:344182:1_692794_CA_C
1 693731 rs12238997 A G . PASS AF=0.11569 ES:SE:LP:AF:SS:ID -0.0043466:0.0038196:0.593256:0.11569:344182:rs12238997
1 707522 rs371890604 G C . PASS AF=0.09719 ES:SE:LP:AF:SS:ID -0.0092753:0.0042946:1.51153:0.09719:344182:rs371890604
1 717587 rs144155419 G A . PASS AF=0.015659 ES:SE:LP:AF:SS:ID 0.016967:0.010248:1.00964:0.015659:344182:rs144155419
1 723329 rs189787166 A T . PASS AF=0.0017229 ES:SE:LP:AF:SS:ID -0.0080245:0.030302:0.101741:0.0017229:344182:rs189787166
1 730087 rs148120343 T C . PASS AF=0.05636 ES:SE:LP:AF:SS:ID -0.011529:0.0053233:1.51808:0.05636:344182:rs148120343
1 731718 rs58276399 T C . PASS AF=0.12161 ES:SE:LP:AF:SS:ID -0.0050137:0.0036221:0.779108:0.12161:344182:rs58276399
1 732032 rs61770163 A C . PASS AF=0.12106 ES:SE:LP:AF:SS:ID -0.0050187:0.003864:0.712198:0.12106:344182:rs61770163
1 734349 rs141242758 T C . PASS AF=0.12083 ES:SE:LP:AF:SS:ID -0.0048791:0.0036241:0.749068:0.12083:344182:rs141242758
1 740284 rs61770167 C T . PASS AF=0.0057445 ES:SE:LP:AF:SS:ID 0.00011436:0.016628:0.00239085:0.0057445:344182:rs61770167
1 742813 rs112573343 C T . PASS AF=0.001891 ES:SE:LP:AF:SS:ID -0.017654:0.031174:0.243235:0.001891:344182:rs112573343
1 749963 rs529266287 T TAA . PASS AF=0.86988 ES:SE:LP:AF:SS:ID 0.0056644:0.0035728:0.947383:0.86988:344182:rs529266287
1 750230 rs190826124 G C . PASS AF=0.0015301 ES:SE:LP:AF:SS:ID 0.0076243:0.03234:0.089573:0.0015301:344182:rs190826124
1 751343 rs28544273 T A . PASS AF=0.12278 ES:SE:LP:AF:SS:ID -0.0055017:0.0035384:0.920855:0.12278:344182:rs28544273
1 751488 rs200141114 G GA . PASS AF=0.14261 ES:SE:LP:AF:SS:ID -0.0040776:0.0034969:0.613323:0.14261:344182:rs200141114
1 751756 rs28527770 T C . PASS AF=0.12289 ES:SE:LP:AF:SS:ID -0.0054814:0.0035335:0.917789:0.12289:344182:rs28527770
1 753405 rs3115860 C A . PASS AF=0.87101 ES:SE:LP:AF:SS:ID 0.0052477:0.0034426:0.894762:0.87101:344182:rs3115860
1 753425 rs3131970 T C . PASS AF=0.8756 ES:SE:LP:AF:SS:ID 0.0052842:0.0035001:0.882331:0.8756:344182:rs3131970
1 753541 rs2073813 G A . PASS AF=0.1285 ES:SE:LP:AF:SS:ID -0.0052801:0.0034514:0.899457:0.1285:344182:rs2073813
1 754105 rs12184325 C T . PASS AF=0.036395 ES:SE:LP:AF:SS:ID -0.010777:0.0062568:1.07058:0.036395:344182:rs12184325
1 754182 rs3131969 A G . PASS AF=0.8706 ES:SE:LP:AF:SS:ID 0.0053288:0.003439:0.916282:0.8706:344182:rs3131969
1 754192 rs3131968 A G . PASS AF=0.8707 ES:SE:LP:AF:SS:ID 0.005389:0.0034405:0.930813:0.8707:344182:rs3131968
1 754334 rs3131967 T C . PASS AF=0.8706 ES:SE:LP:AF:SS:ID 0.0052897:0.0034389:0.906578:0.8706:344182:rs3131967
1 754433 rs150578204 G A . PASS AF=0.0050345 ES:SE:LP:AF:SS:ID 0.011011:0.017661:0.273281:0.0050345:344182:rs150578204
1 754458 rs142682604 G T . PASS AF=0.0050014 ES:SE:LP:AF:SS:ID 0.010258:0.017709:0.249932:0.0050014:344182:rs142682604
