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}
*********************************************************************
* LD Score Regression (LDSC)
* Version 1.0.1
* (C) 2014-2019 Brendan Bulik-Sullivan and Hilary Finucane
* Broad Institute of MIT and Harvard / MIT Department of Mathematics
* GNU General Public License v3
*********************************************************************
Call:
./ldsc.py \
--h2 /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-d-import/processed/ukb-d-22601_21323059/ukb-d-22601_21323059.vcf.gz \
--ref-ld-chr /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/ \
--out /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-d-import/processed/ukb-d-22601_21323059/ldsc.txt \
--w-ld-chr /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/
Beginning analysis at Mon Nov 25 14:57:42 2019
Reading summary statistics from /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-d-import/processed/ukb-d-22601_21323059/ukb-d-22601_21323059.vcf.gz ...
Read summary statistics for 11390347 SNPs.
Dropped 9627 SNPs with duplicated rs numbers.
Reading reference panel LD Score from /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/[1-22] ...
Read reference panel LD Scores for 1290028 SNPs.
Removing partitioned LD Scores with zero variance.
Reading regression weight LD Score from /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/[1-22] ...
Read regression weight LD Scores for 1290028 SNPs.
After merging with reference panel LD, 1282492 SNPs remain.
After merging with regression SNP LD, 1282492 SNPs remain.
Using two-step estimator with cutoff at 30.
Total Observed scale h2: 0.0147 (0.005)
Lambda GC: 1.038
Mean Chi^2: 1.0357
Intercept: 1.0097 (0.0058)
Ratio: 0.2705 (0.1629)
Analysis finished at Mon Nov 25 14:59:35 2019
Total time elapsed: 1.0m:53.3s
{
"af_correlation": 0.9472,
"inflation_factor": 1.0293,
"mean_EFFECT": -9.5915e-06,
"n": 89866,
"n_snps": 11390347,
"n_clumped_hits": 0,
"n_p_sig": 1,
"n_mono": 0,
"n_ns": 1156847,
"n_mac": 0,
"is_snpid_unique": false,
"n_miss_EFFECT": 0,
"n_miss_SE": 0,
"n_miss_PVAL": 0,
"n_miss_AF": 0,
"n_miss_AF_reference": 237471,
"n_est": 90025.942,
"ratio_se_n": 1.0009,
"mean_diff": -0,
"ratio_diff": 23.9343,
"sd_y_est1": 0.1912,
"sd_y_est2": 0.1914,
"r2_sum1": 0,
"r2_sum2": 0,
"r2_sum3": 0,
"r2_sum4": 0,
"ldsc_nsnp_merge_refpanel_ld": 1282492,
"ldsc_nsnp_merge_regression_ld": 1282492,
"ldsc_observed_scale_h2_beta": 0.0147,
"ldsc_observed_scale_h2_se": 0.005,
"ldsc_intercept_beta": 1.0097,
"ldsc_intercept_se": 0.0058,
"ldsc_lambda_gc": 1.038,
"ldsc_mean_chisq": 1.0357,
"ldsc_ratio": 0.2717
}
name | value |
---|---|
af_correlation | FALSE |
inflation_factor | FALSE |
n | FALSE |
is_snpid_non_unique | TRUE |
mean_EFFECT_nonfinite | FALSE |
mean_EFFECT_05 | FALSE |
mean_EFFECT_01 | FALSE |
mean_chisq | FALSE |
n_p_sig | FALSE |
miss_EFFECT | FALSE |
miss_SE | FALSE |
miss_PVAL | FALSE |
ldsc_ratio | FALSE |
ldsc_intercept_beta | FALSE |
n_clumped_hits | FALSE |
r2_sum1 | FALSE |
r2_sum2 | FALSE |
r2_sum3 | FALSE |
r2_sum4 | FALSE |
General metrics
af_correlation
: Correlation coefficient between AF
and AF_reference
.inflation_factor
(lambda
): Genomic inflation factor.mean_EFFECT
: Mean of EFFECT
size.n
: Maximum value of reported sample size across all SNPs, \(n\).n_clumped_hits
: Number of clumped hits.n_snps
: Number of SNPsn_p_sig
: Number of SNPs with pvalue below 5e-8
.n_mono
: Number of monomorphic (MAF == 1
or MAF == 0
) SNPs.n_ns
: Number of SNPs with nonsense values:
A, C, G or T
.< 0
or > 1
.<= 0
or = Infinity
).< 0
or > 1
.n_mac
: Number of cases where MAC
(\(2 \times N \times MAF\)) is less than 6
.is_snpid_unique
: true
if the combination of ID
REF
ALT
is unique and therefore no duplication in snpid.n_miss_<*>
: Number of NA
observations for <*>
column.se_n metrics
n_est
: Estimated sample size value, \(\widehat{n}\).ratio_se_n
: \(\texttt{ratio_se_n} = \frac{\sqrt{\widehat{n}}}{\sqrt{n}}\). We expect ratio_se_n
to be 1. When it is not 1, it implies that the trait did not have a variance of 1, the reported sample size is wrong, or that the SNP-level effective sample sizes differ markedly from the reported sample size.mean_diff
: \(\texttt{mean_diff} = \sum_{j} \frac{\widehat{\beta_j^{std}} - \beta_j}{\texttt{n_snps}}\), mean difference between the standardised beta, predicted from P-values, and the observed beta. The difference should be very close to zero if trait has a variance of 1.
