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}
*********************************************************************
* LD Score Regression (LDSC)
* Version 1.0.1
* (C) 2014-2019 Brendan Bulik-Sullivan and Hilary Finucane
* Broad Institute of MIT and Harvard / MIT Department of Mathematics
* GNU General Public License v3
*********************************************************************
Call:
./ldsc.py \
--h2 /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ieu-a-import/processed/ieu-a-62/ieu-a-62.vcf.gz \
--ref-ld-chr /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/ \
--out /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ieu-a-import/processed/ieu-a-62/ldsc.txt \
--w-ld-chr /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/
Beginning analysis at Tue Feb 4 20:51:46 2020
Reading summary statistics from /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ieu-a-import/processed/ieu-a-62/ieu-a-62.vcf.gz ...
Read summary statistics for 2444518 SNPs.
Reading reference panel LD Score from /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/[1-22] ...
Read reference panel LD Scores for 1290028 SNPs.
Removing partitioned LD Scores with zero variance.
Reading regression weight LD Score from /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/[1-22] ...
Read regression weight LD Scores for 1290028 SNPs.
After merging with reference panel LD, 1142425 SNPs remain.
After merging with regression SNP LD, 1142425 SNPs remain.
Using two-step estimator with cutoff at 30.
Total Observed scale h2: 0.1534 (0.0076)
Lambda GC: 1.032
Mean Chi^2: 1.0824
Intercept: 0.819 (0.0069)
Ratio < 0 (usually indicates GC correction).
Analysis finished at Tue Feb 4 20:52:16 2020
Total time elapsed: 30.03s
{
"af_correlation": 0.917,
"inflation_factor": 1.0475,
"mean_EFFECT": 0.0001,
"n": 134594,
"n_snps": 2444518,
"n_clumped_hits": 19,
"n_p_sig": 495,
"n_mono": 0,
"n_ns": 0,
"n_mac": 0,
"is_snpid_unique": true,
"n_miss_EFFECT": 0,
"n_miss_SE": 0,
"n_miss_PVAL": 0,
"n_miss_AF": 10391,
"n_miss_AF_reference": 20929,
"n_est": 133982.1411,
"ratio_se_n": 0.9977,
"mean_diff": -0,
"ratio_diff": 17.8219,
"sd_y_est1": 1.3906,
"sd_y_est2": 1.3874,
"r2_sum1": 0.0106,
"r2_sum2": 0.0055,
"r2_sum3": 0.0055,
"r2_sum4": 0.0086,
"ldsc_nsnp_merge_refpanel_ld": 1142425,
"ldsc_nsnp_merge_regression_ld": 1142425,
"ldsc_observed_scale_h2_beta": 0.1534,
"ldsc_observed_scale_h2_se": 0.0076,
"ldsc_intercept_beta": 0.819,
"ldsc_intercept_se": 0.0069,
"ldsc_lambda_gc": 1.032,
"ldsc_mean_chisq": 1.0824,
"ldsc_ratio": -2.1966
}
name | value |
---|---|
af_correlation | FALSE |
inflation_factor | FALSE |
n | FALSE |
is_snpid_non_unique | FALSE |
mean_EFFECT_nonfinite | FALSE |
mean_EFFECT_05 | FALSE |
mean_EFFECT_01 | FALSE |
mean_chisq | FALSE |
n_p_sig | FALSE |
miss_EFFECT | FALSE |
miss_SE | FALSE |
miss_PVAL | FALSE |
ldsc_ratio | FALSE |
ldsc_intercept_beta | FALSE |
n_clumped_hits | FALSE |
r2_sum1 | FALSE |
r2_sum2 | FALSE |
r2_sum3 | FALSE |
r2_sum4 | FALSE |
General metrics
af_correlation
: Correlation coefficient between AF
and AF_reference
.inflation_factor
(lambda
): Genomic inflation factor.mean_EFFECT
: Mean of EFFECT
size.n
: Maximum value of reported sample size across all SNPs, \(n\).n_clumped_hits
: Number of clumped hits.n_snps
: Number of SNPsn_p_sig
: Number of SNPs with pvalue below 5e-8
.n_mono
: Number of monomorphic (MAF == 1
or MAF == 0
) SNPs.n_ns
: Number of SNPs with nonsense values:
A, C, G or T
.< 0
or > 1
.<= 0
or = Infinity
).< 0
or > 1
.n_mac
: Number of cases where MAC
(\(2 \times N \times MAF\)) is less than 6
.is_snpid_unique
: true
if the combination of ID
REF
ALT
is unique and therefore no duplication in snpid.n_miss_<*>
: Number of NA
observations for <*>
column.se_n metrics
n_est
: Estimated sample size value, \(\widehat{n}\).ratio_se_n
: \(\texttt{ratio_se_n} = \frac{\sqrt{\widehat{n}}}{\sqrt{n}}\). We expect ratio_se_n
to be 1. When it is not 1, it implies that the trait did not have a variance of 1, the reported sample size is wrong, or that the SNP-level effective sample sizes differ markedly from the reported sample size.mean_diff
: \(\texttt{mean_diff} = \sum_{j} \frac{\widehat{\beta_j^{std}} - \beta_j}{\texttt{n_snps}}\), mean difference between the standardised beta, predicted from P-values, and the observed beta. The difference should be very close to zero if trait has a variance of 1.
