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"gwas_harmonisation_command": "--json /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-a-import/processed/ukb-a-266/ukb-a-266_data.json --ref /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/QC/genomes/b37/human_g1k_v37.fasta; 1.1.1",
"file_date": "2020-02-16T00:23:02.397575",
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"bcftools_annotateCommand": "annotate -a /mnt/storage/home/gh13047/mr-eve/vcf-reference-datasets/dbsnp/dbsnp.v153.b37.vcf.gz -c ID -o /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-a-import/processed/ukb-a-266/ukb-a-266.vcf.gz -O z /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-a-import/processed/ukb-a-266/ukb-a-266_data.vcf.gz; Date=Sun Feb 16 01:00:58 2020",
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"bcftools_viewCommand": "view -h /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/ukb-a-266/ukb-a-266.vcf.gz; Date=Sun May 10 02:29:21 2020"
}
*********************************************************************
* LD Score Regression (LDSC)
* Version 1.0.1
* (C) 2014-2019 Brendan Bulik-Sullivan and Hilary Finucane
* Broad Institute of MIT and Harvard / MIT Department of Mathematics
* GNU General Public License v3
*********************************************************************
Call:
./ldsc.py \
--h2 /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-a-import/processed/ukb-a-266/ukb-a-266.vcf.gz \
--ref-ld-chr /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/ \
--out /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-a-import/processed/ukb-a-266/ldsc.txt \
--w-ld-chr /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/
Beginning analysis at Sun Feb 16 01:58:03 2020
Reading summary statistics from /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ukb-a-import/processed/ukb-a-266/ukb-a-266.vcf.gz ...
Read summary statistics for 10877936 SNPs.
Reading reference panel LD Score from /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/[1-22] ...
Read reference panel LD Scores for 1290028 SNPs.
Removing partitioned LD Scores with zero variance.
Reading regression weight LD Score from /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/[1-22] ...
Read regression weight LD Scores for 1290028 SNPs.
After merging with reference panel LD, 1281483 SNPs remain.
After merging with regression SNP LD, 1281483 SNPs remain.
Using two-step estimator with cutoff at 30.
Total Observed scale h2: 0.2596 (0.0093)
Lambda GC: 2.1354
Mean Chi^2: 2.9877
Intercept: 1.2199 (0.0204)
Ratio: 0.1106 (0.0103)
Analysis finished at Sun Feb 16 01:59:46 2020
Total time elapsed: 1.0m:43.19s
{
"af_correlation": 0.9533,
"inflation_factor": 1.6413,
"mean_EFFECT": -0,
"n": 331291,
"n_snps": 10877936,
"n_clumped_hits": 418,
"n_p_sig": 63023,
"n_mono": 0,
"n_ns": 0,
"n_mac": 0,
"is_snpid_unique": true,
"n_miss_EFFECT": 0,
"n_miss_SE": 0,
"n_miss_PVAL": 0,
"n_miss_AF": 0,
"n_miss_AF_reference": 356865,
"n_est": 329813.5384,
"ratio_se_n": 0.9978,
"mean_diff": -0,
"ratio_diff": 13.7795,
"sd_y_est1": 0.6289,
"sd_y_est2": 0.6275,
"r2_sum1": 0.0354,
"r2_sum2": 0.0894,
"r2_sum3": 0.0898,
"r2_sum4": 0.0898,
"ldsc_nsnp_merge_refpanel_ld": 1281483,
"ldsc_nsnp_merge_regression_ld": 1281483,
"ldsc_observed_scale_h2_beta": 0.2596,
"ldsc_observed_scale_h2_se": 0.0093,
"ldsc_intercept_beta": 1.2199,
"ldsc_intercept_se": 0.0204,
"ldsc_lambda_gc": 2.1354,
"ldsc_mean_chisq": 2.9877,
"ldsc_ratio": 0.1106
}
name | value |
---|---|
af_correlation | FALSE |
inflation_factor | TRUE |
n | FALSE |
is_snpid_non_unique | FALSE |
mean_EFFECT_nonfinite | FALSE |
mean_EFFECT_05 | FALSE |
mean_EFFECT_01 | FALSE |
mean_chisq | TRUE |
n_p_sig | TRUE |
miss_EFFECT | FALSE |
miss_SE | FALSE |
miss_PVAL | FALSE |
ldsc_ratio | FALSE |
ldsc_intercept_beta | FALSE |
n_clumped_hits | FALSE |
