Summary
Summary {data-width=650}
Manhattan plot
manhattan_plot
QQ plot
qq_plot
AF plot
af_plot
P-Z plot
pz_plot
beta_std plot
beta_std_plot
Metadata
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"gwas_harmonisation_command": "--out /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/ukbiobank/vcf_09_19b/bgzip_vcf/data.batch_41202_I48.vcf.gz --id UKB-b:964 --data /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/ukbiobank/raw-output/data.batch_41202_I48.txt.gz --cohort_cases 5669 --cohort_controls 457341 --ref /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/ukbiobank/human_g1k_v37.fasta --json /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/ukbiobank/ukb_gwas.json; 1.1.1",
"file_date": "2019-09-12T19:50:52.961911",
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"bcftools_viewCommand.1": "view -h /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/ukb-b-964/ukb-b-964.vcf.gz; Date=Sun May 10 12:31:03 2020"
}
LDSC
*********************************************************************
* LD Score Regression (LDSC)
* Version 1.0.1
* (C) 2014-2019 Brendan Bulik-Sullivan and Hilary Finucane
* Broad Institute of MIT and Harvard / MIT Department of Mathematics
* GNU General Public License v3
*********************************************************************
Call:
./ldsc.py \
--h2 /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/UKB-b-964/UKB-b-964_data.vcf.gz \
--ref-ld-chr ../reference/eur_w_ld_chr/ \
--out /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/UKB-b-964/ldsc.txt \
--w-ld-chr ../reference/eur_w_ld_chr/
Beginning analysis at Thu Oct 17 14:42:59 2019
Reading summary statistics from /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/UKB-b-964/UKB-b-964_data.vcf.gz ...
Read summary statistics for 5103637 SNPs.
Dropped 1537 SNPs with duplicated rs numbers.
Reading reference panel LD Score from ../reference/eur_w_ld_chr/[1-22] ...
Read reference panel LD Scores for 1290028 SNPs.
Removing partitioned LD Scores with zero variance.
Reading regression weight LD Score from ../reference/eur_w_ld_chr/[1-22] ...
Read regression weight LD Scores for 1290028 SNPs.
After merging with reference panel LD, 1128808 SNPs remain.
After merging with regression SNP LD, 1128808 SNPs remain.
Using two-step estimator with cutoff at 30.
Total Observed scale h2: 0.0151 (0.0022)
Lambda GC: 1.1126
Mean Chi^2: 1.1517
Intercept: 1.0082 (0.0085)
Ratio: 0.0542 (0.0558)
Analysis finished at Thu Oct 17 14:44:11 2019
Total time elapsed: 1.0m:12.27sQC metrics
Metrics
Metrics
{
"af_correlation": 0.9088,
"inflation_factor": 1.0966,
"mean_EFFECT": -3.2055e-07,
"n": "-Inf",
"n_snps": 9851866,
"n_clumped_hits": 21,
"n_p_sig": 1190,
"n_mono": 0,
"n_ns": 0,
"n_mac": 0,
"is_snpid_unique": true,
"n_miss_EFFECT": 0,
"n_miss_SE": 0,
"n_miss_PVAL": 0,
"n_miss_AF": 0,
"n_miss_AF_reference": 43779,
"n_est": "NA",
"ratio_se_n": "NA",
"mean_diff": "NaN",
"ratio_diff": "NaN",
"sd_y_est1": "NaN",
"sd_y_est2": "NA",
"r2_sum1": 0,
"r2_sum2": 0,
"r2_sum3": 0,
"r2_sum4": 0,
"ldsc_nsnp_merge_refpanel_ld": 1128808,
"ldsc_nsnp_merge_regression_ld": 1128808,
"ldsc_observed_scale_h2_beta": 0.0151,
"ldsc_observed_scale_h2_se": 0.0022,
"ldsc_intercept_beta": 1.0082,
"ldsc_intercept_se": 0.0085,
