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"gwas_harmonisation_command": "--json /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-d-import/processed/ukb-d-22606_0/ukb-d-22606_0_data.json --ref /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/QC/genomes/b37/human_g1k_v37.fasta; 1.1.1",
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"bcftools_viewCommand": "view -h /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/ukb-d-22606_0/ukb-d-22606_0.vcf.gz; Date=Sat May 9 18:59:16 2020"
}
*********************************************************************
* LD Score Regression (LDSC)
* Version 1.0.1
* (C) 2014-2019 Brendan Bulik-Sullivan and Hilary Finucane
* Broad Institute of MIT and Harvard / MIT Department of Mathematics
* GNU General Public License v3
*********************************************************************
Call:
./ldsc.py \
--h2 /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-d-import/processed/ukb-d-22606_0/ukb-d-22606_0.vcf.gz \
--ref-ld-chr /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/ \
--out /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-d-import/processed/ukb-d-22606_0/ldsc.txt \
--w-ld-chr /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/
Beginning analysis at Mon Nov 25 16:38:16 2019
Reading summary statistics from /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-d-import/processed/ukb-d-22606_0/ukb-d-22606_0.vcf.gz ...
Read summary statistics for 13566930 SNPs.
Dropped 12681 SNPs with duplicated rs numbers.
Reading reference panel LD Score from /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/[1-22] ...
Read reference panel LD Scores for 1290028 SNPs.
Removing partitioned LD Scores with zero variance.
Reading regression weight LD Score from /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/[1-22] ...
Read regression weight LD Scores for 1290028 SNPs.
After merging with reference panel LD, 1283504 SNPs remain.
After merging with regression SNP LD, 1283504 SNPs remain.
Using two-step estimator with cutoff at 30.
Total Observed scale h2: 0.027 (0.0054)
Lambda GC: 1.0407
Mean Chi^2: 1.0503
Intercept: 1.0031 (0.0058)
Ratio: 0.0613 (0.1162)
Analysis finished at Mon Nov 25 16:40:32 2019
Total time elapsed: 2.0m:15.93s
{
"af_correlation": 0.9521,
"inflation_factor": 1.0317,
"mean_EFFECT": -0,
"n": 90617,
"n_snps": 13566930,
"n_clumped_hits": 0,
"n_p_sig": 1,
"n_mono": 0,
"n_ns": 1251240,
"n_mac": 0,
"is_snpid_unique": false,
"n_miss_EFFECT": 0,
"n_miss_SE": 0,
"n_miss_PVAL": 0,
"n_miss_AF": 0,
"n_miss_AF_reference": 563198,
"n_est": 90939.5631,
"ratio_se_n": 1.0018,
"mean_diff": -0,
"ratio_diff": 21.9083,
"sd_y_est1": 0.4259,
"sd_y_est2": 0.4267,
"r2_sum1": 0,
"r2_sum2": 0,
"r2_sum3": 0,
"r2_sum4": 0,
"ldsc_nsnp_merge_refpanel_ld": 1283504,
"ldsc_nsnp_merge_regression_ld": 1283504,
"ldsc_observed_scale_h2_beta": 0.027,
"ldsc_observed_scale_h2_se": 0.0054,
"ldsc_intercept_beta": 1.0031,
"ldsc_intercept_se": 0.0058,
"ldsc_lambda_gc": 1.0407,
"ldsc_mean_chisq": 1.0503,
"ldsc_ratio": 0.0616
}
name | value |
---|---|
af_correlation | FALSE |
inflation_factor | FALSE |
n | FALSE |
is_snpid_non_unique | TRUE |
mean_EFFECT_nonfinite | FALSE |
mean_EFFECT_05 | FALSE |
mean_EFFECT_01 | FALSE |
mean_chisq | FALSE |
n_p_sig | FALSE |
miss_EFFECT | FALSE |
miss_SE | FALSE |
miss_PVAL | FALSE |
ldsc_ratio | FALSE |
ldsc_intercept_beta | FALSE |
n_clumped_hits | FALSE |
r2_sum1 | FALSE |
r2_sum2 | FALSE |
r2_sum3 | FALSE |
r2_sum4 | FALSE |
General metrics
af_correlation
: Correlation coefficient between AF
and AF_reference
.inflation_factor
(lambda
