manhattan_plot
qq_plot
af_plot
pz_plot
beta_std_plot
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"gwas_harmonisation_command": "--json /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-a-import/processed/ukb-a-483/ukb-a-483_data.json --ref /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/QC/genomes/b37/human_g1k_v37.fasta; 1.1.1",
"file_date": "2020-02-16T00:22:27.407330",
"bcftools_annotateVersion": "1.9-74-g6af271c+htslib-1.9-64-g226b4a8",
"bcftools_annotateCommand": "annotate -a /mnt/storage/home/gh13047/mr-eve/vcf-reference-datasets/dbsnp/dbsnp.v153.b37.vcf.gz -c ID -o /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-a-import/processed/ukb-a-483/ukb-a-483.vcf.gz -O z /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-a-import/processed/ukb-a-483/ukb-a-483_data.vcf.gz; Date=Sun Feb 16 01:00:32 2020",
"bcftools_viewVersion": "1.9-74-g6af271c+htslib-1.9-64-g226b4a8",
"bcftools_viewCommand": "view -h /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/ukb-a-483/ukb-a-483.vcf.gz; Date=Sun May 10 08:47:18 2020"
}
*********************************************************************
* LD Score Regression (LDSC)
* Version 1.0.1
* (C) 2014-2019 Brendan Bulik-Sullivan and Hilary Finucane
* Broad Institute of MIT and Harvard / MIT Department of Mathematics
* GNU General Public License v3
*********************************************************************
Call:
./ldsc.py \
--h2 /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-a-import/processed/ukb-a-483/ukb-a-483.vcf.gz \
--ref-ld-chr /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/ \
--out /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-a-import/processed/ukb-a-483/ldsc.txt \
--w-ld-chr /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/
Beginning analysis at Sun Feb 16 01:50:16 2020
Reading summary statistics from /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-a-import/processed/ukb-a-483/ukb-a-483.vcf.gz ...
Read summary statistics for 10877936 SNPs.
Reading reference panel LD Score from /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/[1-22] ...
Read reference panel LD Scores for 1290028 SNPs.
Removing partitioned LD Scores with zero variance.
Reading regression weight LD Score from /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/[1-22] ...
Read regression weight LD Scores for 1290028 SNPs.
After merging with reference panel LD, 1281483 SNPs remain.
After merging with regression SNP LD, 1281483 SNPs remain.
Using two-step estimator with cutoff at 30.
Total Observed scale h2: 0.0239 (0.0018)
Lambda GC: 1.1526
Mean Chi^2: 1.1717
Intercept: 1.0173 (0.0067)
Ratio: 0.1006 (0.0388)
Analysis finished at Sun Feb 16 01:52:04 2020
Total time elapsed: 1.0m:47.7s
{
"af_correlation": 0.9533,
"inflation_factor": 1.0896,
"mean_EFFECT": 0,
"n": 335599,
"n_snps": 10877936,
"n_clumped_hits": 7,
"n_p_sig": 26,
"n_mono": 0,
"n_ns": 0,
"n_mac": 0,
"is_snpid_unique": true,
"n_miss_EFFECT": 0,
"n_miss_SE": 0,
"n_miss_PVAL": 0,
"n_miss_AF": 0,
"n_miss_AF_reference": 356865,
"n_est": 334113.5988,
"ratio_se_n": 0.9978,
"mean_diff": 0,
"ratio_diff": 28.7014,
"sd_y_est1": 0.2354,
"sd_y_est2": 0.2349,
"r2_sum1": 0,
"r2_sum2": 0.0007,
"r2_sum3": 0.0007,
"r2_sum4": 0.0007,
"ldsc_nsnp_merge_refpanel_ld": 1281483,
"ldsc_nsnp_merge_regression_ld": 1281483,
"ldsc_observed_scale_h2_beta": 0.0239,
"ldsc_observed_scale_h2_se": 0.0018,
"ldsc_intercept_beta": 1.0173,
"ldsc_intercept_se": 0.0067,
"ldsc_lambda_gc": 1.1526,
"ldsc_mean_chisq": 1.1717,
"ldsc_ratio": 0.1008
}
name | value |
---|---|
af_correlation | FALSE |
inflation_factor | FALSE |
n | FALSE |
is_snpid_non_unique | FALSE |
mean_EFFECT_nonfinite | FALSE |
mean_EFFECT_05 | FALSE |
mean_EFFECT_01 | FALSE |
mean_chisq | FALSE |
n_p_sig | FALSE |
miss_EFFECT | FALSE |
miss_SE | FALSE |
miss_PVAL | FALSE |
ldsc_ratio | FALSE |