ratio_diff
: \(\texttt{ratio_diff} = |\frac{\texttt{mean_diff}}{\texttt{mean_diff2}}|\), absolute ratio between the mean of diff
and the mean of diff2
(expected difference between the standardised beta predicted from P-values, and the standardised beta derived from the observed beta divided by the predicted SD; NOT reported). The ratio should be close to 1. If different from 1, then implies that the betas are not in a standard deviation scale.
sd_y_est1
: The standard deviation for the trait inferred from the reported sample size, median standard errors for the SNP-trait assocations and SNP variances.
sd_y_est2
: The standard deviation for the trait inferred from the reported sample size, Z statistics for the SNP-trait effects (beta/se) and allele frequency.
r2 metrics
Sum of variance explained, calculated from the clumped top hits sample.
r2_sum<*>
: r2
statistics under various assumptions
1
: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var1}}}\), \(\texttt{var1} = 1\).2
: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var2}}}\), \(\texttt{var2} = {\widehat{\texttt{sd1}}_{y}}^2\),3
: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var3}}}\), \(\texttt{var3} = {\widehat{\texttt{sd2}}_{y}}^2\),4
: \(r^2 = \sum_j{\frac{F_j}{F_j + n - 2}}\), \(F = \frac{\beta_j^2}{{se}_j^2}\).LDSC metrics
Metrics from LD regression
ldsc_nsnp_merge_refpanel_ld
: Number of remaining SNPs after merging with reference panel LD.ldsc_nsnp_merge_regression_ld
: Number of remaining SNPs after merging with regression SNP LD.ldsc_observed_scale_h2_{beta,se}
Coefficient value and SE for total observed scale h2.ldsc_intercept_{beta,se}
: Coefficient value and SE for intercept. Intercept is expected to be 1.ldsc_lambda_gc
: Lambda GC statistics.ldsc_mean_chisq
: Mean \(\chi^2\) statistics.ldsc_ratio
: \(\frac{\texttt{ldsc_intercept_beta} - 1}{\texttt{ldsc_mean_chisq} - 1}\), the proportion of the inflation in the mean \(\chi^2\) that the LD Score regression intercepts ascribes to causes other than polygenic heritability. The value of ratio should be close to zero, though in practice values of 0.1-0.2 are not uncommon, probably due to sample/reference LD Score mismatch or model misspecification (e.g., low LD variants have slightly higher \(h^2\) per SNP).Flags
When a metric needs attention, the flag should return TRUE.
