Summary
Summary {data-width=650}
Manhattan plot
manhattan_plot
QQ plot
qq_plot
AF plot
af_plot
P-Z plot
pz_plot
beta_std plot
beta_std_plot
Metadata
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"gwas_harmonisation_command": "--out /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/ukbiobank/vcf_09_19b/bgzip_vcf/data.batch_20090_356.vcf.gz --id UKB-b:1830 --data /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/ukbiobank/raw-output/data.batch_20090_356.txt.gz --cohort_cases 1485 --cohort_controls 63464 --ref /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/ukbiobank/human_g1k_v37.fasta --json /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/ukbiobank/ukb_gwas.json; 1.1.1",
"file_date": "2019-09-13T11:42:51.001001",
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"bcftools_viewCommand.1": "view -h /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/ukb-b-1830/ukb-b-1830.vcf.gz; Date=Sun May 10 02:38:54 2020"
}
LDSC
*********************************************************************
* LD Score Regression (LDSC)
* Version 1.0.1
* (C) 2014-2019 Brendan Bulik-Sullivan and Hilary Finucane
* Broad Institute of MIT and Harvard / MIT Department of Mathematics
* GNU General Public License v3
*********************************************************************
Call:
./ldsc.py \
--h2 /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/UKB-b-1830/UKB-b-1830_data.vcf.gz \
--ref-ld-chr ../reference/eur_w_ld_chr/ \
--out /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/UKB-b-1830/ldsc.txt \
--w-ld-chr ../reference/eur_w_ld_chr/
Beginning analysis at Thu Oct 17 14:40:18 2019
Reading summary statistics from /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/UKB-b-1830/UKB-b-1830_data.vcf.gz ...
Read summary statistics for 2473889 SNPs.
Dropped 291 SNPs with duplicated rs numbers.
Reading reference panel LD Score from ../reference/eur_w_ld_chr/[1-22] ...
Read reference panel LD Scores for 1290028 SNPs.
Removing partitioned LD Scores with zero variance.
Reading regression weight LD Score from ../reference/eur_w_ld_chr/[1-22] ...
Read regression weight LD Scores for 1290028 SNPs.
After merging with reference panel LD, 626567 SNPs remain.
After merging with regression SNP LD, 626567 SNPs remain.
Using two-step estimator with cutoff at 30.
Total Observed scale h2: 0.0168 (0.0079)
Lambda GC: 1.0172
Mean Chi^2: 1.0093
Intercept: 0.9843 (0.009)
Ratio < 0 (usually indicates GC correction).
Analysis finished at Thu Oct 17 14:40:51 2019
Total time elapsed: 33.38sQC metrics
Metrics
Metrics
{
"af_correlation": 0.7656,
"inflation_factor": 1,
"mean_EFFECT": -6.5928e-06,
"n": "-Inf",
"n_snps": 9851866,
"n_clumped_hits": 0,
"n_p_sig": 0,
"n_mono": 0,
"n_ns": 0,
"n_mac": 0,
"is_snpid_unique": true,
"n_miss_EFFECT": 0,
"n_miss_SE": 0,
"n_miss_PVAL": 0,
"n_miss_AF": 0,
"n_miss_AF_reference": 19613,
"n_est": "NA",
"ratio_se_n": "NA",
"mean_diff": "NaN",
"ratio_diff": "NaN",
"sd_y_est1": "NaN",
"sd_y_est2": "NA",
"r2_sum1": 0,
"r2_sum2": 0,
"r2_sum3": 0,
"r2_sum4": 0,
"ldsc_nsnp_merge_refpanel_ld": 626567,
"ldsc_nsnp_merge_regression_ld": 626567,
"ldsc_observed_scale_h2_beta": 0.0168,
"ldsc_observed_scale_h2_se": 0.0079,
"ldsc_intercept_beta": 0.9843,
"ldsc_intercept_se": 0.009,