ldsc_intercept_beta | FALSE |
n_clumped_hits | FALSE |
r2_sum1 | FALSE |
r2_sum2 | FALSE |
r2_sum3 | FALSE |
r2_sum4 | FALSE |
General metrics
af_correlation
: Correlation coefficient between AF
and AF_reference
.inflation_factor
(lambda
): Genomic inflation factor.mean_EFFECT
: Mean of EFFECT
size.n
: Maximum value of reported sample size across all SNPs, \(n\).n_clumped_hits
: Number of clumped hits.n_snps
: Number of SNPsn_p_sig
: Number of SNPs with pvalue below 5e-8
.n_mono
: Number of monomorphic (MAF == 1
or MAF == 0
) SNPs.n_ns
: Number of SNPs with nonsense values:
A, C, G or T
.< 0
or > 1
.<= 0
or = Infinity
).< 0
or > 1
.n_mac
: Number of cases where MAC
(\(2 \times N \times MAF\)) is less than 6
.is_snpid_unique
: true
if the combination of ID
REF
ALT
is unique and therefore no duplication in snpid.n_miss_<*>
: Number of NA
observations for <*>
column.se_n metrics
n_est
: Estimated sample size value, \(\widehat{n}\).ratio_se_n
: \(\texttt{ratio_se_n} = \frac{\sqrt{\widehat{n}}}{\sqrt{n}}\). We expect ratio_se_n
to be 1. When it is not 1, it implies that the trait did not have a variance of 1, the reported sample size is wrong, or that the SNP-level effective sample sizes differ markedly from the reported sample size.mean_diff
: \(\texttt{mean_diff} = \sum_{j} \frac{\widehat{\beta_j^{std}} - \beta_j}{\texttt{n_snps}}\), mean difference between the standardised beta, predicted from P-values, and the observed beta. The difference should be very close to zero if trait has a variance of 1.
ratio_diff
: \(\texttt{ratio_diff} = |\frac{\texttt{mean_diff}}{\texttt{mean_diff2}}|\), absolute ratio between the mean of diff
and the mean of diff2
(expected difference between the standardised beta predicted from P-values, and the standardised beta derived from the observed beta divided by the predicted SD; NOT reported). The ratio should be close to 1. If different from 1, then implies that the betas are not in a standard deviation scale.
sd_y_est1
: The standard deviation for the trait inferred from the reported sample size, median standard errors for the SNP-trait assocations and SNP variances.
sd_y_est2
: The standard deviation for the trait inferred from the reported sample size, Z statistics for the SNP-trait effects (beta/se) and allele frequency.
r2 metrics
Sum of variance explained, calculated from the clumped top hits sample.
r2_sum<*>
: r2
statistics under various assumptions
1
: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var1}}}\), \(\texttt{var1} = 1\).2
: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var2}}}\), \(\texttt{var2} = {\widehat{\texttt{sd1}}_{y}}^2\),3
: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var3}}}\), \(\texttt{var3} = {\widehat{\texttt{sd2}}_{y}}^2\),4
: \(r^2 = \sum_j{\frac{F_j}{F_j + n - 2}}\), \(F = \frac{\beta_j^2}{{se}_j^2}\).LDSC metrics
Metrics from LD regression
ldsc_nsnp_merge_refpanel_ld
: Number of remaining SNPs after merging with reference panel LD.ldsc_nsnp_merge_regression_ld
: Number of remaining SNPs after merging with regression SNP LD.ldsc_observed_scale_h2_{beta,se}
Coefficient value and SE for total observed scale h2.ldsc_intercept_{beta,se}
: Coefficient value and SE for intercept. Intercept is expected to be 1.ldsc_lambda_gc
: Lambda GC statistics.ldsc_mean_chisq
: Mean \(\chi^2\) statistics.ldsc_ratio
: \(\frac{\texttt{ldsc_intercept_beta} - 1}{\texttt{ldsc_mean_chisq} - 1}\), the proportion of the inflation in the mean \(\chi^2\) that the LD Score regression intercepts ascribes to causes other than polygenic heritability. The value of ratio should be close to zero, though in practice values of 0.1-0.2 are not uncommon, probably due to sample/reference LD Score mismatch or model misspecification (e.g., low LD variants have slightly higher \(h^2\) per SNP).Flags
When a metric needs attention, the flag should return TRUE.
