{
"fileformat": "VCFv4.2",
"FILTER": "<ID=PASS,Description=\"All filters passed\">",
"INFO": "<ID=AF,Number=A,Type=Float,Description=\"Allele Frequency\">",
"FORMAT": "<ID=ES,Number=A,Type=Float,Description=\"Effect size estimate relative to the alternative allele\">",
"FORMAT.1": "<ID=SE,Number=A,Type=Float,Description=\"Standard error of effect size estimate\">",
"FORMAT.2": "<ID=LP,Number=A,Type=Float,Description=\"-log10 p-value for effect estimate\">",
"FORMAT.3": "<ID=AF,Number=A,Type=Float,Description=\"Alternate allele frequency in the association study\">",
"FORMAT.4": "<ID=SS,Number=A,Type=Float,Description=\"Sample size used to estimate genetic effect\">",
"FORMAT.5": "<ID=EZ,Number=A,Type=Float,Description=\"Z-score provided if it was used to derive the EFFECT and SE fields\">",
"FORMAT.6": "<ID=SI,Number=A,Type=Float,Description=\"Accuracy score of summary data imputation\">",
"FORMAT.7": "<ID=NC,Number=A,Type=Float,Description=\"Number of cases used to estimate genetic effect\">",
"FORMAT.8": "<ID=ID,Number=1,Type=String,Description=\"Study variant identifier\">",
"META": "<ID=TotalVariants,Number=1,Type=Integer,Description=\"Total number of variants in input\">",
"META.1": "<ID=VariantsNotRead,Number=1,Type=Integer,Description=\"Number of variants that could not be read\">",
"META.2": "<ID=HarmonisedVariants,Number=1,Type=Integer,Description=\"Total number of harmonised variants\">",
"META.3": "<ID=VariantsNotHarmonised,Number=1,Type=Integer,Description=\"Total number of variants that could not be harmonised\">",
"META.4": "<ID=SwitchedAlleles,Number=1,Type=Integer,Description=\"Total number of variants strand switched\">",
"META.5": "<ID=TotalControls,Number=1,Type=Integer,Description=\"Total number of controls in the association study\">",
"META.6": "<ID=TotalCases,Number=1,Type=Integer,Description=\"Total number of cases in the association study\">",
"META.7": "<ID=StudyType,Number=1,Type=String,Description=\"Type of GWAS study [Continuous or CaseControl]\">",
"SAMPLE": "<ID=ieu-a-1085,TotalVariants=7481913,VariantsNotRead=0,HarmonisedVariants=7481913,VariantsNotHarmonised=0,SwitchedAlleles=0,StudyType=Continuous>",
"contig": "<ID=1,length=249250621,assembly=HG19/GRCh37>",
"contig.1": "<ID=2,length=243199373,assembly=HG19/GRCh37>",
"contig.2": "<ID=3,length=198022430,assembly=HG19/GRCh37>",
"contig.3": "<ID=4,length=191154276,assembly=HG19/GRCh37>",
"contig.4": "<ID=5,length=180915260,assembly=HG19/GRCh37>",
"contig.5": "<ID=6,length=171115067,assembly=HG19/GRCh37>",
"contig.6": "<ID=7,length=159138663,assembly=HG19/GRCh37>",
"contig.7": "<ID=8,length=146364022,assembly=HG19/GRCh37>",
"contig.8": "<ID=9,length=141213431,assembly=HG19/GRCh37>",
"contig.9": "<ID=10,length=135534747,assembly=HG19/GRCh37>",
"contig.10": "<ID=11,length=135006516,assembly=HG19/GRCh37>",
"contig.11": "<ID=12,length=133851895,assembly=HG19/GRCh37>",
"contig.12": "<ID=13,length=115169878,assembly=HG19/GRCh37>",
"contig.13": "<ID=14,length=107349540,assembly=HG19/GRCh37>",
"contig.14": "<ID=15,length=102531392,assembly=HG19/GRCh37>",
"contig.15": "<ID=16,length=90354753,assembly=HG19/GRCh37>",
"contig.16": "<ID=17,length=81195210,assembly=HG19/GRCh37>",
"contig.17": "<ID=18,length=78077248,assembly=HG19/GRCh37>",
"contig.18": "<ID=19,length=59128983,assembly=HG19/GRCh37>",
"contig.19": "<ID=20,length=63025520,assembly=HG19/GRCh37>",
