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"gwas_harmonisation_command": "--json /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-d-import/processed/ukb-d-20079_1/ukb-d-20079_1_data.json --ref /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/QC/genomes/b37/human_g1k_v37.fasta; 1.1.1",
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"bcftools_viewCommand": "view -h /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/ukb-d-20079_1/ukb-d-20079_1.vcf.gz; Date=Sun May 10 23:10:46 2020"
}
*********************************************************************
* LD Score Regression (LDSC)
* Version 1.0.1
* (C) 2014-2019 Brendan Bulik-Sullivan and Hilary Finucane
* Broad Institute of MIT and Harvard / MIT Department of Mathematics
* GNU General Public License v3
*********************************************************************
Call:
./ldsc.py \
--h2 /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-d-import/processed/ukb-d-20079_1/ukb-d-20079_1.vcf.gz \
--ref-ld-chr /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/ \
--out /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-d-import/processed/ukb-d-20079_1/ldsc.txt \
--w-ld-chr /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/
Beginning analysis at Mon Nov 25 16:43:01 2019
Reading summary statistics from /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-d-import/processed/ukb-d-20079_1/ukb-d-20079_1.vcf.gz ...
Read summary statistics for 12887939 SNPs.
Dropped 11696 SNPs with duplicated rs numbers.
Reading reference panel LD Score from /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/[1-22] ...
Read reference panel LD Scores for 1290028 SNPs.
Removing partitioned LD Scores with zero variance.
Reading regression weight LD Score from /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/[1-22] ...
Read regression weight LD Scores for 1290028 SNPs.
After merging with reference panel LD, 1283357 SNPs remain.
After merging with regression SNP LD, 1283357 SNPs remain.
Using two-step estimator with cutoff at 30.
Total Observed scale h2: 0.0035 (0.0078)
Lambda GC: 1.0045
Mean Chi^2: 0.9993
Intercept: 0.9957 (0.0056)
Ratio: NA (mean chi^2 < 1)
Analysis finished at Mon Nov 25 16:45:08 2019
Total time elapsed: 2.0m:7.08s
{
"af_correlation": 0.951,
"inflation_factor": 1.0041,
"mean_EFFECT": -1.9608e-06,
"n": 51427,
"n_snps": 12887939,
"n_clumped_hits": 0,
"n_p_sig": 0,
"n_mono": 0,
"n_ns": 1224247,
"n_mac": 0,
"is_snpid_unique": false,
"n_miss_EFFECT": 0,
"n_miss_SE": 0,
"n_miss_PVAL": 0,
"n_miss_AF": 0,
"n_miss_AF_reference": 408241,
"n_est": 51641.0562,
"ratio_se_n": 1.0021,
"mean_diff": -1.2682e-06,
"ratio_diff": 0.5928,
"sd_y_est1": 0.3645,
"sd_y_est2": 0.3653,
"r2_sum1": 0,
"r2_sum2": 0,
"r2_sum3": 0,
"r2_sum4": 0,
"ldsc_nsnp_merge_refpanel_ld": 1283357,
"ldsc_nsnp_merge_regression_ld": 1283357,
"ldsc_observed_scale_h2_beta": 0.0035,
"ldsc_observed_scale_h2_se": 0.0078,
"ldsc_intercept_beta": 0.9957,
"ldsc_intercept_se": 0.0056,
"ldsc_lambda_gc": 1.0045,
"ldsc_mean_chisq": 0.9993,
"ldsc_ratio": 6.1429
}
name | value |
---|---|
af_correlation | FALSE |
inflation_factor | FALSE |
n | FALSE |
is_snpid_non_unique | TRUE |
mean_EFFECT_nonfinite | FALSE |
mean_EFFECT_05 | FALSE |
mean_EFFECT_01 | FALSE |
mean_chisq | FALSE |
n_p_sig | FALSE |
miss_EFFECT | FALSE |
miss_SE | FALSE |
miss_PVAL | FALSE |
ldsc_ratio | TRUE |
ldsc_intercept_beta | FALSE |
n_clumped_hits | FALSE |
r2_sum1 | FALSE |
r2_sum2 | FALSE |
r2_sum3 | FALSE |
r2_sum4 | FALSE |
General metrics
af_correlation
: Correlation coefficient between AF
and AF_reference
.inflation_factor
(lambda