ratio_diff
: \(\texttt{ratio_diff} = |\frac{\texttt{mean_diff}}{\texttt{mean_diff2}}|\), absolute ratio between the mean of diff
and the mean of diff2
(expected difference between the standardised beta predicted from P-values, and the standardised beta derived from the observed beta divided by the predicted SD; NOT reported). The ratio should be close to 1. If different from 1, then implies that the betas are not in a standard deviation scale.
sd_y_est1
: The standard deviation for the trait inferred from the reported sample size, median standard errors for the SNP-trait assocations and SNP variances.
sd_y_est2
: The standard deviation for the trait inferred from the reported sample size, Z statistics for the SNP-trait effects (beta/se) and allele frequency.
r2 metrics
Sum of variance explained, calculated from the clumped top hits sample.
r2_sum<*>
: r2
statistics under various assumptions
1
: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var1}}}\), \(\texttt{var1} = 1\).2
: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var2}}}\), \(\texttt{var2} = {\widehat{\texttt{sd1}}_{y}}^2\),3
: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var3}}}\), \(\texttt{var3} = {\widehat{\texttt{sd2}}_{y}}^2\),4
: \(r^2 = \sum_j{\frac{F_j}{F_j + n - 2}}\), \(F = \frac{\beta_j^2}{{se}_j^2}\).LDSC metrics
Metrics from LD regression
ldsc_nsnp_merge_refpanel_ld
: Number of remaining SNPs after merging with reference panel LD.ldsc_nsnp_merge_regression_ld
: Number of remaining SNPs after merging with regression SNP LD.ldsc_observed_scale_h2_{beta,se}
Coefficient value and SE for total observed scale h2.ldsc_intercept_{beta,se}
: Coefficient value and SE for intercept. Intercept is expected to be 1.ldsc_lambda_gc
: Lambda GC statistics.ldsc_mean_chisq
: Mean \(\chi^2\) statistics.ldsc_ratio
: \(\frac{\texttt{ldsc_intercept_beta} - 1}{\texttt{ldsc_mean_chisq} - 1}\), the proportion of the inflation in the mean \(\chi^2\) that the LD Score regression intercepts ascribes to causes other than polygenic heritability. The value of ratio should be close to zero, though in practice values of 0.1-0.2 are not uncommon, probably due to sample/reference LD Score mismatch or model misspecification (e.g., low LD variants have slightly higher \(h^2\) per SNP).Flags
When a metric needs attention, the flag should return TRUE.
