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}
*********************************************************************
* LD Score Regression (LDSC)
* Version 1.0.1
* (C) 2014-2019 Brendan Bulik-Sullivan and Hilary Finucane
* Broad Institute of MIT and Harvard / MIT Department of Mathematics
* GNU General Public License v3
*********************************************************************
Call:
./ldsc.py \
--h2 /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ieu-a-import/processed/ieu-a-16/ieu-a-16.vcf.gz \
--ref-ld-chr /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/ \
--out /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ieu-a-import/processed/ieu-a-16/ldsc.txt \
--w-ld-chr /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/
Beginning analysis at Wed Feb 5 11:33:48 2020
Reading summary statistics from /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ieu-a-import/processed/ieu-a-16/ieu-a-16.vcf.gz ...
Read summary statistics for 1378794 SNPs.
Reading reference panel LD Score from /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/[1-22] ...
Read reference panel LD Scores for 1290028 SNPs.
Removing partitioned LD Scores with zero variance.
Reading regression weight LD Score from /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/[1-22] ...
Read regression weight LD Scores for 1290028 SNPs.
After merging with reference panel LD, 868646 SNPs remain.
After merging with regression SNP LD, 868646 SNPs remain.
Using two-step estimator with cutoff at 30.
Total Observed scale h2: 0.0261 (0.0042)
Lambda GC: 1.0668
Mean Chi^2: 1.0746
Intercept: 1.0009 (0.0091)
Ratio: 0.0124 (0.1214)
Analysis finished at Wed Feb 5 11:34:08 2020
Total time elapsed: 19.82s
{
"af_correlation": 0.9014,
"inflation_factor": 1.0782,
"mean_EFFECT": -0,
"n": 130925,
"n_snps": 1378794,
"n_clumped_hits": 0,
"n_p_sig": 0,
"n_mono": 0,
"n_ns": 0,
"n_mac": 0,
"is_snpid_unique": true,
"n_miss_EFFECT": 0,
"n_miss_SE": 0,
"n_miss_PVAL": 0,
"n_miss_AF": 109,
"n_miss_AF_reference": 9295,
"n_est": 130720.7071,
"ratio_se_n": 0.9992,
"mean_diff": 0,
"ratio_diff": 17.1646,
"sd_y_est1": 3.2794,
"sd_y_est2": 3.2768,
"r2_sum1": 0,
"r2_sum2": 0,
"r2_sum3": 0,
"r2_sum4": 0,
"ldsc_nsnp_merge_refpanel_ld": 868646,
"ldsc_nsnp_merge_regression_ld": 868646,
"ldsc_observed_scale_h2_beta": 0.0261,
"ldsc_observed_scale_h2_se": 0.0042,
"ldsc_intercept_beta": 1.0009,
"ldsc_intercept_se": 0.0091,
"ldsc_lambda_gc": 1.0668,
"ldsc_mean_chisq": 1.0746,
"ldsc_ratio": 0.0121
}
name | value |
---|---|
af_correlation | FALSE |
inflation_factor | FALSE |
n | FALSE |
is_snpid_non_unique | FALSE |
mean_EFFECT_nonfinite | FALSE |
mean_EFFECT_05 | FALSE |
mean_EFFECT_01 | FALSE |
mean_chisq | FALSE |
n_p_sig | FALSE |
miss_EFFECT | FALSE |
miss_SE | FALSE |
miss_PVAL | FALSE |
ldsc_ratio | FALSE |
ldsc_intercept_beta | FALSE |
n_clumped_hits | FALSE |
r2_sum1 | FALSE |
r2_sum2 | FALSE |
r2_sum3 | FALSE |
r2_sum4 | FALSE |
General metrics
af_correlation
: Correlation coefficient between AF
and AF_reference
.inflation_factor
(lambda
): Genomic inflation factor.mean_EFFECT
: Mean of EFFECT
size.n
: Maximum value of reported sample size across all SNPs, \(n\).n_clumped_hits
: Number of clumped hits.n_snps
: Number of SNPsn_p_sig
: Number of SNPs with pvalue below 5e-8
.n_mono
: Number of monomorphic (MAF == 1
or MAF == 0
) SNPs.n_ns
: Number of SNPs with nonsense values:
A, C, G or T
.< 0
or > 1
.<= 0
or = Infinity
).< 0
or > 1
.n_mac
: Number of cases where MAC
(\(2 \times N \times MAF\)) is less than 6
.is_snpid_unique
: true
if the combination of ID
REF
ALT
is unique and therefore no duplication in snpid.n_miss_<*>
: Number of NA
observations for <*>
column.se_n metrics
n_est
: Estimated sample size value, \(\widehat{n}\).ratio_se_n
: \(\texttt{ratio_se_n} = \frac{\sqrt{\widehat{n}}}{\sqrt{n}}\). We expect ratio_se_n
to be 1. When it is not 1, it implies that the trait did not have a variance of 1, the reported sample size is wrong, or that the SNP-level effective sample sizes differ markedly from the reported sample size.mean_diff
: \(\texttt{mean_diff} = \sum_{j} \frac{\widehat{\beta_j^{std}} - \beta_j}{\texttt{n_snps}}\), mean difference between the standardised beta, predicted from P-values, and the observed beta. The difference should be very close to zero if trait has a variance of 1.