"contig.20": "<ID=21,length=48129895,assembly=HG19/GRCh37>",
"contig.21": "<ID=22,length=51304566,assembly=HG19/GRCh37>",
"contig.22": "<ID=X,length=155270560,assembly=HG19/GRCh37>",
"contig.23": "<ID=Y,length=59373566,assembly=HG19/GRCh37>",
"contig.24": "<ID=MT,length=16569,assembly=HG19/GRCh37>",
"contig.25": "<ID=GL000207.1,length=4262,assembly=HG19/GRCh37>",
"contig.26": "<ID=GL000226.1,length=15008,assembly=HG19/GRCh37>",
"contig.27": "<ID=GL000229.1,length=19913,assembly=HG19/GRCh37>",
"contig.28": "<ID=GL000231.1,length=27386,assembly=HG19/GRCh37>",
"contig.29": "<ID=GL000210.1,length=27682,assembly=HG19/GRCh37>",
"contig.30": "<ID=GL000239.1,length=33824,assembly=HG19/GRCh37>",
"contig.31": "<ID=GL000235.1,length=34474,assembly=HG19/GRCh37>",
"contig.32": "<ID=GL000201.1,length=36148,assembly=HG19/GRCh37>",
"contig.33": "<ID=GL000247.1,length=36422,assembly=HG19/GRCh37>",
"contig.34": "<ID=GL000245.1,length=36651,assembly=HG19/GRCh37>",
"contig.35": "<ID=GL000197.1,length=37175,assembly=HG19/GRCh37>",
"contig.36": "<ID=GL000203.1,length=37498,assembly=HG19/GRCh37>",
"contig.37": "<ID=GL000246.1,length=38154,assembly=HG19/GRCh37>",
"contig.38": "<ID=GL000249.1,length=38502,assembly=HG19/GRCh37>",
"contig.39": "<ID=GL000196.1,length=38914,assembly=HG19/GRCh37>",
"contig.40": "<ID=GL000248.1,length=39786,assembly=HG19/GRCh37>",
"contig.41": "<ID=GL000244.1,length=39929,assembly=HG19/GRCh37>",
"contig.42": "<ID=GL000238.1,length=39939,assembly=HG19/GRCh37>",
"contig.43": "<ID=GL000202.1,length=40103,assembly=HG19/GRCh37>",
"contig.44": "<ID=GL000234.1,length=40531,assembly=HG19/GRCh37>",
"contig.45": "<ID=GL000232.1,length=40652,assembly=HG19/GRCh37>",
"contig.46": "<ID=GL000206.1,length=41001,assembly=HG19/GRCh37>",
"contig.47": "<ID=GL000240.1,length=41933,assembly=HG19/GRCh37>",
"contig.48": "<ID=GL000236.1,length=41934,assembly=HG19/GRCh37>",
"contig.49": "<ID=GL000241.1,length=42152,assembly=HG19/GRCh37>",
"contig.50": "<ID=GL000243.1,length=43341,assembly=HG19/GRCh37>",
"contig.51": "<ID=GL000242.1,length=43523,assembly=HG19/GRCh37>",
"contig.52": "<ID=GL000230.1,length=43691,assembly=HG19/GRCh37>",
"contig.53": "<ID=GL000237.1,length=45867,assembly=HG19/GRCh37>",
"contig.54": "<ID=GL000233.1,length=45941,assembly=HG19/GRCh37>",
"contig.55": "<ID=GL000204.1,length=81310,assembly=HG19/GRCh37>",
"contig.56": "<ID=GL000198.1,length=90085,assembly=HG19/GRCh37>",
"contig.57": "<ID=GL000208.1,length=92689,assembly=HG19/GRCh37>",
"contig.58": "<ID=GL000191.1,length=106433,assembly=HG19/GRCh37>",
"contig.59": "<ID=GL000227.1,length=128374,assembly=HG19/GRCh37>",
"contig.60": "<ID=GL000228.1,length=129120,assembly=HG19/GRCh37>",
"contig.61": "<ID=GL000214.1,length=137718,assembly=HG19/GRCh37>",
"contig.62": "<ID=GL000221.1,length=155397,assembly=HG19/GRCh37>",
"contig.63": "<ID=GL000209.1,length=159169,assembly=HG19/GRCh37>",
"contig.64": "<ID=GL000218.1,length=161147,assembly=HG19/GRCh37>",
"contig.65": "<ID=GL000220.1,length=161802,assembly=HG19/GRCh37>",
"contig.66": "<ID=GL000213.1,length=164239,assembly=HG19/GRCh37>",
"contig.67": "<ID=GL000211.1,length=166566,assembly=HG19/GRCh37>",
"contig.68": "<ID=GL000199.1,length=169874,assembly=HG19/GRCh37>",
"contig.69": "<ID=GL000217.1,length=172149,assembly=HG19/GRCh37>",
"contig.70": "<ID=GL000216.1,length=172294,assembly=HG19/GRCh37>",
