Summary
Summary {data-width=650}
Manhattan plot
manhattan_plot
QQ plot
qq_plot
AF plot
af_plot
P-Z plot
pz_plot
beta_std plot
beta_std_plot
Metadata
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"gwas_harmonisation_command": "--out /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/ukbiobank/vcf_09_19b/bgzip_vcf/data.batch_20084_483.vcf.gz --id UKB-b:5536 --data /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/ukbiobank/raw-output/data.batch_20084_483.txt.gz --cohort_cases 1043 --cohort_controls 63906 --ref /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/ukbiobank/human_g1k_v37.fasta --json /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/ukbiobank/ukb_gwas.json; 1.1.1",
"file_date": "2019-09-13T13:36:14.594894",
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"bcftools_viewCommand.1": "view -h /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/ukb-b-5536/ukb-b-5536.vcf.gz; Date=Sun May 10 02:37:47 2020"
}
LDSC
*********************************************************************
* LD Score Regression (LDSC)
* Version 1.0.1
* (C) 2014-2019 Brendan Bulik-Sullivan and Hilary Finucane
* Broad Institute of MIT and Harvard / MIT Department of Mathematics
* GNU General Public License v3
*********************************************************************
Call:
./ldsc.py \
--h2 /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/UKB-b-5536/UKB-b-5536_data.vcf.gz \
--ref-ld-chr ../reference/eur_w_ld_chr/ \
--out /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/UKB-b-5536/ldsc.txt \
--w-ld-chr ../reference/eur_w_ld_chr/
Beginning analysis at Thu Oct 17 14:45:24 2019
Reading summary statistics from /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/UKB-b-5536/UKB-b-5536_data.vcf.gz ...
Read summary statistics for 1467482 SNPs.
Dropped 126 SNPs with duplicated rs numbers.
Reading reference panel LD Score from ../reference/eur_w_ld_chr/[1-22] ...
Read reference panel LD Scores for 1290028 SNPs.
Removing partitioned LD Scores with zero variance.
Reading regression weight LD Score from ../reference/eur_w_ld_chr/[1-22] ...
Read regression weight LD Scores for 1290028 SNPs.
After merging with reference panel LD, 379608 SNPs remain.
After merging with regression SNP LD, 379608 SNPs remain.
Using two-step estimator with cutoff at 30.
Total Observed scale h2: 0.0043 (0.0116)
Lambda GC: 1.0078
Mean Chi^2: 1.0203
Intercept: 1.0135 (0.0124)
Ratio: 0.6667 (0.609)
Analysis finished at Thu Oct 17 14:45:50 2019
Total time elapsed: 25.55sQC metrics
Metrics
Metrics
{
"af_correlation": 0.5836,
"inflation_factor": 1,
"mean_EFFECT": -4.3264e-06,
"n": "-Inf",
"n_snps": 9851866,
"n_clumped_hits": 0,
"n_p_sig": 0,
"n_mono": 0,
"n_ns": 0,
"n_mac": 0,
"is_snpid_unique": true,
"n_miss_EFFECT": 0,
"n_miss_SE": 0,
"n_miss_PVAL": 0,
"n_miss_AF": 0,
"n_miss_AF_reference": 11703,
"n_est": "NA",
"ratio_se_n": "NA",
"mean_diff": "NaN",
"ratio_diff": "NaN",
"sd_y_est1": "NaN",
"sd_y_est2": "NA",
"r2_sum1": 0,
"r2_sum2": 0,
"r2_sum3": 0,
"r2_sum4": 0,
"ldsc_nsnp_merge_refpanel_ld": 379608,
"ldsc_nsnp_merge_regression_ld": 379608,
"ldsc_observed_scale_h2_beta": 0.0043,
"ldsc_observed_scale_h2_se": 0.0116,
"ldsc_intercept_beta": 1.0135,
"ldsc_intercept_se": 0.0124,
