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"bcftools_viewCommand": "view -h /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/ukb-d-22610_2/ukb-d-22610_2.vcf.gz; Date=Fri May 8 02:51:35 2020"
}
*********************************************************************
* LD Score Regression (LDSC)
* Version 1.0.1
* (C) 2014-2019 Brendan Bulik-Sullivan and Hilary Finucane
* Broad Institute of MIT and Harvard / MIT Department of Mathematics
* GNU General Public License v3
*********************************************************************
Call:
./ldsc.py \
--h2 /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-d-import/processed/ukb-d-22610_2/ukb-d-22610_2.vcf.gz \
--ref-ld-chr /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/ \
--out /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-d-import/processed/ukb-d-22610_2/ldsc.txt \
--w-ld-chr /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/
Beginning analysis at Mon Nov 25 16:45:48 2019
Reading summary statistics from /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-d-import/processed/ukb-d-22610_2/ukb-d-22610_2.vcf.gz ...
Read summary statistics for 12324483 SNPs.
Dropped 10913 SNPs with duplicated rs numbers.
Reading reference panel LD Score from /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/[1-22] ...
Read reference panel LD Scores for 1290028 SNPs.
Removing partitioned LD Scores with zero variance.
Reading regression weight LD Score from /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/[1-22] ...
Read regression weight LD Scores for 1290028 SNPs.
After merging with reference panel LD, 1283195 SNPs remain.
After merging with regression SNP LD, 1283195 SNPs remain.
Using two-step estimator with cutoff at 30.
Total Observed scale h2: 0.0148 (0.0049)
Lambda GC: 1.0288
Mean Chi^2: 1.027
Intercept: 1.0013 (0.006)
Ratio: 0.0489 (0.2236)
Analysis finished at Mon Nov 25 16:47:50 2019
Total time elapsed: 2.0m:2.03s
{
"af_correlation": 0.9498,
"inflation_factor": 1.025,
"mean_EFFECT": 0,
"n": 88638,
"n_snps": 12324483,
"n_clumped_hits": 0,
"n_p_sig": 3,
"n_mono": 0,
"n_ns": 1198865,
"n_mac": 0,
"is_snpid_unique": false,
"n_miss_EFFECT": 0,
"n_miss_SE": 0,
"n_miss_PVAL": 0,
"n_miss_AF": 0,
"n_miss_AF_reference": 320347,
"n_est": 88902.0881,
"ratio_se_n": 1.0015,
"mean_diff": 0.0001,
"ratio_diff": 79.3648,
"sd_y_est1": 0.2456,
"sd_y_est2": 0.246,
"r2_sum1": 0,
"r2_sum2": 0,
"r2_sum3": 0,
"r2_sum4": 0,
"ldsc_nsnp_merge_refpanel_ld": 1283195,
"ldsc_nsnp_merge_regression_ld": 1283195,
"ldsc_observed_scale_h2_beta": 0.0148,
"ldsc_observed_scale_h2_se": 0.0049,
"ldsc_intercept_beta": 1.0013,
"ldsc_intercept_se": 0.006,
"ldsc_lambda_gc": 1.0288,
"ldsc_mean_chisq": 1.027,
"ldsc_ratio": 0.0481
}
name | value |
---|---|
af_correlation | FALSE |
inflation_factor | FALSE |
n | FALSE |
is_snpid_non_unique | TRUE |
mean_EFFECT_nonfinite | FALSE |
mean_EFFECT_05 | FALSE |
mean_EFFECT_01 | FALSE |
mean_chisq | FALSE |
n_p_sig | FALSE |
miss_EFFECT | FALSE |
miss_SE | FALSE |
miss_PVAL | FALSE |
ldsc_ratio | FALSE |
ldsc_intercept_beta | FALSE |
n_clumped_hits | FALSE |
r2_sum1 | FALSE |
r2_sum2 | FALSE |
r2_sum3 | FALSE |
r2_sum4 | FALSE |
General metrics
af_correlation
: Correlation coefficient between AF
and AF_reference
.inflation_factor
(lambda
): Genomic inflation factor.mean_EFFECT
: Mean of EFFECT
size.n
: Maximum value of reported sample size across all SNPs, \(n\).n_clumped_hits
: Number of clumped hits.n_snps
: Number of SNPsn_p_sig
: Number of SNPs with pvalue below 5e-8
.n_mono
: Number of monomorphic (MAF == 1
or MAF == 0
) SNPs.n_ns
: Number of SNPs with nonsense values:
A, C, G or T
.< 0
or > 1
.<= 0
or = Infinity
).< 0
or > 1
.n_mac
: Number of cases where MAC
(\(2 \times N \times MAF\)) is less than 6
.is_snpid_unique
: true
if the combination of ID
REF
ALT
is unique and therefore no duplication in snpid.n_miss_<*>
: Number of NA
observations for <*>
column.se_n metrics
n_est
: Estimated sample size value, \(\widehat{n}\).ratio_se_n
: \(\texttt{ratio_se_n} = \frac{\sqrt{\widehat{n}}}{\sqrt{n}}\). We expect ratio_se_n
to be 1. When it is not 1, it implies that the trait did not have a variance of 1, the reported sample size is wrong, or that the SNP-level effective sample sizes differ markedly from the reported sample size.mean_diff
: \(\texttt{mean_diff} = \sum_{j} \frac{\widehat{\beta_j^{std}} - \beta_j}{\texttt{n_snps}}\), mean difference between the standardised beta, predicted from P-values, and the observed beta. The difference should be very close to zero if trait has a variance of 1.