"contig.71": "<ID=GL000215.1,length=172545,assembly=HG19/GRCh37>",
"contig.72": "<ID=GL000205.1,length=174588,assembly=HG19/GRCh37>",
"contig.73": "<ID=GL000219.1,length=179198,assembly=HG19/GRCh37>",
"contig.74": "<ID=GL000224.1,length=179693,assembly=HG19/GRCh37>",
"contig.75": "<ID=GL000223.1,length=180455,assembly=HG19/GRCh37>",
"contig.76": "<ID=GL000195.1,length=182896,assembly=HG19/GRCh37>",
"contig.77": "<ID=GL000212.1,length=186858,assembly=HG19/GRCh37>",
"contig.78": "<ID=GL000222.1,length=186861,assembly=HG19/GRCh37>",
"contig.79": "<ID=GL000200.1,length=187035,assembly=HG19/GRCh37>",
"contig.80": "<ID=GL000193.1,length=189789,assembly=HG19/GRCh37>",
"contig.81": "<ID=GL000194.1,length=191469,assembly=HG19/GRCh37>",
"contig.82": "<ID=GL000225.1,length=211173,assembly=HG19/GRCh37>",
"contig.83": "<ID=GL000192.1,length=547496,assembly=HG19/GRCh37>",
"gwas_harmonisation_command": "--json /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ieu-a-import/processed/ieu-a-1085/ieu-a-1085_data.json --ref /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/QC/genomes/b37/human_g1k_v37.fasta; 1.1.1",
"file_date": "2020-02-04T09:20:47.902213",
"bcftools_annotateVersion": "1.9-74-g6af271c+htslib-1.9-64-g226b4a8",
"bcftools_annotateCommand": "annotate -a /mnt/storage/home/gh13047/mr-eve/vcf-reference-datasets/dbsnp/dbsnp.v153.b37.vcf.gz -c ID -o /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ieu-a-import/processed/ieu-a-1085/ieu-a-1085.vcf.gz -O z /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ieu-a-import/processed/ieu-a-1085/ieu-a-1085_data.vcf.gz; Date=Tue Feb 4 16:05:39 2020",
"bcftools_viewVersion": "1.9-74-g6af271c+htslib-1.9-64-g226b4a8",
"bcftools_viewCommand": "view -h /mnt/storage/private/mrcieu/research/scratch/IGD/data/public/ieu-a-1085/ieu-a-1085.vcf.gz; Date=Sun May 10 06:30:38 2020"
}
*********************************************************************
* LD Score Regression (LDSC)
* Version 1.0.1
* (C) 2014-2019 Brendan Bulik-Sullivan and Hilary Finucane
* Broad Institute of MIT and Harvard / MIT Department of Mathematics
* GNU General Public License v3
*********************************************************************
Call:
./ldsc.py \
--h2 /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ieu-a-import/processed/ieu-a-1085/ieu-a-1085.vcf.gz \
--ref-ld-chr /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/ \
--out /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ieu-a-import/processed/ieu-a-1085/ldsc.txt \
--w-ld-chr /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/
Beginning analysis at Wed Feb 5 09:21:13 2020
Reading summary statistics from /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/ieu-a-import/processed/ieu-a-1085/ieu-a-1085.vcf.gz ...
Read summary statistics for 7481913 SNPs.
Reading reference panel LD Score from /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/[1-22] ...
Read reference panel LD Scores for 1290028 SNPs.
Removing partitioned LD Scores with zero variance.
Reading regression weight LD Score from /mnt/storage/private/mrcieu/research/scratch/IGD/data/dev/reference/eur_w_ld_chr/[1-22] ...
Read regression weight LD Scores for 1290028 SNPs.
After merging with reference panel LD, 1234259 SNPs remain.
After merging with regression SNP LD, 1234259 SNPs remain.
Using two-step estimator with cutoff at 30.