af_correlation
: abs(af_correlation)
< 0.7.inflation_factor
: inflation_factor
> 1.2.n
: n
(max reported sample size) < 10000.is_snpid_non_unique
: NOT is_snpid_unique
.mean_EFFECT_nonfinite
: mean(EFFECT)
is NA
, NaN
, or Inf
.mean_EFFECT_05
: abs(mean(EFFECT))
> 0.5.mean_EFFECT_01
: abs(mean(EFFECT))
> 0.1.mean_chisq
: ldsc_mean_chisq
> 1.3 or ldsc_mean_chisq
< 0.7.n_p_sig
: n_p_sig
> 1000.miss_<*>
: n_miss_<*>
/ n_snps
> 0.01.ldsc_ratio
: ldsc_ratio
> 0.5ldsc_intercept_beta
: ldsc_intercept_beta
> 1.5n_clumped_hits
: n_clumped_hits
> 1000r2_sum<*>
: r2_sum<*>
> 0.5Plots
skim_type | skim_variable | n_missing | complete_rate | character.min | character.max | character.empty | character.n_unique | character.whitespace | numeric.mean | numeric.sd | numeric.p0 | numeric.p25 | numeric.p50 | numeric.p75 | numeric.p100 | numeric.hist |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
character | ID | 0 | 1.0000000 | 3 | 58 | 0 | 10877936 | 0 | NA | NA | NA | NA | NA | NA | NA | NA |
character | REF | 0 | 1.0000000 | 1 | 1 | 0 | 4 | 0 | NA | NA | NA | NA | NA | NA | NA | NA |
character | ALT | 0 | 1.0000000 | 1 | 1 | 0 | 4 | 0 | NA | NA | NA | NA | NA | NA | NA | NA |
numeric | CHROM | 0 | 1.0000000 | NA | NA | NA | NA | NA | 8.598638e+00 | 5.745666e+00 | 1.00000e+00 | 4.000000e+00 | 8.000000e+00 | 1.300000e+01 | 2.200000e+01 | ▇▅▃▂▂ |
numeric | POS | 0 | 1.0000000 | NA | NA | NA | NA | NA | 7.911383e+07 | 5.624931e+07 | 8.28000e+02 | 3.287294e+07 | 6.988889e+07 | 1.148258e+08 | 2.492251e+08 | ▇▆▅▂▁ |
numeric | EFFECT | 0 | 1.0000000 | NA | NA | NA | NA | NA | 1.280000e-05 | 3.440500e-03 | -3.77415e-02 | -9.693000e-04 | 1.000000e-07 | 9.645000e-04 | 4.848950e-02 | ▁▁▇▁▁ |
numeric | SE | 0 | 1.0000000 | NA | NA | NA | NA | NA | 2.475000e-03 | 2.344100e-03 | 5.67800e-04 | 7.013000e-04 | 1.347000e-03 | 3.599200e-03 | 1.292870e-02 | ▇▂▁▁▁ |
numeric | PVAL | 0 | 1.0000000 | NA | NA | NA | NA | NA | 4.861526e-01 | 2.932297e-01 | 0.00000e+00 | 2.281902e-01 | 4.813944e-01 | 7.408478e-01 | 1.000000e+00 | ▇▇▇▇▇ |
numeric | PVAL_ztest | 0 | 1.0000000 | NA | NA | NA | NA | NA | 4.861522e-01 | 2.932300e-01 | 0.00000e+00 | 2.281888e-01 | 4.813938e-01 | 7.408470e-01 | 9.999999e-01 | ▇▇▇▇▇ |
numeric | AF | 0 | 1.0000000 | NA | NA | NA | NA | NA | 1.820865e-01 | 2.503832e-01 | 1.00090e-03 | 6.878700e-03 | 5.191440e-02 | 2.739880e-01 | 9.989990e-01 | ▇▂▁▁▁ |
numeric | AF_reference | 356865 | 0.9671937 | NA | NA | NA | NA | NA | 1.877709e-01 | 2.439191e-01 | 0.00000e+00 | 5.191700e-03 | 7.468050e-02 | 2.873400e-01 | 1.000000e+00 | ▇▂▁▁▁ |