"ldsc_lambda_gc": 1.0172,
"ldsc_mean_chisq": 1.0093,
"ldsc_ratio": -1.6882
}
Flags
| name | value |
|---|---|
| af_correlation | FALSE |
| inflation_factor | FALSE |
| n | TRUE |
| is_snpid_non_unique | FALSE |
| mean_EFFECT_nonfinite | FALSE |
| mean_EFFECT_05 | FALSE |
| mean_EFFECT_01 | FALSE |
| mean_chisq | FALSE |
| n_p_sig | FALSE |
| miss_EFFECT | FALSE |
| miss_SE | FALSE |
| miss_PVAL | FALSE |
| ldsc_ratio | FALSE |
| ldsc_intercept_beta | FALSE |
| n_clumped_hits | FALSE |
| r2_sum1 | FALSE |
| r2_sum2 | FALSE |
| r2_sum3 | FALSE |
| r2_sum4 | FALSE |
Definitions
General metrics
af_correlation: Correlation coefficient betweenAFandAF_reference.inflation_factor(lambda): Genomic inflation factor.mean_EFFECT: Mean ofEFFECTsize.n: Maximum value of reported sample size across all SNPs, \(n\).n_clumped_hits: Number of clumped hits.n_snps: Number of SNPsn_p_sig: Number of SNPs with pvalue below5e-8.n_mono: Number of monomorphic (MAF == 1orMAF == 0) SNPs.n_ns: Number of SNPs with nonsense values:- alleles other than
A, C, G or T. - P-values
< 0or> 1. - negative or infinite standard errors (
<= 0or= Infinity). - infinite beta estimates or allele frequencies
< 0or> 1.
- alleles other than
n_mac: Number of cases whereMAC(\(2 \times N \times MAF\)) is less than6.is_snpid_unique:trueif the combination ofIDREFALTis unique and therefore no duplication in snpid.n_miss_<*>: Number ofNAobservations for<*>column.
se_n metrics
n_est: Estimated sample size value, \(\widehat{n}\).ratio_se_n: \(\texttt{ratio_se_n} = \frac{\sqrt{\widehat{n}}}{\sqrt{n}}\). We expectratio_se_nto be 1. When it is not 1, it implies that the trait did not have a variance of 1, the reported sample size is wrong, or that the SNP-level effective sample sizes differ markedly from the reported sample size.mean_diff: \(\texttt{mean_diff} = \sum_{j} \frac{\widehat{\beta_j^{std}} - \beta_j}{\texttt{n_snps}}\), mean difference between the standardised beta, predicted from P-values, and the observed beta. The difference should be very close to zero if trait has a variance of 1.- \(\widehat{\beta_j^{std}} = \sqrt{\frac{{z}_j^2 / ({z}_j^2 + n -2)}{2 \times {MAF}_j \times (1 - {MAF}_j)}} \times sign({z}_j)\),
- \({z}_j = \frac{\beta_j}{{se}_j}\),
- and \(\beta_j\) is the reported effect size.
ratio_diff: \(\texttt{ratio_diff} = |\frac{\texttt{mean_diff}}{\texttt{mean_diff2}}|\), absolute ratio between the mean ofdiffand the mean ofdiff2(expected difference between the standardised beta predicted from P-values, and the standardised beta derived from the observed beta divided by the predicted SD; NOT reported). The ratio should be close to 1. If different from 1, then implies that the betas are not in a standard deviation scale.- \(\texttt{mean_diff2} = \sum_{j} \frac{\widehat{\beta_j^{std}} - \beta^{\prime}_j}{\texttt{n_snps}}\)
- \(\beta^{\prime}_j = \frac{\beta_j}{\widehat{\texttt{sd2}}_{y}}\)
sd_y_est1: The standard deviation for the trait inferred from the reported sample size, median standard errors for the SNP-trait assocations and SNP variances.- \(\widehat{\texttt{sd1}}_{y} = \frac{\sqrt{n} \times median({se}_j)}{C}\),
- \(C = median(\frac{1}{\sqrt{2 \times {MAF}_j \times (1 - {MAF}_j)}})\),
- and \({se}_j\) is the reported standard error.