ratio_diff
: \(\texttt{ratio_diff} = |\frac{\texttt{mean_diff}}{\texttt{mean_diff2}}|\), absolute ratio between the mean of diff
and the mean of diff2
(expected difference between the standardised beta predicted from P-values, and the standardised beta derived from the observed beta divided by the predicted SD; NOT reported). The ratio should be close to 1. If different from 1, then implies that the betas are not in a standard deviation scale.
sd_y_est1
: The standard deviation for the trait inferred from the reported sample size, median standard errors for the SNP-trait assocations and SNP variances.
sd_y_est2
: The standard deviation for the trait inferred from the reported sample size, Z statistics for the SNP-trait effects (beta/se) and allele frequency.
r2 metrics
Sum of variance explained, calculated from the clumped top hits sample.
r2_sum<*>
: r2
statistics under various assumptions
1
: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var1}}}\), \(\texttt{var1} = 1\).2
: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var2}}}\), \(\texttt{var2} = {\widehat{\texttt{sd1}}_{y}}^2\),3
: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var3}}}\), \(\texttt{var3} = {\widehat{\texttt{sd2}}_{y}}^2\),4
: \(r^2 = \sum_j{\frac{F_j}{F_j + n - 2}}\), \(F = \frac{\beta_j^2}{{se}_j^2}\).LDSC metrics
Metrics from LD regression
ldsc_nsnp_merge_refpanel_ld
: Number of remaining SNPs after merging with reference panel LD.ldsc_nsnp_merge_regression_ld
: Number of remaining SNPs after merging with regression SNP LD.ldsc_observed_scale_h2_{beta,se}
Coefficient value and SE for total observed scale h2.ldsc_intercept_{beta,se}
: Coefficient value and SE for intercept. Intercept is expected to be 1.ldsc_lambda_gc
: Lambda GC statistics.ldsc_mean_chisq
: Mean \(\chi^2\) statistics.ldsc_ratio
: \(\frac{\texttt{ldsc_intercept_beta} - 1}{\texttt{ldsc_mean_chisq} - 1}\), the proportion of the inflation in the mean \(\chi^2\) that the LD Score regression intercepts ascribes to causes other than polygenic heritability. The value of ratio should be close to zero, though in practice values of 0.1-0.2 are not uncommon, probably due to sample/reference LD Score mismatch or model misspecification (e.g., low LD variants have slightly higher \(h^2\) per SNP).Flags
When a metric needs attention, the flag should return TRUE.