af_correlation
: abs(af_correlation)
< 0.7.inflation_factor
: inflation_factor
> 1.2.n
: n
(max reported sample size) < 10000.is_snpid_non_unique
: NOT is_snpid_unique
.mean_EFFECT_nonfinite
: mean(EFFECT)
is NA
, NaN
, or Inf
.mean_EFFECT_05
: abs(mean(EFFECT))
> 0.5.mean_EFFECT_01
: abs(mean(EFFECT))
> 0.1.mean_chisq
: ldsc_mean_chisq
> 1.3 or ldsc_mean_chisq
< 0.7.n_p_sig
: n_p_sig
> 1000.miss_<*>
: n_miss_<*>
/ n_snps
> 0.01.ldsc_ratio
: ldsc_ratio
> 0.5ldsc_intercept_beta
: ldsc_intercept_beta
> 1.5n_clumped_hits
: n_clumped_hits
> 1000r2_sum<*>
: r2_sum<*>
> 0.5Plots
skim_type | skim_variable | n_missing | complete_rate | character.min | character.max | character.empty | character.n_unique | character.whitespace | numeric.mean | numeric.sd | numeric.p0 | numeric.p25 | numeric.p50 | numeric.p75 | numeric.p100 | numeric.hist |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
character | ID | 0 | 1.0000000 | 3 | 42 | 0 | 2444518 | 0 | NA | NA | NA | NA | NA | NA | NA | NA |
character | REF | 0 | 1.0000000 | 1 | 1 | 0 | 4 | 0 | NA | NA | NA | NA | NA | NA | NA | NA |
character | ALT | 0 | 1.0000000 | 1 | 1 | 0 | 4 | 0 | NA | NA | NA | NA | NA | NA | NA | NA |
numeric | CHROM | 0 | 1.0000000 | NA | NA | NA | NA | NA | 8.587686e+00 | 5.657760e+00 | 1.0000 | 4.000000e+00 | 8.000000e+00 | 1.200000e+01 | 2.30000e+01 | ▇▅▅▂▂ |
numeric | POS | 0 | 1.0000000 | NA | NA | NA | NA | NA | 7.884066e+07 | 5.565276e+07 | 11523.0000 | 3.269805e+07 | 7.026171e+07 | 1.143083e+08 | 2.49219e+08 | ▇▆▅▂▁ |
numeric | EFFECT | 0 | 1.0000000 | NA | NA | NA | NA | NA | 6.290000e-05 | 1.034090e-02 | -0.1900 | -5.000000e-03 | 0.000000e+00 | 5.100000e-03 | 1.90000e-01 | ▁▁▇▁▁ |
numeric | SE | 0 | 1.0000000 | NA | NA | NA | NA | NA | 8.786200e-03 | 6.064100e-03 | 0.0042 | 5.600000e-03 | 6.600000e-03 | 9.200000e-03 | 9.60000e-02 | ▇▁▁▁▁ |
numeric | PVAL | 0 | 1.0000000 | NA | NA | NA | NA | NA | 4.946754e-01 | 2.914129e-01 | 0.0000 | 2.399999e-01 | 4.899999e-01 | 7.499995e-01 | 1.00000e+00 | ▇▇▇▇▇ |
numeric | PVAL_ztest | 0 | 1.0000000 | NA | NA | NA | NA | NA | 4.946804e-01 | 2.912100e-01 | 0.0000 | 2.420769e-01 | 4.933871e-01 | 7.475746e-01 | 1.00000e+00 | ▇▇▇▇▇ |
numeric | AF | 10391 | 0.9957493 | NA | NA | NA | NA | NA | 3.570004e-01 | 2.753646e-01 | 0.0083 | 1.167000e-01 | 2.917000e-01 | 5.583000e-01 | 9.91700e-01 | ▇▅▃▂▂ |
numeric | AF_reference | 20929 | 0.9914384 | NA | NA | NA | NA | NA | 3.604140e-01 | 2.563685e-01 | 0.0000 | 1.447680e-01 | 2.979230e-01 | 5.449280e-01 | 1.00000e+00 | ▇▆▃▃▂ |