"ldsc_lambda_gc": 1.1126,
"ldsc_mean_chisq": 1.1517,
"ldsc_ratio": 0.0541
}
Flags
| name | value |
|---|---|
| af_correlation | FALSE |
| inflation_factor | FALSE |
| n | TRUE |
| is_snpid_non_unique | FALSE |
| mean_EFFECT_nonfinite | FALSE |
| mean_EFFECT_05 | FALSE |
| mean_EFFECT_01 | FALSE |
| mean_chisq | FALSE |
| n_p_sig | TRUE |
| miss_EFFECT | FALSE |
| miss_SE | FALSE |
| miss_PVAL | FALSE |
| ldsc_ratio | FALSE |
| ldsc_intercept_beta | FALSE |
| n_clumped_hits | FALSE |
| r2_sum1 | FALSE |
| r2_sum2 | FALSE |
| r2_sum3 | FALSE |
| r2_sum4 | FALSE |
Definitions
General metrics
af_correlation: Correlation coefficient betweenAFandAF_reference.inflation_factor(lambda): Genomic inflation factor.mean_EFFECT: Mean ofEFFECTsize.n: Maximum value of reported sample size across all SNPs, \(n\).n_clumped_hits: Number of clumped hits.n_snps: Number of SNPsn_p_sig: Number of SNPs with pvalue below5e-8.n_mono: Number of monomorphic (MAF == 1orMAF == 0) SNPs.n_ns: Number of SNPs with nonsense values:- alleles other than
A, C, G or T. - P-values
< 0or> 1. - negative or infinite standard errors (
<= 0or= Infinity). - infinite beta estimates or allele frequencies
< 0or> 1.
- alleles other than
n_mac: Number of cases whereMAC(\(2 \times N \times MAF\)) is less than6.is_snpid_unique:trueif the combination ofIDREFALTis unique and therefore no duplication in snpid.n_miss_<*>: Number ofNAobservations for<*>column.
se_n metrics
n_est: Estimated sample size value, \(\widehat{n}\).ratio_se_n: \(\texttt{ratio_se_n} = \frac{\sqrt{\widehat{n}}}{\sqrt{n}}\). We expectratio_se_nto be 1. When it is not 1, it implies that the trait did not have a variance of 1, the reported sample size is wrong, or that the SNP-level effective sample sizes differ markedly from the reported sample size.mean_diff: \(\texttt{mean_diff} = \sum_{j} \frac{\widehat{\beta_j^{std}} - \beta_j}{\texttt{n_snps}}\), mean difference between the standardised beta, predicted from P-values, and the observed beta. The difference should be very close to zero if trait has a variance of 1.- \(\widehat{\beta_j^{std}} = \sqrt{\frac{{z}_j^2 / ({z}_j^2 + n -2)}{2 \times {MAF}_j \times (1 - {MAF}_j)}} \times sign({z}_j)\),
- \({z}_j = \frac{\beta_j}{{se}_j}\),
- and \(\beta_j\) is the reported effect size.
ratio_diff: \(\texttt{ratio_diff} = |\frac{\texttt{mean_diff}}{\texttt{mean_diff2}}|\), absolute ratio between the mean ofdiffand the mean ofdiff2(expected difference between the standardised beta predicted from P-values, and the standardised beta derived from the observed beta divided by the predicted SD; NOT reported). The ratio should be close to 1. If different from 1, then implies that the betas are not in a standard deviation scale.- \(\texttt{mean_diff2} = \sum_{j} \frac{\widehat{\beta_j^{std}} - \beta^{\prime}_j}{\texttt{n_snps}}\)
- \(\beta^{\prime}_j = \frac{\beta_j}{\widehat{\texttt{sd2}}_{y}}\)
sd_y_est1: The standard deviation for the trait inferred from the reported sample size, median standard errors for the SNP-trait assocations and SNP variances.- \(\widehat{\texttt{sd1}}_{y} = \frac{\sqrt{n} \times median({se}_j)}{C}\),
- \(C = median(\frac{1}{\sqrt{2 \times {MAF}_j \times (1 - {MAF}_j)}})\),
- and \({se}_j\) is the reported standard error.