"ldsc_lambda_gc": 1.0078,
"ldsc_mean_chisq": 1.0203,
"ldsc_ratio": 0.665
}
Flags
| name | value |
|---|---|
| af_correlation | TRUE |
| inflation_factor | FALSE |
| n | TRUE |
| is_snpid_non_unique | FALSE |
| mean_EFFECT_nonfinite | FALSE |
| mean_EFFECT_05 | FALSE |
| mean_EFFECT_01 | FALSE |
| mean_chisq | FALSE |
| n_p_sig | FALSE |
| miss_EFFECT | FALSE |
| miss_SE | FALSE |
| miss_PVAL | FALSE |
| ldsc_ratio | TRUE |
| ldsc_intercept_beta | FALSE |
| n_clumped_hits | FALSE |
| r2_sum1 | FALSE |
| r2_sum2 | FALSE |
| r2_sum3 | FALSE |
| r2_sum4 | FALSE |
Definitions
General metrics
af_correlation: Correlation coefficient betweenAFandAF_reference.inflation_factor(lambda): Genomic inflation factor.mean_EFFECT: Mean ofEFFECTsize.n: Maximum value of reported sample size across all SNPs, \(n\).n_clumped_hits: Number of clumped hits.n_snps: Number of SNPsn_p_sig: Number of SNPs with pvalue below5e-8.n_mono: Number of monomorphic (MAF == 1orMAF == 0) SNPs.n_ns: Number of SNPs with nonsense values:- alleles other than
A, C, G or T. - P-values
< 0or> 1. - negative or infinite standard errors (
<= 0or= Infinity). - infinite beta estimates or allele frequencies
< 0or> 1.
- alleles other than
n_mac: Number of cases whereMAC(\(2 \times N \times MAF\)) is less than6.is_snpid_unique:trueif the combination ofIDREFALTis unique and therefore no duplication in snpid.n_miss_<*>: Number ofNAobservations for<*>column.
se_n metrics
n_est: Estimated sample size value, \(\widehat{n}\).ratio_se_n: \(\texttt{ratio_se_n} = \frac{\sqrt{\widehat{n}}}{\sqrt{n}}\). We expectratio_se_nto be 1. When it is not 1, it implies that the trait did not have a variance of 1, the reported sample size is wrong, or that the SNP-level effective sample sizes differ markedly from the reported sample size.mean_diff: \(\texttt{mean_diff} = \sum_{j} \frac{\widehat{\beta_j^{std}} - \beta_j}{\texttt{n_snps}}\), mean difference between the standardised beta, predicted from P-values, and the observed beta. The difference should be very close to zero if trait has a variance of 1.- \(\widehat{\beta_j^{std}} = \sqrt{\frac{{z}_j^2 / ({z}_j^2 + n -2)}{2 \times {MAF}_j \times (1 - {MAF}_j)}} \times sign({z}_j)\),
- \({z}_j = \frac{\beta_j}{{se}_j}\),
- and \(\beta_j\) is the reported effect size.
ratio_diff: \(\texttt{ratio_diff} = |\frac{\texttt{mean_diff}}{\texttt{mean_diff2}}|\), absolute ratio between the mean ofdiffand the mean ofdiff2(expected difference between the standardised beta predicted from P-values, and the standardised beta derived from the observed beta divided by the predicted SD; NOT reported). The ratio should be close to 1. If different from 1, then implies that the betas are not in a standard deviation scale.- \(\texttt{mean_diff2} = \sum_{j} \frac{\widehat{\beta_j^{std}} - \beta^{\prime}_j}{\texttt{n_snps}}\)
- \(\beta^{\prime}_j = \frac{\beta_j}{\widehat{\texttt{sd2}}_{y}}\)
sd_y_est1: The standard deviation for the trait inferred from the reported sample size, median standard errors for the SNP-trait assocations and SNP variances.- \(\widehat{\texttt{sd1}}_{y} = \frac{\sqrt{n} \times median({se}_j)}{C}\),
- \(C = median(\frac{1}{\sqrt{2 \times {MAF}_j \times (1 - {MAF}_j)}})\),
- and \({se}_j\) is the reported standard error.
