Summary
Summary {data-width=650}
Manhattan plot
manhattan_plot
QQ plot
qq_plot
AF plot
af_plot
P-Z plot
pz_plot
beta_std plot
beta_std_plot
Metadata
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"gwas_harmonisation_command": "--out /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/ukbiobank/vcf_09_19b/bgzip_vcf/data.batch_20003_1140876076.vcf.gz --id UKB-b:12831 --data /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/ukbiobank/raw-output/data.batch_20003_1140876076.txt.gz --cohort_cases 1846 --cohort_controls 461087 --ref /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/ukbiobank/human_g1k_v37.fasta --json /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/ukbiobank/ukb_gwas.json; 1.1.1",
"file_date": "2019-09-12T20:06:50.245409",
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"bcftools_viewCommand.1": "view -h /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/ukb-b-12831/ukb-b-12831.vcf.gz; Date=Sun May 10 03:01:04 2020"
}
LDSC
*********************************************************************
* LD Score Regression (LDSC)
* Version 1.0.1
* (C) 2014-2019 Brendan Bulik-Sullivan and Hilary Finucane
* Broad Institute of MIT and Harvard / MIT Department of Mathematics
* GNU General Public License v3
*********************************************************************
Call:
./ldsc.py \
--h2 /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/UKB-b-12831/UKB-b-12831_data.vcf.gz \
--ref-ld-chr ../reference/eur_w_ld_chr/ \
--out /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/UKB-b-12831/ldsc.txt \
--w-ld-chr ../reference/eur_w_ld_chr/
Beginning analysis at Thu Oct 17 14:42:06 2019
Reading summary statistics from /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/UKB-b-12831/UKB-b-12831_data.vcf.gz ...
Read summary statistics for 3006561 SNPs.
Dropped 402 SNPs with duplicated rs numbers.
Reading reference panel LD Score from ../reference/eur_w_ld_chr/[1-22] ...
Read reference panel LD Scores for 1290028 SNPs.
Removing partitioned LD Scores with zero variance.
Reading regression weight LD Score from ../reference/eur_w_ld_chr/[1-22] ...
Read regression weight LD Scores for 1290028 SNPs.
After merging with reference panel LD, 748631 SNPs remain.
After merging with regression SNP LD, 748631 SNPs remain.
Using two-step estimator with cutoff at 30.
Total Observed scale h2: 0.002 (0.0012)
Lambda GC: 1.0184
Mean Chi^2: 1.0247
Intercept: 1.0035 (0.0098)
Ratio: 0.1406 (0.3974)
Analysis finished at Thu Oct 17 14:42:47 2019
Total time elapsed: 41.08sQC metrics
Metrics
Metrics
{
"af_correlation": 0.8175,
"inflation_factor": 1,
"mean_EFFECT": -1.6485e-06,
"n": "-Inf",
"n_snps": 9851866,
"n_clumped_hits": 1,
"n_p_sig": 44,
"n_mono": 0,
"n_ns": 0,
"n_mac": 0,
"is_snpid_unique": true,
"n_miss_EFFECT": 0,
"n_miss_SE": 0,
"n_miss_PVAL": 0,
"n_miss_AF": 0,
"n_miss_AF_reference": 23992,
"n_est": "NA",
"ratio_se_n": "NA",
"mean_diff": "NaN",
"ratio_diff": "NaN",
"sd_y_est1": "NaN",
"sd_y_est2": "NA",
"r2_sum1": 0,
"r2_sum2": 0,
"r2_sum3": 0,
"r2_sum4": 0,
"ldsc_nsnp_merge_refpanel_ld": 748631,
"ldsc_nsnp_merge_regression_ld": 748631,
"ldsc_observed_scale_h2_beta": 0.002,
"ldsc_observed_scale_h2_se": 0.0012,
"ldsc_intercept_beta": 1.0035,
"ldsc_intercept_se": 0.0098,