af_correlation
: abs(af_correlation)
< 0.7.inflation_factor
: inflation_factor
> 1.2.n
: n
(max reported sample size) < 10000.is_snpid_non_unique
: NOT is_snpid_unique
.mean_EFFECT_nonfinite
: mean(EFFECT)
is NA
, NaN
, or Inf
.mean_EFFECT_05
: abs(mean(EFFECT))
> 0.5.mean_EFFECT_01
: abs(mean(EFFECT))
> 0.1.mean_chisq
: ldsc_mean_chisq
> 1.3 or ldsc_mean_chisq
< 0.7.n_p_sig
: n_p_sig
> 1000.miss_<*>
: n_miss_<*>
/ n_snps
> 0.01.ldsc_ratio
: ldsc_ratio
> 0.5ldsc_intercept_beta
: ldsc_intercept_beta
> 1.5n_clumped_hits
: n_clumped_hits
> 1000r2_sum<*>
: r2_sum<*>
> 0.5Plots
skim_type | skim_variable | n_missing | complete_rate | character.min | character.max | character.empty | character.n_unique | character.whitespace | numeric.mean | numeric.sd | numeric.p0 | numeric.p25 | numeric.p50 | numeric.p75 | numeric.p100 | numeric.hist |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
character | ID | 0 | 1.0000000 | 3 | 94 | 0 | 11381318 | 0 | NA | NA | NA | NA | NA | NA | NA | NA |
character | REF | 0 | 1.0000000 | 1 | 100 | 0 | 52020 | 0 | NA | NA | NA | NA | NA | NA | NA | NA |
character | ALT | 0 | 1.0000000 | 1 | 342 | 0 | 31632 | 0 | NA | NA | NA | NA | NA | NA | NA | NA |
numeric | CHROM | 0 | 1.0000000 | NA | NA | NA | NA | NA | 9.074042e+00 | 6.182997e+00 | 1.00000e+00 | 4.000000e+00 | 8.000000e+00 | 1.300000e+01 | 2.300000e+01 | ▇▅▅▂▂ |
numeric | POS | 0 | 1.0000000 | NA | NA | NA | NA | NA | 7.883728e+07 | 5.600143e+07 | 3.02000e+02 | 3.262965e+07 | 6.983755e+07 | 1.147281e+08 | 2.492309e+08 | ▇▆▅▂▁ |
numeric | EFFECT | 0 | 1.0000000 | NA | NA | NA | NA | NA | -9.600000e-06 | 3.059600e-03 | -3.20978e-02 | -1.172000e-03 | -1.730000e-05 | 1.129300e-03 | 3.843340e-02 | ▁▁▇▁▁ |
numeric | SE | 0 | 1.0000000 | NA | NA | NA | NA | NA | 2.415100e-03 | 1.847500e-03 | 7.45900e-04 | 1.022700e-03 | 1.541800e-03 | 3.272300e-03 | 1.079470e-02 | ▇▂▁▁▁ |
numeric | PVAL | 0 | 1.0000000 | NA | NA | NA | NA | NA | 4.955157e-01 | 2.898629e-01 | 0.00000e+00 | 2.433022e-01 | 4.937931e-01 | 7.464866e-01 | 1.000000e+00 | ▇▇▇▇▇ |
numeric | PVAL_ztest | 0 | 1.0000000 | NA | NA | NA | NA | NA | 4.955139e-01 | 2.898640e-01 | 0.00000e+00 | 2.432989e-01 | 4.937907e-01 | 7.464855e-01 | 9.999998e-01 | ▇▇▇▇▇ |
numeric | AF | 0 | 1.0000000 | NA | NA | NA | NA | NA | 2.255327e-01 | 2.609610e-01 | 3.62840e-03 | 2.032460e-02 | 1.078870e-01 | 3.605190e-01 | 9.963720e-01 | ▇▂▁▁▁ |
numeric | AF_reference | 237471 | 0.9791516 | NA | NA | NA | NA | NA | 2.261013e-01 | 2.521776e-01 | 0.00000e+00 | 1.797120e-02 | 1.261980e-01 | 3.600240e-01 | 1.000000e+00 | ▇▂▂▁▁ |
numeric | N | 0 | 1.0000000 | NA | NA | NA | NA | NA | 8.986600e+04 | 0.000000e+00 | 8.98660e+04 | 8.986600e+04 | 8.986600e+04 | 8.986600e+04 | 8.986600e+04 | ▁▁▇▁▁ |