numeric | N | 0 | 1.0000000 | NA | NA | NA | NA | NA | 9.076049e+04 | 1.010572e+04 | 50004.0000 | 8.846200e+04 | 9.254800e+04 | 9.263500e+04 | 1.34594e+05 | ▁▁▇▁▁ |
CHROM | POS | ID | REF | ALT | EFFECT | SE | PVAL | PVAL_ztest | AF | AF_reference | N |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | 775659 | rs2905035 | A | G | 0.0120 | 0.0110 | 0.2900000 | 0.2753129 | 0.87500 | 0.745008 | 50562 |
1 | 777122 | rs2980319 | A | T | 0.0120 | 0.0110 | 0.2800000 | 0.2753129 | 0.87500 | 0.747204 | 50563 |
1 | 785050 | rs2905062 | G | A | 0.0048 | 0.0089 | 0.5900000 | 0.5896620 | NA | 0.626997 | 68064 |
1 | 990380 | rs3121561 | C | T | -0.0052 | 0.0094 | 0.5800000 | 0.5801323 | 0.26670 | 0.343450 | 69016 |
1 | 998501 | rs3813193 | G | C | 0.0030 | 0.0096 | 0.7499995 | 0.7546606 | 0.15000 | 0.206669 | 65358 |
1 | 1003629 | rs4075116 | C | T | 0.0073 | 0.0070 | 0.2999998 | 0.2970145 | 0.73730 | 0.720647 | 89719 |
1 | 1005806 | rs3934834 | C | T | 0.0067 | 0.0087 | 0.4400003 | 0.4412317 | 0.11670 | 0.223442 | 71855 |
1 | 1017170 | rs3766193 | C | G | 0.0063 | 0.0064 | 0.3200000 | 0.3249312 | 0.56670 | 0.575479 | 90609 |
1 | 1017197 | rs3766192 | C | T | 0.0063 | 0.0061 | 0.2999998 | 0.3017036 | 0.57630 | 0.511182 | 90986 |
1 | 1017587 | rs3766191 | C | T | 0.0052 | 0.0091 | 0.5700002 | 0.5677092 | 0.09649 | 0.171126 | 71771 |
CHROM | POS | ID | REF | ALT | EFFECT | SE | PVAL | PVAL_ztest | AF | AF_reference | N |
---|---|---|---|---|---|---|---|---|---|---|---|
22 | 51216564 | rs9616970 | T | C | 0.0082 | 0.0120 | 0.5099998 | 0.4943962 | 0.1500 | 0.1563500 | 67948 |
22 | 51217134 | rs117417021 | A | G | 0.0190 | 0.0095 | 0.0439997 | 0.0455003 | 0.4417 | 0.2671730 | 57461 |
22 | 51222100 | rs114553188 | G | T | -0.0120 | 0.0150 | 0.4400003 | 0.4237108 | 0.0667 | 0.0880591 | 72516 |
22 | 51223637 | rs375798137 | G | A | -0.0120 | 0.0150 | 0.4299995 | 0.4237108 | 0.0667 | 0.0788738 | 72515 |
22 | 51229805 | rs9616985 | T | C | 0.0280 | 0.0190 | 0.1400000 | 0.1405666 | 0.0917 | 0.0730831 | 54476 |
23 | 35921591 | rs2204667 | C | G | 0.0048 | 0.0073 | 0.5099998 | 0.5108375 | 0.1667 | NA | 92611 |
23 | 51666786 | rs14115 | A | G | 0.0180 | 0.0120 | 0.1199999 | 0.1336144 | 0.0250 | NA | 86003 |
23 | 70163799 | rs1626496 | A | C | -0.0110 | 0.0100 | 0.3100002 | 0.2713321 | 0.0750 | NA | 92490 |
23 | 91415872 | rs6562597 | G | A | -0.0130 | 0.0200 | 0.5199996 | 0.5156922 | 0.0083 | 0.0021192 | 82123 |
23 | 118495837 | rs12882977 | G | A | -0.0028 | 0.0053 | 0.5999997 | 0.5972898 | 0.5167 | 0.2307280 | 92638 |
1 775659 rs2905035 A G . PASS AF=0.875 ES:SE:LP:AF:SS:ID 0.012:0.011:0.537602:0.875:50562:rs2905035
