Summary
Summary {data-width=650}
Manhattan plot
manhattan_plot
QQ plot
qq_plot
AF plot
af_plot
P-Z plot
pz_plot
beta_std plot
beta_std_plot
Metadata
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"gwas_harmonisation_command": "--out /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/ukbiobank/vcf_09_19b/bgzip_vcf/data.batch_41230_5N7.vcf.gz --id UKB-b:8197 --data /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/ukbiobank/raw-output/data.batch_41230_5N7.txt.gz --cohort_cases 1530 --cohort_controls 461480 --ref /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/ukbiobank/human_g1k_v37.fasta --json /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/ukbiobank/ukb_gwas.json; 1.1.1",
"file_date": "2019-09-12T19:10:31.986927",
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"bcftools_viewCommand.1": "view -h /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/ukb-b-8197/ukb-b-8197.vcf.gz; Date=Sat May 9 16:09:42 2020"
}
LDSC
*********************************************************************
* LD Score Regression (LDSC)
* Version 1.0.1
* (C) 2014-2019 Brendan Bulik-Sullivan and Hilary Finucane
* Broad Institute of MIT and Harvard / MIT Department of Mathematics
* GNU General Public License v3
*********************************************************************
Call:
./ldsc.py \
--h2 /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/UKB-b-8197/UKB-b-8197_data.vcf.gz \
--ref-ld-chr ../reference/eur_w_ld_chr/ \
--out /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/UKB-b-8197/ldsc.txt \
--w-ld-chr ../reference/eur_w_ld_chr/
Beginning analysis at Thu Oct 17 14:41:24 2019
Reading summary statistics from /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/UKB-b-8197/UKB-b-8197_data.vcf.gz ...
Read summary statistics for 2548569 SNPs.
Dropped 301 SNPs with duplicated rs numbers.
Reading reference panel LD Score from ../reference/eur_w_ld_chr/[1-22] ...
Read reference panel LD Scores for 1290028 SNPs.
Removing partitioned LD Scores with zero variance.
Reading regression weight LD Score from ../reference/eur_w_ld_chr/[1-22] ...
Read regression weight LD Scores for 1290028 SNPs.
After merging with reference panel LD, 644202 SNPs remain.
After merging with regression SNP LD, 644202 SNPs remain.
Using two-step estimator with cutoff at 30.
Total Observed scale h2: 0.0014 (0.0014)
Lambda GC: 1.0641
Mean Chi^2: 1.069
Intercept: 1.0535 (0.0098)
Ratio: 0.7753 (0.1413)
Analysis finished at Thu Oct 17 14:41:57 2019
Total time elapsed: 33.93sQC metrics
Metrics
Metrics
{
"af_correlation": 0.7741,
"inflation_factor": 1.0475,
"mean_EFFECT": -4.9009e-07,
"n": "-Inf",
"n_snps": 9851866,
"n_clumped_hits": 0,
"n_p_sig": 0,
"n_mono": 0,
"n_ns": 0,
"n_mac": 0,
"is_snpid_unique": true,
"n_miss_EFFECT": 0,
"n_miss_SE": 0,
"n_miss_PVAL": 0,
"n_miss_AF": 0,
"n_miss_AF_reference": 20217,
"n_est": "NA",
"ratio_se_n": "NA",
"mean_diff": "NaN",
"ratio_diff": "NaN",
"sd_y_est1": "NaN",
"sd_y_est2": "NA",
"r2_sum1": 0,
"r2_sum2": 0,
"r2_sum3": 0,
"r2_sum4": 0,
"ldsc_nsnp_merge_refpanel_ld": 644202,
"ldsc_nsnp_merge_regression_ld": 644202,
"ldsc_observed_scale_h2_beta": 0.0014,
"ldsc_observed_scale_h2_se": 0.0014,
"ldsc_intercept_beta": 1.0535,
"ldsc_intercept_se": 0.0098,