af_correlation
: abs(af_correlation)
< 0.7.inflation_factor
: inflation_factor
> 1.2.n
: n
(max reported sample size) < 10000.is_snpid_non_unique
: NOT is_snpid_unique
.mean_EFFECT_nonfinite
: mean(EFFECT)
is NA
, NaN
, or Inf
.mean_EFFECT_05
: abs(mean(EFFECT))
> 0.5.mean_EFFECT_01
: abs(mean(EFFECT))
> 0.1.mean_chisq
: ldsc_mean_chisq
> 1.3 or ldsc_mean_chisq
< 0.7.n_p_sig
: n_p_sig
> 1000.miss_<*>
: n_miss_<*>
/ n_snps
> 0.01.ldsc_ratio
: ldsc_ratio
> 0.5ldsc_intercept_beta
: ldsc_intercept_beta
> 1.5n_clumped_hits
: n_clumped_hits
> 1000r2_sum<*>
: r2_sum<*>
> 0.5Plots
skim_type | skim_variable | n_missing | complete_rate | character.min | character.max | character.empty | character.n_unique | character.whitespace | numeric.mean | numeric.sd | numeric.p0 | numeric.p25 | numeric.p50 | numeric.p75 | numeric.p100 | numeric.hist |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
character | ID | 0 | 1.0000000 | 3 | 94 | 0 | 12314197 | 0 | NA | NA | NA | NA | NA | NA | NA | NA |
character | REF | 0 | 1.0000000 | 1 | 100 | 0 | 54162 | 0 | NA | NA | NA | NA | NA | NA | NA | NA |
character | ALT | 0 | 1.0000000 | 1 | 342 | 0 | 32409 | 0 | NA | NA | NA | NA | NA | NA | NA | NA |
numeric | CHROM | 0 | 1.0000000 | NA | NA | NA | NA | NA | 9.064461e+00 | 6.184646e+00 | 1.00000e+00 | 4.000000e+00 | 8.000000e+00 | 1.300000e+01 | 2.300000e+01 | <U+2587><U+2585><U+2585><U+2582><U+2582> |
numeric | POS | 0 | 1.0000000 | NA | NA | NA | NA | NA | 7.892465e+07 | 5.596504e+07 | 3.02000e+02 | 3.274889e+07 | 6.996254e+07 | 1.147895e+08 | 2.492309e+08 | <U+2587><U+2586><U+2585><U+2582><U+2581> |
numeric | EFFECT | 0 | 1.0000000 | NA | NA | NA | NA | NA | 2.710000e-05 | 4.989300e-03 | -5.04827e-02 | -1.618800e-03 | -1.800000e-06 | 1.612800e-03 | 6.693110e-02 | <U+2581><U+2581><U+2587><U+2581><U+2581> |
numeric | SE | 0 | 1.0000000 | NA | NA | NA | NA | NA | 3.768300e-03 | 3.230700e-03 | 9.62400e-04 | 1.351800e-03 | 2.208000e-03 | 5.248100e-03 | 1.974520e-02 | <U+2587><U+2582><U+2581><U+2581><U+2581> |
numeric | PVAL | 0 | 1.0000000 | NA | NA | NA | NA | NA | 4.962651e-01 | 2.897217e-01 | 0.00000e+00 | 2.442907e-01 | 4.946853e-01 | 7.472622e-01 | 1.000000e+00 | <U+2587><U+2587><U+2587><U+2587><U+2587> |
numeric | PVAL_ztest | 0 | 1.0000000 | NA | NA | NA | NA | NA | 4.962633e-01 | 2.897227e-01 | 0.00000e+00 | 2.442878e-01 | 4.946831e-01 | 7.472623e-01 | 1.000000e+00 | <U+2587><U+2587><U+2587><U+2587><U+2587> |
numeric | AF | 0 | 1.0000000 | NA | NA | NA | NA | NA | 2.092983e-01 | 2.584369e-01 | 2.12880e-03 | 1.323700e-02 | 8.481820e-02 | 3.313680e-01 | 9.978710e-01 | <U+2587><U+2582><U+2581><U+2581><U+2581> |
numeric | AF_reference | 320347 | 0.9740073 | NA | NA | NA | NA | NA | 2.112771e-01 | 2.500975e-01 | 0.00000e+00 | 9.984000e-03 | 1.052320e-01 | 3.352640e-01 | 1.000000e+00 | <U+2587><U+2582><U+2581><U+2581><U+2581> |