ratio_diff
: \(\texttt{ratio_diff} = |\frac{\texttt{mean_diff}}{\texttt{mean_diff2}}|\), absolute ratio between the mean of diff
and the mean of diff2
(expected difference between the standardised beta predicted from P-values, and the standardised beta derived from the observed beta divided by the predicted SD; NOT reported). The ratio should be close to 1. If different from 1, then implies that the betas are not in a standard deviation scale.
sd_y_est1
: The standard deviation for the trait inferred from the reported sample size, median standard errors for the SNP-trait assocations and SNP variances.
sd_y_est2
: The standard deviation for the trait inferred from the reported sample size, Z statistics for the SNP-trait effects (beta/se) and allele frequency.
r2 metrics
Sum of variance explained, calculated from the clumped top hits sample.
r2_sum<*>
: r2
statistics under various assumptions
1
: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var1}}}\), \(\texttt{var1} = 1\).2
: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var2}}}\), \(\texttt{var2} = {\widehat{\texttt{sd1}}_{y}}^2\),3
: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var3}}}\), \(\texttt{var3} = {\widehat{\texttt{sd2}}_{y}}^2\),4
: \(r^2 = \sum_j{\frac{F_j}{F_j + n - 2}}\), \(F = \frac{\beta_j^2}{{se}_j^2}\).LDSC metrics
Metrics from LD regression
ldsc_nsnp_merge_refpanel_ld
: Number of remaining SNPs after merging with reference panel LD.ldsc_nsnp_merge_regression_ld
: Number of remaining SNPs after merging with regression SNP LD.ldsc_observed_scale_h2_{beta,se}
Coefficient value and SE for total observed scale h2.ldsc_intercept_{beta,se}
: Coefficient value and SE for intercept. Intercept is expected to be 1.ldsc_lambda_gc
: Lambda GC statistics.ldsc_mean_chisq
: Mean \(\chi^2\) statistics.ldsc_ratio
: \(\frac{\texttt{ldsc_intercept_beta} - 1}{\texttt{ldsc_mean_chisq} - 1}\), the proportion of the inflation in the mean \(\chi^2\) that the LD Score regression intercepts ascribes to causes other than polygenic heritability. The value of ratio should be close to zero, though in practice values of 0.1-0.2 are not uncommon, probably due to sample/reference LD Score mismatch or model misspecification (e.g., low LD variants have slightly higher \(h^2\) per SNP).Flags
When a metric needs attention, the flag should return TRUE.