"ldsc_lambda_gc": 1.0641,
"ldsc_mean_chisq": 1.069,
"ldsc_ratio": 0.7754
}
Flags
| name | value |
|---|---|
| af_correlation | FALSE |
| inflation_factor | FALSE |
| n | TRUE |
| is_snpid_non_unique | FALSE |
| mean_EFFECT_nonfinite | FALSE |
| mean_EFFECT_05 | FALSE |
| mean_EFFECT_01 | FALSE |
| mean_chisq | FALSE |
| n_p_sig | FALSE |
| miss_EFFECT | FALSE |
| miss_SE | FALSE |
| miss_PVAL | FALSE |
| ldsc_ratio | TRUE |
| ldsc_intercept_beta | FALSE |
| n_clumped_hits | FALSE |
| r2_sum1 | FALSE |
| r2_sum2 | FALSE |
| r2_sum3 | FALSE |
| r2_sum4 | FALSE |
Definitions
General metrics
af_correlation: Correlation coefficient betweenAFandAF_reference.inflation_factor(lambda): Genomic inflation factor.mean_EFFECT: Mean ofEFFECTsize.n: Maximum value of reported sample size across all SNPs, \(n\).n_clumped_hits: Number of clumped hits.n_snps: Number of SNPsn_p_sig: Number of SNPs with pvalue below5e-8.n_mono: Number of monomorphic (MAF == 1orMAF == 0) SNPs.n_ns: Number of SNPs with nonsense values:- alleles other than
A, C, G or T. - P-values
< 0or> 1. - negative or infinite standard errors (
<= 0or= Infinity). - infinite beta estimates or allele frequencies
< 0or> 1.
- alleles other than
n_mac: Number of cases whereMAC(\(2 \times N \times MAF\)) is less than6.is_snpid_unique:trueif the combination ofIDREFALTis unique and therefore no duplication in snpid.n_miss_<*>: Number ofNAobservations for<*>column.
se_n metrics
n_est: Estimated sample size value, \(\widehat{n}\).ratio_se_n: \(\texttt{ratio_se_n} = \frac{\sqrt{\widehat{n}}}{\sqrt{n}}\). We expectratio_se_nto be 1. When it is not 1, it implies that the trait did not have a variance of 1, the reported sample size is wrong, or that the SNP-level effective sample sizes differ markedly from the reported sample size.mean_diff: \(\texttt{mean_diff} = \sum_{j} \frac{\widehat{\beta_j^{std}} - \beta_j}{\texttt{n_snps}}\), mean difference between the standardised beta, predicted from P-values, and the observed beta. The difference should be very close to zero if trait has a variance of 1.- \(\widehat{\beta_j^{std}} = \sqrt{\frac{{z}_j^2 / ({z}_j^2 + n -2)}{2 \times {MAF}_j \times (1 - {MAF}_j)}} \times sign({z}_j)\),
- \({z}_j = \frac{\beta_j}{{se}_j}\),
- and \(\beta_j\) is the reported effect size.
ratio_diff: \(\texttt{ratio_diff} = |\frac{\texttt{mean_diff}}{\texttt{mean_diff2}}|\), absolute ratio between the mean ofdiffand the mean ofdiff2(expected difference between the standardised beta predicted from P-values, and the standardised beta derived from the observed beta divided by the predicted SD; NOT reported). The ratio should be close to 1. If different from 1, then implies that the betas are not in a standard deviation scale.- \(\texttt{mean_diff2} = \sum_{j} \frac{\widehat{\beta_j^{std}} - \beta^{\prime}_j}{\texttt{n_snps}}\)
- \(\beta^{\prime}_j = \frac{\beta_j}{\widehat{\texttt{sd2}}_{y}}\)
sd_y_est1: The standard deviation for the trait inferred from the reported sample size, median standard errors for the SNP-trait assocations and SNP variances.- \(\widehat{\texttt{sd1}}_{y} = \frac{\sqrt{n} \times median({se}_j)}{C}\),
- \(C = median(\frac{1}{\sqrt{2 \times {MAF}_j \times (1 - {MAF}_j)}})\),
- and \({se}_j\) is the reported standard error.