sd_y_est2: The standard deviation for the trait inferred from the reported sample size, Z statistics for the SNP-trait effects (beta/se) and allele frequency.- \(\widehat{\texttt{sd2}}_{y} = median(\widehat{sd_j})\),
- \(\widehat{sd_j} = \frac{\beta_j}{\widehat{\beta_j^{std}}}\),
r2 metrics
Sum of variance explained, calculated from the clumped top hits sample.
r2_sum<*>:r2statistics under various assumptions1: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var1}}}\), \(\texttt{var1} = 1\).2: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var2}}}\), \(\texttt{var2} = {\widehat{\texttt{sd1}}_{y}}^2\),3: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var3}}}\), \(\texttt{var3} = {\widehat{\texttt{sd2}}_{y}}^2\),4: \(r^2 = \sum_j{\frac{F_j}{F_j + n - 2}}\), \(F = \frac{\beta_j^2}{{se}_j^2}\).
LDSC metrics
Metrics from LD regression
ldsc_nsnp_merge_refpanel_ld: Number of remaining SNPs after merging with reference panel LD.ldsc_nsnp_merge_regression_ld: Number of remaining SNPs after merging with regression SNP LD.ldsc_observed_scale_h2_{beta,se}Coefficient value and SE for total observed scale h2.ldsc_intercept_{beta,se}: Coefficient value and SE for intercept. Intercept is expected to be 1.ldsc_lambda_gc: Lambda GC statistics.ldsc_mean_chisq: Mean \(\chi^2\) statistics.ldsc_ratio: \(\frac{\texttt{ldsc_intercept_beta} - 1}{\texttt{ldsc_mean_chisq} - 1}\), the proportion of the inflation in the mean \(\chi^2\) that the LD Score regression intercepts ascribes to causes other than polygenic heritability. The value of ratio should be close to zero, though in practice values of 0.1-0.2 are not uncommon, probably due to sample/reference LD Score mismatch or model misspecification (e.g., low LD variants have slightly higher \(h^2\) per SNP).
Flags
When a metric needs attention, the flag should return TRUE.
af_correlation:abs(af_correlation)< 0.7.inflation_factor:inflation_factor> 1.2.n:n(max reported sample size) < 10000.is_snpid_non_unique: NOTis_snpid_unique.mean_EFFECT_nonfinite:mean(EFFECT)isNA,NaN, orInf.mean_EFFECT_05:abs(mean(EFFECT))> 0.5.mean_EFFECT_01:abs(mean(EFFECT))> 0.1.mean_chisq:ldsc_mean_chisq> 1.3 orldsc_mean_chisq< 0.7.n_p_sig:n_p_sig> 1000.miss_<*>:n_miss_<*>/n_snps> 0.01.ldsc_ratio:ldsc_ratio> 0.5ldsc_intercept_beta:ldsc_intercept_beta> 1.5n_clumped_hits:n_clumped_hits> 1000r2_sum<*>:r2_sum<*>> 0.5
Plots
- Manhattan plot
- Red line: \(-log_{10}^{5 \times 10^{-8}}\)
- Blue line: \(-log_{10}^{5 \times 10^{-5}}\)
- QQ plot
- AF plot
- P-Z plot
- beta_std plot: Scatter plot between \(\widehat{\beta_j^{std}}\) and \(\beta_j\)