CHROM | POS | ID | REF | ALT | EFFECT | SE | PVAL | PVAL_ztest | AF | AF_reference | N |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | 692794 | rs530212009 | CA | C | -0.0014828 | 0.0015757 | 0.3467049 | 0.3467022 | 0.1114870 | 0.1894970 | 89866 |
1 | 693731 | rs12238997 | A | G | -0.0017937 | 0.0014926 | 0.2294880 | 0.2294864 | 0.1164980 | 0.1417730 | 89866 |
1 | 707522 | rs371890604 | G | C | -0.0017380 | 0.0016780 | 0.3003371 | 0.3003328 | 0.0978285 | 0.1293930 | 89866 |
1 | 717587 | rs144155419 | G | A | -0.0015955 | 0.0039970 | 0.6897695 | 0.6897702 | 0.0158090 | 0.0045926 | 89866 |
1 | 730087 | rs148120343 | T | C | -0.0008204 | 0.0020698 | 0.6918485 | 0.6918480 | 0.0569661 | 0.0127796 | 89866 |
1 | 731718 | rs142557973 | T | C | -0.0015150 | 0.0014164 | 0.2848053 | 0.2848007 | 0.1223780 | 0.1543530 | 89866 |
1 | 732032 | rs61770163 | A | C | -0.0014887 | 0.0015101 | 0.3242269 | 0.3242237 | 0.1220530 | 0.1555510 | 89866 |
1 | 734349 | rs141242758 | T | C | -0.0014734 | 0.0014175 | 0.2985953 | 0.2985923 | 0.1216170 | 0.1525560 | 89866 |
1 | 740284 | rs61770167 | C | T | -0.0060051 | 0.0064776 | 0.3539036 | 0.3539020 | 0.0057975 | 0.0023962 | 89866 |
1 | 749963 | rs529266287 | T | TAA | 0.0010931 | 0.0013946 | 0.4331597 | 0.4331597 | 0.8689590 | 0.7641770 | 89866 |
CHROM | POS | ID | REF | ALT | EFFECT | SE | PVAL | PVAL_ztest | AF | AF_reference | N |
---|---|---|---|---|---|---|---|---|---|---|---|
23 | 154923311 | rs141127553 | C | T | 0.0023425 | 0.0016579 | 0.1576881 | 0.1576860 | 0.0553576 | 0.0309934 | 89866 |
23 | 154923374 | rs111332691 | T | A | 0.0017222 | 0.0018049 | 0.3400087 | 0.3400062 | 0.0449113 | 0.0116556 | 89866 |
23 | 154925045 | rs509981 | C | T | 0.0003474 | 0.0008705 | 0.6898410 | 0.6898398 | 0.2444280 | 0.3634440 | 89866 |
23 | 154925895 | rs538470 | C | T | 0.0007717 | 0.0008901 | 0.3859340 | 0.3859321 | 0.2408760 | 0.3634440 | 89866 |
23 | 154927581 | rs644138 | G | A | 0.0008431 | 0.0008188 | 0.3031349 | 0.3031315 | 0.3001910 | 0.4635760 | 89866 |
23 | 154929412 | rs557132 | C | T | 0.0003554 | 0.0008708 | 0.6831546 | 0.6831546 | 0.2442750 | 0.3568210 | 89866 |
23 | 154929637 | rs35185538 | CT | C | -0.0001727 | 0.0009092 | 0.8493459 | 0.8493452 | 0.2286930 | 0.3011920 | 89866 |
23 | 154929952 | rs4012982 | CAA | C | 0.0002496 | 0.0009164 | 0.7853043 | 0.7853043 | 0.2381980 | 0.3165560 | 89866 |
23 | 154930230 | rs781880 | A | G | 0.0003285 | 0.0008705 | 0.7059013 | 0.7059018 | 0.2447120 | 0.3618540 | 89866 |
23 | 154930487 | rs781879 | T | A | 0.0044871 | 0.0029527 | 0.1286039 | 0.1286008 | 0.0196791 | 0.1263580 | 89866 |
1 692794 rs530212009 CA C . PASS AF=0.111487 ES:SE:LP:AF:SS:ID -0.00148277:0.00157573:0.46004:0.111487:89866:1_692794_CA_C
1 693731 rs12238997 A G . PASS AF=0.116498 ES:SE:LP:AF:SS:ID -0.00179368:0.00149264:0.63924:0.116498:89866:rs12238997