r2_sum1 | FALSE |
r2_sum2 | FALSE |
r2_sum3 | FALSE |
r2_sum4 | FALSE |
General metrics
af_correlation
: Correlation coefficient between AF
and AF_reference
.inflation_factor
(lambda
): Genomic inflation factor.mean_EFFECT
: Mean of EFFECT
size.n
: Maximum value of reported sample size across all SNPs, \(n\).n_clumped_hits
: Number of clumped hits.n_snps
: Number of SNPsn_p_sig
: Number of SNPs with pvalue below 5e-8
.n_mono
: Number of monomorphic (MAF == 1
or MAF == 0
) SNPs.n_ns
: Number of SNPs with nonsense values:
A, C, G or T
.< 0
or > 1
.<= 0
or = Infinity
).< 0
or > 1
.n_mac
: Number of cases where MAC
(\(2 \times N \times MAF\)) is less than 6
.is_snpid_unique
: true
if the combination of ID
REF
ALT
is unique and therefore no duplication in snpid.n_miss_<*>
: Number of NA
observations for <*>
column.se_n metrics
n_est
: Estimated sample size value, \(\widehat{n}\).ratio_se_n
: \(\texttt{ratio_se_n} = \frac{\sqrt{\widehat{n}}}{\sqrt{n}}\). We expect ratio_se_n
to be 1. When it is not 1, it implies that the trait did not have a variance of 1, the reported sample size is wrong, or that the SNP-level effective sample sizes differ markedly from the reported sample size.mean_diff
: \(\texttt{mean_diff} = \sum_{j} \frac{\widehat{\beta_j^{std}} - \beta_j}{\texttt{n_snps}}\), mean difference between the standardised beta, predicted from P-values, and the observed beta. The difference should be very close to zero if trait has a variance of 1.
ratio_diff
: \(\texttt{ratio_diff} = |\frac{\texttt{mean_diff}}{\texttt{mean_diff2}}|\), absolute ratio between the mean of diff
and the mean of diff2
(expected difference between the standardised beta predicted from P-values, and the standardised beta derived from the observed beta divided by the predicted SD; NOT reported). The ratio should be close to 1. If different from 1, then implies that the betas are not in a standard deviation scale.
sd_y_est1
: The standard deviation for the trait inferred from the reported sample size, median standard errors for the SNP-trait assocations and SNP variances.
sd_y_est2
: The standard deviation for the trait inferred from the reported sample size, Z statistics for the SNP-trait effects (beta/se) and allele frequency.
r2 metrics
Sum of variance explained, calculated from the clumped top hits sample.
r2_sum<*>
: r2
statistics under various assumptions
1
: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var1}}}\), \(\texttt{var1} = 1\).2
: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var2}}}\), \(\texttt{var2} = {\widehat{\texttt{sd1}}_{y}}^2\),3
: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var3}}}\), \(\texttt{var3} = {\widehat{\texttt{sd2}}_{y}}^2\),4
: \(r^2 = \sum_j{\frac{F_j}{F_j + n - 2}}\), \(F = \frac{\beta_j^2}{{se}_j^2}\).LDSC metrics
Metrics from LD regression
ldsc_nsnp_merge_refpanel_ld
: Number of remaining SNPs after merging with reference panel LD.ldsc_nsnp_merge_regression_ld
: Number of remaining SNPs after merging with regression SNP LD.ldsc_observed_scale_h2_{beta,se}
Coefficient value and SE for total observed scale h2.ldsc_intercept_{beta,se}
: Coefficient value and SE for intercept. Intercept is expected to be 1.ldsc_lambda_gc
: Lambda GC statistics.ldsc_mean_chisq
: Mean \(\chi^2\) statistics.ldsc_ratio
: \(\frac{\texttt{ldsc_intercept_beta} - 1}{\texttt{ldsc_mean_chisq} - 1}\), the proportion of the inflation in the mean \(\chi^2\) that the LD Score regression intercepts ascribes to causes other than polygenic heritability. The value of ratio should be close to zero, though in practice values of 0.1-0.2 are not uncommon, probably due to sample/reference LD Score mismatch or model misspecification (e.g., low LD variants have slightly higher \(h^2\) per SNP).Flags
When a metric needs attention, the flag should return TRUE.