Diagnostics
Details
Summary stats
| skim_type | skim_variable | n_missing | complete_rate | character.min | character.max | character.empty | character.n_unique | character.whitespace | logical.mean | logical.count | numeric.mean | numeric.sd | numeric.p0 | numeric.p25 | numeric.p50 | numeric.p75 | numeric.p100 | numeric.hist |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| character | ID | 0 | 1.000000 | 4 | 58 | 0 | 2473601 | 0 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| character | REF | 0 | 1.000000 | 1 | 1 | 0 | 4 | 0 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| character | ALT | 0 | 1.000000 | 1 | 1 | 0 | 4 | 0 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| logical | N | 2473889 | 0.000000 | NA | NA | NA | NA | NA | NaN | : | NA | NA | NA | NA | NA | NA | NA | NA |
| numeric | CHROM | 0 | 1.000000 | NA | NA | NA | NA | NA | NA | NA | 8.652909e+00 | 5.766290e+00 | 1.0000000 | 4.000000e+00 | 8.000000e+00 | 1.300000e+01 | 2.200000e+01 | ▇▅▃▂▂ |
| numeric | POS | 0 | 1.000000 | NA | NA | NA | NA | NA | NA | NA | 7.854991e+07 | 5.661339e+07 | 5687.0000000 | 3.168199e+07 | 6.898204e+07 | 1.147456e+08 | 2.491917e+08 | ▇▆▅▂▁ |
| numeric | EFFECT | 0 | 1.000000 | NA | NA | NA | NA | NA | NA | NA | -6.600000e-06 | 8.835000e-04 | -0.0048275 | -6.033000e-04 | -6.200000e-06 | 5.890000e-04 | 4.152700e-03 | ▁▁▇▃▁ |
| numeric | SE | 0 | 1.000000 | NA | NA | NA | NA | NA | NA | NA | 8.808000e-04 | 4.690000e-05 | 0.0008009 | 8.410000e-04 | 8.674000e-04 | 9.131000e-04 | 1.736000e-03 | ▇▁▁▁▁ |
| numeric | PVAL | 0 | 1.000000 | NA | NA | NA | NA | NA | NA | NA | 4.988051e-01 | 2.890445e-01 | 0.0000010 | 2.500000e-01 | 5.000000e-01 | 7.499995e-01 | 1.000000e+00 | ▇▇▇▇▇ |
| numeric | PVAL_ztest | 0 | 1.000000 | NA | NA | NA | NA | NA | NA | NA | 4.988061e-01 | 2.890194e-01 | 0.0000010 | 2.485702e-01 | 4.974262e-01 | 7.495464e-01 | 9.999994e-01 | ▇▇▇▇▇ |
| numeric | AF | 0 | 1.000000 | NA | NA | NA | NA | NA | NA | NA | 4.542737e-01 | 1.503257e-01 | 0.2356910 | 3.220990e-01 | 4.322750e-01 | 5.751290e-01 | 7.643090e-01 | ▇▆▅▅▃ |
| numeric | AF_reference | 19613 | 0.992072 | NA | NA | NA | NA | NA | NA | NA | 4.357917e-01 | 1.755779e-01 | 0.0001997 | 2.973240e-01 | 4.205270e-01 | 5.640970e-01 | 1.000000e+00 | ▂▇▇▃▁ |
Head and tail
| CHROM | POS | ID | REF | ALT | EFFECT | SE | PVAL | PVAL_ztest | AF | AF_reference | N |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 49298 | rs200943160 | T | C | 0.0000614 | 0.0014760 | 0.9699999 | 0.9668284 | 0.623812 | 0.7821490 | NA |
