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"bcftools_viewCommand": "view -h /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/ukb-d-22614_1/ukb-d-22614_1.vcf.gz; Date=Sat May 9 15:28:10 2020"
}
*********************************************************************
* LD Score Regression (LDSC)
* Version 1.0.1
* (C) 2014-2019 Brendan Bulik-Sullivan and Hilary Finucane
* Broad Institute of MIT and Harvard / MIT Department of Mathematics
* GNU General Public License v3
*********************************************************************
Call:
./ldsc.py \
--h2 /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-d-import/processed/ukb-d-22614_1/ukb-d-22614_1.vcf.gz \
--ref-ld-chr /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/ \
--out /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-d-import/processed/ukb-d-22614_1/ldsc.txt \
--w-ld-chr /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/
Beginning analysis at Mon Nov 25 16:32:56 2019
Reading summary statistics from /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-d-import/processed/ukb-d-22614_1/ukb-d-22614_1.vcf.gz ...
Read summary statistics for 11359742 SNPs.
Dropped 9580 SNPs with duplicated rs numbers.
Reading reference panel LD Score from /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/[1-22] ...
Read reference panel LD Scores for 1290028 SNPs.
Removing partitioned LD Scores with zero variance.
Reading regression weight LD Score from /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/[1-22] ...
Read regression weight LD Scores for 1290028 SNPs.
After merging with reference panel LD, 1282450 SNPs remain.
After merging with regression SNP LD, 1282450 SNPs remain.
Using two-step estimator with cutoff at 30.
Total Observed scale h2: 0.0038 (0.0045)
Lambda GC: 1.0264
Mean Chi^2: 1.0165
Intercept: 1.01 (0.0057)
Ratio: 0.6101 (0.3454)
Analysis finished at Mon Nov 25 16:34:57 2019
Total time elapsed: 2.0m:1.74s
{
"af_correlation": 0.9471,
"inflation_factor": 1.0267,
"mean_EFFECT": 3.6264e-06,
"n": 87998,
"n_snps": 11359742,
"n_clumped_hits": 0,
"n_p_sig": 1,
"n_mono": 0,
"n_ns": 1155315,
"n_mac": 0,
"is_snpid_unique": false,
"n_miss_EFFECT": 0,
"n_miss_SE": 0,
"n_miss_PVAL": 0,
"n_miss_AF": 0,
"n_miss_AF_reference": 235816,
"n_est": 88165.746,
"ratio_se_n": 1.001,
"mean_diff": 0,
"ratio_diff": 9.3023,
"sd_y_est1": 0.1882,
"sd_y_est2": 0.1884,
"r2_sum1": 0,
"r2_sum2": 0,
"r2_sum3": 0,
"r2_sum4": 0,
"ldsc_nsnp_merge_refpanel_ld": 1282450,
"ldsc_nsnp_merge_regression_ld": 1282450,
"ldsc_observed_scale_h2_beta": 0.0038,
"ldsc_observed_scale_h2_se": 0.0045,
"ldsc_intercept_beta": 1.01,
"ldsc_intercept_se": 0.0057,
"ldsc_lambda_gc": 1.0264,
"ldsc_mean_chisq": 1.0165,
"ldsc_ratio": 0.6061
}
name | value |
---|---|
af_correlation | FALSE |
inflation_factor | FALSE |
n | FALSE |
is_snpid_non_unique | TRUE |
mean_EFFECT_nonfinite | FALSE |
mean_EFFECT_05 | FALSE |
mean_EFFECT_01 | FALSE |
mean_chisq | FALSE |
n_p_sig | FALSE |
miss_EFFECT | FALSE |
miss_SE | FALSE |
miss_PVAL | FALSE |
ldsc_ratio | TRUE |
ldsc_intercept_beta | FALSE |
n_clumped_hits | FALSE |
r2_sum1 | FALSE |
r2_sum2 | FALSE |
r2_sum3 | FALSE |
r2_sum4 | FALSE |
General metrics
af_correlation
: Correlation coefficient between AF
and AF_reference
.inflation_factor
(lambda
): Genomic inflation factor.mean_EFFECT
: Mean of EFFECT
size.n
: Maximum value of reported sample size across all SNPs, \(n\).n_clumped_hits
: Number of clumped hits.n_snps
: Number of SNPsn_p_sig
: Number of SNPs with pvalue below 5e-8
.n_mono
: Number of monomorphic (MAF == 1
or MAF == 0
) SNPs.n_ns
: Number of SNPs with nonsense values:
A, C, G or T
.< 0
or > 1
.<= 0
or = Infinity
).< 0
or > 1
.n_mac
: Number of cases where MAC
(\(2 \times N \times MAF\)) is less than 6
.is_snpid_unique
: true
if the combination of ID
REF
ALT
is unique and therefore no duplication in snpid.n_miss_<*>
: Number of NA
observations for <*>
column.se_n metrics
n_est
: Estimated sample size value, \(\widehat{n}\).ratio_se_n
: \(\texttt{ratio_se_n} = \frac{\sqrt{\widehat{n}}}{\sqrt{n}}\). We expect ratio_se_n
to be 1. When it is not 1, it implies that the trait did not have a variance of 1, the reported sample size is wrong, or that the SNP-level effective sample sizes differ markedly from the reported sample size.mean_diff
: \(\texttt{mean_diff} = \sum_{j} \frac{\widehat{\beta_j^{std}} - \beta_j}{\texttt{n_snps}}\), mean difference between the standardised beta, predicted from P-values, and the observed beta. The difference should be very close to zero if trait has a variance of 1.