sd_y_est2: The standard deviation for the trait inferred from the reported sample size, Z statistics for the SNP-trait effects (beta/se) and allele frequency.- \(\widehat{\texttt{sd2}}_{y} = median(\widehat{sd_j})\),
- \(\widehat{sd_j} = \frac{\beta_j}{\widehat{\beta_j^{std}}}\),
r2 metrics
Sum of variance explained, calculated from the clumped top hits sample.
r2_sum<*>:r2statistics under various assumptions1: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var1}}}\), \(\texttt{var1} = 1\).2: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var2}}}\), \(\texttt{var2} = {\widehat{\texttt{sd1}}_{y}}^2\),3: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var3}}}\), \(\texttt{var3} = {\widehat{\texttt{sd2}}_{y}}^2\),4: \(r^2 = \sum_j{\frac{F_j}{F_j + n - 2}}\), \(F = \frac{\beta_j^2}{{se}_j^2}\).
LDSC metrics
Metrics from LD regression
ldsc_nsnp_merge_refpanel_ld: Number of remaining SNPs after merging with reference panel LD.ldsc_nsnp_merge_regression_ld: Number of remaining SNPs after merging with regression SNP LD.ldsc_observed_scale_h2_{beta,se}Coefficient value and SE for total observed scale h2.ldsc_intercept_{beta,se}: Coefficient value and SE for intercept. Intercept is expected to be 1.ldsc_lambda_gc: Lambda GC statistics.ldsc_mean_chisq: Mean \(\chi^2\) statistics.ldsc_ratio: \(\frac{\texttt{ldsc_intercept_beta} - 1}{\texttt{ldsc_mean_chisq} - 1}\), the proportion of the inflation in the mean \(\chi^2\) that the LD Score regression intercepts ascribes to causes other than polygenic heritability. The value of ratio should be close to zero, though in practice values of 0.1-0.2 are not uncommon, probably due to sample/reference LD Score mismatch or model misspecification (e.g., low LD variants have slightly higher \(h^2\) per SNP).
Flags
When a metric needs attention, the flag should return TRUE.
af_correlation:abs(af_correlation)< 0.7.inflation_factor:inflation_factor> 1.2.n:n(max reported sample size) < 10000.is_snpid_non_unique: NOTis_snpid_unique.mean_EFFECT_nonfinite:mean(EFFECT)isNA,NaN, orInf.mean_EFFECT_05:abs(mean(EFFECT))> 0.5.mean_EFFECT_01:abs(mean(EFFECT))> 0.1.mean_chisq:ldsc_mean_chisq> 1.3 orldsc_mean_chisq< 0.7.n_p_sig:n_p_sig> 1000.miss_<*>:n_miss_<*>/n_snps> 0.01.ldsc_ratio:ldsc_ratio> 0.5ldsc_intercept_beta:ldsc_intercept_beta> 1.5n_clumped_hits:n_clumped_hits> 1000r2_sum<*>:r2_sum<*>> 0.5
Plots
- Manhattan plot
- Red line: \(-log_{10}^{5 \times 10^{-8}}\)
- Blue line: \(-log_{10}^{5 \times 10^{-5}}\)
- QQ plot
- AF plot
- P-Z plot
- beta_std plot: Scatter plot between \(\widehat{\beta_j^{std}}\) and \(\beta_j\)