af_correlation
: abs(af_correlation)
< 0.7.inflation_factor
: inflation_factor
> 1.2.n
: n
(max reported sample size) < 10000.is_snpid_non_unique
: NOT is_snpid_unique
.mean_EFFECT_nonfinite
: mean(EFFECT)
is NA
, NaN
, or Inf
.mean_EFFECT_05
: abs(mean(EFFECT))
> 0.5.mean_EFFECT_01
: abs(mean(EFFECT))
> 0.1.mean_chisq
: ldsc_mean_chisq
> 1.3 or ldsc_mean_chisq
< 0.7.n_p_sig
: n_p_sig
> 1000.miss_<*>
: n_miss_<*>
/ n_snps
> 0.01.ldsc_ratio
: ldsc_ratio
> 0.5ldsc_intercept_beta
: ldsc_intercept_beta
> 1.5n_clumped_hits
: n_clumped_hits
> 1000r2_sum<*>
: r2_sum<*>
> 0.5Plots
skim_type | skim_variable | n_missing | complete_rate | character.min | character.max | character.empty | character.n_unique | character.whitespace | numeric.mean | numeric.sd | numeric.p0 | numeric.p25 | numeric.p50 | numeric.p75 | numeric.p100 | numeric.hist |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
character | ID | 0 | 1.0000000 | 3 | 58 | 0 | 10877936 | 0 | NA | NA | NA | NA | NA | NA | NA | NA |
character | REF | 0 | 1.0000000 | 1 | 1 | 0 | 4 | 0 | NA | NA | NA | NA | NA | NA | NA | NA |
character | ALT | 0 | 1.0000000 | 1 | 1 | 0 | 4 | 0 | NA | NA | NA | NA | NA | NA | NA | NA |
numeric | CHROM | 0 | 1.0000000 | NA | NA | NA | NA | NA | 8.598638e+00 | 5.745666e+00 | 1.00000e+00 | 4.000000e+00 | 8.000000e+00 | 1.300000e+01 | 2.200000e+01 | ▇▅▃▂▂ |
numeric | POS | 0 | 1.0000000 | NA | NA | NA | NA | NA | 7.911383e+07 | 5.624931e+07 | 8.28000e+02 | 3.287294e+07 | 6.988889e+07 | 1.148258e+08 | 2.492251e+08 | ▇▆▅▂▁ |
numeric | EFFECT | 0 | 1.0000000 | NA | NA | NA | NA | NA | -2.820000e-05 | 1.008950e-02 | -1.73549e-01 | -3.419000e-03 | -8.700000e-06 | 3.391200e-03 | 1.907710e-01 | ▁▁▇▁▁ |
numeric | SE | 0 | 1.0000000 | NA | NA | NA | NA | NA | 6.654700e-03 | 6.302900e-03 | 1.52670e-03 | 1.885600e-03 | 3.621700e-03 | 9.677400e-03 | 3.457020e-02 | ▇▂▁▁▁ |
numeric | PVAL | 0 | 1.0000000 | NA | NA | NA | NA | NA | 4.191473e-01 | 3.086865e-01 | 0.00000e+00 | 1.313179e-01 | 3.875270e-01 | 6.855577e-01 | 1.000000e+00 | ▇▅▅▃▃ |
numeric | PVAL_ztest | 0 | 1.0000000 | NA | NA | NA | NA | NA | 4.191468e-01 | 3.086868e-01 | 0.00000e+00 | 1.313174e-01 | 3.875263e-01 | 6.855571e-01 | 1.000000e+00 | ▇▅▅▃▃ |
numeric | AF | 0 | 1.0000000 | NA | NA | NA | NA | NA | 1.820865e-01 | 2.503832e-01 | 1.00090e-03 | 6.878700e-03 | 5.191440e-02 | 2.739880e-01 | 9.989990e-01 | ▇▂▁▁▁ |
numeric | AF_reference | 356865 | 0.9671937 | NA | NA | NA | NA | NA | 1.877709e-01 | 2.439191e-01 | 0.00000e+00 | 5.191700e-03 | 7.468050e-02 | 2.873400e-01 | 1.000000e+00 | ▇▂▁▁▁ |
numeric | N | 0 | 1.0000000 | NA | NA | NA | NA | NA | 3.312910e+05 | 0.000000e+00 | 3.31291e+05 | 3.312910e+05 | 3.312910e+05 | 3.312910e+05 | 3.312910e+05 | ▁▁▇▁▁ |