): Genomic inflation factor.mean_EFFECT
: Mean of EFFECT
size.n
: Maximum value of reported sample size across all SNPs, \(n\).n_clumped_hits
: Number of clumped hits.n_snps
: Number of SNPsn_p_sig
: Number of SNPs with pvalue below 5e-8
.n_mono
: Number of monomorphic (MAF == 1
or MAF == 0
) SNPs.n_ns
: Number of SNPs with nonsense values:
A, C, G or T
.< 0
or > 1
.<= 0
or = Infinity
).< 0
or > 1
.n_mac
: Number of cases where MAC
(\(2 \times N \times MAF\)) is less than 6
.is_snpid_unique
: true
if the combination of ID
REF
ALT
is unique and therefore no duplication in snpid.n_miss_<*>
: Number of NA
observations for <*>
column.se_n metrics
n_est
: Estimated sample size value, \(\widehat{n}\).ratio_se_n
: \(\texttt{ratio_se_n} = \frac{\sqrt{\widehat{n}}}{\sqrt{n}}\). We expect ratio_se_n
to be 1. When it is not 1, it implies that the trait did not have a variance of 1, the reported sample size is wrong, or that the SNP-level effective sample sizes differ markedly from the reported sample size.mean_diff
: \(\texttt{mean_diff} = \sum_{j} \frac{\widehat{\beta_j^{std}} - \beta_j}{\texttt{n_snps}}\), mean difference between the standardised beta, predicted from P-values, and the observed beta. The difference should be very close to zero if trait has a variance of 1.
ratio_diff
: \(\texttt{ratio_diff} = |\frac{\texttt{mean_diff}}{\texttt{mean_diff2}}|\), absolute ratio between the mean of diff
and the mean of diff2
(expected difference between the standardised beta predicted from P-values, and the standardised beta derived from the observed beta divided by the predicted SD; NOT reported). The ratio should be close to 1. If different from 1, then implies that the betas are not in a standard deviation scale.
sd_y_est1
: The standard deviation for the trait inferred from the reported sample size, median standard errors for the SNP-trait assocations and SNP variances.
sd_y_est2
: The standard deviation for the trait inferred from the reported sample size, Z statistics for the SNP-trait effects (beta/se) and allele frequency.
r2 metrics
Sum of variance explained, calculated from the clumped top hits sample.
r2_sum<*>
: r2
statistics under various assumptions
1
: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var1}}}\), \(\texttt{var1} = 1\).2
: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var2}}}\), \(\texttt{var2} = {\widehat{\texttt{sd1}}_{y}}^2\),3
: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var3}}}\), \(\texttt{var3} = {\widehat{\texttt{sd2}}_{y}}^2\),4
: \(r^2 = \sum_j{\frac{F_j}{F_j + n - 2}}\), \(F = \frac{\beta_j^2}{{se}_j^2}\).LDSC metrics
Metrics from LD regression
ldsc_nsnp_merge_refpanel_ld
: Number of remaining SNPs after merging with reference panel LD.ldsc_nsnp_merge_regression_ld
: Number of remaining SNPs after merging with regression SNP LD.ldsc_observed_scale_h2_{beta,se}
Coefficient value and SE for total observed scale h2.ldsc_intercept_{beta,se}
: Coefficient value and SE for intercept. Intercept is expected to be 1.ldsc_lambda_gc
: Lambda GC statistics.ldsc_mean_chisq
: Mean \(\chi^2\) statistics.ldsc_ratio
: \(\frac{\texttt{ldsc_intercept_beta} - 1}{\texttt{ldsc_mean_chisq} - 1}\), the proportion of the inflation in the mean \(\chi^2\) that the LD Score regression intercepts ascribes to causes other than polygenic heritability. The value of ratio should be close to zero, though in practice values of 0.1-0.2 are not uncommon, probably due to sample/reference LD Score mismatch or model misspecification (e.g., low LD variants have slightly higher \(h^2\) per SNP).Flags
When a metric needs attention, the flag should return TRUE.