| 1 | 54676 | rs2462492 | C | T | 0.0010774 | 0.0014717 | 0.4600002 | 0.4641217 | 0.399144 | NA | NA |
| 1 | 91536 | rs6702460 | G | T | 0.0016938 | 0.0014475 | 0.2399999 | 0.2419389 | 0.455916 | 0.4207270 | NA |
| 1 | 534192 | rs6680723 | C | T | -0.0048275 | 0.0016486 | 0.0034000 | 0.0034098 | 0.242057 | NA | NA |
| 1 | 706368 | rs55727773 | A | G | 0.0020728 | 0.0010204 | 0.0420001 | 0.0422184 | 0.513304 | 0.2751600 | NA |
| 1 | 763394 | rs369924889 | G | A | 0.0027339 | 0.0011954 | 0.0219999 | 0.0221988 | 0.705804 | 0.6176120 | NA |
| 1 | 768253 | rs2977608 | A | C | 0.0009577 | 0.0009689 | 0.3200000 | 0.3229308 | 0.758252 | 0.4894170 | NA |
| 1 | 776546 | rs12124819 | A | G | 0.0002860 | 0.0010948 | 0.7899998 | 0.7939225 | 0.263729 | 0.0756789 | NA |
| 1 | 814495 | rs74461805 | C | A | 0.0004254 | 0.0013973 | 0.7600007 | 0.7607911 | 0.340108 | NA | NA |
| 1 | 830181 | rs28444699 | A | G | 0.0010239 | 0.0009348 | 0.2700001 | 0.2734083 | 0.696612 | 0.6912940 | NA |
| CHROM | POS | ID | REF | ALT | EFFECT | SE | PVAL | PVAL_ztest | AF | AF_reference | N |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 22 | 51180501 | rs5770999 | T | C | 0.0010785 | 0.0009562 | 0.2599998 | 0.2593295 | 0.712571 | 0.6369810 | NA |
| 22 | 51181919 | rs9616825 | G | C | 0.0010023 | 0.0009522 | 0.2900000 | 0.2925352 | 0.695031 | 0.6194090 | NA |
| 22 | 51182485 | rs6009961 | A | G | 0.0010801 | 0.0009593 | 0.2599998 | 0.2602145 | 0.714237 | 0.6383790 | NA |
| 22 | 51186143 | rs2879914 | T | C | 0.0010795 | 0.0008934 | 0.2300001 | 0.2269542 | 0.380077 | 0.2733630 | NA |
| 22 | 51186228 | rs3865766 | C | T | 0.0006137 | 0.0008702 | 0.4799997 | 0.4806817 | 0.449547 | 0.4532750 | NA |
| 22 | 51197266 | rs61290853 | A | G | 0.0008367 | 0.0008968 | 0.3500000 | 0.3508341 | 0.386693 | 0.4229230 | NA |
| 22 | 51198027 | rs34939255 | A | G | 0.0000689 | 0.0010171 | 0.9500000 | 0.9459697 | 0.254586 | 0.0984425 | NA |
| 22 | 51211106 | rs9628250 | T | C | -0.0000618 | 0.0010089 | 0.9500000 | 0.9511452 | 0.271468 | 0.1671330 | NA |
| 22 | 51212875 | rs2238837 | A | C | 0.0010935 | 0.0009590 | 0.2500000 | 0.2541865 | 0.331351 | 0.3724040 | NA |
| 22 | 51237063 | rs3896457 | T | C | 0.0009734 | 0.0009798 | 0.3200000 | 0.3204815 | 0.298393 | 0.2050720 | NA |
bcf preview
1 49298 rs10399793 T C . PASS AF=0.623812 ES:SE:LP:AF:ID 6.13811e-05:0.00147599:0.0132283:0.623812:rs10399793
1 54676 rs2462492 C T . PASS AF=0.399144 ES:SE:LP:AF:ID 0.00107739:0.00147169:0.337242:0.399144:rs2462492
1 91536 rs6702460 G T . PASS AF=0.455916 ES:SE:LP:AF:ID 0.00169381:0.00144751:0.619789:0.455916:rs6702460