CHROM | POS | ID | REF | ALT | EFFECT | SE | PVAL | PVAL_ztest | AF | AF_reference | N |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | 693731 | rs12238997 | A | G | -0.0023236 | 0.0025502 | 0.3622246 | 0.3622232 | 0.1169260 | 0.1417730 | 331291 |
1 | 717587 | rs144155419 | G | A | -0.0012853 | 0.0068502 | 0.8511670 | 0.8511668 | 0.0143862 | 0.0045926 | 331291 |
1 | 730087 | rs148120343 | T | C | -0.0061722 | 0.0035533 | 0.0823816 | 0.0823794 | 0.0554733 | 0.0127796 | 331291 |
1 | 731718 | rs142557973 | T | C | -0.0019907 | 0.0024192 | 0.4105755 | 0.4105738 | 0.1216580 | 0.1543530 | 331291 |
1 | 734349 | rs141242758 | T | C | -0.0018709 | 0.0024206 | 0.4395882 | 0.4395871 | 0.1215130 | 0.1525560 | 331291 |
1 | 740284 | rs61770167 | C | T | 0.0132761 | 0.0110075 | 0.2277781 | 0.2277805 | 0.0058556 | 0.0023962 | 331291 |
1 | 742813 | rs112573343 | C | T | 0.0009836 | 0.0207381 | 0.9621700 | 0.9621704 | 0.0015525 | 0.1030350 | 331291 |
1 | 753405 | rs3115860 | C | A | 0.0019566 | 0.0022996 | 0.3948353 | 0.3948363 | 0.8706760 | 0.7517970 | 331291 |
1 | 753541 | rs2073813 | G | A | -0.0020549 | 0.0023054 | 0.3727512 | 0.3727524 | 0.1288330 | 0.3019170 | 331291 |
1 | 754182 | rs3131969 | A | G | 0.0020653 | 0.0022971 | 0.3686184 | 0.3686181 | 0.8703180 | 0.6785140 | 331291 |
CHROM | POS | ID | REF | ALT | EFFECT | SE | PVAL | PVAL_ztest | AF | AF_reference | N |
---|---|---|---|---|---|---|---|---|---|---|---|
22 | 51219387 | rs9616832 | T | C | 0.0014127 | 0.0029594 | 0.6331112 | 0.6331105 | 0.0729806 | 0.0654952 | 331291 |
22 | 51219704 | rs147475742 | G | A | -0.0030729 | 0.0039669 | 0.4385529 | 0.4385520 | 0.0418225 | 0.0473243 | 331291 |
22 | 51219766 | rs182321900 | C | T | -0.0234824 | 0.0203414 | 0.2483328 | 0.2483304 | 0.0014546 | NA | 331291 |
22 | 51220088 | rs566371895 | G | A | -0.0133366 | 0.0133805 | 0.3189011 | 0.3189009 | 0.0039843 | 0.0003994 | 331291 |
22 | 51220146 | rs868950473 | C | T | -0.0235895 | 0.0200346 | 0.2390221 | 0.2390207 | 0.0015139 | NA | 331291 |
22 | 51221731 | rs115055839 | T | C | 0.0013582 | 0.0029613 | 0.6464903 | 0.6464908 | 0.0728101 | 0.0625000 | 331291 |
22 | 51223637 | rs375798137 | G | A | -0.0013880 | 0.0034883 | 0.6907136 | 0.6907116 | 0.0540289 | 0.0788738 | 331291 |
22 | 51226692 | rs150189434 | G | A | -0.0203896 | 0.0207877 | 0.3266691 | 0.3266671 | 0.0013983 | 0.0155751 | 331291 |
22 | 51229805 | rs9616985 | T | C | 0.0014217 | 0.0029724 | 0.6324395 | 0.6324376 | 0.0727671 | 0.0730831 | 331291 |
22 | 51237063 | rs3896457 | T | C | 0.0020526 | 0.0018099 | 0.2567562 | 0.2567573 | 0.2968410 | 0.2050720 | 331291 |
1 693731 rs12238997 A G . PASS AF=0.116926 ES:SE:LP:AF:SS:ID -0.0023236:0.00255022:0.441022:0.116926:331291:rs12238997
1 717587 rs144155419 G A . PASS AF=0.0143862 ES:SE:LP:AF:SS:ID -0.0012853:0.00685019:0.0699852:0.0143862:331291:rs144155419
1 730087 rs148120343 T C . PASS AF=0.0554733 ES:SE:LP:AF:SS:ID -0.00617217:0.00355326:1.08417:0.0554733:331291:rs148120343