numeric | N | 0 | 1.0000000 | NA | NA | NA | NA | NA | 8.863800e+04 | 0.000000e+00 | 8.86380e+04 | 8.863800e+04 | 8.863800e+04 | 8.863800e+04 | 8.863800e+04 | <U+2581><U+2581><U+2587><U+2581><U+2581> |
CHROM | POS | ID | REF | ALT | EFFECT | SE | PVAL | PVAL_ztest | AF | AF_reference | N |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | 692794 | rs530212009 | CA | C | 0.0005932 | 0.0020393 | 0.7711378 | 0.7711360 | 0.1113450 | 0.1894970 | 88638 |
1 | 693731 | rs12238997 | A | G | -0.0004687 | 0.0019322 | 0.8083350 | 0.8083345 | 0.1163190 | 0.1417730 | 88638 |
1 | 707522 | rs371890604 | G | C | -0.0004285 | 0.0021715 | 0.8435699 | 0.8435690 | 0.0977362 | 0.1293930 | 88638 |
1 | 717587 | rs144155419 | G | A | 0.0018606 | 0.0051674 | 0.7188098 | 0.7188073 | 0.0158097 | 0.0045926 | 88638 |
1 | 730087 | rs148120343 | T | C | -0.0000228 | 0.0026805 | 0.9932130 | 0.9932128 | 0.0567943 | 0.0127796 | 88638 |
1 | 731718 | rs142557973 | T | C | -0.0001014 | 0.0018334 | 0.9558840 | 0.9558841 | 0.1221780 | 0.1543530 | 88638 |
1 | 732032 | rs61770163 | A | C | -0.0005088 | 0.0019550 | 0.7946691 | 0.7946690 | 0.1218840 | 0.1555510 | 88638 |
1 | 734349 | rs141242758 | T | C | -0.0000643 | 0.0018348 | 0.9720520 | 0.9720516 | 0.1214140 | 0.1525560 | 88638 |
1 | 740284 | rs61770167 | C | T | -0.0023125 | 0.0084082 | 0.7832908 | 0.7832910 | 0.0057548 | 0.0023962 | 88638 |
1 | 749963 | rs529266287 | T | TAA | 0.0001790 | 0.0018044 | 0.9209679 | 0.9209683 | 0.8690870 | 0.7641770 | 88638 |
CHROM | POS | ID | REF | ALT | EFFECT | SE | PVAL | PVAL_ztest | AF | AF_reference | N |
---|---|---|---|---|---|---|---|---|---|---|---|
23 | 154923311 | rs141127553 | C | T | 0.0053101 | 0.0021447 | 0.0132920 | 0.0132902 | 0.0550976 | 0.0309934 | 88638 |
23 | 154923374 | rs111332691 | T | A | -0.0032925 | 0.0023268 | 0.1570710 | 0.1570676 | 0.0449751 | 0.0116556 | 88638 |
23 | 154925045 | rs509981 | C | T | -0.0000313 | 0.0011232 | 0.9777720 | 0.9777722 | 0.2446440 | 0.3634440 | 88638 |
23 | 154925895 | rs538470 | C | T | -0.0000768 | 0.0011482 | 0.9466571 | 0.9466573 | 0.2411540 | 0.3634440 | 88638 |
23 | 154927581 | rs644138 | G | A | 0.0012312 | 0.0010565 | 0.2438670 | 0.2438674 | 0.3001550 | 0.4635760 | 88638 |
23 | 154929412 | rs557132 | C | T | -0.0000502 | 0.0011235 | 0.9643340 | 0.9643334 | 0.2444980 | 0.3568210 | 88638 |
23 | 154929637 | rs35185538 | CT | C | -0.0002206 | 0.0011731 | 0.8508600 | 0.8508586 | 0.2289290 | 0.3011920 | 88638 |
23 | 154929952 | rs4012982 | CAA | C | -0.0002293 | 0.0011826 | 0.8462389 | 0.8462379 | 0.2384260 | 0.3165560 | 88638 |
23 | 154930230 | rs781880 | A | G | -0.0000593 | 0.0011231 | 0.9578610 | 0.9578611 | 0.2449550 | 0.3618540 | 88638 |
23 | 154930487 | rs781879 | T | A | 0.0018218 | 0.0038096 | 0.6325021 | 0.6325013 | 0.0196537 | 0.1263580 | 88638 |
1 692794 rs530212009 CA C . PASS AF=0.111345 ES:SE:LP:AF:SS:ID 0.000593199:0.00203926:0.112868:0.111345:88638:1_692794_CA_C