Total Observed scale h2: 0.0379 (0.0159)
Lambda GC: 1.1183
Mean Chi^2: 1.1298
Intercept: 1.1024 (0.0078)
Ratio: 0.7893 (0.0602)
Analysis finished at Wed Feb 5 09:22:29 2020
Total time elapsed: 1.0m:16.48s
{
"af_correlation": 0.932,
"inflation_factor": 1.1172,
"mean_EFFECT": 0,
"n": 36052,
"n_snps": 7481913,
"n_clumped_hits": 7,
"n_p_sig": 153,
"n_mono": 0,
"n_ns": 503785,
"n_mac": 0,
"is_snpid_unique": true,
"n_miss_EFFECT": 0,
"n_miss_SE": 0,
"n_miss_PVAL": 0,
"n_miss_AF": 0,
"n_miss_AF_reference": 351700,
"n_est": 35376.8989,
"ratio_se_n": 0.9906,
"mean_diff": 0,
"ratio_diff": 16.9064,
"sd_y_est1": 0.4671,
"sd_y_est2": 0.4627,
"r2_sum1": 0.0019,
"r2_sum2": 0.0087,
"r2_sum3": 0.0088,
"r2_sum4": 0.0087,
"ldsc_nsnp_merge_refpanel_ld": 1234259,
"ldsc_nsnp_merge_regression_ld": 1234259,
"ldsc_observed_scale_h2_beta": 0.0379,
"ldsc_observed_scale_h2_se": 0.0159,
"ldsc_intercept_beta": 1.1024,
"ldsc_intercept_se": 0.0078,
"ldsc_lambda_gc": 1.1183,
"ldsc_mean_chisq": 1.1298,
"ldsc_ratio": 0.7889
}
name | value |
---|---|
af_correlation | FALSE |
inflation_factor | FALSE |
n | FALSE |
is_snpid_non_unique | FALSE |
mean_EFFECT_nonfinite | FALSE |
mean_EFFECT_05 | FALSE |
mean_EFFECT_01 | FALSE |
mean_chisq | FALSE |
n_p_sig | FALSE |
miss_EFFECT | FALSE |
miss_SE | FALSE |
miss_PVAL | FALSE |
ldsc_ratio | TRUE |
ldsc_intercept_beta | FALSE |
n_clumped_hits | FALSE |
r2_sum1 | FALSE |
r2_sum2 | FALSE |
r2_sum3 | FALSE |
r2_sum4 | FALSE |
General metrics
af_correlation
: Correlation coefficient between AF
and AF_reference
.inflation_factor
(lambda
): Genomic inflation factor.mean_EFFECT
: Mean of EFFECT
size.n
: Maximum value of reported sample size across all SNPs, \(n\).n_clumped_hits
: Number of clumped hits.n_snps
: Number of SNPsn_p_sig
: Number of SNPs with pvalue below 5e-8
.n_mono
: Number of monomorphic (MAF == 1
or MAF == 0
) SNPs.n_ns
: Number of SNPs with nonsense values:
A, C, G or T
.< 0
or > 1
.<= 0
or = Infinity
).< 0
or > 1
.n_mac
: Number of cases where MAC
(\(2 \times N \times MAF\)) is less than 6
.is_snpid_unique
: true
if the combination of ID
REF
ALT
is unique and therefore no duplication in snpid.n_miss_<*>
: Number of NA
observations for <*>
column.se_n metrics
n_est
: Estimated sample size value, \(\widehat{n}\).ratio_se_n
: \(\texttt{ratio_se_n} = \frac{\sqrt{\widehat{n}}}{\sqrt{n}}\). We expect ratio_se_n
to be 1. When it is not 1, it implies that the trait did not have a variance of 1, the reported sample size is wrong, or that the SNP-level effective sample sizes differ markedly from the reported sample size.mean_diff
: \(\texttt{mean_diff} = \sum_{j} \frac{\widehat{\beta_j^{std}} - \beta_j}{\texttt{n_snps}}\), mean difference between the standardised beta, predicted from P-values, and the observed beta. The difference should be very close to zero if trait has a variance of 1.
ratio_diff
: \(\texttt{ratio_diff} = |\frac{\texttt{mean_diff}}{\texttt{mean_diff2}}|\), absolute ratio between the mean of diff
and the mean of diff2
(expected difference between the standardised beta predicted from P-values, and the standardised beta derived from the observed beta divided by the predicted SD; NOT reported). The ratio should be close to 1. If different from 1, then implies that the betas are not in a standard deviation scale.
sd_y_est1
: The standard deviation for the trait inferred from the reported sample size, median standard errors for the SNP-trait assocations and SNP variances.
sd_y_est2
: The standard deviation for the trait inferred from the reported sample size, Z statistics for the SNP-trait effects (beta/se) and allele frequency.
r2 metrics
Sum of variance explained, calculated from the clumped top hits sample.