1 731718 rs58276399 T C . PASS AF=0.121658 ES:SE:LP:AF:SS:ID -0.00199073:0.00241921:0.386607:0.121658:331291:rs58276399
1 734349 rs141242758 T C . PASS AF=0.121513 ES:SE:LP:AF:SS:ID -0.00187089:0.00242064:0.356954:0.121513:331291:rs141242758
1 740284 rs61770167 C T . PASS AF=0.00585559 ES:SE:LP:AF:SS:ID 0.0132761:0.0110075:0.642488:0.00585559:331291:rs61770167
1 742813 rs112573343 C T . PASS AF=0.0015525 ES:SE:LP:AF:SS:ID 0.000983611:0.0207381:0.0167482:0.0015525:331291:rs112573343
1 753405 rs3115860 C A . PASS AF=0.870676 ES:SE:LP:AF:SS:ID 0.00195664:0.00229955:0.403584:0.870676:331291:rs3115860
1 753541 rs2073813 G A . PASS AF=0.128833 ES:SE:LP:AF:SS:ID -0.00205488:0.00230541:0.428581:0.128833:331291:rs2073813
1 754182 rs3131969 A G . PASS AF=0.870318 ES:SE:LP:AF:SS:ID 0.00206526:0.00229712:0.433423:0.870318:331291:rs3131969
1 754192 rs3131968 A G . PASS AF=0.870409 ES:SE:LP:AF:SS:ID 0.00209211:0.00229821:0.440509:0.870409:331291:rs3131968
1 754334 rs3131967 T C . PASS AF=0.870037 ES:SE:LP:AF:SS:ID 0.00212223:0.00229702:0.449116:0.870037:331291:rs3131967
1 754433 rs150578204 G A . PASS AF=0.00465304 ES:SE:LP:AF:SS:ID -0.00569476:0.0117098:0.202913:0.00465304:331291:rs150578204
1 754458 rs142682604 G T . PASS AF=0.00464711 ES:SE:LP:AF:SS:ID -0.00628011:0.0117411:0.227141:0.00464711:331291:rs142682604
1 755435 rs184270342 T G . PASS AF=0.00590897 ES:SE:LP:AF:SS:ID 0.00385648:0.011443:0.133061:0.00590897:331291:rs184270342
1 755890 rs3115858 A T . PASS AF=0.870329 ES:SE:LP:AF:SS:ID 0.00190869:0.00229303:0.39234:0.870329:331291:rs3115858
1 756604 rs3131962 A G . PASS AF=0.87002 ES:SE:LP:AF:SS:ID 0.00183658:0.00228759:0.374621:0.87002:331291:rs3131962
1 757640 rs3115853 G A . PASS AF=0.869421 ES:SE:LP:AF:SS:ID 0.00190787:0.00228536:0.393814:0.869421:331291:rs3115853
1 757734 rs4951929 C T . PASS AF=0.870219 ES:SE:LP:AF:SS:ID 0.00181789:0.00228944:0.369392:0.870219:331291:rs4951929
1 757936 rs4951862 C A . PASS AF=0.870219 ES:SE:LP:AF:SS:ID 0.00181565:0.0022896:0.368781:0.870219:331291:rs4951862
1 758144 rs3131956 A G . PASS AF=0.870222 ES:SE:LP:AF:SS:ID 0.00183383:0.00228967:0.373474:0.870222:331291:rs3131956
1 758626 rs3131954 C T . PASS AF=0.870396 ES:SE:LP:AF:SS:ID 0.00196483:0.00229554:0.406673:0.870396:331291:rs3131954
1 761732 rs2286139 C T . PASS AF=0.867743 ES:SE:LP:AF:SS:ID 0.00275295:0.00228459:0.641682:0.867743:331291:rs2286139
1 766007 rs61768174 A C . PASS AF=0.106958 ES:SE:LP:AF:SS:ID -0.0029793:0.00254408:0.616955:0.106958:331291:rs61768174
1 768253 rs2977608 A C . PASS AF=0.763932 ES:SE:LP:AF:SS:ID -0.00260862:0.00181175:0.824155:0.763932:331291:rs2977608
1 768448 rs12562034 G A . PASS AF=0.105257 ES:SE:LP:AF:SS:ID 0.00742348:0.00250042:2.52449:0.105257:331291:rs12562034