"ldsc_lambda_gc": 1.0184,
"ldsc_mean_chisq": 1.0247,
"ldsc_ratio": 0.1417
}
Flags
| name | value |
|---|---|
| af_correlation | FALSE |
| inflation_factor | FALSE |
| n | TRUE |
| is_snpid_non_unique | FALSE |
| mean_EFFECT_nonfinite | FALSE |
| mean_EFFECT_05 | FALSE |
| mean_EFFECT_01 | FALSE |
| mean_chisq | FALSE |
| n_p_sig | FALSE |
| miss_EFFECT | FALSE |
| miss_SE | FALSE |
| miss_PVAL | FALSE |
| ldsc_ratio | FALSE |
| ldsc_intercept_beta | FALSE |
| n_clumped_hits | FALSE |
| r2_sum1 | FALSE |
| r2_sum2 | FALSE |
| r2_sum3 | FALSE |
| r2_sum4 | FALSE |
Definitions
General metrics
af_correlation: Correlation coefficient betweenAFandAF_reference.inflation_factor(lambda): Genomic inflation factor.mean_EFFECT: Mean ofEFFECTsize.n: Maximum value of reported sample size across all SNPs, \(n\).n_clumped_hits: Number of clumped hits.n_snps: Number of SNPsn_p_sig: Number of SNPs with pvalue below5e-8.n_mono: Number of monomorphic (MAF == 1orMAF == 0) SNPs.n_ns: Number of SNPs with nonsense values:- alleles other than
A, C, G or T. - P-values
< 0or> 1. - negative or infinite standard errors (
<= 0or= Infinity). - infinite beta estimates or allele frequencies
< 0or> 1.
- alleles other than
n_mac: Number of cases whereMAC(\(2 \times N \times MAF\)) is less than6.is_snpid_unique:trueif the combination ofIDREFALTis unique and therefore no duplication in snpid.n_miss_<*>: Number ofNAobservations for<*>column.
se_n metrics
n_est: Estimated sample size value, \(\widehat{n}\).ratio_se_n: \(\texttt{ratio_se_n} = \frac{\sqrt{\widehat{n}}}{\sqrt{n}}\). We expectratio_se_nto be 1. When it is not 1, it implies that the trait did not have a variance of 1, the reported sample size is wrong, or that the SNP-level effective sample sizes differ markedly from the reported sample size.mean_diff: \(\texttt{mean_diff} = \sum_{j} \frac{\widehat{\beta_j^{std}} - \beta_j}{\texttt{n_snps}}\), mean difference between the standardised beta, predicted from P-values, and the observed beta. The difference should be very close to zero if trait has a variance of 1.- \(\widehat{\beta_j^{std}} = \sqrt{\frac{{z}_j^2 / ({z}_j^2 + n -2)}{2 \times {MAF}_j \times (1 - {MAF}_j)}} \times sign({z}_j)\),
- \({z}_j = \frac{\beta_j}{{se}_j}\),
- and \(\beta_j\) is the reported effect size.
ratio_diff: \(\texttt{ratio_diff} = |\frac{\texttt{mean_diff}}{\texttt{mean_diff2}}|\), absolute ratio between the mean ofdiffand the mean ofdiff2(expected difference between the standardised beta predicted from P-values, and the standardised beta derived from the observed beta divided by the predicted SD; NOT reported). The ratio should be close to 1. If different from 1, then implies that the betas are not in a standard deviation scale.- \(\texttt{mean_diff2} = \sum_{j} \frac{\widehat{\beta_j^{std}} - \beta^{\prime}_j}{\texttt{n_snps}}\)
- \(\beta^{\prime}_j = \frac{\beta_j}{\widehat{\texttt{sd2}}_{y}}\)
sd_y_est1: The standard deviation for the trait inferred from the reported sample size, median standard errors for the SNP-trait assocations and SNP variances.- \(\widehat{\texttt{sd1}}_{y} = \frac{\sqrt{n} \times median({se}_j)}{C}\),
- \(C = median(\frac{1}{\sqrt{2 \times {MAF}_j \times (1 - {MAF}_j)}})\),
- and \({se}_j\) is the reported standard error.