af_correlation
: abs(af_correlation)
< 0.7.inflation_factor
: inflation_factor
> 1.2.n
: n
(max reported sample size) < 10000.is_snpid_non_unique
: NOT is_snpid_unique
.mean_EFFECT_nonfinite
: mean(EFFECT)
is NA
, NaN
, or Inf
.mean_EFFECT_05
: abs(mean(EFFECT))
> 0.5.mean_EFFECT_01
: abs(mean(EFFECT))
> 0.1.mean_chisq
: ldsc_mean_chisq
> 1.3 or ldsc_mean_chisq
< 0.7.n_p_sig
: n_p_sig
> 1000.miss_<*>
: n_miss_<*>
/ n_snps
> 0.01.ldsc_ratio
: ldsc_ratio
> 0.5ldsc_intercept_beta
: ldsc_intercept_beta
> 1.5n_clumped_hits
: n_clumped_hits
> 1000r2_sum<*>
: r2_sum<*>
> 0.5Plots
skim_type | skim_variable | n_missing | complete_rate | character.min | character.max | character.empty | character.n_unique | character.whitespace | numeric.mean | numeric.sd | numeric.p0 | numeric.p25 | numeric.p50 | numeric.p75 | numeric.p100 | numeric.hist |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
character | ID | 0 | 1.0000000 | 3 | 94 | 0 | 12876892 | 0 | NA | NA | NA | NA | NA | NA | NA | NA |
character | REF | 0 | 1.0000000 | 1 | 100 | 0 | 55570 | 0 | NA | NA | NA | NA | NA | NA | NA | NA |
character | ALT | 0 | 1.0000000 | 1 | 342 | 0 | 32867 | 0 | NA | NA | NA | NA | NA | NA | NA | NA |
numeric | CHROM | 0 | 1.0000000 | NA | NA | NA | NA | NA | 9.059403e+00 | 6.185834e+00 | 1.00000e+00 | 4.000000e+00 | 8.000000e+00 | 1.300000e+01 | 2.300000e+01 | ▇▅▅▂▂ |
numeric | POS | 0 | 1.0000000 | NA | NA | NA | NA | NA | 7.897314e+07 | 5.594381e+07 | 3.02000e+02 | 3.282590e+07 | 7.004258e+07 | 1.148240e+08 | 2.492309e+08 | ▇▆▅▂▁ |
numeric | EFFECT | 0 | 1.0000000 | NA | NA | NA | NA | NA | -2.000000e-06 | 1.113360e-02 | -1.27129e-01 | -3.314900e-03 | -2.730000e-05 | 3.251900e-03 | 1.562320e-01 | ▁▁▇▁▁ |
numeric | SE | 0 | 1.0000000 | NA | NA | NA | NA | NA | 8.246900e-03 | 7.483000e-03 | 1.87150e-03 | 2.670800e-03 | 4.598400e-03 | 1.166490e-02 | 4.222270e-02 | ▇▂▁▁▁ |
numeric | PVAL | 0 | 1.0000000 | NA | NA | NA | NA | NA | 4.996099e-01 | 2.885843e-01 | 1.00000e-07 | 2.495313e-01 | 4.991315e-01 | 7.494696e-01 | 1.000000e+00 | ▇▇▇▇▇ |
numeric | PVAL_ztest | 0 | 1.0000000 | NA | NA | NA | NA | NA | 4.996068e-01 | 2.885861e-01 | 1.00000e-07 | 2.495256e-01 | 4.991275e-01 | 7.494688e-01 | 9.999999e-01 | ▇▇▇▇▇ |
numeric | AF | 0 | 1.0000000 | NA | NA | NA | NA | NA | 2.006105e-01 | 2.566921e-01 | 1.55450e-03 | 1.021150e-02 | 7.290590e-02 | 3.147210e-01 | 9.984450e-01 | ▇▂▁▁▁ |
numeric | AF_reference | 408241 | 0.9683238 | NA | NA | NA | NA | NA | 2.039347e-01 | 2.487330e-01 | 0.00000e+00 | 7.587900e-03 | 9.484820e-02 | 3.222840e-01 | 1.000000e+00 | ▇▂▁▁▁ |
numeric | N | 0 | 1.0000000 | NA | NA | NA | NA | NA | 5.142700e+04 | 0.000000e+00 | 5.14270e+04 | 5.142700e+04 | 5.142700e+04 | 5.142700e+04 | 5.142700e+04 | ▁▁▇▁▁ |