1 534192 rs6680723 C T . PASS AF=0.242057 ES:SE:LP:AF:ID -0.00482748:0.00164864:2.46852:0.242057:rs6680723
1 706368 rs12029736 A G . PASS AF=0.513304 ES:SE:LP:AF:ID 0.00207278:0.00102039:1.37675:0.513304:rs12029736
1 763394 rs3115847 G A . PASS AF=0.705804 ES:SE:LP:AF:ID 0.00273391:0.00119544:1.65758:0.705804:rs3115847
1 768253 rs2977608 A C . PASS AF=0.758252 ES:SE:LP:AF:ID 0.000957722:0.00096891:0.49485:0.758252:rs2977608
1 776546 rs12124819 A G . PASS AF=0.263729 ES:SE:LP:AF:ID 0.000285992:0.00109483:0.102373:0.263729:rs12124819
1 814495 rs74461805 C A . PASS AF=0.340108 ES:SE:LP:AF:ID 0.0004254:0.00139731:0.119186:0.340108:rs74461805
1 830181 rs28444699 A G . PASS AF=0.696612 ES:SE:LP:AF:ID 0.00102388:0.000934839:0.568636:0.696612:rs28444699
1 831489 rs4970385 C T . PASS AF=0.705031 ES:SE:LP:AF:ID 0.00139136:0.000917904:0.886057:0.705031:rs4970385
1 831909 rs9697642 C T . PASS AF=0.705083 ES:SE:LP:AF:ID 0.00134763:0.000917903:0.853872:0.705083:rs9697642
1 832066 rs9697380 G C . PASS AF=0.705261 ES:SE:LP:AF:ID 0.00137456:0.000917861:0.886057:0.705261:rs9697380
1 832318 rs4500250 C A . PASS AF=0.705286 ES:SE:LP:AF:ID 0.00133716:0.000917988:0.823909:0.705286:rs4500250
1 832398 rs4553118 T C . PASS AF=0.730154 ES:SE:LP:AF:ID 0.00116715:0.000943312:0.657577:0.730154:rs4553118
1 832918 rs28765502 T C . PASS AF=0.294729 ES:SE:LP:AF:ID -0.001376:0.00091796:0.886057:0.294729:rs28765502
1 833223 rs13303211 C T . PASS AF=0.237157 ES:SE:LP:AF:ID -0.000909723:0.000977278:0.455932:0.237157:rs13303211
1 833302 rs28752186 C T . PASS AF=0.237168 ES:SE:LP:AF:ID -0.000910862:0.000977293:0.455932:0.237168:rs28752186
1 833641 rs28594623 T C . PASS AF=0.240204 ES:SE:LP:AF:ID -0.000988607:0.00097439:0.508638:0.240204:rs28594623
1 833824 rs28484835 T C . PASS AF=0.23716 ES:SE:LP:AF:ID -0.000909617:0.000977335:0.455932:0.23716:rs28484835
1 834832 rs4411087 G C . PASS AF=0.237633 ES:SE:LP:AF:ID -0.000939223:0.000976602:0.468521:0.237633:rs4411087
1 835499 rs4422948 A G . PASS AF=0.241744 ES:SE:LP:AF:ID -0.000727528:0.000969299:0.346787:0.241744:rs4422948
1 836896 rs28705752 T C . PASS AF=0.269687 ES:SE:LP:AF:ID -0.00183857:0.000936601:1.30103:0.269687:rs28705752
1 838555 rs4970383 C A . PASS AF=0.245985 ES:SE:LP:AF:ID -0.00180201:0.000964235:1.20761:0.245985:rs4970383
1 839103 rs28562941 A G . PASS AF=0.270067 ES:SE:LP:AF:ID -0.00184943:0.000937369:1.31876:0.270067:rs28562941
1 840753 rs4970382 T C . PASS AF=0.400406 ES:SE:LP:AF:ID -1.95623e-05:0.000847368:0.00877392:0.400406:rs4970382