1 768819 rs12562811 C T . PASS AF=0.00692766 ES:SE:LP:AF:SS:ID 0.00544774:0.0092849:0.253845:0.00692766:331291:rs12562811
1 769223 rs60320384 C G . PASS AF=0.128651 ES:SE:LP:AF:SS:ID -0.00212309:0.00230202:0.448079:0.128651:331291:rs60320384
1 769224 rs141644775 G A . PASS AF=0.00143239 ES:SE:LP:AF:SS:ID 0.0101935:0.0216257:0.195598:0.00143239:331291:rs141644775
1 770181 rs146076599 A G . PASS AF=0.00907328 ES:SE:LP:AF:SS:ID 0.00470756:0.00881227:0.226799:0.00907328:331291:rs146076599
1 770377 rs112563271 A T . PASS AF=0.00692321 ES:SE:LP:AF:SS:ID 0.00569149:0.00932449:0.266313:0.00692321:331291:rs112563271
1 771823 rs2977605 T C . PASS AF=0.869934 ES:SE:LP:AF:SS:ID 0.00212256:0.00229169:0.450577:0.869934:331291:rs2977605
1 771967 rs59066358 G A . PASS AF=0.128709 ES:SE:LP:AF:SS:ID -0.00215416:0.00230095:0.456962:0.128709:331291:rs59066358
1 772755 rs2905039 A C . PASS AF=0.870112 ES:SE:LP:AF:SS:ID 0.00213082:0.00229179:0.452846:0.870112:331291:rs2905039
1 774736 rs28830877 A C . PASS AF=0.998797 ES:SE:LP:AF:SS:ID 0.00525285:0.0237917:0.0834092:0.998797:331291:rs28830877
1 776556 rs151160018 C T . PASS AF=0.00851871 ES:SE:LP:AF:SS:ID 0.0128886:0.00859832:0.873278:0.00851871:331291:rs151160018
1 777122 rs2980319 A T . PASS AF=0.871122 ES:SE:LP:AF:SS:ID 0.00267451:0.00229566:0.612596:0.871122:331291:rs2980319
1 777232 rs112618790 C T . PASS AF=0.0961319 ES:SE:LP:AF:SS:ID 0.00740608:0.00264837:2.28678:0.0961319:331291:rs112618790
1 778745 rs1055606 A G . PASS AF=0.127871 ES:SE:LP:AF:SS:ID -0.0027286:0.00230327:0.62681:0.127871:331291:rs1055606
1 779322 rs4040617 A G . PASS AF=0.127984 ES:SE:LP:AF:SS:ID -0.002776:0.00230015:0.643057:0.127984:331291:rs4040617
1 780785 rs2977612 T A . PASS AF=0.870455 ES:SE:LP:AF:SS:ID 0.00271268:0.0022919:0.626031:0.870455:331291:rs2977612
1 781367 rs149821290 A C . PASS AF=0.00989772 ES:SE:LP:AF:SS:ID 0.0125785:0.00814283:0.912172:0.00989772:331291:rs149821290
1 781845 rs61768199 A G . PASS AF=0.1044 ES:SE:LP:AF:SS:ID -0.00339825:0.00257755:0.727302:0.1044:331291:rs61768199
1 782721 rs185280546 G A . PASS AF=0.0143713 ES:SE:LP:AF:SS:ID 0.0146381:0.00697285:1.44623:0.0143713:331291:rs185280546
1 782981 rs6594026 C T . PASS AF=0.128338 ES:SE:LP:AF:SS:ID -0.00281902:0.00230145:0.656359:0.128338:331291:rs6594026
1 783193 rs145767270 G C . PASS AF=0.0143639 ES:SE:LP:AF:SS:ID 0.0147054:0.00700241:1.44702:0.0143639:331291:rs145767270
1 783194 rs138555831 G T . PASS AF=0.0143713 ES:SE:LP:AF:SS:ID 0.0146896:0.00700163:1.44486:0.0143713:331291:rs138555831
1 783711 rs184266993 G A . PASS AF=0.00541372 ES:SE:LP:AF:SS:ID 0.00872483:0.0111895:0.360963:0.00541372:331291:rs184266993
1 785050 rs2905062 G A . PASS AF=0.87014 ES:SE:LP:AF:SS:ID 0.00272519:0.00229229:0.629857:0.87014:331291:rs2905062
1 785989 rs2980300 T C . PASS AF=0.87009 ES:SE:LP:AF:SS:ID 0.00279462:0.00229375:0.651528:0.87009:331291:rs2980300