1 693731 rs12238997 A G . PASS AF=0.116319 ES:SE:LP:AF:SS:ID -0.000468694:0.00193216:0.0924086:0.116319:88638:rs12238997
1 707522 rs371890604 G C . PASS AF=0.0977362 ES:SE:LP:AF:SS:ID -0.000428507:0.00217152:0.0738789:0.0977362:88638:rs371890604
1 717587 rs144155419 G A . PASS AF=0.0158097 ES:SE:LP:AF:SS:ID 0.00186055:0.00516743:0.143386:0.0158097:88638:rs144155419
1 730087 rs148120343 T C . PASS AF=0.0567943 ES:SE:LP:AF:SS:ID -2.28022e-05:0.00268052:0.0029576:0.0567943:88638:rs148120343
1 731718 rs58276399 T C . PASS AF=0.122178 ES:SE:LP:AF:SS:ID -0.000101423:0.00183341:0.0195948:0.122178:88638:rs58276399
1 732032 rs61770163 A C . PASS AF=0.121884 ES:SE:LP:AF:SS:ID -0.000508804:0.00195504:0.0998137:0.121884:88638:rs61770163
1 734349 rs141242758 T C . PASS AF=0.121414 ES:SE:LP:AF:SS:ID -6.42817e-05:0.00183477:0.0123105:0.121414:88638:rs141242758
1 740284 rs61770167 C T . PASS AF=0.00575478 ES:SE:LP:AF:SS:ID -0.00231254:0.00840823:0.106077:0.00575478:88638:rs61770167
1 749963 rs529266287 T TAA . PASS AF=0.869087 ES:SE:LP:AF:SS:ID 0.00017902:0.00180438:0.0357555:0.869087:88638:rs529266287
1 751343 rs28544273 T A . PASS AF=0.12356 ES:SE:LP:AF:SS:ID -0.000305859:0.00178884:0.0633661:0.12356:88638:rs28544273
1 751488 rs200141114 G GA . PASS AF=0.1431 ES:SE:LP:AF:SS:ID -0.000579754:0.00177057:0.128814:0.1431:88638:rs200141114
1 751756 rs28527770 T C . PASS AF=0.123692 ES:SE:LP:AF:SS:ID -0.000291114:0.00178628:0.0602108:0.123692:88638:rs28527770
1 753405 rs3115860 C A . PASS AF=0.87006 ES:SE:LP:AF:SS:ID 0.000341742:0.00174064:0.0734765:0.87006:88638:rs3115860
1 753425 rs3131970 T C . PASS AF=0.874702 ES:SE:LP:AF:SS:ID 0.000540193:0.00176889:0.119144:0.874702:88638:rs3131970
1 753541 rs2073813 G A . PASS AF=0.129376 ES:SE:LP:AF:SS:ID -0.000261075:0.00174594:0.054958:0.129376:88638:rs2073813
1 754105 rs12184325 C T . PASS AF=0.0357522 ES:SE:LP:AF:SS:ID 0.00420071:0.00319125:0.725683:0.0357522:88638:rs12184325
1 754182 rs3131969 A G . PASS AF=0.869698 ES:SE:LP:AF:SS:ID 0.000430847:0.00173915:0.0945603:0.869698:88638:rs3131969
1 754192 rs3131968 A G . PASS AF=0.869776 ES:SE:LP:AF:SS:ID 0.000383363:0.0017399:0.0832251:0.869776:88638:rs3131968
1 754334 rs3131967 T C . PASS AF=0.869694 ES:SE:LP:AF:SS:ID 0.000434687:0.00173907:0.0954879:0.869694:88638:rs3131967
1 754433 rs150578204 G A . PASS AF=0.00531348 ES:SE:LP:AF:SS:ID 0.00181092:0.00868023:0.0784483:0.00531348:88638:rs150578204
1 754458 rs142682604 G T . PASS AF=0.00527862 ES:SE:LP:AF:SS:ID 0.00177941:0.00870153:0.0767726:0.00527862:88638:rs142682604
1 755435 rs184270342 T G . PASS AF=0.00567028 ES:SE:LP:AF:SS:ID 0.0102576:0.00854845:0.637955:0.00567028:88638:rs184270342
1 755890 rs3115858 A T . PASS AF=0.869688 ES:SE:LP:AF:SS:ID 0.000413053:0.00173552:0.0905071:0.869688:88638:rs3115858
1 756434 rs61768170 G C . PASS AF=0.126767 ES:SE:LP:AF:SS:ID -0.000324404:0.00177146:0.0681873:0.126767:88638:rs61768170