r2_sum<*>
: r2
statistics under various assumptions
1
: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var1}}}\), \(\texttt{var1} = 1\).2
: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var2}}}\), \(\texttt{var2} = {\widehat{\texttt{sd1}}_{y}}^2\),3
: \(r^2 = \sum_j{\frac{2 \times \beta_j^2 \times {MAF}_j \times (1 - {MAF}_j)}{\texttt{var3}}}\), \(\texttt{var3} = {\widehat{\texttt{sd2}}_{y}}^2\),4
: \(r^2 = \sum_j{\frac{F_j}{F_j + n - 2}}\), \(F = \frac{\beta_j^2}{{se}_j^2}\).LDSC metrics
Metrics from LD regression
ldsc_nsnp_merge_refpanel_ld
: Number of remaining SNPs after merging with reference panel LD.ldsc_nsnp_merge_regression_ld
: Number of remaining SNPs after merging with regression SNP LD.ldsc_observed_scale_h2_{beta,se}
Coefficient value and SE for total observed scale h2.ldsc_intercept_{beta,se}
: Coefficient value and SE for intercept. Intercept is expected to be 1.ldsc_lambda_gc
: Lambda GC statistics.ldsc_mean_chisq
: Mean \(\chi^2\) statistics.ldsc_ratio
: \(\frac{\texttt{ldsc_intercept_beta} - 1}{\texttt{ldsc_mean_chisq} - 1}\), the proportion of the inflation in the mean \(\chi^2\) that the LD Score regression intercepts ascribes to causes other than polygenic heritability. The value of ratio should be close to zero, though in practice values of 0.1-0.2 are not uncommon, probably due to sample/reference LD Score mismatch or model misspecification (e.g., low LD variants have slightly higher \(h^2\) per SNP).Flags
When a metric needs attention, the flag should return TRUE.
af_correlation
: abs(af_correlation)
< 0.7.inflation_factor
: inflation_factor
> 1.2.n
: n
(max reported sample size) < 10000.is_snpid_non_unique
: NOT is_snpid_unique
.mean_EFFECT_nonfinite
: mean(EFFECT)
is NA
, NaN
, or Inf
.mean_EFFECT_05
: abs(mean(EFFECT))
> 0.5.mean_EFFECT_01
: abs(mean(EFFECT))
> 0.1.mean_chisq
: ldsc_mean_chisq
> 1.3 or ldsc_mean_chisq
< 0.7.n_p_sig
: n_p_sig
> 1000.miss_<*>
: n_miss_<*>
/ n_snps
> 0.01.ldsc_ratio
: ldsc_ratio
> 0.5ldsc_intercept_beta
: ldsc_intercept_beta
> 1.5n_clumped_hits
: n_clumped_hits
> 1000r2_sum<*>
: r2_sum<*>
> 0.5Plots
skim_type | skim_variable | n_missing | complete_rate | character.min | character.max | character.empty | character.n_unique | character.whitespace | numeric.mean | numeric.sd | numeric.p0 | numeric.p25 | numeric.p50 | numeric.p75 | numeric.p100 | numeric.hist |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
character | ID | 0 | 1.0000000 | 3 | 59 | 0 | 7481912 | 0 | NA | NA | NA | NA | NA | NA | NA | NA |
character | REF | 0 | 1.0000000 | 1 | 44 | 0 | 19630 | 0 | NA | NA | NA | NA | NA | NA | NA | NA |
character | ALT | 0 | 1.0000000 | 1 | 40 | 0 | 9815 | 0 | NA | NA | NA | NA | NA | NA | NA | NA |
numeric | CHROM | 0 | 1.0000000 | NA | NA | NA | NA | NA | 8.681703e+00 | 5.775558e+00 | 1.00000e+00 | 4.000000e+00 | 8.000000e+00 | 1.300000e+01 | 2.300000e+01 | ▇▅▅▂▂ |
numeric | POS | 0 | 1.0000000 | NA | NA | NA | NA | NA | 7.847136e+07 | 5.667005e+07 | 3.02000e+02 | 3.178035e+07 | 6.891596e+07 | 1.144324e+08 | 2.492391e+08 | ▇▆▅▂▁ |
numeric | EFFECT | 0 | 1.0000000 | NA | NA | NA | NA | NA | 1.140000e-05 | 6.601900e-03 | -6.62175e-02 | -3.620500e-03 | -6.500000e-06 | 3.575100e-03 | 1.180090e-01 | ▁▇▁▁▁ |