1 707522 rs371890604 G C . PASS AF=0.0978285 ES:SE:LP:AF:SS:ID -0.00173799:0.00167805:0.522391:0.0978285:89866:rs371890604
1 717587 rs144155419 G A . PASS AF=0.015809 ES:SE:LP:AF:SS:ID -0.00159549:0.00399705:0.161296:0.015809:89866:rs144155419
1 730087 rs148120343 T C . PASS AF=0.0569661 ES:SE:LP:AF:SS:ID -0.000820354:0.00206978:0.159989:0.0569661:89866:rs148120343
1 731718 rs58276399 T C . PASS AF=0.122378 ES:SE:LP:AF:SS:ID -0.00151502:0.00141644:0.545452:0.122378:89866:rs58276399
1 732032 rs61770163 A C . PASS AF=0.122053 ES:SE:LP:AF:SS:ID -0.00148867:0.00151009:0.489151:0.122053:89866:rs61770163
1 734349 rs141242758 T C . PASS AF=0.121617 ES:SE:LP:AF:SS:ID -0.00147343:0.0014175:0.524917:0.121617:89866:rs141242758
1 740284 rs61770167 C T . PASS AF=0.00579754 ES:SE:LP:AF:SS:ID -0.00600506:0.00647762:0.451115:0.00579754:89866:rs61770167
1 749963 rs529266287 T TAA . PASS AF=0.868959 ES:SE:LP:AF:SS:ID 0.00109309:0.00139461:0.363352:0.868959:89866:rs529266287
1 751343 rs28544273 T A . PASS AF=0.123678 ES:SE:LP:AF:SS:ID -0.00109596:0.00138255:0.368608:0.123678:89866:rs28544273
1 751488 rs200141114 G GA . PASS AF=0.143191 ES:SE:LP:AF:SS:ID -0.00240271:0.00136879:1.10127:0.143191:89866:rs200141114
1 751756 rs28527770 T C . PASS AF=0.123813 ES:SE:LP:AF:SS:ID -0.00112599:0.00138056:0.382237:0.123813:89866:rs28527770
1 753405 rs3115860 C A . PASS AF=0.869927 ES:SE:LP:AF:SS:ID 0.00162496:0.00134515:0.643886:0.869927:89866:rs3115860
1 753425 rs3131970 T C . PASS AF=0.87461 ES:SE:LP:AF:SS:ID 0.00150934:0.00136708:0.569325:0.87461:89866:rs3131970
1 753541 rs2073813 G A . PASS AF=0.12951 ES:SE:LP:AF:SS:ID -0.00160918:0.00134926:0.632618:0.12951:89866:rs2073813
1 754105 rs12184325 C T . PASS AF=0.0357365 ES:SE:LP:AF:SS:ID 0.00032111:0.00246851:0.0474487:0.0357365:89866:rs12184325
1 754182 rs3131969 A G . PASS AF=0.869574 ES:SE:LP:AF:SS:ID 0.00165193:0.00134397:0.659514:0.869574:89866:rs3131969
1 754192 rs3131968 A G . PASS AF=0.869652 ES:SE:LP:AF:SS:ID 0.00167758:0.00134456:0.673355:0.869652:89866:rs3131968
1 754334 rs3131967 T C . PASS AF=0.86957 ES:SE:LP:AF:SS:ID 0.0016546:0.00134391:0.661032:0.86957:89866:rs3131967
1 754433 rs150578204 G A . PASS AF=0.00528163 ES:SE:LP:AF:SS:ID 0.00301144:0.00674333:0.183639:0.00528163:89866:rs150578204
1 754458 rs142682604 G T . PASS AF=0.00524722 ES:SE:LP:AF:SS:ID 0.00306768:0.00676015:0.187099:0.00524722:89866:rs142682604
1 755435 rs184270342 T G . PASS AF=0.0056565 ES:SE:LP:AF:SS:ID -0.00657847:0.00662008:0.494356:0.0056565:89866:rs184270342
1 755890 rs3115858 A T . PASS AF=0.869566 ES:SE:LP:AF:SS:ID 0.00154246:0.00134125:0.601819:0.869566:89866:rs3115858
1 756434 rs61768170 G C . PASS AF=0.126879 ES:SE:LP:AF:SS:ID -0.00145654:0.00136921:0.541469:0.126879:89866:rs61768170
1 756604 rs3131962 A G . PASS AF=0.869094 ES:SE:LP:AF:SS:ID 0.0015857:0.00133777:0.627289:0.869094:89866:rs3131962