ratio_diff
: \(\texttt{ratio_diff} = |\frac{\texttt{mean_diff}}{\texttt{mean_diff2}}|\), absolute ratio between the mean of diff
and the mean of diff2
(expected difference between the standardised beta predicted from P-values, and the standardised beta derived from the observed beta divided by the predicted SD; NOT reported). The ratio should be close to 1. If different from 1, then implies that the betas are not in a standard deviation scale.
sd_y_est1
: The standard deviation for the trait inferred from the reported sample size, median standard errors for the SNP-trait assocations and SNP variances.
sd_y_est2
: The standard deviation for the trait inferred from the reported sample size, Z statistics for the SNP-trait effects (beta/se) and allele frequency.
r2 metrics
Sum of variance explained, calculated from the clumped top hits sample.
r2_sum<*>
: r2
statistics under various assumptions
1
: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var1}}}\), \(\texttt{var1} = 1\).2
: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var2}}}\), \(\texttt{var2} = {\widehat{\texttt{sd1}}_{y}}^2\),3
: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var3}}}\), \(\texttt{var3} = {\widehat{\texttt{sd2}}_{y}}^2\),4
: \(r^2 = \sum_j{\frac{F_j}{F_j + n - 2}}\), \(F = \frac{\beta_j^2}{{se}_j^2}\).LDSC metrics
Metrics from LD regression
ldsc_nsnp_merge_refpanel_ld
: Number of remaining SNPs after merging with reference panel LD.ldsc_nsnp_merge_regression_ld
: Number of remaining SNPs after merging with regression SNP LD.ldsc_observed_scale_h2_{beta,se}
Coefficient value and SE for total observed scale h2.ldsc_intercept_{beta,se}
: Coefficient value and SE for intercept. Intercept is expected to be 1.ldsc_lambda_gc
: Lambda GC statistics.ldsc_mean_chisq
: Mean \(\chi^2\) statistics.ldsc_ratio
: \(\frac{\texttt{ldsc_intercept_beta} - 1}{\texttt{ldsc_mean_chisq} - 1}\), the proportion of the inflation in the mean \(\chi^2\) that the LD Score regression intercepts ascribes to causes other than polygenic heritability. The value of ratio should be close to zero, though in practice values of 0.1-0.2 are not uncommon, probably due to sample/reference LD Score mismatch or model misspecification (e.g., low LD variants have slightly higher \(h^2\) per SNP).Flags
When a metric needs attention, the flag should return TRUE.