sd_y_est2: The standard deviation for the trait inferred from the reported sample size, Z statistics for the SNP-trait effects (beta/se) and allele frequency.- \(\widehat{\texttt{sd2}}_{y} = median(\widehat{sd_j})\),
- \(\widehat{sd_j} = \frac{\beta_j}{\widehat{\beta_j^{std}}}\),
r2 metrics
Sum of variance explained, calculated from the clumped top hits sample.
r2_sum<*>:r2statistics under various assumptions1: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var1}}}\), \(\texttt{var1} = 1\).2: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var2}}}\), \(\texttt{var2} = {\widehat{\texttt{sd1}}_{y}}^2\),3: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var3}}}\), \(\texttt{var3} = {\widehat{\texttt{sd2}}_{y}}^2\),4: \(r^2 = \sum_j{\frac{F_j}{F_j + n - 2}}\), \(F = \frac{\beta_j^2}{{se}_j^2}\).
LDSC metrics
Metrics from LD regression
ldsc_nsnp_merge_refpanel_ld: Number of remaining SNPs after merging with reference panel LD.ldsc_nsnp_merge_regression_ld: Number of remaining SNPs after merging with regression SNP LD.ldsc_observed_scale_h2_{beta,se}Coefficient value and SE for total observed scale h2.ldsc_intercept_{beta,se}: Coefficient value and SE for intercept. Intercept is expected to be 1.ldsc_lambda_gc: Lambda GC statistics.ldsc_mean_chisq: Mean \(\chi^2\) statistics.ldsc_ratio: \(\frac{\texttt{ldsc_intercept_beta} - 1}{\texttt{ldsc_mean_chisq} - 1}\), the proportion of the inflation in the mean \(\chi^2\) that the LD Score regression intercepts ascribes to causes other than polygenic heritability. The value of ratio should be close to zero, though in practice values of 0.1-0.2 are not uncommon, probably due to sample/reference LD Score mismatch or model misspecification (e.g., low LD variants have slightly higher \(h^2\) per SNP).
Flags
When a metric needs attention, the flag should return TRUE.
af_correlation:abs(af_correlation)< 0.7.inflation_factor:inflation_factor> 1.2.n:n(max reported sample size) < 10000.is_snpid_non_unique: NOTis_snpid_unique.mean_EFFECT_nonfinite:mean(EFFECT)isNA,NaN, orInf.mean_EFFECT_05:abs(mean(EFFECT))> 0.5.mean_EFFECT_01:abs(mean(EFFECT))> 0.1.mean_chisq:ldsc_mean_chisq> 1.3 orldsc_mean_chisq< 0.7.n_p_sig:n_p_sig> 1000.miss_<*>:n_miss_<*>/n_snps> 0.01.ldsc_ratio:ldsc_ratio> 0.5ldsc_intercept_beta:ldsc_intercept_beta> 1.5n_clumped_hits:n_clumped_hits> 1000r2_sum<*>:r2_sum<*>> 0.5
Plots
- Manhattan plot
- Red line: \(-log_{10}^{5 \times 10^{-8}}\)
- Blue line: \(-log_{10}^{5 \times 10^{-5}}\)
- QQ plot
- AF plot
- P-Z plot
- beta_std plot: Scatter plot between \(\widehat{\beta_j^{std}}\) and \(\beta_j\)