af_correlation
: abs(af_correlation)
< 0.7.inflation_factor
: inflation_factor
> 1.2.n
: n
(max reported sample size) < 10000.is_snpid_non_unique
: NOT is_snpid_unique
.mean_EFFECT_nonfinite
: mean(EFFECT)
is NA
, NaN
, or Inf
.mean_EFFECT_05
: abs(mean(EFFECT))
> 0.5.mean_EFFECT_01
: abs(mean(EFFECT))
> 0.1.mean_chisq
: ldsc_mean_chisq
> 1.3 or ldsc_mean_chisq
< 0.7.n_p_sig
: n_p_sig
> 1000.miss_<*>
: n_miss_<*>
/ n_snps
> 0.01.ldsc_ratio
: ldsc_ratio
> 0.5ldsc_intercept_beta
: ldsc_intercept_beta
> 1.5n_clumped_hits
: n_clumped_hits
> 1000r2_sum<*>
: r2_sum<*>
> 0.5Plots
skim_type | skim_variable | n_missing | complete_rate | character.min | character.max | character.empty | character.n_unique | character.whitespace | numeric.mean | numeric.sd | numeric.p0 | numeric.p25 | numeric.p50 | numeric.p75 | numeric.p100 | numeric.hist |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
character | ID | 0 | 1.0000000 | 3 | 33 | 0 | 1378794 | 0 | NA | NA | NA | NA | NA | NA | NA | NA |
character | REF | 0 | 1.0000000 | 1 | 1 | 0 | 4 | 0 | NA | NA | NA | NA | NA | NA | NA | NA |
character | ALT | 0 | 1.0000000 | 1 | 1 | 0 | 4 | 0 | NA | NA | NA | NA | NA | NA | NA | NA |
numeric | CHROM | 0 | 1.0000000 | NA | NA | NA | NA | NA | 8.418373e+00 | 5.584493e+00 | 1.00000e+00 | 4.000000e+00 | 7.000000e+00 | 1.200000e+01 | 2.300000e+01 | ▇▅▅▂▁ |
numeric | POS | 0 | 1.0000000 | NA | NA | NA | NA | NA | 8.004734e+07 | 5.497822e+07 | 3.37990e+04 | 3.469297e+07 | 7.181955e+07 | 1.148427e+08 | 2.491707e+08 | ▇▇▅▂▁ |
numeric | EFFECT | 0 | 1.0000000 | NA | NA | NA | NA | NA | -4.150000e-05 | 1.853850e-02 | -1.91700e-01 | -1.130000e-02 | -1.000000e-04 | 1.120000e-02 | 2.000000e-01 | ▁▁▇▁▁ |
numeric | SE | 0 | 1.0000000 | NA | NA | NA | NA | NA | 1.699700e-02 | 5.779000e-03 | 1.26000e-02 | 1.340000e-02 | 1.480000e-02 | 1.830000e-02 | 6.760000e-02 | ▇▁▁▁▁ |
numeric | PVAL | 0 | 1.0000000 | NA | NA | NA | NA | NA | 4.873074e-01 | 2.921266e-01 | 3.60000e-06 | 2.305998e-01 | 4.836999e-01 | 7.403993e-01 | 1.000000e+00 | ▇▇▇▇▇ |
numeric | PVAL_ztest | 0 | 1.0000000 | NA | NA | NA | NA | NA | 4.873103e-01 | 2.921299e-01 | 3.80000e-06 | 2.304910e-01 | 4.839273e-01 | 7.405832e-01 | 1.000000e+00 | ▇▇▇▇▇ |
numeric | AF | 109 | 0.9999209 | NA | NA | NA | NA | NA | 3.853598e-01 | 2.555432e-01 | 8.00000e-03 | 1.670000e-01 | 3.330000e-01 | 5.760000e-01 | 9.920000e-01 | ▇▇▅▃▂ |
numeric | AF_reference | 9295 | 0.9932586 | NA | NA | NA | NA | NA | 3.859263e-01 | 2.403072e-01 | 1.99700e-04 | 1.837060e-01 | 3.384580e-01 | 5.643970e-01 | 9.970050e-01 | ▇▇▆▃▂ |