numeric | SE | 0 | 1.0000000 | NA | NA | NA | NA | NA | 5.711200e-03 | 2.566900e-03 | 3.33060e-03 | 3.725100e-03 | 4.660300e-03 | 6.965500e-03 | 2.308620e-02 | ▇▂▁▁▁ |
numeric | PVAL | 0 | 1.0000000 | NA | NA | NA | NA | NA | 4.822477e-01 | 2.936359e-01 | 0.00000e+00 | 2.231038e-01 | 4.758905e-01 | 7.367820e-01 | 1.000000e+00 | ▇▇▇▇▇ |
numeric | PVAL_ztest | 0 | 1.0000000 | NA | NA | NA | NA | NA | 4.822477e-01 | 2.936359e-01 | 0.00000e+00 | 2.231041e-01 | 4.758899e-01 | 7.367817e-01 | 9.999996e-01 | ▇▇▇▇▇ |
numeric | AF | 0 | 1.0000000 | NA | NA | NA | NA | NA | 2.913287e-01 | 2.592639e-01 | 1.20090e-02 | 7.335100e-02 | 2.010460e-01 | 4.539820e-01 | 9.870730e-01 | ▇▃▂▂▁ |
numeric | AF_reference | 351700 | 0.9529933 | NA | NA | NA | NA | NA | 2.885181e-01 | 2.504129e-01 | 0.00000e+00 | 8.286740e-02 | 2.112620e-01 | 4.452880e-01 | 1.000000e+00 | ▇▃▂▂▁ |
numeric | N | 0 | 1.0000000 | NA | NA | NA | NA | NA | 3.605200e+04 | 0.000000e+00 | 3.60520e+04 | 3.605200e+04 | 3.605200e+04 | 3.605200e+04 | 3.605200e+04 | ▁▁▇▁▁ |
CHROM | POS | ID | REF | ALT | EFFECT | SE | PVAL | PVAL_ztest | AF | AF_reference | N |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | 10583 | rs58108140 | G | A | 0.0034029 | 0.0077076 | 0.6588552 | 0.6588545 | 0.158153 | NA | 36052 |
1 | 51479 | rs116400033 | T | A | 0.0108971 | 0.0072451 | 0.1325669 | 0.1325657 | 0.183122 | 0.1281950 | 36052 |
1 | 54676 | rs2462492 | C | T | -0.0159222 | 0.0079343 | 0.0447765 | 0.0447757 | 0.153919 | NA | 36052 |
1 | 55299 | rs10399749 | C | T | -0.0076824 | 0.0073605 | 0.2966060 | 0.2966055 | 0.177563 | NA | 36052 |
1 | 61987 | rs76735897 | A | G | -0.0122878 | 0.0062170 | 0.0480994 | 0.0480996 | 0.303514 | NA | 36052 |
1 | 61989 | rs77573425 | G | C | -0.0122958 | 0.0062170 | 0.0479535 | 0.0479539 | 0.303512 | NA | 36052 |
1 | 66162 | rs62639105 | A | T | -0.0094384 | 0.0060367 | 0.1179351 | 0.1179350 | 0.329955 | NA | 36052 |
1 | 73841 | rs143773730 | C | T | -0.0009135 | 0.0074509 | 0.9024231 | 0.9024227 | 0.176353 | NA | 36052 |
1 | 82163 | rs139113303 | G | A | 0.0143658 | 0.0106687 | 0.1781312 | 0.1781294 | 0.074582 | 0.0327476 | 36052 |
1 | 82609 | rs149189449 | C | G | 0.0143658 | 0.0106687 | 0.1781312 | 0.1781294 | 0.074582 | 0.0327476 | 36052 |
CHROM | POS | ID | REF | ALT | EFFECT | SE | PVAL | PVAL_ztest | AF | AF_reference | N |
---|---|---|---|---|---|---|---|---|---|---|---|
22 | 51224600 | rs187908482 | G | A | 0.0056764 | 0.0061457 | 0.3556706 | 0.3556710 | 0.133329 | 0.0387380 | 36052 |
22 | 51224718 | rs189454695 | T | G | 0.0000889 | 0.0049530 | 0.9856830 | 0.9856833 | 0.231318 | NA | 36052 |
22 | 51227891 | rs6010091 | G | A | 0.0007610 | 0.0039750 | 0.8481741 | 0.8481742 | 0.406363 | 0.4039540 | 36052 |
22 | 51229805 | rs9616985 | T | C | 0.0072660 | 0.0077363 | 0.3476250 | 0.3476255 | 0.069207 | 0.0730831 | 36052 |
22 | 51229855 | rs144549712 | G | A | -0.0029729 | 0.0055087 | 0.5894215 | 0.5894226 | 0.148164 | 0.1160140 | 36052 |
22 | 51236013 | rs200507571 | A | AT | 0.0003262 | 0.0044760 | 0.9418989 | 0.9418993 | 0.263895 | 0.1487620 | 36052 |