numeric | N | 0 | 1.0000000 | NA | NA | NA | NA | NA | 3.355990e+05 | 0.000000e+00 | 3.35599e+05 | 3.355990e+05 | 3.355990e+05 | 3.355990e+05 | 3.355990e+05 | ▁▁▇▁▁ |
CHROM | POS | ID | REF | ALT | EFFECT | SE | PVAL | PVAL_ztest | AF | AF_reference | N |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | 693731 | rs12238997 | A | G | 0.0000791 | 0.0009476 | 0.9334950 | 0.9334952 | 0.1169260 | 0.1417730 | 335599 |
1 | 717587 | rs144155419 | G | A | -0.0004132 | 0.0025469 | 0.8711160 | 0.8711157 | 0.0143862 | 0.0045926 | 335599 |
1 | 730087 | rs148120343 | T | C | 0.0012335 | 0.0013205 | 0.3502370 | 0.3502329 | 0.0554733 | 0.0127796 | 335599 |
1 | 731718 | rs142557973 | T | C | 0.0001724 | 0.0008990 | 0.8478970 | 0.8478966 | 0.1216580 | 0.1543530 | 335599 |
1 | 734349 | rs141242758 | T | C | 0.0002803 | 0.0008995 | 0.7553322 | 0.7553330 | 0.1215130 | 0.1525560 | 335599 |
1 | 740284 | rs61770167 | C | T | 0.0037063 | 0.0040917 | 0.3650388 | 0.3650381 | 0.0058556 | 0.0023962 | 335599 |
1 | 742813 | rs112573343 | C | T | -0.0053671 | 0.0077251 | 0.4872087 | 0.4872085 | 0.0015525 | 0.1030350 | 335599 |
1 | 753405 | rs3115860 | C | A | -0.0002477 | 0.0008547 | 0.7719319 | 0.7719321 | 0.8706760 | 0.7517970 | 335599 |
1 | 753541 | rs2073813 | G | A | 0.0004160 | 0.0008568 | 0.6273444 | 0.6273450 | 0.1288330 | 0.3019170 | 335599 |
1 | 754182 | rs3131969 | A | G | -0.0003086 | 0.0008538 | 0.7177645 | 0.7177653 | 0.8703180 | 0.6785140 | 335599 |
CHROM | POS | ID | REF | ALT | EFFECT | SE | PVAL | PVAL_ztest | AF | AF_reference | N |
---|---|---|---|---|---|---|---|---|---|---|---|
22 | 51219387 | rs9616832 | T | C | -0.0002015 | 0.0011010 | 0.8547549 | 0.8547551 | 0.0729806 | 0.0654952 | 335599 |
22 | 51219704 | rs147475742 | G | A | -0.0017358 | 0.0014761 | 0.2396111 | 0.2396107 | 0.0418225 | 0.0473243 | 335599 |
22 | 51219766 | rs182321900 | C | T | -0.0145182 | 0.0075756 | 0.0553108 | 0.0553104 | 0.0014546 | NA | 335599 |
22 | 51220088 | rs566371895 | G | A | 0.0024510 | 0.0049674 | 0.6217102 | 0.6217101 | 0.0039843 | 0.0003994 | 335599 |
22 | 51220146 | rs868950473 | C | T | -0.0156209 | 0.0074658 | 0.0364108 | 0.0364097 | 0.0015139 | NA | 335599 |
22 | 51221731 | rs115055839 | T | C | -0.0002537 | 0.0011017 | 0.8178689 | 0.8178680 | 0.0728101 | 0.0625000 | 335599 |
22 | 51223637 | rs375798137 | G | A | 0.0003151 | 0.0012977 | 0.8081471 | 0.8081459 | 0.0540289 | 0.0788738 | 335599 |