numeric | N | 0 | 1.0000000 | NA | NA | NA | NA | NA | 1.309250e+05 | 0.000000e+00 | 1.30925e+05 | 1.309250e+05 | 1.309250e+05 | 1.309250e+05 | 1.309250e+05 | ▁▁▇▁▁ |
CHROM | POS | ID | REF | ALT | EFFECT | SE | PVAL | PVAL_ztest | AF | AF_reference | N |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | 1018562 | rs9442371 | C | T | 0.0134 | 0.0131 | 0.3043000 | 0.3063548 | 0.592 | 0.530152 | 130925 |
1 | 1018704 | rs9442372 | A | G | 0.0127 | 0.0131 | 0.3309002 | 0.3323129 | 0.602 | 0.611022 | 130925 |
1 | 1040026 | rs6671356 | T | C | 0.0101 | 0.0195 | 0.6028996 | 0.6044940 | 0.075 | 0.282947 | 130925 |
1 | 1048955 | rs4970405 | A | G | 0.0117 | 0.0208 | 0.5737002 | 0.5737754 | 0.052 | 0.110623 | 130925 |
1 | 1049950 | rs12726255 | A | G | 0.0043 | 0.0189 | 0.8208001 | 0.8200247 | 0.067 | 0.289736 | 130925 |
1 | 1053452 | rs4970409 | G | A | 0.0063 | 0.0208 | 0.7614002 | 0.7619778 | 0.050 | 0.136182 | 130925 |
1 | 1097335 | rs9442385 | T | G | -0.0257 | 0.0263 | 0.3291001 | 0.3284769 | 0.942 | 0.834665 | 130925 |
1 | 1129672 | rs11260554 | G | T | -0.0034 | 0.0201 | 0.8645000 | 0.8656753 | 0.125 | 0.254393 | 130925 |
1 | 1156131 | rs2887286 | T | C | 0.0018 | 0.0179 | 0.9218000 | 0.9199008 | 0.183 | 0.511182 | 130925 |
1 | 1158277 | rs3813199 | G | A | 0.0157 | 0.0217 | 0.4681004 | 0.4693713 | 0.100 | 0.124201 | 130925 |
CHROM | POS | ID | REF | ALT | EFFECT | SE | PVAL | PVAL_ztest | AF | AF_reference | N |
---|---|---|---|---|---|---|---|---|---|---|---|
22 | 51101938 | rs6010044 | A | C | 0.0147 | 0.0161 | 0.3597999 | 0.3612197 | 0.245 | 0.2390180 | 130925 |
22 | 51103692 | rs8138460 | A | G | 0.0149 | 0.0129 | 0.2471997 | 0.2480746 | 0.442 | 0.2951280 | 130925 |
22 | 51104680 | rs9616906 | G | A | 0.0176 | 0.0128 | 0.1695001 | 0.1691314 | 0.450 | 0.2689700 | 130925 |
22 | 51105556 | rs9616812 | C | T | 0.0093 | 0.0128 | 0.4685004 | 0.4674940 | 0.483 | 0.3628190 | 130925 |
22 | 51109992 | rs9628185 | T | C | 0.0084 | 0.0128 | 0.5117997 | 0.5116633 | 0.483 | 0.4053510 | 130925 |
22 | 51150473 | rs5770820 | G | A | -0.0471 | 0.0155 | 0.0024160 | 0.0023759 | 0.190 | 0.2462060 | 130925 |
22 | 51163138 | rs715586 | C | T | 0.0352 | 0.0184 | 0.0557096 | 0.0557425 | 0.150 | 0.0902556 | 130925 |
22 | 51175626 | rs3810648 | A | G | 0.0681 | 0.0280 | 0.0149599 | 0.0150098 | 0.067 | 0.1084270 | 130925 |
23 | 51666786 | rs14115 | A | G | 0.0735 | 0.0315 | 0.0194998 | 0.0196307 | 0.025 | NA | 130925 |
23 | 118495837 | rs12882977 | G | A | 0.0135 | 0.0128 | 0.2939998 | 0.2915683 | 0.509 | 0.2307280 | 130925 |