CHROM | POS | ID | REF | ALT | EFFECT | SE | PVAL | PVAL_ztest | AF | AF_reference | N |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | 692794 | rs530212009 | CA | C | 0.0031373 | 0.0039576 | 0.4279352 | 0.4279317 | 0.1121000 | 0.1894970 | 51427 |
1 | 693731 | rs12238997 | A | G | 0.0032966 | 0.0037608 | 0.3807238 | 0.3807193 | 0.1168090 | 0.1417730 | 51427 |
1 | 707522 | rs371890604 | G | C | 0.0012796 | 0.0042180 | 0.7616194 | 0.7616176 | 0.0982930 | 0.1293930 | 51427 |
1 | 717587 | rs144155419 | G | A | 0.0026965 | 0.0101972 | 0.7914455 | 0.7914460 | 0.0154808 | 0.0045926 | 51427 |
1 | 723329 | rs189787166 | A | T | 0.0162756 | 0.0289816 | 0.5744021 | 0.5743996 | 0.0017973 | 0.0003994 | 51427 |
1 | 730087 | rs148120343 | T | C | 0.0041241 | 0.0052373 | 0.4310285 | 0.4310260 | 0.0570822 | 0.0127796 | 51427 |
1 | 731718 | rs142557973 | T | C | 0.0033605 | 0.0035738 | 0.3470627 | 0.3470597 | 0.1225210 | 0.1543530 | 51427 |
1 | 732032 | rs61770163 | A | C | 0.0023830 | 0.0038097 | 0.5316466 | 0.5316446 | 0.1216510 | 0.1555510 | 51427 |
1 | 734349 | rs141242758 | T | C | 0.0030106 | 0.0035758 | 0.3998269 | 0.3998237 | 0.1217650 | 0.1525560 | 51427 |
1 | 740284 | rs61770167 | C | T | 0.0236056 | 0.0156268 | 0.1309001 | 0.1308944 | 0.0062329 | 0.0023962 | 51427 |
CHROM | POS | ID | REF | ALT | EFFECT | SE | PVAL | PVAL_ztest | AF | AF_reference | N |
---|---|---|---|---|---|---|---|---|---|---|---|
23 | 154923311 | rs141127553 | C | T | -0.0014002 | 0.0042046 | 0.7391218 | 0.7391202 | 0.0542488 | 0.0309934 | 51427 |
23 | 154923374 | rs111332691 | T | A | -0.0021788 | 0.0045546 | 0.6323813 | 0.6323798 | 0.0445389 | 0.0116556 | 51427 |
23 | 154925045 | rs509981 | C | T | 0.0044972 | 0.0021894 | 0.0399761 | 0.0399708 | 0.2434190 | 0.3634440 | 51427 |
23 | 154925895 | rs538470 | C | T | 0.0046471 | 0.0022365 | 0.0377320 | 0.0377275 | 0.2401390 | 0.3634440 | 51427 |
23 | 154927581 | rs644138 | G | A | 0.0038475 | 0.0020594 | 0.0617362 | 0.0617306 | 0.2981050 | 0.4635760 | 51427 |
23 | 154929412 | rs557132 | C | T | 0.0045317 | 0.0021902 | 0.0385452 | 0.0385403 | 0.2432580 | 0.3568210 | 51427 |
23 | 154929637 | rs35185538 | CT | C | 0.0032028 | 0.0022821 | 0.1605029 | 0.1604970 | 0.2278210 | 0.3011920 | 51427 |
23 | 154929952 | rs4012982 | CAA | C | 0.0045680 | 0.0023044 | 0.0474504 | 0.0474443 | 0.2374290 | 0.3165560 | 51427 |
23 | 154930230 | rs781880 | A | G | 0.0043879 | 0.0021892 | 0.0450433 | 0.0450381 | 0.2438260 | 0.3618540 | 51427 |
23 | 154930487 | rs781879 | T | A | 0.0043197 | 0.0076130 | 0.5704374 | 0.5704347 | 0.0189843 | 0.1263580 | 51427 |
1 692794 rs530212009 CA C . PASS AF=0.1121 ES:SE:LP:AF:SS:ID 0.0031373:0.00395756:0.368622:0.1121:51427:1_692794_CA_C
1 693731 rs12238997 A G . PASS AF=0.116809 ES:SE:LP:AF:SS:ID 0.00329662:0.00376081:0.41939:0.116809:51427:rs12238997