af_correlation
: abs(af_correlation)
< 0.7.inflation_factor
: inflation_factor
> 1.2.n
: n
(max reported sample size) < 10000.is_snpid_non_unique
: NOT is_snpid_unique
.mean_EFFECT_nonfinite
: mean(EFFECT)
is NA
, NaN
, or Inf
.mean_EFFECT_05
: abs(mean(EFFECT))
> 0.5.mean_EFFECT_01
: abs(mean(EFFECT))
> 0.1.mean_chisq
: ldsc_mean_chisq
> 1.3 or ldsc_mean_chisq
< 0.7.n_p_sig
: n_p_sig
> 1000.miss_<*>
: n_miss_<*>
/ n_snps
> 0.01.ldsc_ratio
: ldsc_ratio
> 0.5ldsc_intercept_beta
: ldsc_intercept_beta
> 1.5n_clumped_hits
: n_clumped_hits
> 1000r2_sum<*>
: r2_sum<*>
> 0.5Plots
skim_type | skim_variable | n_missing | complete_rate | character.min | character.max | character.empty | character.n_unique | character.whitespace | numeric.mean | numeric.sd | numeric.p0 | numeric.p25 | numeric.p50 | numeric.p75 | numeric.p100 | numeric.hist |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
character | ID | 0 | 1.0000000 | 3 | 94 | 0 | 11350759 | 0 | NA | NA | NA | NA | NA | NA | NA | NA |
character | REF | 0 | 1.0000000 | 1 | 100 | 0 | 51941 | 0 | NA | NA | NA | NA | NA | NA | NA | NA |
character | ALT | 0 | 1.0000000 | 1 | 342 | 0 | 31607 | 0 | NA | NA | NA | NA | NA | NA | NA | NA |
numeric | CHROM | 0 | 1.0000000 | NA | NA | NA | NA | NA | 9.073903e+00 | 6.182617e+00 | 1.00000e+00 | 4.000000e+00 | 8.000000e+00 | 1.300000e+01 | 2.300000e+01 | ▇▅▅▂▂ |
numeric | POS | 0 | 1.0000000 | NA | NA | NA | NA | NA | 7.883509e+07 | 5.600438e+07 | 3.02000e+02 | 3.262630e+07 | 6.983279e+07 | 1.147284e+08 | 2.492309e+08 | ▇▆▅▂▁ |
numeric | EFFECT | 0 | 1.0000000 | NA | NA | NA | NA | NA | 3.600000e-06 | 3.003600e-03 | -2.92736e-02 | -1.151000e-03 | -7.900000e-06 | 1.123900e-03 | 4.135520e-02 | ▁▃▇▁▁ |
numeric | SE | 0 | 1.0000000 | NA | NA | NA | NA | NA | 2.388100e-03 | 1.819200e-03 | 7.41600e-04 | 1.016600e-03 | 1.528800e-03 | 3.232800e-03 | 1.072620e-02 | ▇▂▁▁▁ |
numeric | PVAL | 0 | 1.0000000 | NA | NA | NA | NA | NA | 4.962620e-01 | 2.892884e-01 | 0.00000e+00 | 2.446718e-01 | 4.943266e-01 | 7.470506e-01 | 1.000000e+00 | ▇▇▇▇▇ |
numeric | PVAL_ztest | 0 | 1.0000000 | NA | NA | NA | NA | NA | 4.962602e-01 | 2.892895e-01 | 0.00000e+00 | 2.446691e-01 | 4.943246e-01 | 7.470490e-01 | 1.000000e+00 | ▇▇▇▇▇ |
numeric | AF | 0 | 1.0000000 | NA | NA | NA | NA | NA | 2.261046e-01 | 2.610305e-01 | 3.69280e-03 | 2.061640e-02 | 1.086960e-01 | 3.614660e-01 | 9.963070e-01 | ▇▂▁▁▁ |
numeric | AF_reference | 235816 | 0.9792411 | NA | NA | NA | NA | NA | 2.266436e-01 | 2.522373e-01 | 0.00000e+00 | 1.817090e-02 | 1.269970e-01 | 3.610220e-01 | 1.000000e+00 | ▇▂▂▁▁ |
numeric | N | 0 | 1.0000000 | NA | NA | NA | NA | NA | 8.799800e+04 | 0.000000e+00 | 8.79980e+04 | 8.799800e+04 | 8.799800e+04 | 8.799800e+04 | 8.799800e+04 | ▁▁▇▁▁ |