22 | 51226692 | rs150189434 | G | A | -0.0153083 | 0.0077479 | 0.0481781 | 0.0481783 | 0.0013983 | 0.0155751 | 335599 |
22 | 51229805 | rs9616985 | T | C | -0.0002839 | 0.0011059 | 0.7973770 | 0.7973774 | 0.0727671 | 0.0730831 | 335599 |
22 | 51237063 | rs3896457 | T | C | -0.0004191 | 0.0006730 | 0.5333877 | 0.5333879 | 0.2968410 | 0.2050720 | 335599 |
1 693731 rs12238997 A G . PASS AF=0.116926 ES:SE:LP:AF:SS:ID 7.9077e-05:0.000947618:0.029888:0.116926:335599:rs12238997
1 717587 rs144155419 G A . PASS AF=0.0143862 ES:SE:LP:AF:SS:ID -0.000413216:0.00254692:0.059924:0.0143862:335599:rs144155419
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1 740284 rs61770167 C T . PASS AF=0.00585559 ES:SE:LP:AF:SS:ID 0.00370629:0.0040917:0.437661:0.00585559:335599:rs61770167
1 742813 rs112573343 C T . PASS AF=0.0015525 ES:SE:LP:AF:SS:ID -0.00536707:0.00772512:0.312285:0.0015525:335599:rs112573343
1 753405 rs3115860 C A . PASS AF=0.870676 ES:SE:LP:AF:SS:ID -0.000247731:0.000854691:0.112421:0.870676:335599:rs3115860
1 753541 rs2073813 G A . PASS AF=0.128833 ES:SE:LP:AF:SS:ID 0.000415956:0.000856816:0.202494:0.128833:335599:rs2073813
1 754182 rs3131969 A G . PASS AF=0.870318 ES:SE:LP:AF:SS:ID -0.000308598:0.000853785:0.144018:0.870318:335599:rs3131969
1 754192 rs3131968 A G . PASS AF=0.870409 ES:SE:LP:AF:SS:ID -0.000285816:0.000854189:0.131988:0.870409:335599:rs3131968
1 754334 rs3131967 T C . PASS AF=0.870037 ES:SE:LP:AF:SS:ID -0.000298118:0.000853751:0.138495:0.870037:335599:rs3131967
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1 770377 rs112563271 A T . PASS AF=0.00692321 ES:SE:LP:AF:SS:ID -0.00350338:0.00346917:0.505062:0.00692321:335599:rs112563271
1 771823 rs2977605 T C . PASS AF=0.869934 ES:SE:LP:AF:SS:ID -0.000265108:0.000851749:0.121703:0.869934:335599:rs2977605
1 771967 rs59066358 G A . PASS AF=0.128709 ES:SE:LP:AF:SS:ID 0.000356963:0.000855147:0.169819:0.128709:335599:rs59066358
1 772755 rs2905039 A C . PASS AF=0.870112 ES:SE:LP:AF:SS:ID -0.000252753:0.000851788:0.115391:0.870112:335599:rs2905039
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1 783194 rs138555831 G T . PASS AF=0.0143713 ES:SE:LP:AF:SS:ID -0.00463919:0.00260406:1.12594:0.0143713:335599:rs138555831
1 783711 rs184266993 G A . PASS AF=0.00541372 ES:SE:LP:AF:SS:ID -0.00119199:0.00416175:0.110944:0.00541372:335599:rs184266993
1 785050 rs2905062 G A . PASS AF=0.87014 ES:SE:LP:AF:SS:ID -0.000420398:0.000851942:0.206427:0.87014:335599:rs2905062
1 785989 rs2980300 T C . PASS AF=0.87009 ES:SE:LP:AF:SS:ID -0.000414653:0.000852485:0.202954:0.87009:335599:rs2980300