Diagnostics
Details
Summary stats
| skim_type | skim_variable | n_missing | complete_rate | character.min | character.max | character.empty | character.n_unique | character.whitespace | logical.mean | logical.count | numeric.mean | numeric.sd | numeric.p0 | numeric.p25 | numeric.p50 | numeric.p75 | numeric.p100 | numeric.hist |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| character | ID | 0 | 1.0000000 | 4 | 58 | 0 | 1467358 | 0 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| character | REF | 0 | 1.0000000 | 1 | 1 | 0 | 4 | 0 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| character | ALT | 0 | 1.0000000 | 1 | 1 | 0 | 4 | 0 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| logical | N | 1467482 | 0.0000000 | NA | NA | NA | NA | NA | NaN | : | NA | NA | NA | NA | NA | NA | NA | NA |
| numeric | CHROM | 0 | 1.0000000 | NA | NA | NA | NA | NA | NA | NA | 8.675856e+00 | 5.768188e+00 | 1.00000e+00 | 4.000000e+00 | 8.000000e+00 | 1.300000e+01 | 2.200000e+01 | ▇▅▅▂▂ |
| numeric | POS | 0 | 1.0000000 | NA | NA | NA | NA | NA | NA | NA | 7.854805e+07 | 5.657664e+07 | 1.23330e+04 | 3.162054e+07 | 6.905149e+07 | 1.145462e+08 | 2.491722e+08 | ▇▆▅▂▁ |
| numeric | EFFECT | 0 | 1.0000000 | NA | NA | NA | NA | NA | NA | NA | -4.300000e-06 | 7.206000e-04 | -3.61460e-03 | -4.860000e-04 | -3.200000e-06 | 4.787000e-04 | 3.711200e-03 | ▁▂▇▂▁ |
| numeric | SE | 0 | 1.0000000 | NA | NA | NA | NA | NA | NA | NA | 7.129000e-04 | 1.900000e-05 | 6.72200e-04 | 7.008000e-04 | 7.089000e-04 | 7.219000e-04 | 1.333200e-03 | ▇▁▁▁▁ |
| numeric | PVAL | 0 | 1.0000000 | NA | NA | NA | NA | NA | NA | NA | 4.986592e-01 | 2.906824e-01 | 7.00000e-07 | 2.399999e-01 | 5.000000e-01 | 7.499995e-01 | 1.000000e+00 | ▇▇▇▇▇ |
| numeric | PVAL_ztest | 0 | 1.0000000 | NA | NA | NA | NA | NA | NA | NA | 4.986563e-01 | 2.906568e-01 | 7.00000e-07 | 2.449319e-01 | 4.987375e-01 | 7.519790e-01 | 9.999998e-01 | ▇▇▇▇▇ |
| numeric | AF | 0 | 1.0000000 | NA | NA | NA | NA | NA | NA | NA | 4.826427e-01 | 9.436470e-02 | 3.35571e-01 | 3.996372e-01 | 4.740395e-01 | 5.609600e-01 | 6.644290e-01 | ▇▇▆▅▅ |
| numeric | AF_reference | 11703 | 0.9920251 | NA | NA | NA | NA | NA | NA | NA | 4.608863e-01 | 1.443369e-01 | 1.99700e-04 | 3.530350e-01 | 4.550720e-01 | 5.638980e-01 | 1.000000e+00 | ▁▆▇▃▁ |
Head and tail
| CHROM | POS | ID | REF | ALT | EFFECT | SE | PVAL | PVAL_ztest | AF | AF_reference | N |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 49298 | rs200943160 | T | C | -0.0003277 | 0.0012389 | 0.7899998 | 0.7913914 | 0.623812 | 0.782149 | NA |