): Genomic inflation factor.mean_EFFECT
: Mean of EFFECT
size.n
: Maximum value of reported sample size across all SNPs, \(n\).n_clumped_hits
: Number of clumped hits.n_snps
: Number of SNPsn_p_sig
: Number of SNPs with pvalue below 5e-8
.n_mono
: Number of monomorphic (MAF == 1
or MAF == 0
) SNPs.n_ns
: Number of SNPs with nonsense values:
A, C, G or T
.< 0
or > 1
.<= 0
or = Infinity
).< 0
or > 1
.n_mac
: Number of cases where MAC
(\(2 \times N \times MAF\)) is less than 6
.is_snpid_unique
: true
if the combination of ID
REF
ALT
is unique and therefore no duplication in snpid.n_miss_<*>
: Number of NA
observations for <*>
column.se_n metrics
n_est
: Estimated sample size value, \(\widehat{n}\).ratio_se_n
: \(\texttt{ratio_se_n} = \frac{\sqrt{\widehat{n}}}{\sqrt{n}}\). We expect ratio_se_n
to be 1. When it is not 1, it implies that the trait did not have a variance of 1, the reported sample size is wrong, or that the SNP-level effective sample sizes differ markedly from the reported sample size.mean_diff
: \(\texttt{mean_diff} = \sum_{j} \frac{\widehat{\beta_j^{std}} - \beta_j}{\texttt{n_snps}}\), mean difference between the standardised beta, predicted from P-values, and the observed beta. The difference should be very close to zero if trait has a variance of 1.
ratio_diff
: \(\texttt{ratio_diff} = |\frac{\texttt{mean_diff}}{\texttt{mean_diff2}}|\), absolute ratio between the mean of diff
and the mean of diff2
(expected difference between the standardised beta predicted from P-values, and the standardised beta derived from the observed beta divided by the predicted SD; NOT reported). The ratio should be close to 1. If different from 1, then implies that the betas are not in a standard deviation scale.
sd_y_est1
: The standard deviation for the trait inferred from the reported sample size, median standard errors for the SNP-trait assocations and SNP variances.
sd_y_est2
: The standard deviation for the trait inferred from the reported sample size, Z statistics for the SNP-trait effects (beta/se) and allele frequency.
r2 metrics
Sum of variance explained, calculated from the clumped top hits sample.
r2_sum<*>
: r2
statistics under various assumptions
1
: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var1}}}\), \(\texttt{var1} = 1\).2
: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var2}}}\), \(\texttt{var2} = {\widehat{\texttt{sd1}}_{y}}^2\),3
: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var3}}}\), \(\texttt{var3} = {\widehat{\texttt{sd2}}_{y}}^2\),4
: \(r^2 = \sum_j{\frac{F_j}{F_j + n - 2}}\), \(F = \frac{\beta_j^2}{{se}_j^2}\).LDSC metrics
Metrics from LD regression
ldsc_nsnp_merge_refpanel_ld
: Number of remaining SNPs after merging with reference panel LD.ldsc_nsnp_merge_regression_ld
: Number of remaining SNPs after merging with regression SNP LD.ldsc_observed_scale_h2_{beta,se}
Coefficient value and SE for total observed scale h2.ldsc_intercept_{beta,se}
: Coefficient value and SE for intercept. Intercept is expected to be 1.ldsc_lambda_gc
: Lambda GC statistics.ldsc_mean_chisq
: Mean \(\chi^2\) statistics.ldsc_ratio
: \(\frac{\texttt{ldsc_intercept_beta} - 1}{\texttt{ldsc_mean_chisq} - 1}\), the proportion of the inflation in the mean \(\chi^2\) that the LD Score regression intercepts ascribes to causes other than polygenic heritability. The value of ratio should be close to zero, though in practice values of 0.1-0.2 are not uncommon, probably due to sample/reference LD Score mismatch or model misspecification (e.g., low LD variants have slightly higher \(h^2\) per SNP).Flags
When a metric needs attention, the flag should return TRUE.