CHROM | POS | ID | REF | ALT | EFFECT | SE | PVAL | PVAL_ztest | AF | AF_reference | N |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | 692794 | rs530212009 | CA | C | 0.0004880 | 0.0015676 | 0.7555618 | 0.7555607 | 0.1114960 | 0.1894970 | 87998 |
1 | 693731 | rs12238997 | A | G | 0.0016667 | 0.0014850 | 0.2617369 | 0.2617350 | 0.1165300 | 0.1417730 | 87998 |
1 | 707522 | rs371890604 | G | C | -0.0001638 | 0.0016690 | 0.9218191 | 0.9218186 | 0.0979575 | 0.1293930 | 87998 |
1 | 717587 | rs144155419 | G | A | 0.0027708 | 0.0039808 | 0.4864072 | 0.4864055 | 0.0157767 | 0.0045926 | 87998 |
1 | 730087 | rs148120343 | T | C | -0.0006313 | 0.0020596 | 0.7592031 | 0.7592029 | 0.0570081 | 0.0127796 | 87998 |
1 | 731718 | rs142557973 | T | C | 0.0011933 | 0.0014088 | 0.3969913 | 0.3969892 | 0.1224500 | 0.1543530 | 87998 |
1 | 732032 | rs61770163 | A | C | 0.0006713 | 0.0015028 | 0.6550976 | 0.6550968 | 0.1220280 | 0.1555510 | 87998 |
1 | 734349 | rs141242758 | T | C | 0.0012956 | 0.0014099 | 0.3581311 | 0.3581308 | 0.1216690 | 0.1525560 | 87998 |
1 | 740284 | rs61770167 | C | T | 0.0038849 | 0.0064477 | 0.5468245 | 0.5468225 | 0.0057907 | 0.0023962 | 87998 |
1 | 749963 | rs529266287 | T | TAA | -0.0009397 | 0.0013871 | 0.4981166 | 0.4981139 | 0.8688370 | 0.7641770 | 87998 |
CHROM | POS | ID | REF | ALT | EFFECT | SE | PVAL | PVAL_ztest | AF | AF_reference | N |
---|---|---|---|---|---|---|---|---|---|---|---|
23 | 154923311 | rs141127553 | C | T | 0.0010461 | 0.0016527 | 0.5267615 | 0.5267591 | 0.0551068 | 0.0309934 | 87998 |
23 | 154923374 | rs111332691 | T | A | -0.0004136 | 0.0017956 | 0.8178169 | 0.8178165 | 0.0448647 | 0.0116556 | 87998 |
23 | 154925045 | rs509981 | C | T | 0.0000106 | 0.0008652 | 0.9902150 | 0.9902148 | 0.2446380 | 0.3634440 | 87998 |
23 | 154925895 | rs538470 | C | T | -0.0000276 | 0.0008845 | 0.9751380 | 0.9751379 | 0.2411250 | 0.3634440 | 87998 |
23 | 154927581 | rs644138 | G | A | 0.0002807 | 0.0008140 | 0.7302154 | 0.7302149 | 0.3001550 | 0.4635760 | 87998 |
23 | 154929412 | rs557132 | C | T | -0.0000288 | 0.0008654 | 0.9734351 | 0.9734350 | 0.2444910 | 0.3568210 | 87998 |
23 | 154929637 | rs35185538 | CT | C | 0.0002926 | 0.0009038 | 0.7461274 | 0.7461263 | 0.2288010 | 0.3011920 | 87998 |
23 | 154929952 | rs4012982 | CAA | C | -0.0000164 | 0.0009106 | 0.9856050 | 0.9856045 | 0.2384500 | 0.3165560 | 87998 |
23 | 154930230 | rs781880 | A | G | 0.0000004 | 0.0008652 | 0.9996380 | 0.9996376 | 0.2449290 | 0.3618540 | 87998 |
23 | 154930487 | rs781879 | T | A | -0.0026477 | 0.0029233 | 0.3650816 | 0.3650805 | 0.0197684 | 0.1263580 | 87998 |
1 692794 rs530212009 CA C . PASS AF=0.111496 ES:SE:LP:AF:SS:ID 0.000488009:0.00156757:0.12173:0.111496:87998:1_692794_CA_C
1 693731 rs12238997 A G . PASS AF=0.11653 ES:SE:LP:AF:SS:ID 0.00166666:0.00148504:0.582135:0.11653:87998:rs12238997