| 1 | 54676 | rs2462492 | C | T | -0.0001058 | 0.0012353 | 0.9299999 | 0.9317586 | 0.399144 | NA | NA |
| 1 | 91536 | rs6702460 | G | T | -0.0002034 | 0.0012150 | 0.8700001 | 0.8670298 | 0.455916 | 0.420727 | NA |
| 1 | 706368 | rs55727773 | A | G | 0.0006439 | 0.0008565 | 0.4500005 | 0.4521676 | 0.513304 | 0.275160 | NA |
| 1 | 814495 | rs74461805 | C | A | -0.0014881 | 0.0011728 | 0.2000000 | 0.2045100 | 0.340108 | NA | NA |
| 1 | 840753 | rs4970382 | T | C | -0.0008766 | 0.0007112 | 0.2200002 | 0.2177449 | 0.400406 | 0.468850 | NA |
| 1 | 843405 | rs11516185 | A | G | 0.0002532 | 0.0008849 | 0.7700005 | 0.7747652 | 0.362367 | 0.375399 | NA |
| 1 | 850218 | rs6664536 | T | A | 0.0012160 | 0.0007074 | 0.0860003 | 0.0856127 | 0.589315 | 0.345248 | NA |
| 1 | 850371 | rs6679046 | G | T | 0.0012842 | 0.0007108 | 0.0710003 | 0.0707967 | 0.603035 | 0.508786 | NA |
| 1 | 850780 | rs6657440 | C | T | 0.0012314 | 0.0007108 | 0.0830004 | 0.0831988 | 0.603381 | 0.560304 | NA |
| CHROM | POS | ID | REF | ALT | EFFECT | SE | PVAL | PVAL_ztest | AF | AF_reference | N |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 22 | 51158017 | rs6010065 | G | C | -0.0011723 | 0.0006974 | 0.0929994 | 0.0927635 | 0.459676 | 0.547524 | NA |
| 22 | 51158499 | rs8136930 | T | G | -0.0011371 | 0.0006979 | 0.1000000 | 0.1032501 | 0.459892 | 0.544728 | NA |
| 22 | 51161019 | rs5770994 | C | T | 0.0013356 | 0.0006954 | 0.0549997 | 0.0547725 | 0.483487 | 0.425719 | NA |
| 22 | 51163039 | rs715584 | G | T | -0.0007670 | 0.0007059 | 0.2800000 | 0.2772161 | 0.425020 | 0.473642 | NA |
| 22 | 51164109 | rs5770995 | G | C | -0.0011201 | 0.0007024 | 0.1100001 | 0.1107918 | 0.450784 | 0.510982 | NA |
| 22 | 51164115 | rs5770996 | C | T | -0.0010456 | 0.0007020 | 0.1400000 | 0.1363802 | 0.454945 | 0.514776 | NA |
| 22 | 51174048 | rs9628245 | G | C | -0.0009222 | 0.0007957 | 0.2500000 | 0.2464897 | 0.377819 | 0.433107 | NA |
| 22 | 51186143 | rs2879914 | T | C | 0.0013212 | 0.0007499 | 0.0779992 | 0.0781157 | 0.380077 | 0.273363 | NA |
| 22 | 51186228 | rs3865766 | C | T | 0.0007068 | 0.0007305 | 0.3300000 | 0.3332609 | 0.449547 | 0.453275 | NA |
| 22 | 51197266 | rs61290853 | A | G | 0.0009357 | 0.0007527 | 0.2099999 | 0.2138571 | 0.386693 | 0.422923 | NA |
bcf preview
1 49298 rs10399793 T C . PASS AF=0.623812 ES:SE:LP:AF:ID -0.000327689:0.00123888:0.102373:0.623812:rs10399793
1 54676 rs2462492 C T . PASS AF=0.399144 ES:SE:LP:AF:ID -0.00010578:0.00123528:0.0315171:0.399144:rs2462492
1 91536 rs6702460 G T . PASS AF=0.455916 ES:SE:LP:AF:ID -0.000203427:0.00121498:0.0604807:0.455916:rs6702460