af_correlation
: abs(af_correlation)
< 0.7.inflation_factor
: inflation_factor
> 1.2.n
: n
(max reported sample size) < 10000.is_snpid_non_unique
: NOT is_snpid_unique
.mean_EFFECT_nonfinite
: mean(EFFECT)
is NA
, NaN
, or Inf
.mean_EFFECT_05
: abs(mean(EFFECT))
> 0.5.mean_EFFECT_01
: abs(mean(EFFECT))
> 0.1.mean_chisq
: ldsc_mean_chisq
> 1.3 or ldsc_mean_chisq
< 0.7.n_p_sig
: n_p_sig
> 1000.miss_<*>
: n_miss_<*>
/ n_snps
> 0.01.ldsc_ratio
: ldsc_ratio
> 0.5ldsc_intercept_beta
: ldsc_intercept_beta
> 1.5n_clumped_hits
: n_clumped_hits
> 1000r2_sum<*>
: r2_sum<*>
> 0.5Plots
skim_type | skim_variable | n_missing | complete_rate | character.min | character.max | character.empty | character.n_unique | character.whitespace | numeric.mean | numeric.sd | numeric.p0 | numeric.p25 | numeric.p50 | numeric.p75 | numeric.p100 | numeric.hist |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
character | ID | 0 | 1.0000000 | 3 | 94 | 0 | 13554913 | 0 | NA | NA | NA | NA | NA | NA | NA | NA |
character | REF | 0 | 1.0000000 | 1 | 100 | 0 | 57048 | 0 | NA | NA | NA | NA | NA | NA | NA | NA |
character | ALT | 0 | 1.0000000 | 1 | 342 | 0 | 33333 | 0 | NA | NA | NA | NA | NA | NA | NA | NA |
numeric | CHROM | 0 | 1.0000000 | NA | NA | NA | NA | NA | 9.051348e+00 | 6.184958e+00 | 1.00000e+00 | 4.000000e+00 | 8.000000e+00 | 1.300000e+01 | 2.300000e+01 | ▇▅▅▂▂ |
numeric | POS | 0 | 1.0000000 | NA | NA | NA | NA | NA | 7.902470e+07 | 5.591654e+07 | 3.02000e+02 | 3.292786e+07 | 7.013474e+07 | 1.148620e+08 | 2.492309e+08 | ▇▆▅▂▁ |
numeric | EFFECT | 0 | 1.0000000 | NA | NA | NA | NA | NA | -1.640000e-05 | 1.169500e-02 | -1.55196e-01 | -3.117100e-03 | 4.600000e-06 | 3.154600e-03 | 1.328350e-01 | ▁▁▇▁▁ |
numeric | SE | 0 | 1.0000000 | NA | NA | NA | NA | NA | 8.374100e-03 | 8.070100e-03 | 1.65170e-03 | 2.392600e-03 | 4.400900e-03 | 1.202480e-02 | 4.058850e-02 | ▇▂▁▁▁ |
numeric | PVAL | 0 | 1.0000000 | NA | NA | NA | NA | NA | 4.947110e-01 | 2.902451e-01 | 0.00000e+00 | 2.421040e-01 | 4.932772e-01 | 7.459917e-01 | 1.000000e+00 | ▇▇▇▇▇ |
numeric | PVAL_ztest | 0 | 1.0000000 | NA | NA | NA | NA | NA | 4.947092e-01 | 2.902461e-01 | 0.00000e+00 | 2.421012e-01 | 4.932753e-01 | 7.459903e-01 | 1.000000e+00 | ▇▇▇▇▇ |
numeric | AF | 0 | 1.0000000 | NA | NA | NA | NA | NA | 1.910661e-01 | 2.544735e-01 | 1.00000e-03 | 7.499200e-03 | 6.029850e-02 | 2.957758e-01 | 9.990000e-01 | ▇▂▁▁▁ |
numeric | AF_reference | 563198 | 0.9584874 | NA | NA | NA | NA | NA | 1.965231e-01 | 2.471450e-01 | 0.00000e+00 | 5.790700e-03 | 8.446490e-02 | 3.085060e-01 | 1.000000e+00 | ▇▂▁▁▁ |
numeric | N | 0 | 1.0000000 | NA | NA | NA | NA | NA | 9.061700e+04 | 0.000000e+00 | 9.06170e+04 | 9.061700e+04 | 9.061700e+04 | 9.061700e+04 | 9.061700e+04 | ▁▁▇▁▁ |