1 707522 rs371890604 G C . PASS AF=0.098293 ES:SE:LP:AF:SS:ID 0.00127957:0.00421803:0.118262:0.098293:51427:rs371890604
1 717587 rs144155419 G A . PASS AF=0.0154808 ES:SE:LP:AF:SS:ID 0.00269648:0.0101972:0.101579:0.0154808:51427:rs144155419
1 723329 rs189787166 A T . PASS AF=0.00179726 ES:SE:LP:AF:SS:ID 0.0162756:0.0289816:0.240784:0.00179726:51427:rs189787166
1 730087 rs148120343 T C . PASS AF=0.0570822 ES:SE:LP:AF:SS:ID 0.00412406:0.00523732:0.365494:0.0570822:51427:rs148120343
1 731718 rs58276399 T C . PASS AF=0.122521 ES:SE:LP:AF:SS:ID 0.0033605:0.00357383:0.459592:0.122521:51427:rs58276399
1 732032 rs61770163 A C . PASS AF=0.121651 ES:SE:LP:AF:SS:ID 0.00238297:0.00380972:0.274377:0.121651:51427:rs61770163
1 734349 rs141242758 T C . PASS AF=0.121765 ES:SE:LP:AF:SS:ID 0.00301057:0.00357577:0.398128:0.121765:51427:rs141242758
1 740284 rs61770167 C T . PASS AF=0.0062329 ES:SE:LP:AF:SS:ID 0.0236056:0.0156268:0.88306:0.0062329:51427:rs61770167
1 742813 rs112573343 C T . PASS AF=0.00176649 ES:SE:LP:AF:SS:ID 0.025215:0.032473:0.35906:0.00176649:51427:rs112573343
1 749963 rs529266287 T TAA . PASS AF=0.868613 ES:SE:LP:AF:SS:ID -0.0016241:0.00352004:0.190761:0.868613:51427:rs529266287
1 750230 rs190826124 G C . PASS AF=0.00158492 ES:SE:LP:AF:SS:ID 0.0221271:0.0315842:0.315538:0.00158492:51427:rs190826124
1 751343 rs28544273 T A . PASS AF=0.123957 ES:SE:LP:AF:SS:ID 0.00214442:0.00348709:0.268746:0.123957:51427:rs28544273
1 751488 rs200141114 G GA . PASS AF=0.143385 ES:SE:LP:AF:SS:ID 0.000789176:0.00345974:0.0864155:0.143385:51427:rs200141114
1 751756 rs28527770 T C . PASS AF=0.124126 ES:SE:LP:AF:SS:ID 0.00215745:0.0034813:0.271288:0.124126:51427:rs28527770
1 753405 rs3115860 C A . PASS AF=0.869933 ES:SE:LP:AF:SS:ID -0.0020323:0.00339285:0.260285:0.869933:51427:rs3115860
1 753425 rs3131970 T C . PASS AF=0.874426 ES:SE:LP:AF:SS:ID -0.0025808:0.00344679:0.342937:0.874426:51427:rs3131970
1 753541 rs2073813 G A . PASS AF=0.129659 ES:SE:LP:AF:SS:ID 0.00144403:0.00340122:0.173176:0.129659:51427:rs2073813
1 754105 rs12184325 C T . PASS AF=0.0369164 ES:SE:LP:AF:SS:ID -0.00246371:0.00612605:0.162689:0.0369164:51427:rs12184325
1 754182 rs3131969 A G . PASS AF=0.869554 ES:SE:LP:AF:SS:ID -0.00180436:0.00338969:0.225836:0.869554:51427:rs3131969
1 754192 rs3131968 A G . PASS AF=0.869648 ES:SE:LP:AF:SS:ID -0.00177499:0.00339145:0.221329:0.869648:51427:rs3131968
1 754334 rs3131967 T C . PASS AF=0.86957 ES:SE:LP:AF:SS:ID -0.00184315:0.00338969:0.231648:0.86957:51427:rs3131967
1 754433 rs150578204 G A . PASS AF=0.00531261 ES:SE:LP:AF:SS:ID 0.00299456:0.0169893:0.0654566:0.00531261:51427:rs150578204
1 754458 rs142682604 G T . PASS AF=0.00527727 ES:SE:LP:AF:SS:ID 0.00315999:0.0170339:0.0691385:0.00527727:51427:rs142682604
1 755435 rs184270342 T G . PASS AF=0.0057746 ES:SE:LP:AF:SS:ID -0.00864895:0.0166134:0.219937:0.0057746:51427:rs184270342