sd_y_est2: The standard deviation for the trait inferred from the reported sample size, Z statistics for the SNP-trait effects (beta/se) and allele frequency.- \(\widehat{\texttt{sd2}}_{y} = median(\widehat{sd_j})\),
- \(\widehat{sd_j} = \frac{\beta_j}{\widehat{\beta_j^{std}}}\),
r2 metrics
Sum of variance explained, calculated from the clumped top hits sample.
r2_sum<*>:r2statistics under various assumptions1: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var1}}}\), \(\texttt{var1} = 1\).2: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var2}}}\), \(\texttt{var2} = {\widehat{\texttt{sd1}}_{y}}^2\),3: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var3}}}\), \(\texttt{var3} = {\widehat{\texttt{sd2}}_{y}}^2\),4: \(r^2 = \sum_j{\frac{F_j}{F_j + n - 2}}\), \(F = \frac{\beta_j^2}{{se}_j^2}\).
LDSC metrics
Metrics from LD regression
ldsc_nsnp_merge_refpanel_ld: Number of remaining SNPs after merging with reference panel LD.ldsc_nsnp_merge_regression_ld: Number of remaining SNPs after merging with regression SNP LD.ldsc_observed_scale_h2_{beta,se}Coefficient value and SE for total observed scale h2.ldsc_intercept_{beta,se}: Coefficient value and SE for intercept. Intercept is expected to be 1.ldsc_lambda_gc: Lambda GC statistics.ldsc_mean_chisq: Mean \(\chi^2\) statistics.ldsc_ratio: \(\frac{\texttt{ldsc_intercept_beta} - 1}{\texttt{ldsc_mean_chisq} - 1}\), the proportion of the inflation in the mean \(\chi^2\) that the LD Score regression intercepts ascribes to causes other than polygenic heritability. The value of ratio should be close to zero, though in practice values of 0.1-0.2 are not uncommon, probably due to sample/reference LD Score mismatch or model misspecification (e.g., low LD variants have slightly higher \(h^2\) per SNP).
Flags
When a metric needs attention, the flag should return TRUE.
af_correlation:abs(af_correlation)< 0.7.inflation_factor:inflation_factor> 1.2.n:n(max reported sample size) < 10000.is_snpid_non_unique: NOTis_snpid_unique.mean_EFFECT_nonfinite:mean(EFFECT)isNA,NaN, orInf.mean_EFFECT_05:abs(mean(EFFECT))> 0.5.mean_EFFECT_01:abs(mean(EFFECT))> 0.1.mean_chisq:ldsc_mean_chisq> 1.3 orldsc_mean_chisq< 0.7.n_p_sig:n_p_sig> 1000.miss_<*>:n_miss_<*>/n_snps> 0.01.ldsc_ratio:ldsc_ratio> 0.5ldsc_intercept_beta:ldsc_intercept_beta> 1.5n_clumped_hits:n_clumped_hits> 1000r2_sum<*>:r2_sum<*>> 0.5
Plots
- Manhattan plot
- Red line: \(-log_{10}^{5 \times 10^{-8}}\)
- Blue line: \(-log_{10}^{5 \times 10^{-5}}\)
- QQ plot
- AF plot
- P-Z plot
- beta_std plot: Scatter plot between \(\widehat{\beta_j^{std}}\) and \(\beta_j\)