1 707522 rs371890604 G C . PASS AF=0.0979575 ES:SE:LP:AF:SS:ID -0.000163804:0.00166903:0.0353543:0.0979575:87998:rs371890604
1 717587 rs144155419 G A . PASS AF=0.0157767 ES:SE:LP:AF:SS:ID 0.00277082:0.00398085:0.313:0.0157767:87998:rs144155419
1 730087 rs148120343 T C . PASS AF=0.0570081 ES:SE:LP:AF:SS:ID -0.000631309:0.00205955:0.119642:0.0570081:87998:rs148120343
1 731718 rs58276399 T C . PASS AF=0.12245 ES:SE:LP:AF:SS:ID 0.00119326:0.00140879:0.401219:0.12245:87998:rs58276399
1 732032 rs61770163 A C . PASS AF=0.122028 ES:SE:LP:AF:SS:ID 0.000671308:0.00150284:0.183694:0.122028:87998:rs61770163
1 734349 rs141242758 T C . PASS AF=0.121669 ES:SE:LP:AF:SS:ID 0.00129564:0.00140994:0.445958:0.121669:87998:rs141242758
1 740284 rs61770167 C T . PASS AF=0.00579073 ES:SE:LP:AF:SS:ID 0.00388494:0.00644773:0.262152:0.00579073:87998:rs61770167
1 749963 rs529266287 T TAA . PASS AF=0.868837 ES:SE:LP:AF:SS:ID -0.000939712:0.00138711:0.302669:0.868837:87998:rs529266287
1 751343 rs28544273 T A . PASS AF=0.123774 ES:SE:LP:AF:SS:ID 0.00106656:0.00137528:0.358492:0.123774:87998:rs28544273
1 751488 rs200141114 G GA . PASS AF=0.143283 ES:SE:LP:AF:SS:ID 0.00081886:0.00136123:0.26164:0.143283:87998:rs200141114
1 751756 rs28527770 T C . PASS AF=0.123911 ES:SE:LP:AF:SS:ID 0.00103995:0.00137326:0.347868:0.123911:87998:rs28527770
1 753405 rs3115860 C A . PASS AF=0.86982 ES:SE:LP:AF:SS:ID -0.00126075:0.00133799:0.460852:0.86982:87998:rs3115860
1 753425 rs3131970 T C . PASS AF=0.874474 ES:SE:LP:AF:SS:ID -0.000775855:0.00135989:0.245407:0.874474:87998:rs3131970
1 753541 rs2073813 G A . PASS AF=0.129597 ES:SE:LP:AF:SS:ID 0.00130157:0.00134216:0.478644:0.129597:87998:rs2073813
1 754105 rs12184325 C T . PASS AF=0.0357167 ES:SE:LP:AF:SS:ID 0.00885183:0.00245598:3.50405:0.0357167:87998:rs12184325
1 754182 rs3131969 A G . PASS AF=0.869462 ES:SE:LP:AF:SS:ID -0.00129622:0.00133686:0.478538:0.869462:87998:rs3131969
1 754192 rs3131968 A G . PASS AF=0.869541 ES:SE:LP:AF:SS:ID -0.00133033:0.00133745:0.49499:0.869541:87998:rs3131968
1 754334 rs3131967 T C . PASS AF=0.869458 ES:SE:LP:AF:SS:ID -0.00130041:0.0013368:0.48061:0.869458:87998:rs3131967
1 754433 rs150578204 G A . PASS AF=0.00530476 ES:SE:LP:AF:SS:ID 0.00294264:0.00668863:0.180471:0.00530476:87998:rs150578204
1 754458 rs142682604 G T . PASS AF=0.00526955 ES:SE:LP:AF:SS:ID 0.00305445:0.00670549:0.187929:0.00526955:87998:rs142682604
1 755435 rs184270342 T G . PASS AF=0.00561078 ES:SE:LP:AF:SS:ID -0.00137355:0.00661263:0.078079:0.00561078:87998:rs184270342
1 755890 rs3115858 A T . PASS AF=0.869456 ES:SE:LP:AF:SS:ID -0.00121829:0.00133409:0.442323:0.869456:87998:rs3115858
1 756434 rs61768170 G C . PASS AF=0.126997 ES:SE:LP:AF:SS:ID 0.000941426:0.00136185:0.310346:0.126997:87998:rs61768170
1 756604 rs3131962 A G . PASS AF=0.86898 ES:SE:LP:AF:SS:ID -0.0011234:0.00133061:0.399554:0.86898:87998:rs3131962