1 756604 rs3131962 A G . PASS AF=0.869215 ES:SE:LP:AF:SS:ID 0.000482315:0.00173098:0.107613:0.869215:88638:rs3131962
1 757640 rs3115853 G A . PASS AF=0.86859 ES:SE:LP:AF:SS:ID 0.000394929:0.00172983:0.0864987:0.86859:88638:rs3115853
1 757734 rs4951929 C T . PASS AF=0.869368 ES:SE:LP:AF:SS:ID 0.000459314:0.00173259:0.101861:0.869368:88638:rs4951929
1 757936 rs4951862 C A . PASS AF=0.869374 ES:SE:LP:AF:SS:ID 0.000460028:0.00173271:0.102028:0.869374:88638:rs4951862
1 758144 rs3131956 A G . PASS AF=0.869376 ES:SE:LP:AF:SS:ID 0.000457104:0.00173272:0.101313:0.869376:88638:rs3131956
1 758626 rs3131954 C T . PASS AF=0.86985 ES:SE:LP:AF:SS:ID 0.000430368:0.00173735:0.0945522:0.86985:88638:rs3131954
1 759293 rs10157329 T A . PASS AF=0.0990386 ES:SE:LP:AF:SS:ID -0.00110721:0.0020218:0.233629:0.0990386:88638:rs10157329
1 759600 rs545998451 AGT A . PASS AF=0.00651513 ES:SE:LP:AF:SS:ID 0.00838998:0.00778346:0.551185:0.00651513:88638:1_759600_AGT_A
1 759837 rs3115851 T A . PASS AF=0.873831 ES:SE:LP:AF:SS:ID 0.0007607:0.00176301:0.176447:0.873831:88638:rs3115851
1 761732 rs2286139 C T . PASS AF=0.863222 ES:SE:LP:AF:SS:ID 0.000210299:0.00172934:0.0442108:0.863222:88638:rs2286139
1 761752 rs1057213 C T . PASS AF=0.868644 ES:SE:LP:AF:SS:ID 0.000670067:0.00174653:0.154137:0.868644:88638:rs1057213
1 762273 rs3115849 G A . PASS AF=0.865523 ES:SE:LP:AF:SS:ID 0.000674643:0.00174697:0.155296:0.865523:88638:rs3115849
1 762485 rs12095200 C A . PASS AF=0.0993726 ES:SE:LP:AF:SS:ID -0.00113097:0.00209143:0.230127:0.0993726:88638:rs12095200
1 762589 rs3115848 G C . PASS AF=0.870804 ES:SE:LP:AF:SS:ID 0.000679236:0.00176682:0.154496:0.870804:88638:rs3115848
1 762592 rs3131950 C G . PASS AF=0.870804 ES:SE:LP:AF:SS:ID 0.000679049:0.00176682:0.154448:0.870804:88638:rs3131950
1 762601 rs3131949 T C . PASS AF=0.870801 ES:SE:LP:AF:SS:ID 0.000679571:0.00176683:0.154583:0.870801:88638:rs3131949
1 762632 rs3131948 T A . PASS AF=0.871168 ES:SE:LP:AF:SS:ID 0.000837426:0.00176764:0.196764:0.871168:88638:rs3131948
1 764191 rs7515915 T G . PASS AF=0.126371 ES:SE:LP:AF:SS:ID -0.000569489:0.0017694:0.126352:0.126371:88638:rs7515915
1 766007 rs61768174 A C . PASS AF=0.105855 ES:SE:LP:AF:SS:ID -0.00131643:0.00192421:0.306373:0.105855:88638:rs61768174
1 766105 rs2519015 T A . PASS AF=0.854488 ES:SE:LP:AF:SS:ID 0.0007628:0.00172848:0.181122:0.854488:88638:rs2519015
1 768116 rs376645387 A AGTTTT . PASS AF=0.839146 ES:SE:LP:AF:SS:ID 0.00159527:0.00170748:0.455733:0.839146:88638:rs376645387
1 768253 rs2977608 A C . PASS AF=0.763277 ES:SE:LP:AF:SS:ID 0.00106763:0.00137309:0.359673:0.763277:88638:rs2977608
1 768448 rs12562034 G A . PASS AF=0.105164 ES:SE:LP:AF:SS:ID -0.0016612:0.00189113:0.420537:0.105164:88638:rs12562034
1 768819 rs12562811 C T . PASS AF=0.00769457 ES:SE:LP:AF:SS:ID 0.000482075:0.00702222:0.024445:0.00769457:88638:rs12562811
1 769138 rs59306077 CAT C . PASS AF=0.129738 ES:SE:LP:AF:SS:ID -0.000491512:0.00174485:0.10892:0.129738:88638:rs762168062