sd_y_est2: The standard deviation for the trait inferred from the reported sample size, Z statistics for the SNP-trait effects (beta/se) and allele frequency.- \(\widehat{\texttt{sd2}}_{y} = median(\widehat{sd_j})\),
- \(\widehat{sd_j} = \frac{\beta_j}{\widehat{\beta_j^{std}}}\),
r2 metrics
Sum of variance explained, calculated from the clumped top hits sample.
r2_sum<*>:r2statistics under various assumptions1: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var1}}}\), \(\texttt{var1} = 1\).2: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var2}}}\), \(\texttt{var2} = {\widehat{\texttt{sd1}}_{y}}^2\),3: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var3}}}\), \(\texttt{var3} = {\widehat{\texttt{sd2}}_{y}}^2\),4: \(r^2 = \sum_j{\frac{F_j}{F_j + n - 2}}\), \(F = \frac{\beta_j^2}{{se}_j^2}\).
LDSC metrics
Metrics from LD regression
ldsc_nsnp_merge_refpanel_ld: Number of remaining SNPs after merging with reference panel LD.ldsc_nsnp_merge_regression_ld: Number of remaining SNPs after merging with regression SNP LD.ldsc_observed_scale_h2_{beta,se}Coefficient value and SE for total observed scale h2.ldsc_intercept_{beta,se}: Coefficient value and SE for intercept. Intercept is expected to be 1.ldsc_lambda_gc: Lambda GC statistics.ldsc_mean_chisq: Mean \(\chi^2\) statistics.ldsc_ratio: \(\frac{\texttt{ldsc_intercept_beta} - 1}{\texttt{ldsc_mean_chisq} - 1}\), the proportion of the inflation in the mean \(\chi^2\) that the LD Score regression intercepts ascribes to causes other than polygenic heritability. The value of ratio should be close to zero, though in practice values of 0.1-0.2 are not uncommon, probably due to sample/reference LD Score mismatch or model misspecification (e.g., low LD variants have slightly higher \(h^2\) per SNP).
Flags
When a metric needs attention, the flag should return TRUE.
af_correlation:abs(af_correlation)< 0.7.inflation_factor:inflation_factor> 1.2.n:n(max reported sample size) < 10000.is_snpid_non_unique: NOTis_snpid_unique.mean_EFFECT_nonfinite:mean(EFFECT)isNA,NaN, orInf.mean_EFFECT_05:abs(mean(EFFECT))> 0.5.mean_EFFECT_01:abs(mean(EFFECT))> 0.1.mean_chisq:ldsc_mean_chisq> 1.3 orldsc_mean_chisq< 0.7.n_p_sig:n_p_sig> 1000.miss_<*>:n_miss_<*>/n_snps> 0.01.ldsc_ratio:ldsc_ratio> 0.5ldsc_intercept_beta:ldsc_intercept_beta> 1.5n_clumped_hits:n_clumped_hits> 1000r2_sum<*>:r2_sum<*>> 0.5
Plots
- Manhattan plot
- Red line: \(-log_{10}^{5 \times 10^{-8}}\)
- Blue line: \(-log_{10}^{5 \times 10^{-5}}\)
- QQ plot
- AF plot
- P-Z plot
- beta_std plot: Scatter plot between \(\widehat{\beta_j^{std}}\) and \(\beta_j\)