Diagnostics
Details
Summary stats
| skim_type | skim_variable | n_missing | complete_rate | character.min | character.max | character.empty | character.n_unique | character.whitespace | logical.mean | logical.count | numeric.mean | numeric.sd | numeric.p0 | numeric.p25 | numeric.p50 | numeric.p75 | numeric.p100 | numeric.hist |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| character | ID | 0 | 1.000000 | 3 | 58 | 0 | 5102111 | 0 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| character | REF | 0 | 1.000000 | 1 | 1 | 0 | 4 | 0 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| character | ALT | 0 | 1.000000 | 1 | 1 | 0 | 4 | 0 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| logical | N | 5103637 | 0.000000 | NA | NA | NA | NA | NA | NaN | : | NA | NA | NA | NA | NA | NA | NA | NA |
| numeric | CHROM | 0 | 1.000000 | NA | NA | NA | NA | NA | NA | NA | 8.671996e+00 | 5.766055e+00 | 1.0000000 | 4.000000e+00 | 8.000000e+00 | 1.300000e+01 | 2.200000e+01 | ▇▅▅▂▂ |
| numeric | POS | 0 | 1.000000 | NA | NA | NA | NA | NA | NA | NA | 7.854455e+07 | 5.661549e+07 | 828.0000000 | 3.188141e+07 | 6.894659e+07 | 1.145363e+08 | 2.492385e+08 | ▇▆▅▂▁ |
| numeric | EFFECT | 0 | 1.000000 | NA | NA | NA | NA | NA | NA | NA | -3.000000e-07 | 3.272000e-04 | -0.0078816 | -2.060000e-04 | -1.100000e-06 | 2.038000e-04 | 7.986000e-03 | ▁▁▇▁▁ |
| numeric | SE | 0 | 1.000000 | NA | NA | NA | NA | NA | NA | NA | 2.983000e-04 | 6.970000e-05 | 0.0002203 | 2.393000e-04 | 2.731000e-04 | 3.423000e-04 | 8.459000e-04 | ▇▂▁▁▁ |
| numeric | PVAL | 0 | 1.000000 | NA | NA | NA | NA | NA | NA | NA | 4.826415e-01 | 2.930112e-01 | 0.0000000 | 2.300001e-01 | 4.799997e-01 | 7.400005e-01 | 1.000000e+00 | ▇▇▇▆▇ |
| numeric | PVAL_ztest | 0 | 1.000000 | NA | NA | NA | NA | NA | NA | NA | 4.826410e-01 | 2.929870e-01 | 0.0000000 | 2.252611e-01 | 4.761280e-01 | 7.360957e-01 | 9.999998e-01 | ▇▇▇▇▇ |
| numeric | AF | 0 | 1.000000 | NA | NA | NA | NA | NA | NA | NA | 3.474339e-01 | 2.403333e-01 | 0.0617400 | 1.405470e-01 | 2.801950e-01 | 5.141510e-01 | 9.382600e-01 | ▇▅▃▂▂ |
| numeric | AF_reference | 43779 | 0.991422 | NA | NA | NA | NA | NA | NA | NA | 3.411631e-01 | 2.365992e-01 | 0.0000000 | 1.459660e-01 | 2.829470e-01 | 5.035940e-01 | 1.000000e+00 | ▇▆▃▃▁ |
Head and tail
| CHROM | POS | ID | REF | ALT | EFFECT | SE | PVAL | PVAL_ztest | AF | AF_reference | N |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 49298 | rs200943160 | T | C | 0.0002337 | 0.0004053 | 0.5600000 | 0.5642270 | 0.623765 | 0.7821490 | NA |