CHROM | POS | ID | REF | ALT | EFFECT | SE | PVAL | PVAL_ztest | AF | AF_reference | N |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | 692794 | rs530212009 | CA | C | -0.0039648 | 0.0034953 | 0.2566540 | 0.2566511 | 0.1113950 | 0.1894970 | 90617 |
1 | 693731 | rs12238997 | A | G | -0.0021710 | 0.0033101 | 0.5119046 | 0.5119030 | 0.1163860 | 0.1417730 | 90617 |
1 | 707522 | rs371890604 | G | C | -0.0002022 | 0.0037190 | 0.9566481 | 0.9566479 | 0.0978590 | 0.1293930 | 90617 |
1 | 717587 | rs144155419 | G | A | -0.0140304 | 0.0088759 | 0.1139449 | 0.1139402 | 0.0157467 | 0.0045926 | 90617 |
1 | 723329 | rs189787166 | A | T | 0.0180278 | 0.0258648 | 0.4858028 | 0.4858020 | 0.0017779 | 0.0003994 | 90617 |
1 | 730087 | rs148120343 | T | C | -0.0014151 | 0.0045878 | 0.7577396 | 0.7577401 | 0.0569496 | 0.0127796 | 90617 |
1 | 731718 | rs142557973 | T | C | -0.0019601 | 0.0031410 | 0.5326145 | 0.5326127 | 0.1222710 | 0.1543530 | 90617 |
1 | 732032 | rs61770163 | A | C | -0.0018508 | 0.0033492 | 0.5805224 | 0.5805226 | 0.1219580 | 0.1555510 | 90617 |
1 | 734349 | rs141242758 | T | C | -0.0022752 | 0.0031435 | 0.4692032 | 0.4692015 | 0.1215020 | 0.1525560 | 90617 |
1 | 740284 | rs61770167 | C | T | 0.0199956 | 0.0144240 | 0.1656659 | 0.1656636 | 0.0057474 | 0.0023962 | 90617 |
CHROM | POS | ID | REF | ALT | EFFECT | SE | PVAL | PVAL_ztest | AF | AF_reference | N |
---|---|---|---|---|---|---|---|---|---|---|---|
23 | 154923311 | rs141127553 | C | T | 0.0072522 | 0.0036740 | 0.0483894 | 0.0483869 | 0.0553245 | 0.0309934 | 90617 |
23 | 154923374 | rs111332691 | T | A | -0.0050485 | 0.0040004 | 0.2069512 | 0.2069477 | 0.0448150 | 0.0116556 | 90617 |
23 | 154925045 | rs509981 | C | T | 0.0007896 | 0.0019273 | 0.6820434 | 0.6820419 | 0.2445590 | 0.3634440 | 90617 |
23 | 154925895 | rs538470 | C | T | 0.0013980 | 0.0019703 | 0.4779902 | 0.4779867 | 0.2410610 | 0.3634440 | 90617 |
23 | 154927581 | rs644138 | G | A | 0.0024528 | 0.0018128 | 0.1760492 | 0.1760459 | 0.3002870 | 0.4635760 | 90617 |
23 | 154929412 | rs557132 | C | T | 0.0008626 | 0.0019278 | 0.6545442 | 0.6545429 | 0.2444160 | 0.3568210 | 90617 |
23 | 154929637 | rs35185538 | CT | C | 0.0013172 | 0.0020130 | 0.5128850 | 0.5128840 | 0.2287530 | 0.3011920 | 90617 |
23 | 154929952 | rs4012982 | CAA | C | 0.0010128 | 0.0020290 | 0.6176679 | 0.6176669 | 0.2383300 | 0.3165560 | 90617 |
23 | 154930230 | rs781880 | A | G | 0.0008571 | 0.0019272 | 0.6565155 | 0.6565144 | 0.2448690 | 0.3618540 | 90617 |
23 | 154930487 | rs781879 | T | A | -0.0060916 | 0.0065352 | 0.3512780 | 0.3512760 | 0.0196492 | 0.1263580 | 90617 |
1 692794 rs530212009 CA C . PASS AF=0.111395 ES:SE:LP:AF:SS:ID -0.00396482:0.00349526:0.590652:0.111395:90617:1_692794_CA_C
1 693731 rs12238997 A G . PASS AF=0.116386 ES:SE:LP:AF:SS:ID -0.00217102:0.0033101:0.290811:0.116386:90617:rs12238997