Diagnostics
Details
Summary stats
| skim_type | skim_variable | n_missing | complete_rate | character.min | character.max | character.empty | character.n_unique | character.whitespace | logical.mean | logical.count | numeric.mean | numeric.sd | numeric.p0 | numeric.p25 | numeric.p50 | numeric.p75 | numeric.p100 | numeric.hist |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| character | ID | 0 | 1.0000000 | 3 | 58 | 0 | 3006162 | 0 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| character | REF | 0 | 1.0000000 | 1 | 1 | 0 | 4 | 0 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| character | ALT | 0 | 1.0000000 | 1 | 1 | 0 | 4 | 0 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| logical | N | 3006561 | 0.0000000 | NA | NA | NA | NA | NA | NaN | : | NA | NA | NA | NA | NA | NA | NA | NA |
| numeric | CHROM | 0 | 1.0000000 | NA | NA | NA | NA | NA | NA | NA | 8.662482e+00 | 5.772218e+00 | 1.0000000 | 4.000000e+00 | 8.000000e+00 | 1.300000e+01 | 2.200000e+01 | ▇▅▃▂▂ |
| numeric | POS | 0 | 1.0000000 | NA | NA | NA | NA | NA | NA | NA | 7.856331e+07 | 5.669519e+07 | 828.0000000 | 3.163486e+07 | 6.895144e+07 | 1.147973e+08 | 2.492013e+08 | ▇▆▅▂▁ |
| numeric | EFFECT | 0 | 1.0000000 | NA | NA | NA | NA | NA | NA | NA | -1.600000e-06 | 1.457000e-04 | -0.0010428 | -9.860000e-05 | -1.400000e-06 | 9.580000e-05 | 9.405000e-04 | ▁▁▇▂▁ |
| numeric | SE | 0 | 1.0000000 | NA | NA | NA | NA | NA | NA | NA | 1.430000e-04 | 1.100000e-05 | 0.0001264 | 1.335000e-04 | 1.397000e-04 | 1.508000e-04 | 2.997000e-04 | ▇▁▁▁▁ |
| numeric | PVAL | 0 | 1.0000000 | NA | NA | NA | NA | NA | NA | NA | 4.966579e-01 | 2.908520e-01 | 0.0000000 | 2.399999e-01 | 5.000000e-01 | 7.499995e-01 | 1.000000e+00 | ▇▇▇▇▇ |
| numeric | PVAL_ztest | 0 | 1.0000000 | NA | NA | NA | NA | NA | NA | NA | 4.966600e-01 | 2.908255e-01 | 0.0000000 | 2.437439e-01 | 4.953779e-01 | 7.496709e-01 | 9.999990e-01 | ▇▇▇▇▇ |
| numeric | AF | 0 | 1.0000000 | NA | NA | NA | NA | NA | NA | NA | 4.347229e-01 | 1.753885e-01 | 0.1896000 | 2.806880e-01 | 4.040010e-01 | 5.720680e-01 | 8.104000e-01 | ▇▆▅▃▃ |
| numeric | AF_reference | 23992 | 0.9920201 | NA | NA | NA | NA | NA | NA | NA | 4.186759e-01 | 1.916153e-01 | 0.0001997 | 2.645770e-01 | 3.953670e-01 | 5.593050e-01 | 1.000000e+00 | ▃▇▆▃▁ |
Head and tail
| CHROM | POS | ID | REF | ALT | EFFECT | SE | PVAL | PVAL_ztest | AF | AF_reference | N |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 49298 | rs200943160 | T | C | -0.0000752 | 0.0002326 | 0.7499995 | 0.7465069 | 0.623763 | 0.7821490 | NA |