| 1 | 54676 | rs2462492 | C | T | 0.0000417 | 0.0004015 | 0.9199999 | 0.9172061 | 0.400401 | NA | NA |
| 1 | 86028 | rs114608975 | T | C | 0.0001464 | 0.0006420 | 0.8200001 | 0.8195809 | 0.103556 | 0.0277556 | NA |
| 1 | 91536 | rs6702460 | G | T | 0.0000959 | 0.0003954 | 0.8100000 | 0.8082977 | 0.456846 | 0.4207270 | NA |
| 1 | 234313 | rs8179466 | C | T | 0.0006918 | 0.0007796 | 0.3700002 | 0.3748441 | 0.074506 | NA | NA |
| 1 | 534192 | rs6680723 | C | T | 0.0011068 | 0.0004516 | 0.0140001 | 0.0142515 | 0.240959 | NA | NA |
| 1 | 546697 | rs12025928 | A | G | -0.0005642 | 0.0005634 | 0.3200000 | 0.3166093 | 0.913475 | NA | NA |
| 1 | 693731 | rs12238997 | A | G | 0.0001192 | 0.0003785 | 0.7499995 | 0.7527752 | 0.116329 | 0.1417730 | NA |
| 1 | 705882 | rs72631875 | G | A | -0.0002281 | 0.0005546 | 0.6800001 | 0.6809282 | 0.067288 | 0.0315495 | NA |
| 1 | 706368 | rs55727773 | A | G | 0.0000974 | 0.0002804 | 0.7300002 | 0.7282593 | 0.515645 | 0.2751600 | NA |
| CHROM | POS | ID | REF | ALT | EFFECT | SE | PVAL | PVAL_ztest | AF | AF_reference | N |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 22 | 51213613 | rs34726907 | C | T | 0.0006596 | 0.0003470 | 0.0569994 | 0.0573251 | 0.127814 | 0.1727240 | NA |
| 22 | 51216564 | rs9616970 | T | C | 0.0006626 | 0.0003456 | 0.0549997 | 0.0551612 | 0.128328 | 0.1563500 | NA |
| 22 | 51217954 | rs9616974 | G | A | 0.0003152 | 0.0004385 | 0.4700002 | 0.4721657 | 0.073312 | 0.0621006 | NA |
| 22 | 51218224 | rs9616975 | C | A | 0.0003168 | 0.0004387 | 0.4700002 | 0.4701994 | 0.073333 | 0.0619010 | NA |
| 22 | 51218377 | rs2519461 | G | C | 0.0003583 | 0.0004381 | 0.4100001 | 0.4134470 | 0.073622 | 0.0826677 | NA |
| 22 | 51219006 | rs28729663 | G | A | 0.0005320 | 0.0003382 | 0.1199999 | 0.1157058 | 0.137950 | 0.2052720 | NA |
| 22 | 51219387 | rs9616832 | T | C | 0.0003673 | 0.0004390 | 0.4000000 | 0.4028424 | 0.073744 | 0.0654952 | NA |
| 22 | 51221731 | rs115055839 | T | C | 0.0003211 | 0.0004393 | 0.4600002 | 0.4648611 | 0.073235 | 0.0625000 | NA |
| 22 | 51229805 | rs9616985 | T | C | 0.0002602 | 0.0004409 | 0.5600000 | 0.5550473 | 0.073071 | 0.0730831 | NA |
| 22 | 51237063 | rs3896457 | T | C | 0.0001942 | 0.0002696 | 0.4700002 | 0.4714526 | 0.297974 | 0.2050720 | NA |
bcf preview
1 49298 rs10399793 T C . PASS AF=0.623765 ES:SE:LP:AF:ID 0.000233696:0.000405318:0.251812:0.623765:rs10399793
1 54676 rs2462492 C T . PASS AF=0.400401 ES:SE:LP:AF:ID 4.17421e-05:0.000401545:0.0362122:0.400401:rs2462492
1 86028 rs114608975 T C . PASS AF=0.103556 ES:SE:LP:AF:ID 0.000146427:0.000641987:0.0861861:0.103556:rs114608975