1 755890 rs3115858 A T . PASS AF=0.869706 ES:SE:LP:AF:SS:ID -0.00217098:0.00338457:0.28296:0.869706:51427:rs3115858
1 756434 rs61768170 G C . PASS AF=0.12702 ES:SE:LP:AF:SS:ID 0.001948:0.00345189:0.242199:0.12702:51427:rs61768170
1 756604 rs3131962 A G . PASS AF=0.869213 ES:SE:LP:AF:SS:ID -0.00222192:0.00337567:0.292088:0.869213:51427:rs3131962
1 757640 rs3115853 G A . PASS AF=0.868449 ES:SE:LP:AF:SS:ID -0.00200427:0.0033724:0.257821:0.868449:51427:rs3115853
1 757734 rs4951929 C T . PASS AF=0.869419 ES:SE:LP:AF:SS:ID -0.00220262:0.00337939:0.288576:0.869419:51427:rs4951929
1 757936 rs4951862 C A . PASS AF=0.869426 ES:SE:LP:AF:SS:ID -0.00220613:0.00337961:0.289119:0.869426:51427:rs4951862
1 758144 rs3131956 A G . PASS AF=0.869437 ES:SE:LP:AF:SS:ID -0.00214076:0.00337977:0.278624:0.869437:51427:rs3131956
1 758626 rs3131954 C T . PASS AF=0.869848 ES:SE:LP:AF:SS:ID -0.00225389:0.00338766:0.295981:0.869848:51427:rs3131954
1 759293 rs10157329 T A . PASS AF=0.0999077 ES:SE:LP:AF:SS:ID 0.00289019:0.00392853:0.335433:0.0999077:51427:rs10157329
1 759600 rs545998451 AGT A . PASS AF=0.00659027 ES:SE:LP:AF:SS:ID -0.0178684:0.0150896:0.626432:0.00659027:51427:1_759600_AGT_A
1 759837 rs3115851 T A . PASS AF=0.87358 ES:SE:LP:AF:SS:ID -0.00235678:0.0034366:0.307285:0.87358:51427:rs3115851
1 761732 rs2286139 C T . PASS AF=0.86295 ES:SE:LP:AF:SS:ID -0.00182198:0.00337149:0.229946:0.86295:51427:rs2286139
1 761752 rs1057213 C T . PASS AF=0.868667 ES:SE:LP:AF:SS:ID -0.00231071:0.00340456:0.303361:0.868667:51427:rs1057213
1 762273 rs3115849 G A . PASS AF=0.8652 ES:SE:LP:AF:SS:ID -0.002228:0.00340305:0.290171:0.8652:51427:rs3115849
1 762485 rs12095200 C A . PASS AF=0.0992889 ES:SE:LP:AF:SS:ID 0.0011433:0.00408425:0.108165:0.0992889:51427:rs12095200
1 762589 rs3115848 G C . PASS AF=0.870459 ES:SE:LP:AF:SS:ID -0.00233494:0.0034413:0.303247:0.870459:51427:rs3115848
1 762592 rs3131950 C G . PASS AF=0.870459 ES:SE:LP:AF:SS:ID -0.00233489:0.0034413:0.303238:0.870459:51427:rs3131950
1 762601 rs3131949 T C . PASS AF=0.870456 ES:SE:LP:AF:SS:ID -0.00233527:0.00344132:0.303299:0.870456:51427:rs3131949
1 762632 rs3131948 T A . PASS AF=0.870829 ES:SE:LP:AF:SS:ID -0.00254454:0.00344327:0.337321:0.870829:51427:rs3131948
1 764191 rs7515915 T G . PASS AF=0.126636 ES:SE:LP:AF:SS:ID 0.00189416:0.00344712:0.234577:0.126636:51427:rs7515915
1 766007 rs61768174 A C . PASS AF=0.106247 ES:SE:LP:AF:SS:ID 0.00189393:0.00375397:0.2119:0.106247:51427:rs61768174
1 766105 rs2519015 T A . PASS AF=0.854084 ES:SE:LP:AF:SS:ID -0.00172475:0.00337114:0.215441:0.854084:51427:rs2519015
1 767393 rs538667473 A C . PASS AF=0.00168817 ES:SE:LP:AF:SS:ID 0.0162649:0.0292373:0.23807:0.00168817:51427:rs538667473
1 768116 rs376645387 A AGTTTT . PASS AF=0.836377 ES:SE:LP:AF:SS:ID -0.00123893:0.00330149:0.150295:0.836377:51427:rs376645387