1 707522 rs371890604 G C . PASS AF=0.097859 ES:SE:LP:AF:SS:ID -0.000202168:0.00371902:0.0192478:0.097859:90617:rs371890604
1 717587 rs144155419 G A . PASS AF=0.0157467 ES:SE:LP:AF:SS:ID -0.0140304:0.00887591:0.943305:0.0157467:90617:rs144155419
1 723329 rs189787166 A T . PASS AF=0.0017779 ES:SE:LP:AF:SS:ID 0.0180278:0.0258648:0.31354:0.0017779:90617:rs189787166
1 730087 rs148120343 T C . PASS AF=0.0569496 ES:SE:LP:AF:SS:ID -0.0014151:0.00458778:0.12048:0.0569496:90617:rs148120343
1 731718 rs58276399 T C . PASS AF=0.122271 ES:SE:LP:AF:SS:ID -0.00196008:0.00314104:0.273587:0.122271:90617:rs58276399
1 732032 rs61770163 A C . PASS AF=0.121958 ES:SE:LP:AF:SS:ID -0.00185084:0.0033492:0.236181:0.121958:90617:rs61770163
1 734349 rs141242758 T C . PASS AF=0.121502 ES:SE:LP:AF:SS:ID -0.00227517:0.00314346:0.328639:0.121502:90617:rs141242758
1 740284 rs61770167 C T . PASS AF=0.00574737 ES:SE:LP:AF:SS:ID 0.0199956:0.014424:0.780767:0.00574737:90617:rs61770167
1 742813 rs112573343 C T . PASS AF=0.00181683 ES:SE:LP:AF:SS:ID 4.11369e-05:0.0276516:0.000515814:0.00181683:90617:rs112573343
1 749963 rs529266287 T TAA . PASS AF=0.869026 ES:SE:LP:AF:SS:ID 0.00220319:0.00309234:0.322231:0.869026:90617:rs529266287
1 750230 rs190826124 G C . PASS AF=0.00160564 ES:SE:LP:AF:SS:ID 0.0309746:0.0272607:0.591998:0.00160564:90617:rs190826124
1 751343 rs28544273 T A . PASS AF=0.123594 ES:SE:LP:AF:SS:ID -0.00183748:0.00306573:0.26048:0.123594:90617:rs28544273
1 751488 rs200141114 G GA . PASS AF=0.143072 ES:SE:LP:AF:SS:ID -0.000634832:0.0030349:0.0786726:0.143072:90617:rs200141114
1 751756 rs28527770 T C . PASS AF=0.123729 ES:SE:LP:AF:SS:ID -0.00177926:0.00306129:0.25096:0.123729:90617:rs28527770
1 753405 rs3115860 C A . PASS AF=0.870018 ES:SE:LP:AF:SS:ID 0.00192698:0.00298293:0.285436:0.870018:90617:rs3115860
1 753425 rs3131970 T C . PASS AF=0.874674 ES:SE:LP:AF:SS:ID 0.00163932:0.00303149:0.230126:0.874674:90617:rs3131970
1 753541 rs2073813 G A . PASS AF=0.129419 ES:SE:LP:AF:SS:ID -0.0022432:0.00299216:0.343479:0.129419:90617:rs2073813
1 754105 rs12184325 C T . PASS AF=0.0358211 ES:SE:LP:AF:SS:ID 0.00535708:0.00546451:0.485559:0.0358211:90617:rs12184325
1 754182 rs3131969 A G . PASS AF=0.869667 ES:SE:LP:AF:SS:ID 0.00209486:0.00298046:0.316825:0.869667:90617:rs3131969
1 754192 rs3131968 A G . PASS AF=0.869744 ES:SE:LP:AF:SS:ID 0.0020545:0.00298177:0.309085:0.869744:90617:rs3131968
1 754334 rs3131967 T C . PASS AF=0.869663 ES:SE:LP:AF:SS:ID 0.00210988:0.00298034:0.319674:0.869663:90617:rs3131967
1 754433 rs150578204 G A . PASS AF=0.00530957 ES:SE:LP:AF:SS:ID 0.0103728:0.0148912:0.313299:0.00530957:90617:rs150578204
1 754458 rs142682604 G T . PASS AF=0.00527495 ES:SE:LP:AF:SS:ID 0.0101246:0.0149282:0.303089:0.00527495:90617:rs142682604
1 755435 rs184270342 T G . PASS AF=0.00566967 ES:SE:LP:AF:SS:ID 0.0162951:0.0146582:0.574655:0.00566967:90617:rs184270342