1 757640 rs3115853 G A . PASS AF=0.868353 ES:SE:LP:AF:SS:ID -0.00109307:0.00132971:0.386097:0.868353:87998:rs3115853
1 757734 rs4951929 C T . PASS AF=0.869132 ES:SE:LP:AF:SS:ID -0.00118998:0.00133183:0.429928:0.869132:87998:rs4951929
1 757936 rs4951862 C A . PASS AF=0.869137 ES:SE:LP:AF:SS:ID -0.00119107:0.00133191:0.430405:0.869137:87998:rs4951862
1 758144 rs3131956 A G . PASS AF=0.86914 ES:SE:LP:AF:SS:ID -0.0011931:0.00133193:0.431352:0.86914:87998:rs3131956
1 758626 rs3131954 C T . PASS AF=0.869616 ES:SE:LP:AF:SS:ID -0.00126266:0.00133551:0.4629:0.869616:87998:rs3131954
1 759293 rs10157329 T A . PASS AF=0.099274 ES:SE:LP:AF:SS:ID 0.000373412:0.00155457:0.0914217:0.099274:87998:rs10157329
1 759600 rs545998451 AGT A . PASS AF=0.00645507 ES:SE:LP:AF:SS:ID -0.00114733:0.00602289:0.0711327:0.00645507:87998:1_759600_AGT_A
1 759837 rs3115851 T A . PASS AF=0.873585 ES:SE:LP:AF:SS:ID -0.00109529:0.00135529:0.377786:0.873585:87998:rs3115851
1 761732 rs2286139 C T . PASS AF=0.862972 ES:SE:LP:AF:SS:ID -0.0017391:0.00132936:0.719417:0.862972:87998:rs2286139
1 761752 rs1057213 C T . PASS AF=0.868391 ES:SE:LP:AF:SS:ID -0.0013664:0.00134255:0.510334:0.868391:87998:rs1057213
1 762273 rs3115849 G A . PASS AF=0.865279 ES:SE:LP:AF:SS:ID -0.00159735:0.00134272:0.630428:0.865279:87998:rs3115849
1 762485 rs12095200 C A . PASS AF=0.0995469 ES:SE:LP:AF:SS:ID 0.00200158:0.00160782:0.67127:0.0995469:87998:rs12095200
1 762589 rs3115848 G C . PASS AF=0.87056 ES:SE:LP:AF:SS:ID -0.00118723:0.00135812:0.417905:0.87056:87998:rs3115848
1 762592 rs3131950 C G . PASS AF=0.87056 ES:SE:LP:AF:SS:ID -0.00118742:0.00135812:0.417995:0.87056:87998:rs3131950
1 762601 rs3131949 T C . PASS AF=0.870557 ES:SE:LP:AF:SS:ID -0.0011879:0.00135813:0.418208:0.870557:87998:rs3131949
1 762632 rs3131948 T A . PASS AF=0.870925 ES:SE:LP:AF:SS:ID -0.00117335:0.00135877:0.411345:0.870925:87998:rs3131948
1 764191 rs7515915 T G . PASS AF=0.126601 ES:SE:LP:AF:SS:ID 0.00119202:0.00136026:0.419234:0.126601:87998:rs7515915
1 766007 rs61768174 A C . PASS AF=0.106143 ES:SE:LP:AF:SS:ID 0.00104707:0.00147858:0.319803:0.106143:87998:rs61768174
1 766105 rs2519015 T A . PASS AF=0.854323 ES:SE:LP:AF:SS:ID -0.00115529:0.00132898:0.414896:0.854323:87998:rs2519015
1 768116 rs376645387 A AGTTTT . PASS AF=0.839279 ES:SE:LP:AF:SS:ID -0.000886316:0.00131415:0.301001:0.839279:87998:rs376645387
1 768253 rs2977608 A C . PASS AF=0.76317 ES:SE:LP:AF:SS:ID -0.000796459:0.00105605:0.346073:0.76317:87998:rs2977608
1 768448 rs12562034 G A . PASS AF=0.105042 ES:SE:LP:AF:SS:ID 0.000171049:0.00145616:0.0426365:0.105042:87998:rs12562034
1 768819 rs12562811 C T . PASS AF=0.00770606 ES:SE:LP:AF:SS:ID -4.93485e-05:0.00539408:0.00318154:0.00770606:87998:rs12562811
1 769138 rs59306077 CAT C . PASS AF=0.129977 ES:SE:LP:AF:SS:ID 0.00130612:0.00134123:0.481291:0.129977:87998:rs762168062