22 | 51237063 | rs3896457 | T | C | -0.0028892 | 0.0043315 | 0.5047508 | 0.5047521 | 0.291447 | 0.2050720 | 36052 |
22 | 51238249 | rs149733995 | A | C | 0.0077582 | 0.0078375 | 0.3222337 | 0.3222343 | 0.070647 | NA | 36052 |
23 | 57596530 | rs36177845 | A | AT | -0.0018928 | 0.0034645 | 0.5848305 | 0.5848311 | 0.558975 | NA | 36052 |
23 | 100784211 | rs188350543 | C | A | 0.0042025 | 0.0041203 | 0.3077471 | 0.3077464 | 0.748382 | 0.6498010 | 36052 |
1 10583 rs58108140 G A . PASS AF=0.158153 ES:SE:LP:AF:SS:ID 0.00340286:0.00770758:0.18121:0.158153:36052:rs58108140
1 51479 rs116400033 T A . PASS AF=0.183122 ES:SE:LP:AF:SS:ID 0.0108971:0.00724512:0.877565:0.183122:36052:rs116400033
1 54676 rs2462492 C T . PASS AF=0.153919 ES:SE:LP:AF:SS:ID -0.0159222:0.0079343:1.34895:0.153919:36052:rs2462492
1 55299 rs10399749 C T . PASS AF=0.177563 ES:SE:LP:AF:SS:ID -0.00768241:0.00736046:0.52782:0.177563:36052:rs10399749
1 61987 rs76735897 A G . PASS AF=0.303514 ES:SE:LP:AF:SS:ID -0.0122878:0.00621699:1.31786:0.303514:36052:rs76735897
1 61989 rs77573425 G C . PASS AF=0.303512 ES:SE:LP:AF:SS:ID -0.0122958:0.00621698:1.31918:0.303512:36052:rs77573425
1 66162 rs62639105 A T . PASS AF=0.329955 ES:SE:LP:AF:SS:ID -0.00943835:0.00603668:0.928357:0.329955:36052:rs62639105
1 73841 rs143773730 C T . PASS AF=0.176353 ES:SE:LP:AF:SS:ID -0.000913492:0.00745091:0.0445898:0.176353:36052:rs143773730
1 82163 rs139113303 G A . PASS AF=0.074582 ES:SE:LP:AF:SS:ID 0.0143658:0.0106687:0.74926:0.074582:36052:rs139113303
1 82609 rs149189449 C G . PASS AF=0.074582 ES:SE:LP:AF:SS:ID 0.0143658:0.0106687:0.74926:0.074582:36052:rs149189449
1 86028 rs114608975 T C . PASS AF=0.094621 ES:SE:LP:AF:SS:ID 0.00823631:0.00958433:0.408773:0.094621:36052:rs114608975
1 86065 rs116504101 G C . PASS AF=0.094629 ES:SE:LP:AF:SS:ID 0.00812642:0.00958437:0.401754:0.094629:36052:rs116504101
1 86303 rs2949417 G T . PASS AF=0.08279 ES:SE:LP:AF:SS:ID -0.0187542:0.0102669:1.16909:0.08279:36052:rs2949417
1 86331 rs115209712 A G . PASS AF=0.082575 ES:SE:LP:AF:SS:ID -0.018644:0.0102796:1.15662:0.082575:36052:rs115209712
1 87409 rs139490478 C T . PASS AF=0.094644 ES:SE:LP:AF:SS:ID 0.00800137:0.00958452:0.393814:0.094644:36052:rs139490478
1 88172 rs940551 G A . PASS AF=0.065736 ES:SE:LP:AF:SS:ID 0.0052302:0.0114257:0.189011:0.065736:36052:rs940551
1 88177 rs143215837 G C . PASS AF=0.065633 ES:SE:LP:AF:SS:ID 0.00495241:0.0114327:0.177255:0.065633:36052:rs143215837
1 88316 rs113759966 G A . PASS AF=0.065947 ES:SE:LP:AF:SS:ID 0.00602148:0.0114101:0.223528:0.065947:36052:rs113759966
1 88338 rs55700207 G A . PASS AF=0.089174 ES:SE:LP:AF:SS:ID 0.00260613:0.00989929:0.101085:0.089174:36052:rs55700207
1 88710 rs186575039 C G . PASS AF=0.094391 ES:SE:LP:AF:SS:ID 0.00948938:0.00960366:0.490658:0.094391:36052:rs186575039
1 89946 rs138808727 A T . PASS AF=0.15244 ES:SE:LP:AF:SS:ID 0.00507945:0.00797513:0.280517:0.15244:36052:rs138808727
1 91190 rs143856811 G A . PASS AF=0.093758 ES:SE:LP:AF:SS:ID 0.00868046:0.0096412:0.43423:0.093758:36052:rs143856811
1 92858 rs147061536 G T . PASS AF=0.157743 ES:SE:LP:AF:SS:ID 0.00444316:0.00780078:0.244916:0.157743:36052:rs147061536