1 1018562 rs9442371 C T . PASS AF=0.592 ES:SE:LP:AF:SS:ID 0.0134:0.0131:0.516698:0.592:130925:rs9442371
1 1018704 rs9442372 A G . PASS AF=0.602 ES:SE:LP:AF:SS:ID 0.0127:0.0131:0.480303:0.602:130925:rs9442372
1 1040026 rs6671356 T C . PASS AF=0.075 ES:SE:LP:AF:SS:ID 0.0101:0.0195:0.219755:0.075:130925:rs6671356
1 1048955 rs4970405 A G . PASS AF=0.052 ES:SE:LP:AF:SS:ID 0.0117:0.0208:0.241315:0.052:130925:rs4970405
1 1049950 rs12726255 A G . PASS AF=0.067 ES:SE:LP:AF:SS:ID 0.0043:0.0189:0.0857626:0.067:130925:rs12726255
1 1053452 rs4970409 G A . PASS AF=0.05 ES:SE:LP:AF:SS:ID 0.0063:0.0208:0.118387:0.05:130925:rs4970409
1 1097335 rs9442385 T G . PASS AF=0.942 ES:SE:LP:AF:SS:ID -0.0257:0.0263:0.482672:0.942:130925:rs9442385
1 1129672 rs11260554 G T . PASS AF=0.125 ES:SE:LP:AF:SS:ID -0.0034:0.0201:0.063235:0.125:130925:rs11260554
1 1156131 rs2887286 T C . PASS AF=0.183 ES:SE:LP:AF:SS:ID 0.0018:0.0179:0.0353633:0.183:130925:rs2887286
1 1158277 rs3813199 G A . PASS AF=0.1 ES:SE:LP:AF:SS:ID 0.0157:0.0217:0.329661:0.1:130925:rs3813199
1 1162435 rs3766186 C A . PASS AF=0.1 ES:SE:LP:AF:SS:ID 0.0157:0.022:0.322941:0.1:130925:rs3766186
1 1165310 rs11260562 G A . PASS AF=0.052 ES:SE:LP:AF:SS:ID -0.0654:0.0295:1.57988:0.052:130925:rs11260562
1 1211292 rs6685064 C T . PASS AF=0.1 ES:SE:LP:AF:SS:ID -0.0539:0.0254:1.4675:0.1:130925:rs6685064
1 1462766 rs9439462 C T . PASS AF=0.042 ES:SE:LP:AF:SS:ID -0.0364:0.0357:0.511873:0.042:130925:rs9439462
1 1477244 rs7290 T C . PASS AF=0.25 ES:SE:LP:AF:SS:ID 0.0067:0.0142:0.195111:0.25:130925:rs7290
1 1478153 rs3766180 T C . PASS AF=0.242 ES:SE:LP:AF:SS:ID 0.007:0.0142:0.208309:0.242:130925:rs3766180
1 1478180 rs3766178 T C . PASS AF=0.267 ES:SE:LP:AF:SS:ID 0.0081:0.0142:0.244735:0.267:130925:rs3766178
1 1479333 rs7533 A G . PASS AF=0.246 ES:SE:LP:AF:SS:ID 0.0069:0.0142:0.203495:0.246:130925:rs7533
1 1497201 rs3766169 A C . PASS AF=0.246 ES:SE:LP:AF:SS:ID 0.0056:0.0142:0.158015:0.246:130925:rs3766169
1 1499298 rs9439468 A G . PASS AF=0.31 ES:SE:LP:AF:SS:ID -0.0119:0.0136:0.417709:0.31:130925:rs9439468
1 1500941 rs6603791 A G . PASS AF=0.3 ES:SE:LP:AF:SS:ID -0.0125:0.0136:0.445996:0.3:130925:rs6603791
1 1505255 rs6603793 C T . PASS AF=0.3 ES:SE:LP:AF:SS:ID -0.0116:0.0136:0.405166:0.3:130925:rs6603793
1 1509034 rs7520996 T C . PASS AF=0.28 ES:SE:LP:AF:SS:ID -0.0152:0.0141:0.549905:0.28:130925:rs7520996
1 1510801 rs7519837 C T . PASS AF=0.292 ES:SE:LP:AF:SS:ID -0.0137:0.0141:0.479385:0.292:130925:rs7519837
1 1706160 rs7531583 A G . PASS AF=0.783 ES:SE:LP:AF:SS:ID 0.0073:0.0156:0.193413:0.783:130925:rs7531583