Diagnostics
Details
Summary stats
| skim_type | skim_variable | n_missing | complete_rate | character.min | character.max | character.empty | character.n_unique | character.whitespace | logical.mean | logical.count | numeric.mean | numeric.sd | numeric.p0 | numeric.p25 | numeric.p50 | numeric.p75 | numeric.p100 | numeric.hist |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| character | ID | 0 | 1.0000000 | 4 | 58 | 0 | 2548271 | 0 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| character | REF | 0 | 1.0000000 | 1 | 1 | 0 | 4 | 0 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| character | ALT | 0 | 1.0000000 | 1 | 1 | 0 | 4 | 0 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| logical | N | 2548569 | 0.0000000 | NA | NA | NA | NA | NA | NaN | : | NA | NA | NA | NA | NA | NA | NA | NA |
| numeric | CHROM | 0 | 1.0000000 | NA | NA | NA | NA | NA | NA | NA | 8.657591e+00 | 5.766730e+00 | 1.0000000 | 4.000000e+00 | 8.000000e+00 | 1.300000e+01 | 2.200000e+01 | ▇▅▃▂▂ |
| numeric | POS | 0 | 1.0000000 | NA | NA | NA | NA | NA | NA | NA | 7.853946e+07 | 5.662202e+07 | 5687.0000000 | 3.168301e+07 | 6.894240e+07 | 1.147414e+08 | 2.491917e+08 | ▇▆▅▂▁ |
| numeric | EFFECT | 0 | 1.0000000 | NA | NA | NA | NA | NA | NA | NA | -5.000000e-07 | 1.318000e-04 | -0.0007328 | -8.900000e-05 | -5.000000e-07 | 8.770000e-05 | 6.656000e-04 | ▁▁▇▂▁ |
| numeric | SE | 0 | 1.0000000 | NA | NA | NA | NA | NA | NA | NA | 1.271000e-04 | 7.100000e-06 | 0.0001151 | 1.210000e-04 | 1.250000e-04 | 1.321000e-04 | 2.495000e-04 | ▇▁▁▁▁ |
| numeric | PVAL | 0 | 1.0000000 | NA | NA | NA | NA | NA | NA | NA | 4.893662e-01 | 2.917938e-01 | 0.0000012 | 2.300001e-01 | 4.899999e-01 | 7.400005e-01 | 1.000000e+00 | ▇▇▇▇▇ |
| numeric | PVAL_ztest | 0 | 1.0000000 | NA | NA | NA | NA | NA | NA | NA | 4.893649e-01 | 2.917702e-01 | 0.0000012 | 2.331409e-01 | 4.857854e-01 | 7.421838e-01 | 9.999998e-01 | ▇▇▇▇▇ |
| numeric | AF | 0 | 1.0000000 | NA | NA | NA | NA | NA | NA | NA | 4.516085e-01 | 1.540366e-01 | 0.2287590 | 3.161780e-01 | 4.285090e-01 | 5.749240e-01 | 7.712410e-01 | ▇▆▅▅▃ |
| numeric | AF_reference | 20217 | 0.9920673 | NA | NA | NA | NA | NA | NA | NA | 4.334650e-01 | 1.779425e-01 | 0.0001997 | 2.927320e-01 | 4.171330e-01 | 5.636980e-01 | 1.000000e+00 | ▂▇▇▃▁ |
Head and tail
| CHROM | POS | ID | REF | ALT | EFFECT | SE | PVAL | PVAL_ztest | AF | AF_reference | N |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 49298 | rs200943160 | T | C | -0.0000396 | 0.0002118 | 0.8499999 | 0.8515772 | 0.623765 | 0.7821490 | NA |