1 706368 rs12029736 A G . PASS AF=0.513304 ES:SE:LP:AF:ID 0.000643901:0.000856472:0.346787:0.513304:rs12029736
1 814495 rs74461805 C A . PASS AF=0.340108 ES:SE:LP:AF:ID -0.00148812:0.00117285:0.69897:0.340108:rs74461805
1 840753 rs4970382 T C . PASS AF=0.400406 ES:SE:LP:AF:ID -0.000876644:0.000711246:0.657577:0.400406:rs4970382
1 843405 rs11516185 A G . PASS AF=0.362367 ES:SE:LP:AF:ID 0.000253215:0.000884911:0.113509:0.362367:rs11516185
1 850218 rs6664536 T A . PASS AF=0.589315 ES:SE:LP:AF:ID 0.00121601:0.00070739:1.0655:0.589315:rs6664536
1 850371 rs6679046 G T . PASS AF=0.603035 ES:SE:LP:AF:ID 0.00128421:0.000710773:1.14874:0.603035:rs6679046
1 850780 rs6657440 C T . PASS AF=0.603381 ES:SE:LP:AF:ID 0.00123138:0.000710786:1.08092:0.603381:rs6657440
1 852037 rs4970463 G A . PASS AF=0.588673 ES:SE:LP:AF:ID 0.00122762:0.000708399:1.08092:0.588673:rs4970463
1 852063 rs28436996 G A . PASS AF=0.588649 ES:SE:LP:AF:ID 0.00127021:0.00070808:1.13668:0.588649:rs28436996
1 852875 rs13303369 C T . PASS AF=0.606715 ES:SE:LP:AF:ID 0.00141859:0.000711956:1.33724:0.606715:rs13303369
1 853954 rs1806509 C A . PASS AF=0.60688 ES:SE:LP:AF:ID 0.00141614:0.00071203:1.3279:0.60688:rs1806509
1 854777 rs13303019 A G . PASS AF=0.609504 ES:SE:LP:AF:ID 0.00142341:0.000712742:1.33724:0.609504:rs13303019
1 854978 rs13303057 A C . PASS AF=0.602505 ES:SE:LP:AF:ID 0.00132083:0.000710898:1.20066:0.602505:rs13303057
1 855075 rs6673914 C G . PASS AF=0.609473 ES:SE:LP:AF:ID 0.00143521:0.000712647:1.35655:0.609473:rs6673914
1 856099 rs28534711 T G . PASS AF=0.390835 ES:SE:LP:AF:ID -0.0014474:0.000712937:1.37675:0.390835:rs28534711
1 856108 rs28742275 A G . PASS AF=0.390777 ES:SE:LP:AF:ID -0.00144561:0.00071301:1.36653:0.390777:rs28742275
1 856476 rs4040605 A G . PASS AF=0.352504 ES:SE:LP:AF:ID -0.000930527:0.000731884:0.69897:0.352504:rs4040605
1 866893 rs2880024 T C . PASS AF=0.608083 ES:SE:LP:AF:ID 4.28286e-05:0.000719243:0.0222764:0.608083:rs2880024
1 875770 rs4970379 A G . PASS AF=0.598464 ES:SE:LP:AF:ID 0.000533772:0.000724621:0.337242:0.598464:rs4970379
1 881627 rs2272757 G A . PASS AF=0.65048 ES:SE:LP:AF:ID 0.000198936:0.000732:0.102373:0.65048:rs2272757
1 891059 rs13303065 C T . PASS AF=0.650626 ES:SE:LP:AF:ID 0.000298783:0.000731928:0.167491:0.650626:rs13303065
1 891945 rs13303106 A G . PASS AF=0.650689 ES:SE:LP:AF:ID 0.000285398:0.000732766:0.154902:0.650689:rs13303106
1 903245 rs28690976 A G . PASS AF=0.565133 ES:SE:LP:AF:ID -0.000190071:0.000727628:0.102373:0.565133:rs28690976