1 777122 rs2980319 A T . PASS AF=0.875 ES:SE:LP:AF:SS:ID 0.012:0.011:0.552842:0.875:50563:rs2980319
1 785050 rs2905062 G A . PASS . ES:SE:LP:SS:ID 0.0048:0.0089:0.229148:68064:rs2905062
1 990380 rs3121561 C T . PASS AF=0.2667 ES:SE:LP:AF:SS:ID -0.0052:0.0094:0.236572:0.2667:69016:rs3121561
1 998501 rs3813193 G C . PASS AF=0.15 ES:SE:LP:AF:SS:ID 0.003:0.0096:0.124939:0.15:65358:rs3813193
1 1003629 rs4075116 C T . PASS AF=0.7373 ES:SE:LP:AF:SS:ID 0.0073:0.007:0.522879:0.7373:89719:rs4075116
1 1005806 rs3934834 C T . PASS AF=0.1167 ES:SE:LP:AF:SS:ID 0.0067:0.0087:0.356547:0.1167:71855:rs3934834
1 1017170 rs3766193 C G . PASS AF=0.5667 ES:SE:LP:AF:SS:ID 0.0063:0.0064:0.49485:0.5667:90609:rs3766193
1 1017197 rs3766192 C T . PASS AF=0.5763 ES:SE:LP:AF:SS:ID 0.0063:0.0061:0.522879:0.5763:90986:rs3766192
1 1017587 rs3766191 C T . PASS AF=0.09649 ES:SE:LP:AF:SS:ID 0.0052:0.0091:0.244125:0.09649:71771:rs3766191
1 1018562 rs9442371 C T . PASS AF=0.5917 ES:SE:LP:AF:SS:ID 0.005:0.006:0.39794:0.5917:91038:rs9442371
1 1018704 rs9442372 A G . PASS AF=0.6017 ES:SE:LP:AF:SS:ID 0.005:0.006:0.39794:0.6017:91025:rs9442372
1 1021346 rs10907177 A G . PASS AF=0.1271 ES:SE:LP:AF:SS:ID 0.0073:0.0092:0.366532:0.1271:71746:rs10907177
1 1021415 rs3737728 A G . PASS AF=0.7167 ES:SE:LP:AF:SS:ID 0.0087:0.0064:0.769551:0.7167:91357:rs3737728
1 1021583 rs10907178 A C . PASS . ES:SE:LP:SS:ID 0.0063:0.0093:0.30103:69544:rs10907178
1 1021695 rs9442398 A G . PASS AF=0.725 ES:SE:LP:AF:SS:ID 0.009:0.0066:0.769551:0.725:91218:rs9442398
1 1022037 rs6701114 C T . PASS AF=0.5667 ES:SE:LP:AF:SS:ID 0.0045:0.0064:0.318759:0.5667:85023:rs6701114
1 1026707 rs4074137 C A . PASS AF=0.6 ES:SE:LP:AF:SS:ID -0.005:0.0069:0.327902:0.6:73071:rs4074137
1 1030565 rs6687776 C T . PASS AF=0.08333 ES:SE:LP:AF:SS:ID 0.008:0.0082:0.481486:0.08333:72887:rs6687776
1 1030633 rs6678318 G A . PASS AF=0.08621 ES:SE:LP:AF:SS:ID 0.0017:0.0091:0.0705811:0.08621:64294:rs6678318
1 1031540 rs9651273 A G . PASS AF=0.6583 ES:SE:LP:AF:SS:ID -0.0002:0.007:0.00877392:0.6583:71059:rs9651273
1 1036959 rs11579015 T C . PASS AF=0.05 ES:SE:LP:AF:SS:ID 0.013:0.0097:0.69897:0.05:82271:rs11579015
1 1040026 rs6671356 T C . PASS AF=0.075 ES:SE:LP:AF:SS:ID 0.01:0.0088:0.585027:0.075:77062:rs6671356
1 1046164 rs6666280 C T . PASS AF=0.06667 ES:SE:LP:AF:SS:ID 0.012:0.0091:0.69897:0.06667:80499:rs6666280
1 1048955 rs4970405 A G . PASS AF=0.05172 ES:SE:LP:AF:SS:ID 0.013:0.0097:0.721246:0.05172:82215:rs4970405