| 1 | 54676 | rs2462492 | C | T | -0.0000870 | 0.0002098 | 0.6800001 | 0.6784842 | 0.400401 | NA | NA |
| 1 | 91536 | rs6702460 | G | T | 0.0001132 | 0.0002066 | 0.5800000 | 0.5835651 | 0.456846 | 0.4207270 | NA |
| 1 | 534192 | rs6680723 | C | T | 0.0000118 | 0.0002360 | 0.9599999 | 0.9601150 | 0.240959 | NA | NA |
| 1 | 706368 | rs55727773 | A | G | 0.0000442 | 0.0001465 | 0.7600007 | 0.7630032 | 0.515645 | 0.2751600 | NA |
| 1 | 763394 | rs369924889 | G | A | 0.0000347 | 0.0001717 | 0.8400000 | 0.8399139 | 0.706753 | 0.6176120 | NA |
| 1 | 768253 | rs2977608 | A | C | -0.0000368 | 0.0001402 | 0.7899998 | 0.7928201 | 0.761297 | 0.4894170 | NA |
| 1 | 776546 | rs12124819 | A | G | -0.0002648 | 0.0001566 | 0.0909997 | 0.0907445 | 0.265385 | 0.0756789 | NA |
| 1 | 814495 | rs74461805 | C | A | -0.0002093 | 0.0002009 | 0.2999998 | 0.2973124 | 0.340396 | NA | NA |
| 1 | 830181 | rs28444699 | A | G | -0.0000077 | 0.0001344 | 0.9500000 | 0.9541541 | 0.697255 | 0.6912940 | NA |
| CHROM | POS | ID | REF | ALT | EFFECT | SE | PVAL | PVAL_ztest | AF | AF_reference | N |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 22 | 51180501 | rs5770999 | T | C | -0.0001141 | 0.0001379 | 0.4100001 | 0.4078580 | 0.713656 | 0.6369810 | NA |
| 22 | 51181919 | rs9616825 | G | C | -0.0000541 | 0.0001372 | 0.6899999 | 0.6931448 | 0.695470 | 0.6194090 | NA |
| 22 | 51182485 | rs6009961 | A | G | -0.0001021 | 0.0001383 | 0.4600002 | 0.4605265 | 0.715502 | 0.6383790 | NA |
| 22 | 51186143 | rs2879914 | T | C | -0.0000071 | 0.0001283 | 0.9599999 | 0.9560140 | 0.381825 | 0.2733630 | NA |
| 22 | 51186228 | rs3865766 | C | T | -0.0000236 | 0.0001250 | 0.8499999 | 0.8504687 | 0.451061 | 0.4532750 | NA |
| 22 | 51197266 | rs61290853 | A | G | 0.0000622 | 0.0001291 | 0.6300007 | 0.6298274 | 0.386333 | 0.4229230 | NA |
| 22 | 51198027 | rs34939255 | A | G | -0.0001318 | 0.0001461 | 0.3700002 | 0.3671049 | 0.254562 | 0.0984425 | NA |
| 22 | 51211106 | rs9628250 | T | C | -0.0002099 | 0.0001448 | 0.1499999 | 0.1472647 | 0.271547 | 0.1671330 | NA |
| 22 | 51212875 | rs2238837 | A | C | 0.0000950 | 0.0001376 | 0.4899999 | 0.4902100 | 0.331457 | 0.3724040 | NA |
| 22 | 51237063 | rs3896457 | T | C | 0.0000593 | 0.0001409 | 0.6700003 | 0.6737370 | 0.297974 | 0.2050720 | NA |
bcf preview
1 49298 rs10399793 T C . PASS AF=0.623765 ES:SE:LP:AF:ID -3.96252e-05:0.000211779:0.0705811:0.623765:rs10399793
1 54676 rs2462492 C T . PASS AF=0.400401 ES:SE:LP:AF:ID -8.69718e-05:0.000209807:0.167491:0.400401:rs2462492
1 91536 rs6702460 G T . PASS AF=0.456846 ES:SE:LP:AF:ID 0.000113244:0.00020658:0.236572:0.456846:rs6702460