1 1708801 rs12044597 A G . PASS AF=0.517 ES:SE:LP:AF:SS:ID -0.0005:0.0129:0.0146634:0.517:130925:rs12044597
1 1721479 rs2272908 C T . PASS AF=0.517 ES:SE:LP:AF:SS:ID -0.0002:0.0129:0.00607904:0.517:130925:rs2272908
1 1722932 rs3737628 C T . PASS AF=0.508 ES:SE:LP:AF:SS:ID -0.0008:0.0132:0.022505:0.508:130925:rs3737628
1 1723031 rs9660180 G A . PASS AF=0.5 ES:SE:LP:AF:SS:ID -0.0012:0.0129:0.0334828:0.5:130925:rs9660180
1 1748734 rs2180311 T C . PASS AF=0.517 ES:SE:LP:AF:SS:ID 0.0007:0.0129:0.0180003:0.517:130925:rs2180311
1 1759054 rs10907187 G A . PASS AF=0.275 ES:SE:LP:AF:SS:ID 0.0074:0.0143:0.219467:0.275:130925:rs10907187
1 1776269 rs4648727 C A . PASS AF=0.458 ES:SE:LP:AF:SS:ID -0.0028:0.0129:0.0818123:0.458:130925:rs4648727
1 1778090 rs12126768 T G . PASS AF=0.186 ES:SE:LP:AF:SS:ID -0.0151:0.0171:0.423659:0.186:130925:rs12126768
1 1778469 rs6687065 A G . PASS AF=0.517 ES:SE:LP:AF:SS:ID 0.0005:0.0129:0.0142144:0.517:130925:rs6687065
1 1783201 rs12402876 G A . PASS AF=0.275 ES:SE:LP:AF:SS:ID 0.0077:0.0143:0.227752:0.275:130925:rs12402876
1 1787378 rs12125422 G A . PASS AF=0.192 ES:SE:LP:AF:SS:ID -0.0162:0.0171:0.46382:0.192:130925:rs12125422
1 1797947 rs9660106 A G . PASS AF=0.517 ES:SE:LP:AF:SS:ID 0.0004:0.0129:0.0116194:0.517:130925:rs9660106
1 1801034 rs4648592 G A . PASS AF=0.275 ES:SE:LP:AF:SS:ID 0.008:0.0143:0.237772:0.275:130925:rs4648592
1 1805391 rs10907193 G A . PASS AF=0.275 ES:SE:LP:AF:SS:ID 0.0077:0.0143:0.230106:0.275:130925:rs10907193
1 1810090 rs7525092 C T . PASS AF=0.275 ES:SE:LP:AF:SS:ID 0.0077:0.0143:0.229074:0.275:130925:rs7525092
1 1812688 rs6603803 A G . PASS AF=0.517 ES:SE:LP:AF:SS:ID 0.0008:0.0129:0.0229627:0.517:130925:rs6603803
1 1818129 rs16824526 A C . PASS AF=0.192 ES:SE:LP:AF:SS:ID -0.0168:0.0171:0.485187:0.192:130925:rs16824526
1 1888193 rs3820011 C A . PASS AF=0.292 ES:SE:LP:AF:SS:ID -0.0042:0.0143:0.113622:0.292:130925:rs3820011
1 2024064 rs2459994 C T . PASS AF=0.116 ES:SE:LP:AF:SS:ID 0.0302:0.0194:0.922996:0.116:130925:rs2459994
1 2027901 rs7513222 G A . PASS AF=0.292 ES:SE:LP:AF:SS:ID 0.0156:0.0143:0.559878:0.292:130925:rs7513222
1 2033256 rs908742 G A . PASS AF=0.339 ES:SE:LP:AF:SS:ID 0.0029:0.0139:0.0771189:0.339:130925:rs908742
1 2039719 rs1878752 G A . PASS AF=0.911 ES:SE:LP:AF:SS:ID 0.0003:0.0197:0.00572685:0.911:130925:rs1878752
1 2040763 rs4648805 G A . PASS AF=0.89 ES:SE:LP:AF:SS:ID 0.0003:0.0197:0.00572685:0.89:130925:rs4648805
1 2040898 rs4648807 T C . PASS AF=0.625 ES:SE:LP:AF:SS:ID 0.0015:0.0133:0.039672:0.625:130925:rs4648807
1 2040936 rs4648808 T C . PASS AF=0.89 ES:SE:LP:AF:SS:ID 0.0005:0.0196:0.008641:0.89:130925:rs4648808