1 755435 rs184270342 T G . PASS AF=0.0056138 ES:SE:LP:AF:SS:ID -0.006274:0.017046:0.147014:0.0056138:344182:rs184270342
1 755890 rs3115858 A T . PASS AF=0.87067 ES:SE:LP:AF:SS:ID 0.0051896:0.0034328:0.88409:0.87067:344182:rs3115858
1 756434 rs61768170 G C . PASS AF=0.12585 ES:SE:LP:AF:SS:ID -0.005077:0.0035032:0.831886:0.12585:344182:rs61768170
1 756604 rs3131962 A G . PASS AF=0.87024 ES:SE:LP:AF:SS:ID 0.0052037:0.0034245:0.890692:0.87024:344182:rs3131962
1 757640 rs3115853 G A . PASS AF=0.86953 ES:SE:LP:AF:SS:ID 0.0049763:0.0034214:0.836183:0.86953:344182:rs3115853
1 757734 rs4951929 C T . PASS AF=0.87039 ES:SE:LP:AF:SS:ID 0.0051675:0.0034274:0.880645:0.87039:344182:rs4951929
1 757936 rs4951862 C A . PASS AF=0.8704 ES:SE:LP:AF:SS:ID 0.0051751:0.0034277:0.882397:0.8704:344182:rs4951862
1 758144 rs3131956 A G . PASS AF=0.8704 ES:SE:LP:AF:SS:ID 0.005181:0.0034278:0.883824:0.8704:344182:rs3131956
1 758626 rs3131954 C T . PASS AF=0.87085 ES:SE:LP:AF:SS:ID 0.0051674:0.0034366:0.877227:0.87085:344182:rs3131954
1 759293 rs10157329 T A . PASS AF=0.098736 ES:SE:LP:AF:SS:ID -0.010092:0.0039945:1.9384:0.098736:344182:rs10157329
1 759600 rs545998451 AGT A . PASS AF=0.0065064 ES:SE:LP:AF:SS:ID -0.0040179:0.015399:0.100097:0.0065064:344182:1_759600_AGT_A
1 759837 rs3115851 T A . PASS AF=0.87476 ES:SE:LP:AF:SS:ID 0.0053982:0.0034882:0.914602:0.87476:344182:rs3115851
1 761732 rs2286139 C T . PASS AF=0.86414 ES:SE:LP:AF:SS:ID 0.0064452:0.0034201:1.2255:0.86414:344182:rs2286139
1 761752 rs1057213 C T . PASS AF=0.86955 ES:SE:LP:AF:SS:ID 0.0055698:0.0034537:0.971388:0.86955:344182:rs1057213
1 762273 rs3115849 G A . PASS AF=0.86649 ES:SE:LP:AF:SS:ID 0.0060781:0.0034543:1.10522:0.86649:344182:rs3115849
1 762485 rs12095200 C A . PASS AF=0.098689 ES:SE:LP:AF:SS:ID -0.0059323:0.0041351:0.819874:0.098689:344182:rs12095200
1 762589 rs3115848 G C . PASS AF=0.87168 ES:SE:LP:AF:SS:ID 0.0056528:0.003494:0.975925:0.87168:344182:rs3115848
1 762592 rs3131950 C G . PASS AF=0.87168 ES:SE:LP:AF:SS:ID 0.0056531:0.003494:0.976007:0.87168:344182:rs3131950
1 762601 rs3131949 T C . PASS AF=0.87168 ES:SE:LP:AF:SS:ID 0.0056547:0.0034941:0.976377:0.87168:344182:rs3131949
1 762632 rs3131948 T A . PASS AF=0.87206 ES:SE:LP:AF:SS:ID 0.0055624:0.0034962:0.952297:0.87206:344182:rs3131948
1 764191 rs7515915 T G . PASS AF=0.12543 ES:SE:LP:AF:SS:ID -0.0054412:0.0034989:0.921108:0.12543:344182:rs7515915
1 766007 rs61768174 A C . PASS AF=0.10533 ES:SE:LP:AF:SS:ID -0.008724:0.0038099:1.65693:0.10533:344182:rs61768174
1 766105 rs2519015 T A . PASS AF=0.85548 ES:SE:LP:AF:SS:ID 0.0068517:0.0034189:1.34617:0.85548:344182:rs2519015
1 767393 rs538667473 A C . PASS AF=0.0016444 ES:SE:LP:AF:SS:ID -0.019924:0.030367:0.290934:0.0016444:344182:rs538667473
1 768116 rs376645387 A AGTTTT . PASS AF=0.83838 ES:SE:LP:AF:SS:ID -0.0013694:0.003367:0.164798:0.83838:344182:rs376645387