1 1049950 rs12726255 A G . PASS AF=0.06667 ES:SE:LP:AF:SS:ID 0.01:0.009:0.619789:0.06667:80493:rs12726255
1 1053452 rs4970409 G A . PASS AF=0.05 ES:SE:LP:AF:SS:ID 0.013:0.01:0.69897:0.05:80037:rs4970409
1 1060174 rs7548798 C T . PASS AF=0.3981 ES:SE:LP:AF:SS:ID -0.0013:0.0088:0.0555173:0.3981:54888:rs7548798
1 1060235 rs7540009 G A . PASS AF=0.01667 ES:SE:LP:AF:SS:ID -0.0059:0.019:0.119186:0.01667:65908:rs7540009
1 1060608 rs17160824 G A . PASS AF=0.05833 ES:SE:LP:AF:SS:ID 0.011:0.01:0.552842:0.05833:82185:rs17160824
1 1061115 rs17160826 T C . PASS AF=0.05455 ES:SE:LP:AF:SS:ID 0.013:0.01:0.69897:0.05455:82194:rs17160826
1 1061152 rs12748370 T C . PASS . ES:SE:LP:SS:ID 0.014:0.01:0.744727:79992:rs12748370
1 1061166 rs11807848 T C . PASS AF=0.4123 ES:SE:LP:AF:SS:ID 0.005:0.0072:0.309804:0.4123:70304:rs11807848
1 1062015 rs9659914 C T . PASS AF=0.01667 ES:SE:LP:AF:SS:ID 0.0007:0.021:0.0132283:0.01667:59511:rs9659914
1 1062638 rs9442373 C A . PASS AF=0.5517 ES:SE:LP:AF:SS:ID -0.0023:0.0071:0.124939:0.5517:69840:rs9442373
1 1064535 rs6682475 G C . PASS AF=0.7542 ES:SE:LP:AF:SS:ID -0.01:0.01:0.522879:0.7542:57005:rs6682475
1 1064979 rs2298217 C T . PASS AF=0.08333 ES:SE:LP:AF:SS:ID 0.008:0.0092:0.420216:0.08333:66491:rs2298217
1 1066403 rs10907182 T C . PASS AF=0.675 ES:SE:LP:AF:SS:ID -0.0041:0.0075:0.236572:0.675:68044:rs10907182
1 1071118 rs10907183 G C . PASS AF=0.6833 ES:SE:LP:AF:SS:ID -0.0053:0.0081:0.29243:0.6833:65525:rs10907183
1 1077064 rs4970357 C A . PASS AF=0.92373 ES:SE:LP:AF:SS:ID -0.012:0.013:0.455932:0.92373:79360:rs4970357
1 1087683 rs9442380 T C . PASS AF=0.91228 ES:SE:LP:AF:SS:ID -0.0089:0.011:0.366532:0.91228:84389:rs9442380
1 1089262 rs4970358 A G . PASS AF=0.9661 ES:SE:LP:AF:SS:ID -0.012:0.015:0.366532:0.9661:85671:rs4970358
1 1097335 rs9442385 T G . PASS AF=0.94167 ES:SE:LP:AF:SS:ID -0.0074:0.011:0.30103:0.94167:89710:rs9442385
1 1099342 rs9660710 A C . PASS AF=0.94068 ES:SE:LP:AF:SS:ID -0.0044:0.01:0.167491:0.94068:90923:rs9660710
1 1100217 rs1891905 C T . PASS AF=0.95833 ES:SE:LP:AF:SS:ID -0.0001:0.015:0.00436481:0.95833:89512:rs1891905
1 1106473 rs4970420 G A . PASS AF=0.1441 ES:SE:LP:AF:SS:ID -0.0066:0.011:0.259637:0.1441:53680:rs4970420
1 1113121 rs12092254 G A . PASS AF=0.1 ES:SE:LP:AF:SS:ID -0.0078:0.015:0.221849:0.1:60178:rs12092254
1 1119858 rs1320565 C T . PASS AF=0.09167 ES:SE:LP:AF:SS:ID 0.002:0.013:0.0604807:0.09167:56551:rs1320565
1 1120431 rs1320571 G A . PASS AF=0.04167 ES:SE:LP:AF:SS:ID 0.019:0.018:0.522879:0.04167:73778:rs1320571
1 1121014 rs3813204 G A . PASS AF=0.1121 ES:SE:LP:AF:SS:ID 0.0075:0.01:0.327902:0.1121:65706:rs3813204