1 534192 rs6680723 C T . PASS AF=0.240959 ES:SE:LP:AF:ID 1.18007e-05:0.00023597:0.0177288:0.240959:rs6680723
1 706368 rs12029736 A G . PASS AF=0.515645 ES:SE:LP:AF:ID 4.4171e-05:0.000146485:0.119186:0.515645:rs12029736
1 763394 rs3115847 G A . PASS AF=0.706753 ES:SE:LP:AF:ID 3.46921e-05:0.00017174:0.0757207:0.706753:rs3115847
1 768253 rs2977608 A C . PASS AF=0.761297 ES:SE:LP:AF:ID -3.68157e-05:0.00014017:0.102373:0.761297:rs2977608
1 776546 rs12124819 A G . PASS AF=0.265385 ES:SE:LP:AF:ID -0.000264844:0.000156575:1.04096:0.265385:rs12124819
1 814495 rs74461805 C A . PASS AF=0.340396 ES:SE:LP:AF:ID -0.000209336:0.000200857:0.522879:0.340396:rs74461805
1 830181 rs28444699 A G . PASS AF=0.697255 ES:SE:LP:AF:ID -7.72586e-06:0.000134384:0.0222764:0.697255:rs28444699
1 831489 rs4970385 C T . PASS AF=0.705397 ES:SE:LP:AF:ID 0.000154101:0.000131952:0.619789:0.705397:rs4970385
1 831909 rs9697642 C T . PASS AF=0.705442 ES:SE:LP:AF:ID 0.000161924:0.000131947:0.657577:0.705442:rs9697642
1 832066 rs9697380 G C . PASS AF=0.705627 ES:SE:LP:AF:ID 0.000161708:0.000131953:0.657577:0.705627:rs9697380
1 832318 rs4500250 C A . PASS AF=0.705655 ES:SE:LP:AF:ID 0.000161344:0.000131967:0.657577:0.705655:rs4500250
1 832398 rs4553118 T C . PASS AF=0.730129 ES:SE:LP:AF:ID 0.000129954:0.000135563:0.468521:0.730129:rs4553118
1 832918 rs28765502 T C . PASS AF=0.294377 ES:SE:LP:AF:ID -0.000161607:0.000131961:0.657577:0.294377:rs28765502
1 833223 rs13303211 C T . PASS AF=0.236703 ES:SE:LP:AF:ID -0.000176043:0.000140493:0.677781:0.236703:rs13303211
1 833302 rs28752186 C T . PASS AF=0.236691 ES:SE:LP:AF:ID -0.000175993:0.000140494:0.677781:0.236691:rs28752186
1 833641 rs28594623 T C . PASS AF=0.23975 ES:SE:LP:AF:ID -0.000142883:0.000140044:0.508638:0.23975:rs28594623
1 833824 rs28484835 T C . PASS AF=0.236693 ES:SE:LP:AF:ID -0.00017603:0.000140493:0.677781:0.236693:rs28484835
1 834832 rs4411087 G C . PASS AF=0.237178 ES:SE:LP:AF:ID -0.000172662:0.000140386:0.657577:0.237178:rs4411087
1 835499 rs4422948 A G . PASS AF=0.241162 ES:SE:LP:AF:ID -0.000228347:0.000139406:1:0.241162:rs4422948
1 836896 rs28705752 T C . PASS AF=0.269511 ES:SE:LP:AF:ID -0.000131575:0.000134516:0.481486:0.269511:rs28705752
1 838555 rs4970383 C A . PASS AF=0.246204 ES:SE:LP:AF:ID -9.81735e-05:0.000138447:0.318759:0.246204:rs4970383
1 839103 rs28562941 A G . PASS AF=0.270019 ES:SE:LP:AF:ID -0.000135113:0.000134611:0.49485:0.270019:rs28562941
1 840753 rs4970382 T C . PASS AF=0.400124 ES:SE:LP:AF:ID 2.63607e-05:0.000121714:0.0809219:0.400124:rs4970382
1 841085 rs1574243 C G . PASS AF=0.237102 ES:SE:LP:AF:ID -0.000177733:0.000141375:0.677781:0.237102:rs1574243