1 841085 rs1574243 C G . PASS AF=0.236925 ES:SE:LP:AF:ID -0.00235365:0.000985101:1.76955:0.236925:rs1574243
1 843405 rs11516185 A G . PASS AF=0.362367 ES:SE:LP:AF:ID -6.4081e-05:0.00105427:0.0222764:0.362367:rs11516185
1 850218 rs6664536 T A . PASS AF=0.589315 ES:SE:LP:AF:ID 0.00150678:0.000842774:1.13077:0.589315:rs6664536
1 850371 rs6679046 G T . PASS AF=0.603035 ES:SE:LP:AF:ID 0.00125387:0.000846805:0.853872:0.603035:rs6679046
1 850780 rs6657440 C T . PASS AF=0.603381 ES:SE:LP:AF:ID 0.00122788:0.000846821:0.823909:0.603381:rs6657440
1 852037 rs4970463 G A . PASS AF=0.588673 ES:SE:LP:AF:ID 0.00149825:0.000843977:1.11919:0.588673:rs4970463
1 852063 rs28436996 G A . PASS AF=0.588649 ES:SE:LP:AF:ID 0.0015324:0.000843596:1.16115:0.588649:rs28436996
1 852875 rs13303369 C T . PASS AF=0.606715 ES:SE:LP:AF:ID 0.00121468:0.000848214:0.823909:0.606715:rs13303369
1 853954 rs1806509 C A . PASS AF=0.60688 ES:SE:LP:AF:ID 0.00120163:0.000848302:0.79588:0.60688:rs1806509
1 854777 rs13303019 A G . PASS AF=0.609504 ES:SE:LP:AF:ID 0.00106518:0.00084915:0.677781:0.609504:rs13303019
1 854978 rs13303057 A C . PASS AF=0.602505 ES:SE:LP:AF:ID 0.00126088:0.000846953:0.853872:0.602505:rs13303057
1 855075 rs6673914 C G . PASS AF=0.609473 ES:SE:LP:AF:ID 0.00102005:0.000849038:0.638272:0.609473:rs6673914
1 856099 rs28534711 T G . PASS AF=0.390835 ES:SE:LP:AF:ID -0.00108202:0.000849383:0.69897:0.390835:rs28534711
1 856108 rs28742275 A G . PASS AF=0.390777 ES:SE:LP:AF:ID -0.00108017:0.00084947:0.69897:0.390777:rs28742275
1 856476 rs4040605 A G . PASS AF=0.352504 ES:SE:LP:AF:ID -0.000917136:0.000871957:0.537602:0.352504:rs4040605
1 858801 rs7418179 A G . PASS AF=0.764009 ES:SE:LP:AF:ID 0.00144619:0.000979604:0.853872:0.764009:rs7418179
1 860688 rs60837925 G A . PASS AF=0.764073 ES:SE:LP:AF:ID 0.00184221:0.000979267:1.22185:0.764073:rs60837925
1 861630 rs2879816 G A . PASS AF=0.764174 ES:SE:LP:AF:ID 0.00178956:0.000979425:1.16749:0.764174:rs2879816
1 862866 rs3892970 C T . PASS AF=0.761109 ES:SE:LP:AF:ID 0.00196034:0.000978784:1.34679:0.761109:rs3892970
1 864938 rs2340587 G A . PASS AF=0.758149 ES:SE:LP:AF:ID 0.00172875:0.00097139:1.12494:0.758149:rs2340587
1 866893 rs2880024 T C . PASS AF=0.608083 ES:SE:LP:AF:ID 0.00103236:0.000856896:0.638272:0.608083:rs2880024
1 868418 rs28546443 C T . PASS AF=0.301063 ES:SE:LP:AF:ID -0.000447355:0.000938505:0.200659:0.301063:rs28546443
1 870645 rs28576697 T C . PASS AF=0.293389 ES:SE:LP:AF:ID -0.00135969:0.000928247:0.853872:0.293389:rs28576697
1 871334 rs4072383 G T . PASS AF=0.717959 ES:SE:LP:AF:ID 0.00158825:0.000923429:1.07058:0.717959:rs4072383