1 909073 rs3892467 C T . PASS AF=0.386217 ES:SE:LP:AF:ID 0.00122555:0.000726107:1.04096:0.386217:rs3892467
1 909238 rs3829740 G C . PASS AF=0.572164 ES:SE:LP:AF:ID 0.000673186:0.000702469:0.468521:0.572164:rs3829740
1 912049 rs7367995 T C . PASS AF=0.585242 ES:SE:LP:AF:ID 0.000536516:0.00070928:0.346787:0.585242:rs7367995
1 913889 rs2340596 G A . PASS AF=0.600025 ES:SE:LP:AF:ID 0.000611449:0.00071069:0.408935:0.600025:rs2340596
1 914333 rs13302979 C G . PASS AF=0.60338 ES:SE:LP:AF:ID 0.000780533:0.000713101:0.568636:0.60338:rs13302979
1 914852 rs13303368 G C . PASS AF=0.60101 ES:SE:LP:AF:ID 0.000565122:0.000711788:0.366532:0.60101:rs13303368
1 914940 rs13303033 T C . PASS AF=0.585327 ES:SE:LP:AF:ID 0.000482649:0.000708247:0.30103:0.585327:rs13303033
1 916834 rs6694632 G A . PASS AF=0.590116 ES:SE:LP:AF:ID 0.000738785:0.000709221:0.522879:0.590116:rs6694632
1 918384 rs13303118 G T . PASS AF=0.585329 ES:SE:LP:AF:ID 0.000491628:0.000707982:0.309804:0.585329:rs13303118
1 918573 rs2341354 A G . PASS AF=0.590348 ES:SE:LP:AF:ID 0.000741105:0.000708722:0.522879:0.590348:rs2341354
1 919501 rs4970414 G T . PASS AF=0.583818 ES:SE:LP:AF:ID 0.000913758:0.000734901:0.677781:0.583818:rs4970414
1 921716 rs13303278 C A . PASS AF=0.569359 ES:SE:LP:AF:ID 0.000279538:0.00070937:0.161151:0.569359:rs13303278
1 924528 rs34712273 C A . PASS AF=0.579293 ES:SE:LP:AF:ID 0.000383041:0.000712115:0.229148:0.579293:rs34712273
1 930533 rs3128110 C G . PASS AF=0.384463 ES:SE:LP:AF:ID -0.000437803:0.000721689:0.267606:0.384463:rs3128110
1 930567 rs3121574 A G . PASS AF=0.384502 ES:SE:LP:AF:ID -0.000440665:0.000721717:0.267606:0.384502:rs3121574
1 930751 rs3128111 C G . PASS AF=0.383433 ES:SE:LP:AF:ID -0.000447067:0.000722363:0.267606:0.383433:rs3128111
1 931166 rs2710880 A G . PASS AF=0.385119 ES:SE:LP:AF:ID -0.000472142:0.000721898:0.29243:0.385119:rs2710880
1 931362 rs2799060 G A . PASS AF=0.383925 ES:SE:LP:AF:ID -0.000436654:0.000722407:0.259637:0.383925:rs2799060
1 933790 rs9442392 G A . PASS AF=0.579341 ES:SE:LP:AF:ID 0.000408893:0.000711461:0.244125:0.579341:rs9442392
1 936111 rs1936360 C T . PASS AF=0.574447 ES:SE:LP:AF:ID 0.000226665:0.000711508:0.124939:0.574447:rs1936360
1 940005 rs2799056 A G . PASS AF=0.396767 ES:SE:LP:AF:ID -0.000602374:0.000719701:0.39794:0.396767:rs2799056
1 940096 rs4503294 C T . PASS AF=0.56692 ES:SE:LP:AF:ID 0.000499713:0.000709359:0.318759:0.56692:rs4503294
1 941284 rs3128116 C T . PASS AF=0.39488 ES:SE:LP:AF:ID -0.000548528:0.000719662:0.346787:0.39488:rs3128116
1 941334 rs57683598 G A . PASS AF=0.394898 ES:SE:LP:AF:ID -0.000547398:0.000719659:0.346787:0.394898:rs57683598