1 842362 rs28540380 C T . PASS AF=0.235323 ES:SE:LP:AF:ID -6.67005e-05:0.000143493:0.19382:0.235323:rs28540380
1 843405 rs11516185 A G . PASS AF=0.362606 ES:SE:LP:AF:ID -0.000324529:0.000151091:1.49485:0.362606:rs11516185
1 850218 rs6664536 T A . PASS AF=0.590331 ES:SE:LP:AF:ID 4.97266e-05:0.000121359:0.167491:0.590331:rs6664536
1 850371 rs6679046 G T . PASS AF=0.603723 ES:SE:LP:AF:ID 2.47146e-05:0.00012204:0.0757207:0.603723:rs6679046
1 850780 rs6657440 C T . PASS AF=0.603942 ES:SE:LP:AF:ID 3.38895e-05:0.000122023:0.107905:0.603942:rs6657440
1 852037 rs4970463 G A . PASS AF=0.589686 ES:SE:LP:AF:ID 5.15021e-05:0.000121556:0.173925:0.589686:rs4970463
1 852063 rs28436996 G A . PASS AF=0.589665 ES:SE:LP:AF:ID 5.29296e-05:0.000121502:0.180456:0.589665:rs28436996
1 852875 rs13303369 C T . PASS AF=0.607671 ES:SE:LP:AF:ID 2.56937e-05:0.000122296:0.0809219:0.607671:rs13303369
1 853954 rs1806509 C A . PASS AF=0.607829 ES:SE:LP:AF:ID 2.42899e-05:0.000122312:0.0757207:0.607829:rs1806509
1 854777 rs13303019 A G . PASS AF=0.610316 ES:SE:LP:AF:ID 2.15321e-05:0.000122433:0.0655015:0.610316:rs13303019
1 854978 rs13303057 A C . PASS AF=0.603283 ES:SE:LP:AF:ID 2.64987e-05:0.00012207:0.0809219:0.603283:rs13303057
1 855075 rs6673914 C G . PASS AF=0.610337 ES:SE:LP:AF:ID 3.07306e-05:0.000122435:0.09691:0.610337:rs6673914
1 856099 rs28534711 T G . PASS AF=0.389936 ES:SE:LP:AF:ID -2.62181e-05:0.000122458:0.0809219:0.389936:rs28534711
1 856108 rs28742275 A G . PASS AF=0.38992 ES:SE:LP:AF:ID -2.57607e-05:0.000122464:0.0809219:0.38992:rs28742275
1 856476 rs4040605 A G . PASS AF=0.350356 ES:SE:LP:AF:ID 5.90428e-06:0.000125805:0.0177288:0.350356:rs4040605
1 858801 rs7418179 A G . PASS AF=0.765846 ES:SE:LP:AF:ID 1.76205e-05:0.000141221:0.0457575:0.765846:rs7418179
1 860416 rs61464428 G A . PASS AF=0.766638 ES:SE:LP:AF:ID -1.43535e-05:0.000141291:0.0362122:0.766638:rs61464428
1 860688 rs60837925 G A . PASS AF=0.766104 ES:SE:LP:AF:ID -1.1134e-05:0.000141194:0.0268721:0.766104:rs60837925
1 861630 rs2879816 G A . PASS AF=0.766256 ES:SE:LP:AF:ID -1.35771e-05:0.000141228:0.0362122:0.766256:rs2879816
1 862866 rs3892970 C T . PASS AF=0.763122 ES:SE:LP:AF:ID -3.31277e-06:0.000141099:0.00877392:0.763122:rs3892970
1 864938 rs2340587 G A . PASS AF=0.760006 ES:SE:LP:AF:ID -8.12887e-05:0.000140053:0.251812:0.760006:rs2340587
1 866893 rs2880024 T C . PASS AF=0.610552 ES:SE:LP:AF:ID 6.83094e-05:0.000123122:0.236572:0.610552:rs2880024
1 866938 rs74047407 G A . PASS AF=0.229963 ES:SE:LP:AF:ID 5.47342e-05:0.000141707:0.154902:0.229963:rs74047407