1 757640 rs3115853 G A . PASS AF=0.868498 ES:SE:LP:AF:SS:ID 0.00158855:0.00133695:0.629372:0.868498:89866:rs3115853
1 757734 rs4951929 C T . PASS AF=0.869245 ES:SE:LP:AF:SS:ID 0.00154427:0.00133899:0.604171:0.869245:89866:rs4951929
1 757936 rs4951862 C A . PASS AF=0.869251 ES:SE:LP:AF:SS:ID 0.0015423:0.00133908:0.603065:0.869251:89866:rs4951862
1 758144 rs3131956 A G . PASS AF=0.869252 ES:SE:LP:AF:SS:ID 0.00154283:0.00133909:0.60334:0.869252:89866:rs3131956
1 758626 rs3131954 C T . PASS AF=0.869724 ES:SE:LP:AF:SS:ID 0.00150195:0.00134266:0.579556:0.869724:89866:rs3131954
1 759293 rs10157329 T A . PASS AF=0.0991203 ES:SE:LP:AF:SS:ID -0.00141077:0.00156308:0.435614:0.0991203:89866:rs10157329
1 759600 rs545998451 AGT A . PASS AF=0.00649047 ES:SE:LP:AF:SS:ID -0.00535722:0.00603254:0.426532:0.00649047:89866:1_759600_AGT_A
1 759837 rs3115851 T A . PASS AF=0.873732 ES:SE:LP:AF:SS:ID 0.00134792:0.0013626:0.491396:0.873732:89866:rs3115851
1 761732 rs2286139 C T . PASS AF=0.863116 ES:SE:LP:AF:SS:ID 0.00174945:0.0013365:0.720005:0.863116:89866:rs2286139
1 761752 rs1057213 C T . PASS AF=0.868511 ES:SE:LP:AF:SS:ID 0.00152003:0.00134985:0.584795:0.868511:89866:rs1057213
1 762273 rs3115849 G A . PASS AF=0.86539 ES:SE:LP:AF:SS:ID 0.00164056:0.00135005:0.649175:0.86539:89866:rs3115849
1 762485 rs12095200 C A . PASS AF=0.0994301 ES:SE:LP:AF:SS:ID -0.000968933:0.0016167:0.260462:0.0994301:89866:rs12095200
1 762589 rs3115848 G C . PASS AF=0.870696 ES:SE:LP:AF:SS:ID 0.00132645:0.00136558:0.479671:0.870696:89866:rs3115848
1 762592 rs3131950 C G . PASS AF=0.870695 ES:SE:LP:AF:SS:ID 0.00132644:0.00136558:0.479667:0.870695:89866:rs3131950
1 762601 rs3131949 T C . PASS AF=0.870693 ES:SE:LP:AF:SS:ID 0.00132648:0.00136559:0.479687:0.870693:89866:rs3131949
1 762632 rs3131948 T A . PASS AF=0.871061 ES:SE:LP:AF:SS:ID 0.00133783:0.00136623:0.484815:0.871061:89866:rs3131948
1 764191 rs7515915 T G . PASS AF=0.126484 ES:SE:LP:AF:SS:ID -0.00131807:0.00136761:0.474747:0.126484:89866:rs7515915
1 766007 rs61768174 A C . PASS AF=0.106022 ES:SE:LP:AF:SS:ID -0.00168039:0.00148671:0.587771:0.106022:89866:rs61768174
1 766105 rs2519015 T A . PASS AF=0.854451 ES:SE:LP:AF:SS:ID 0.00166836:0.00133618:0.674045:0.854451:89866:rs2519015
1 768116 rs376645387 A AGTTTT . PASS AF=0.839008 ES:SE:LP:AF:SS:ID 0.00091993:0.00132002:0.313487:0.839008:89866:rs376645387
1 768253 rs2977608 A C . PASS AF=0.76317 ES:SE:LP:AF:SS:ID 0.00127787:0.00106128:0.641002:0.76317:89866:rs2977608
1 768448 rs12562034 G A . PASS AF=0.10519 ES:SE:LP:AF:SS:ID -0.00040641:0.00146262:0.107284:0.10519:89866:rs12562034
1 768819 rs12562811 C T . PASS AF=0.00773441 ES:SE:LP:AF:SS:ID -0.000200977:0.00541872:0.0130429:0.00773441:89866:rs12562811
1 769138 rs59306077 CAT C . PASS AF=0.129876 ES:SE:LP:AF:SS:ID -0.00136627:0.00134846:0.507291:0.129876:89866:rs762168062