1 98929 rs12184306 A G . PASS AF=0.080661 ES:SE:LP:AF:SS:ID -0.0253613:0.0103126:1.85627:0.080661:36052:rs12184306
1 98974 rs12184307 A G . PASS AF=0.079988 ES:SE:LP:AF:SS:ID -0.0258108:0.0103781:1.89005:0.079988:36052:rs12184307
1 120983 rs182468771 C T . PASS AF=0.084269 ES:SE:LP:AF:SS:ID -0.00283142:0.00990956:0.110649:0.084269:36052:rs182468771
1 121009 rs1851943 C T . PASS AF=0.131238 ES:SE:LP:AF:SS:ID 0.000678637:0.00827994:0.0293384:0.131238:36052:rs1851943
1 137825 rs147252685 G A . PASS AF=0.17979 ES:SE:LP:AF:SS:ID 0.00937777:0.00724441:0.708855:0.17979:36052:rs147252685
1 162463 rs143399298 T C . PASS AF=0.08252 ES:SE:LP:AF:SS:ID -0.0241424:0.0103218:1.71361:0.08252:36052:rs143399298
1 234432 rs8179455 A G . PASS AF=0.074895 ES:SE:LP:AF:SS:ID 0.0028993:0.0105153:0.106371:0.074895:36052:rs8179455
1 249275 rs200079338 GT G . PASS AF=0.865096 ES:SE:LP:AF:SS:ID 0.00665704:0.00841985:0.367385:0.865096:36052:rs200079338
1 251627 rs72502741 AC A . PASS AF=0.140351 ES:SE:LP:AF:SS:ID -0.0107968:0.0083215:0.711136:0.140351:36052:rs72502741
1 255923 rs199745078 G GTC . PASS AF=0.266223 ES:SE:LP:AF:SS:ID -0.00711638:0.00641974:0.572451:0.266223:36052:rs199745078
1 540975 rs80246094 G A . PASS AF=0.086384 ES:SE:LP:AF:SS:ID -0.000129917:0.00997436:0.0045368:0.086384:36052:rs80246094
1 662613 rs151190501 G A . PASS AF=0.022293 ES:SE:LP:AF:SS:ID -0.0115643:0.0174474:0.294603:0.022293:36052:rs151190501
1 662622 rs61769339 G A . PASS AF=0.10955 ES:SE:LP:AF:SS:ID 0.0229681:0.00737058:2.73705:0.10955:36052:rs61769339
1 691541 rs201999089 AT A . PASS AF=0.10754 ES:SE:LP:AF:SS:ID -0.00322526:0.00860772:0.150035:0.10754:36052:rs201999089
1 693625 rs190214723 T C . PASS AF=0.044048 ES:SE:LP:AF:SS:ID 0.000789312:0.0131881:0.0212376:0.044048:36052:rs190214723
1 704637 rs142559957 G A . PASS AF=0.052775 ES:SE:LP:AF:SS:ID -0.00158721:0.0111474:0.0521861:0.052775:36052:rs142559957
1 718505 rs181440659 G A . PASS AF=0.03238 ES:SE:LP:AF:SS:ID -0.00429824:0.0136:0.123801:0.03238:36052:rs181440659
1 722670 rs116030099 T C . PASS AF=0.101886 ES:SE:LP:AF:SS:ID -0.00599479:0.00818109:0.333759:0.101886:36052:rs116030099
1 729679 rs4951859 C G . PASS AF=0.832886 ES:SE:LP:AF:SS:ID -0.00640064:0.00593554:0.55149:0.832886:36052:rs4951859
1 732809 rs12131618 T C . PASS AF=0.083236 ES:SE:LP:AF:SS:ID 0.0143285:0.00777994:1.18365:0.083236:36052:rs12131618
1 734349 rs141242758 T C . PASS AF=0.132061 ES:SE:LP:AF:SS:ID 0.0155058:0.00644472:1.79238:0.132061:36052:rs141242758
1 734462 rs12564807 G A . PASS AF=0.88634 ES:SE:LP:AF:SS:ID 0.0138319:0.00874023:0.944916:0.88634:36052:rs12564807
1 735682 rs138174321 G C . PASS AF=0.04706 ES:SE:LP:AF:SS:ID -0.0252399:0.0129359:1.29209:0.04706:36052:rs138174321
1 736289 rs79010578 T A . PASS AF=0.134639 ES:SE:LP:AF:SS:ID 0.00511974:0.00649569:0.365932:0.134639:36052:rs79010578
1 742990 rs202009397 C T . PASS AF=0.070901 ES:SE:LP:AF:SS:ID 0.0253763:0.00893355:2.34646:0.070901:36052:rs202009397
1 743021 rs3964475 T C . PASS AF=0.277884 ES:SE:LP:AF:SS:ID -0.00464113:0.0056138:0.388928:0.277884:36052:rs3964475
1 743420 rs201920982 G A . PASS AF=0.049864 ES:SE:LP:AF:SS:ID 0.0206885:0.0103565:1.33955:0.049864:36052:rs201920982