1 91536 rs6702460 G T . PASS AF=0.456846 ES:SE:LP:AF:ID 9.59255e-05:0.000395369:0.091515:0.456846:rs6702460
1 234313 rs8179466 C T . PASS AF=0.074506 ES:SE:LP:AF:ID 0.000691824:0.000779576:0.431798:0.074506:rs8179466
1 534192 rs6680723 C T . PASS AF=0.240959 ES:SE:LP:AF:ID 0.00110685:0.000451617:1.85387:0.240959:rs6680723
1 546697 rs12025928 A G . PASS AF=0.913475 ES:SE:LP:AF:ID -0.000564233:0.000563416:0.49485:0.913475:rs12025928
1 693731 rs12238997 A G . PASS AF=0.116329 ES:SE:LP:AF:ID 0.000119211:0.000378469:0.124939:0.116329:rs12238997
1 705882 rs72631875 G A . PASS AF=0.067288 ES:SE:LP:AF:ID -0.000228051:0.000554603:0.167491:0.067288:rs72631875
1 706368 rs12029736 A G . PASS AF=0.515645 ES:SE:LP:AF:ID 9.74071e-05:0.000280355:0.136677:0.515645:rs12029736
1 722670 rs116030099 T C . PASS AF=0.1012 ES:SE:LP:AF:ID -0.000193483:0.000462568:0.167491:0.1012:rs116030099
1 729679 rs4951859 C G . PASS AF=0.843204 ES:SE:LP:AF:ID -5.35154e-06:0.000327992:0.00436481:0.843204:rs4951859
1 731718 rs58276399 T C . PASS AF=0.122312 ES:SE:LP:AF:ID 3.64806e-05:0.000359015:0.0362122:0.122312:rs58276399
1 734349 rs141242758 T C . PASS AF=0.121554 ES:SE:LP:AF:ID 3.31459e-05:0.000359166:0.0315171:0.121554:rs141242758
1 736289 rs79010578 T A . PASS AF=0.132335 ES:SE:LP:AF:ID -0.000243329:0.000353994:0.309804:0.132335:rs79010578
1 752566 rs3094315 G A . PASS AF=0.838945 ES:SE:LP:AF:ID 7.55222e-05:0.000317638:0.091515:0.838945:rs3094315
1 752721 rs3131972 A G . PASS AF=0.838573 ES:SE:LP:AF:ID 7.34268e-05:0.000317296:0.0861861:0.838573:rs3131972
1 753405 rs3115860 C A . PASS AF=0.869776 ES:SE:LP:AF:ID 9.32516e-05:0.00034047:0.107905:0.869776:rs3115860
1 753541 rs2073813 G A . PASS AF=0.129876 ES:SE:LP:AF:ID -8.80523e-05:0.000341167:0.09691:0.129876:rs2073813
1 754182 rs3131969 A G . PASS AF=0.869117 ES:SE:LP:AF:ID 8.55334e-05:0.000339803:0.09691:0.869117:rs3131969
1 754192 rs3131968 A G . PASS AF=0.869215 ES:SE:LP:AF:ID 0.000113033:0.000339938:0.130768:0.869215:rs3131968
1 754334 rs3131967 T C . PASS AF=0.869121 ES:SE:LP:AF:ID 9.36526e-05:0.000339797:0.107905:0.869121:rs3131967
1 754503 rs3115859 G A . PASS AF=0.838026 ES:SE:LP:AF:ID 8.02264e-05:0.000316416:0.09691:0.838026:rs3115859
1 754964 rs3131966 C T . PASS AF=0.838657 ES:SE:LP:AF:ID 8.81438e-05:0.000317305:0.107905:0.838657:rs3131966
1 755775 rs3131965 A G . PASS AF=0.83977 ES:SE:LP:AF:ID 0.000117842:0.000321596:0.148742:0.83977:rs3131965
1 755890 rs3115858 A T . PASS AF=0.8694 ES:SE:LP:AF:ID 7.77849e-05:0.000339404:0.0861861:0.8694:rs3115858
1 756604 rs3131962 A G . PASS AF=0.868947 ES:SE:LP:AF:ID 5.75534e-05:0.00033855:0.0604807:0.868947:rs3131962