| 1 | 54676 | rs2462492 | C | T | 0.0001626 | 0.0002305 | 0.4799997 | 0.4805822 | 0.400401 | NA | NA |
| 1 | 91536 | rs6702460 | G | T | -0.0000625 | 0.0002269 | 0.7800007 | 0.7828862 | 0.456851 | 0.4207270 | NA |
| 1 | 534192 | rs6680723 | C | T | 0.0004259 | 0.0002592 | 0.1000000 | 0.1004003 | 0.240960 | NA | NA |
| 1 | 706368 | rs55727773 | A | G | -0.0002817 | 0.0001609 | 0.0800000 | 0.0799718 | 0.515650 | 0.2751600 | NA |
| 1 | 763394 | rs369924889 | G | A | -0.0000979 | 0.0001887 | 0.5999997 | 0.6038214 | 0.706753 | 0.6176120 | NA |
| 1 | 768253 | rs2977608 | A | C | -0.0001116 | 0.0001540 | 0.4700002 | 0.4685830 | 0.761304 | 0.4894170 | NA |
| 1 | 776546 | rs12124819 | A | G | -0.0004264 | 0.0001720 | 0.0129999 | 0.0131689 | 0.265390 | 0.0756789 | NA |
| 1 | 798400 | rs10900604 | A | G | 0.0002451 | 0.0001643 | 0.1400000 | 0.1356623 | 0.206580 | 0.4105430 | NA |
| 1 | 798959 | rs11240777 | G | A | 0.0002464 | 0.0001643 | 0.1299999 | 0.1337193 | 0.206409 | 0.4099440 | NA |
| CHROM | POS | ID | REF | ALT | EFFECT | SE | PVAL | PVAL_ztest | AF | AF_reference | N |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 22 | 51180501 | rs5770999 | T | C | 3.45e-05 | 0.0001514 | 0.8200001 | 0.8197528 | 0.713658 | 0.6369810 | NA |
| 22 | 51181919 | rs9616825 | G | C | 3.95e-05 | 0.0001507 | 0.7899998 | 0.7932611 | 0.695471 | 0.6194090 | NA |
| 22 | 51182485 | rs6009961 | A | G | 2.25e-05 | 0.0001519 | 0.8800001 | 0.8824322 | 0.715505 | 0.6383790 | NA |
| 22 | 51186143 | rs2879914 | T | C | 4.98e-05 | 0.0001409 | 0.7199992 | 0.7238679 | 0.381826 | 0.2733630 | NA |
| 22 | 51186228 | rs3865766 | C | T | 3.50e-06 | 0.0001373 | 0.9800000 | 0.9799156 | 0.451063 | 0.4532750 | NA |
| 22 | 51197266 | rs61290853 | A | G | -6.26e-05 | 0.0001418 | 0.6600001 | 0.6585528 | 0.386333 | 0.4229230 | NA |
| 22 | 51198027 | rs34939255 | A | G | -6.75e-05 | 0.0001605 | 0.6700003 | 0.6738903 | 0.254557 | 0.0984425 | NA |
| 22 | 51211106 | rs9628250 | T | C | 7.00e-07 | 0.0001591 | 1.0000000 | 0.9964154 | 0.271547 | 0.1671330 | NA |
| 22 | 51212875 | rs2238837 | A | C | 7.40e-06 | 0.0001512 | 0.9599999 | 0.9610571 | 0.331455 | 0.3724040 | NA |
| 22 | 51237063 | rs3896457 | T | C | 1.00e-07 | 0.0001548 | 1.0000000 | 0.9997105 | 0.297971 | 0.2050720 | NA |
bcf preview
1 49298 rs10399793 T C . PASS AF=0.623763 ES:SE:LP:AF:ID -7.51983e-05:0.000232633:0.124939:0.623763:rs10399793
1 54676 rs2462492 C T . PASS AF=0.400401 ES:SE:LP:AF:ID 0.000162563:0.000230466:0.318759:0.400401:rs2462492
1 91536 rs6702460 G T . PASS AF=0.456851 ES:SE:LP:AF:ID -6.25314e-05:0.000226925:0.107905:0.456851:rs6702460