1 755890 rs3115858 A T . PASS AF=0.869648 ES:SE:LP:AF:SS:ID 0.00184397:0.00297419:0.271431:0.869648:90617:rs3115858
1 756434 rs61768170 G C . PASS AF=0.126804 ES:SE:LP:AF:SS:ID -0.00200358:0.00303609:0.29302:0.126804:90617:rs61768170
1 756604 rs3131962 A G . PASS AF=0.86918 ES:SE:LP:AF:SS:ID 0.00163701:0.00296666:0.23576:0.86918:90617:rs3131962
1 757640 rs3115853 G A . PASS AF=0.86857 ES:SE:LP:AF:SS:ID 0.00185433:0.00296478:0.274355:0.86857:90617:rs3115853
1 757734 rs4951929 C T . PASS AF=0.869333 ES:SE:LP:AF:SS:ID 0.0018093:0.00296936:0.265751:0.869333:90617:rs4951929
1 757936 rs4951862 C A . PASS AF=0.869339 ES:SE:LP:AF:SS:ID 0.00180989:0.00296956:0.265835:0.869339:90617:rs4951862
1 758144 rs3131956 A G . PASS AF=0.869341 ES:SE:LP:AF:SS:ID 0.00181265:0.00296958:0.266325:0.869341:90617:rs3131956
1 758626 rs3131954 C T . PASS AF=0.869817 ES:SE:LP:AF:SS:ID 0.00172431:0.00297737:0.24988:0.869817:90617:rs3131954
1 759293 rs10157329 T A . PASS AF=0.0991224 ES:SE:LP:AF:SS:ID -0.00110376:0.00346454:0.124916:0.0991224:90617:rs10157329
1 759600 rs545998451 AGT A . PASS AF=0.00650958 ES:SE:LP:AF:SS:ID 0.0168648:0.0133492:0.685156:0.00650958:90617:1_759600_AGT_A
1 759837 rs3115851 T A . PASS AF=0.873813 ES:SE:LP:AF:SS:ID 0.00188189:0.00302161:0.27294:0.873813:90617:rs3115851
1 761732 rs2286139 C T . PASS AF=0.863196 ES:SE:LP:AF:SS:ID 0.00254665:0.00296401:0.40867:0.863196:90617:rs2286139
1 761752 rs1057213 C T . PASS AF=0.86861 ES:SE:LP:AF:SS:ID 0.00229427:0.00299334:0.353198:0.86861:90617:rs1057213
1 762273 rs3115849 G A . PASS AF=0.865497 ES:SE:LP:AF:SS:ID 0.00214352:0.00299383:0.324216:0.865497:90617:rs3115849
1 762485 rs12095200 C A . PASS AF=0.0994329 ES:SE:LP:AF:SS:ID -0.00168429:0.00358316:0.194965:0.0994329:90617:rs12095200
1 762589 rs3115848 G C . PASS AF=0.870776 ES:SE:LP:AF:SS:ID 0.00221355:0.00302791:0.332781:0.870776:90617:rs3115848
1 762592 rs3131950 C G . PASS AF=0.870776 ES:SE:LP:AF:SS:ID 0.00221359:0.00302791:0.332788:0.870776:90617:rs3131950
1 762601 rs3131949 T C . PASS AF=0.870773 ES:SE:LP:AF:SS:ID 0.00221382:0.00302792:0.332829:0.870773:90617:rs3131949
1 762632 rs3131948 T A . PASS AF=0.87114 ES:SE:LP:AF:SS:ID 0.00224813:0.00302934:0.339119:0.87114:90617:rs3131948
1 764191 rs7515915 T G . PASS AF=0.1264 ES:SE:LP:AF:SS:ID -0.00206413:0.00303265:0.304428:0.1264:90617:rs7515915
1 766007 rs61768174 A C . PASS AF=0.105965 ES:SE:LP:AF:SS:ID -0.000961371:0.00329625:0.113199:0.105965:90617:rs61768174
1 766105 rs2519015 T A . PASS AF=0.85452 ES:SE:LP:AF:SS:ID 0.00209693:0.0029629:0.319558:0.85452:90617:rs2519015
1 767393 rs538667473 A C . PASS AF=0.0016878 ES:SE:LP:AF:SS:ID 0.0200192:0.0259518:0.356083:0.0016878:90617:rs538667473
1 768116 rs376645387 A AGTTTT . PASS AF=0.839298 ES:SE:LP:AF:SS:ID 0.00124457:0.00292699:0.17348:0.839298:90617:rs376645387