1 757640 rs3115853 G A . PASS AF=0.867898 ES:SE:LP:AF:ID 2.86903e-05:0.0003379:0.0315171:0.867898:rs3115853
1 757734 rs4951929 C T . PASS AF=0.86909 ES:SE:LP:AF:ID 5.94263e-05:0.000338827:0.0655015:0.86909:rs4951929
1 757936 rs4951862 C A . PASS AF=0.869098 ES:SE:LP:AF:ID 5.64906e-05:0.000338853:0.0604807:0.869098:rs4951862
1 758144 rs3131956 A G . PASS AF=0.869106 ES:SE:LP:AF:ID 6.27141e-05:0.000338861:0.0705811:0.869106:rs3131956
1 758626 rs3131954 C T . PASS AF=0.869584 ES:SE:LP:AF:ID 8.20906e-05:0.000339791:0.091515:0.869584:rs3131954
1 760912 rs1048488 C T . PASS AF=0.838306 ES:SE:LP:AF:ID 8.45957e-05:0.000315816:0.102373:0.838306:rs1048488
1 761147 rs3115850 T C . PASS AF=0.838427 ES:SE:LP:AF:ID 8.4924e-05:0.000316039:0.102373:0.838427:rs3115850
1 761732 rs2286139 C T . PASS AF=0.862254 ES:SE:LP:AF:ID 1.4832e-05:0.000337635:0.0177288:0.862254:rs2286139
1 763394 rs3115847 G A . PASS AF=0.706753 ES:SE:LP:AF:ID -0.000282436:0.000328689:0.408935:0.706753:rs3115847
1 766007 rs61768174 A C . PASS AF=0.105145 ES:SE:LP:AF:ID -0.000288476:0.000378643:0.346787:0.105145:rs61768174
1 768253 rs2977608 A C . PASS AF=0.761297 ES:SE:LP:AF:ID 0.000201178:0.000268268:0.346787:0.761297:rs2977608
1 768448 rs12562034 G A . PASS AF=0.10649 ES:SE:LP:AF:ID -0.000263111:0.000369756:0.318759:0.10649:rs12562034
1 769223 rs60320384 C G . PASS AF=0.129581 ES:SE:LP:AF:ID -8.62039e-05:0.000340964:0.09691:0.129581:rs60320384
1 771823 rs2977605 T C . PASS AF=0.868906 ES:SE:LP:AF:ID 6.83028e-05:0.000339142:0.0757207:0.868906:rs2977605
1 771967 rs59066358 G A . PASS AF=0.129682 ES:SE:LP:AF:ID -8.31736e-05:0.000340744:0.091515:0.129682:rs59066358
1 772755 rs2905039 A C . PASS AF=0.868916 ES:SE:LP:AF:ID 9.45172e-05:0.000339149:0.107905:0.868916:rs2905039
1 776546 rs12124819 A G . PASS AF=0.265385 ES:SE:LP:AF:ID 8.08403e-05:0.000299665:0.102373:0.265385:rs12124819
1 777122 rs2980319 A T . PASS AF=0.870039 ES:SE:LP:AF:ID 0.000104673:0.000339841:0.119186:0.870039:rs2980319
1 777232 rs112618790 C T . PASS AF=0.095141 ES:SE:LP:AF:ID -0.000287487:0.000393869:0.327902:0.095141:rs112618790
1 778745 rs1055606 A G . PASS AF=0.12858 ES:SE:LP:AF:ID -0.000126738:0.000341182:0.148742:0.12858:rs1055606
1 779322 rs4040617 A G . PASS AF=0.128877 ES:SE:LP:AF:ID -0.000129156:0.000340604:0.154902:0.128877:rs4040617
1 780785 rs2977612 T A . PASS AF=0.86878 ES:SE:LP:AF:ID 0.000105781:0.000338934:0.124939:0.86878:rs2977612
1 781845 rs61768199 A G . PASS AF=0.101873 ES:SE:LP:AF:ID -0.000296669:0.000384045:0.356547:0.101873:rs61768199