1 534192 rs6680723 C T . PASS AF=0.24096 ES:SE:LP:AF:ID 0.000425852:0.000259205:1:0.24096:rs6680723
1 706368 rs12029736 A G . PASS AF=0.51565 ES:SE:LP:AF:ID -0.000281731:0.000160911:1.09691:0.51565:rs12029736
1 763394 rs3115847 G A . PASS AF=0.706753 ES:SE:LP:AF:ID -9.78945e-05:0.000188653:0.221849:0.706753:rs3115847
1 768253 rs2977608 A C . PASS AF=0.761304 ES:SE:LP:AF:ID -0.000111599:0.000153975:0.327902:0.761304:rs2977608
1 776546 rs12124819 A G . PASS AF=0.26539 ES:SE:LP:AF:ID -0.000426397:0.000171992:1.88606:0.26539:rs12124819
1 798400 rs10900604 A G . PASS AF=0.20658 ES:SE:LP:AF:ID 0.000245102:0.000164262:0.853872:0.20658:rs10900604
1 798959 rs11240777 G A . PASS AF=0.206409 ES:SE:LP:AF:ID 0.000246433:0.000164333:0.886057:0.206409:rs11240777
1 808631 rs11240779 G A . PASS AF=0.772626 ES:SE:LP:AF:ID -0.000227132:0.000156324:0.823909:0.772626:rs11240779
1 808928 rs11240780 C T . PASS AF=0.772854 ES:SE:LP:AF:ID -0.000235846:0.000156588:0.886057:0.772854:rs11240780
1 814495 rs74461805 C A . PASS AF=0.340397 ES:SE:LP:AF:ID -0.000200622:0.000220641:0.443698:0.340397:rs74461805
1 830181 rs28444699 A G . PASS AF=0.697259 ES:SE:LP:AF:ID -6.76194e-05:0.000147615:0.187087:0.697259:rs28444699
1 831489 rs4970385 C T . PASS AF=0.705403 ES:SE:LP:AF:ID -3.37544e-05:0.000144944:0.0861861:0.705403:rs4970385
1 831909 rs9697642 C T . PASS AF=0.705448 ES:SE:LP:AF:ID -3.67815e-05:0.00014494:0.09691:0.705448:rs9697642
1 832066 rs9697380 G C . PASS AF=0.705634 ES:SE:LP:AF:ID -3.44123e-05:0.000144946:0.091515:0.705634:rs9697380
1 832318 rs4500250 C A . PASS AF=0.705662 ES:SE:LP:AF:ID -3.29121e-05:0.000144962:0.0861861:0.705662:rs4500250
1 832398 rs4553118 T C . PASS AF=0.730134 ES:SE:LP:AF:ID -5.90221e-05:0.000148912:0.161151:0.730134:rs4553118
1 832918 rs28765502 T C . PASS AF=0.294371 ES:SE:LP:AF:ID 3.15786e-05:0.000144955:0.0809219:0.294371:rs28765502
1 833223 rs13303211 C T . PASS AF=0.236696 ES:SE:LP:AF:ID 4.73742e-05:0.000154328:0.119186:0.236696:rs13303211
1 833302 rs28752186 C T . PASS AF=0.236684 ES:SE:LP:AF:ID 4.48587e-05:0.000154329:0.113509:0.236684:rs28752186
1 833641 rs28594623 T C . PASS AF=0.239743 ES:SE:LP:AF:ID 2.51641e-05:0.000153834:0.0604807:0.239743:rs28594623
1 833824 rs28484835 T C . PASS AF=0.236686 ES:SE:LP:AF:ID 4.48356e-05:0.000154328:0.113509:0.236686:rs28484835
1 833927 rs28593608 T C . PASS AF=0.212416 ES:SE:LP:AF:ID 6.89435e-05:0.000160403:0.173925:0.212416:rs28593608
1 834198 rs28385272 T C . PASS AF=0.212311 ES:SE:LP:AF:ID 7.18379e-05:0.000160431:0.187087:0.212311:rs28385272
1 834832 rs4411087 G C . PASS AF=0.237171 ES:SE:LP:AF:ID 4.18079e-05:0.00015421:0.102373:0.237171:rs4411087
1 834928 rs4422949 A G . PASS AF=0.212956 ES:SE:LP:AF:ID 6.24707e-05:0.000160203:0.154902:0.212956:rs4422949
1 834999 rs28570054 G A . PASS AF=0.212918 ES:SE:LP:AF:ID 6.48291e-05:0.000160236:0.161151:0.212918:rs28570054
1 835499 rs4422948 A G . PASS AF=0.241155 ES:SE:LP:AF:ID 7.01237e-05:0.000153133:0.187087:0.241155:rs4422948
1 836529 rs28731045 C G . PASS AF=0.213538 ES:SE:LP:AF:ID 7.22892e-05:0.000159999:0.187087:0.213538:rs28731045
1 836896 rs28705752 T C . PASS AF=0.269503 ES:SE:LP:AF:ID -6.72464e-06:0.000147762:0.0177288:0.269503:rs28705752
1 836924 rs72890788 G A . PASS AF=0.213508 ES:SE:LP:AF:ID 7.23259e-05:0.000160019:0.187087:0.213508:rs72890788
1 838387 rs4970384 T C . PASS AF=0.214583 ES:SE:LP:AF:ID 0.000101049:0.000159711:0.275724:0.214583:rs4970384
1 838555 rs4970383 C A . PASS AF=0.246197 ES:SE:LP:AF:ID 2.17421e-05:0.000152081:0.05061:0.246197:rs4970383
1 839103 rs28562941 A G . PASS AF=0.27001 ES:SE:LP:AF:ID -1.3045e-05:0.000147866:0.0315171:0.27001:rs28562941
1 840753 rs4970382 T C . PASS AF=0.400106 ES:SE:LP:AF:ID -2.81137e-06:0.000133699:0.00877392:0.400106:rs4970382
1 841085 rs1574243 C G . PASS AF=0.237094 ES:SE:LP:AF:ID 4.50451e-05:0.000155298:0.113509:0.237094:rs1574243
1 842013 rs7419119 T G . PASS AF=0.215384 ES:SE:LP:AF:ID 6.23548e-05:0.000159817:0.154902:0.215384:rs7419119
1 842362 rs28540380 C T . PASS AF=0.235321 ES:SE:LP:AF:ID 1.39191e-05:0.000157621:0.0315171:0.235321:rs28540380
1 843405 rs11516185 A G . PASS AF=0.362599 ES:SE:LP:AF:ID -0.000100561:0.000165973:0.267606:0.362599:rs11516185
1 845635 rs117086422 C T . PASS AF=0.20543 ES:SE:LP:AF:ID 0.00012654:0.000162535:0.356547:0.20543:rs117086422
1 845938 rs57760052 G A . PASS AF=0.210865 ES:SE:LP:AF:ID 0.000115938:0.000160971:0.327902:0.210865:rs57760052
1 846078 rs28612348 C T . PASS AF=0.196786 ES:SE:LP:AF:ID 0.000108154:0.000165026:0.29243:0.196786:rs28612348
1 846398 rs58781670 G A . PASS AF=0.204448 ES:SE:LP:AF:ID 0.000124985:0.000163091:0.356547:0.204448:rs58781670
1 846808 rs4475691 C T . PASS AF=0.198378 ES:SE:LP:AF:ID 7.04011e-05:0.000164557:0.173925:0.198378:rs4475691
1 846864 rs950122 G C . PASS AF=0.198107 ES:SE:LP:AF:ID 0.000111358:0.000164464:0.30103:0.198107:rs950122
1 847228 rs3905286 C T . PASS AF=0.203588 ES:SE:LP:AF:ID 6.58806e-05:0.000163234:0.161151:0.203588:rs3905286
1 847491 rs28407778 G A . PASS AF=0.2142 ES:SE:LP:AF:ID -1.46427e-05:0.000159897:0.0315171:0.2142:rs28407778
1 848090 rs4246505 G A . PASS AF=0.212516 ES:SE:LP:AF:ID -1.26977e-07:0.000160317:-0:0.212516:rs4246505